专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09133178B2 Alpha-7 nicotinic receptor modulators for the treatment of pain, a psychotic disorder, cognitive impairment or alzheimer'S disease 有权
标题翻译：用于治疗疼痛，精神障碍，认知障碍或阿尔茨海默氏病的α-7烟碱受体调节剂
公开(公告)号：US09133178B2
公开(公告)日：2015-09-15
申请号：US13881962
申请日：2011-10-26
申请人： David Dean , Andrew Lightfoot , Susan Roomans
发明人： David Dean , Andrew Lightfoot , Susan Roomans
IPC分类号： C07D413/14 , C07D413/10 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D405/14
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D405/14 , C07D413/10 , A61K2300/00
摘要： Compounds are disclosed which modulate the α7 nicotinic acetyl choline receptor (nAChR), having the formula (I) wherein the variables are as specified in the description and claims.
摘要翻译：公开了调节具有式（I）的α7烟碱乙酰胆碱受体（nAChR）的化合物，其中变量如说明书和权利要求中所述。

2. 发明申请

US20130310380A1 ALPHA-7 NICOTINIC RECEPTOR MODULATORS FOR THE TREATMENT OF PAIN, A PSYCHOTIC DISORDER, COGNITIVE IMPAIRMENT OR ALZHEIMER'S DISEASE 有权
标题翻译：用于治疗疼痛，心理障碍，认知障碍或阿尔茨海默病的ALPHA-7非诺贝特受体调节剂
公开(公告)号：US20130310380A1
公开(公告)日：2013-11-21
申请号：US13881962
申请日：2011-10-26
申请人： David Dean , Andrew Lightfoot , Susan Roomans
发明人： David Dean , Andrew Lightfoot , Susan Roomans
IPC分类号： C07D413/14 , A61K45/06 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D405/14 , C07D413/10 , A61K2300/00
摘要： Compounds are disclosed which modulate the α7 nicotinic acetyl choline receptor (nAChR), having the formula (I) wherein the variables are as specified in the description and claims.
摘要翻译：公开了调节具有式（I）的α7烟碱乙酰胆碱受体（nAChR）的化合物，其中变量如说明书和权利要求中所述。

3. 发明授权

US08950456B2 Radial tire with specified bead for light heavy-weight vehicle 有权
标题翻译：具有指定珠子的轻型重型车辆的径向轮胎
公开(公告)号：US08950456B2
公开(公告)日：2015-02-10
申请号：US13508855
申请日：2010-10-25
申请人： Christophe Laurent , David Dean , David Lavialle
发明人： Christophe Laurent , David Dean , David Lavialle
IPC分类号： B60C15/06 , B60C15/00 , B60C15/02 , B60B21/10 , B60C1/00
CPC分类号： B60C15/06 , B60B21/104 , B60C1/00 , B60C15/00 , B60C15/0009 , B60C15/02 , B60C15/0607 , B60C2001/0058 , B60C2015/009 , B60C2015/0614 , B60C2015/0617 , B60C2015/0621 , Y10T152/10819 , Y10T152/10828 , Y10T152/10837 , Y10T152/10846
摘要： An assembly including a tire having beads, said bead axially including outside the turn-up a layer of a material defining a bead outer profile, such that the distance A, between the carcass frame and the bead outer profile, is as defined in formula (Z), B being the distance between the end of the turn-up, said bead including first and second profiles between the carcass frame and the turn-up, the first profile extends from the bead wire and is made of a material having an extension secant modulus at a 10% elongation higher than 20 MPa, a second profile arranged in the bead such as to be in contact with a surface of the first profile and the turn-up, made of a material having an extension secant modulus at a 10% elongation of at least 7 MPa and an extension secant modulus at a 100*% extension of at least 4.5 MPa.
摘要翻译：一种包括具有珠的轮胎的组件，所述胎圈在轴向上包括限定出胎圈外轮廓的材料的一层，使得胎体框架和胎圈外轮廓之间的距离A如公式（ Z），B是折叠端部之间的距离，所述胎圈包括胎体框架和翻转之间的第一和第二轮廓，第一轮廓从胎圈丝延伸并且由具有延伸部的材料制成在10％伸长率下高于20MPa的正割模量，布置在胎圈中的第二轮廓，以便与第一轮廓的表面接触，并且由具有10秒的延伸分割模数的材料制成至少7MPa的伸长率和至少4.5MPa的100 *％延伸率的延伸法线模量。

4. 发明授权

US07887358B2 Connector clamp 有权
标题翻译：连接器夹
公开(公告)号：US07887358B2
公开(公告)日：2011-02-15
申请号：US12183006
申请日：2008-07-30
申请人： David Dean
发明人： David Dean
IPC分类号： H01R4/28
CPC分类号： H01R13/6392 , H01R13/512
摘要： A connector clamp, for a hard drive having a first connector for mating with an external connector, having a top clamp and a bottom clamp. The top clamp includes a longitudinal section from which two arms extend, each arm including an integrally formed hole, and a bottom face, wherein a first gasket is attached to the bottom face and contacts the external connector when mated with the first connector. The bottom clamp includes an integrally formed first set of holes to receive a first set of screws for insertion into the hard drive, an integrally formed second set of holes to receive a second set of screws for insertion into the holes of the top clamp, and a top face, wherein a second gasket is attached to the top face and contacts the external connector when mated with the first connector.
摘要翻译：连接器夹具，用于具有用于与外部连接器配合的第一连接器的硬盘驱动器，具有顶部夹具和底部夹具。顶部夹具包括两个臂延伸的纵向部分，每个臂包括一体形成的孔和底面，其中第一垫圈附接到底面并且当与第一连接器配合时接触外部连接器。底部夹具包括一体形成的第一组孔，以容纳用于插入到硬盘驱动器中的第一组螺钉，一体形成的第二组孔，以容纳用于插入顶部夹具的孔中的第二组螺钉，以及顶面，其中第二垫圈附接到顶面并且当与第一连接器配合时接触外部连接器。

5. 发明授权

US07747305B2 Computer-aided-design of skeletal implants 有权
标题翻译：骨骼植入物的计算机辅助设计
公开(公告)号：US07747305B2
公开(公告)日：2010-06-29
申请号：US11299138
申请日：2005-12-09
申请人： David Dean , Kyoung-June Min , Robert A. Ratcheson
发明人： David Dean , Kyoung-June Min , Robert A. Ratcheson
IPC分类号： A61B5/00
CPC分类号： A61F2/30942 , A61F2/2875 , A61F2002/30943 , A61F2002/30952 , B33Y50/00 , B33Y80/00 , G05B2219/45168 , G06F19/00 , G06T17/10 , G16H50/50 , Y10S623/901
摘要： The present invention is directed to a computer aided design method for producing an implant for a patient prior to operation comprising the steps of: generating data with a non-invasive 3D (3-dimensional) scan of the patient's defect site that digitally represents the area that will receive the implant; designing and validating an implant on a computer based on digital data generated from a volume image of the patient; and fabricating the implant based solely on the implant design data generated on computer.
摘要翻译：本发明涉及一种用于在手术之前产生用于患者的植入物的计算机辅助设计方法，包括以下步骤：利用数字地代表所述区域的患者缺陷部位的非侵入式3D（3维）扫描生成数据将接收植入物; 基于从患者的体积图像生成的数字数据来设计和验证计算机上的植入物; 并且仅基于在计算机上产生的植入物设计数据来制造植入物。

6. 发明授权

US07616735B2 Tomosurgery 有权
标题翻译：手术
公开(公告)号：US07616735B2
公开(公告)日：2009-11-10
申请号：US11728927
申请日：2007-03-27
申请人： Robert Maciunas , David Dean , Xiaoliang X. H. Hu
发明人： Robert Maciunas , David Dean , Xiaoliang X. H. Hu
IPC分类号： G21K5/10
CPC分类号： A61N5/103 , A61N5/1084
摘要： Systems, methods, and other embodiments associated with Tomosurgery are described. One method embodiment includes logically dividing a target volume into treatment slices to be radiated individually by co-planar beams. The method embodiment also includes planning a two dimensional path for moving a shaped isocenter through a treatment slice where the isocenter is produced by the intersection of the co-planar beams. The method embodiment also includes planning a three dimensional path for moving the shaped isocenter through the target volume based, at least in part, on two dimensional paths. The method provides a signal to control a radio surgery device to deliver radiation using the coplanar beams to the target volume based, at least in part, on the three dimensional path.
摘要翻译：描述了与手术相关的系统，方法和其它实施例。一个方法实施例包括将目标体积逻辑地划分成待由共平面射束单独辐射的治疗切片。该方法实施例还包括规划用于移动成形等角点通过处理片的二维路径，其中等角点由共平面梁的相交产生。方法实施例还包括规划三维路径，用于至少部分地基于二维路径移动成形的等角点穿过目标体积。该方法提供信号以控制无线电手术装置，以至少部分地基于三维路径，使用共面波束将辐射传送到目标体积。

7. 发明申请

US20070133102A1 REDUCED-FOOTPRINT ILLUMINATION SYSTEM USING HIGHLY-EFFICIENT OPTICAL COLLECTION AND REFLECTION SURFACE(S) AND METHOD FOR MANUFACTURING OPTICAL ELEMENTS USED THEREIN 失效
标题翻译：使用高效的光学收集和反射表面（S）的减少光束照明系统和用于制造其中使用的光学元件的方法
公开(公告)号：US20070133102A1
公开(公告)日：2007-06-14
申请号：US11675252
申请日：2007-02-15
申请人： David Dean , Richard Drumsta , Wieslaw Zaydel , Michelle Winowski-Zaydel
发明人： David Dean , Richard Drumsta , Wieslaw Zaydel , Michelle Winowski-Zaydel
IPC分类号： G02B3/00
CPC分类号： G02B27/0927 , G02B5/02 , G02B27/0994
摘要： An improved optical collection and transmission surface includes a plastic mold injection surface including staggered multiple transmission sites each with a recessed portion in which incident light is not lost during reflection towards the propagation surface. A device implementing the surfaces is plastic-mold injected of high quality acrylic at in a preferred embodiment and can be economically optionally polished or finished to achieve desired quality surfaces.
摘要翻译：改进的光学收集和透射表面包括塑料模具注射表面，该塑料模具注射表面包括交错的多个传输部位，每个传输部位具有凹入部分，入射光在向着传播表面反射期间不会丢失。实施这些表面的装置是在优选实施例中由高质量丙烯酸注塑的塑料模具，并且可经济地任选地抛光或精加工以实现所需的质量表面。

8. 发明申请

US20070098328A1 Molded ferrule with reference surface for end face geometry measurement 有权
标题翻译：用于端面几何测量的带有参考表面的模制套圈
公开(公告)号：US20070098328A1
公开(公告)日：2007-05-03
申请号：US11642214
申请日：2006-12-20
申请人： David Dean , Robert Elkins , James Luther
发明人： David Dean , Robert Elkins , James Luther
IPC分类号： G02B6/38
CPC分类号： G02B6/3865 , G02B6/3839 , G02B6/3863 , G02B6/3885
摘要： A ferrule comprising a molded ferrule body defining fiber bores, an end face of a connective end of the ferrule positioned about the fiber bores, and an integral reference surface for determining the angularity of the end face. The integral reference surface is not machined subsequent to a ferrule molding process and is accessible after assembly of the ferrule body into a connector body. A multi-fiber ferrule comprising a connective end defining an end face, a rear non-connective portion defining a protruding shoulder, and an integral reference datum positioned on a surface of the shoulder accessible for determining the angularity of a plane defined by the end face, wherein the integral datum is accessible when the ferrule is received within a connector body.
摘要翻译：一种套圈，其包括限定纤维孔的模制套圈主体，围绕所述纤维孔定位的所述套圈的连接端的端面以及用于确定所述端面的角度的整体参考表面。整体参考表面在套圈模制过程之后不加工，并且在将套圈主体组装到连接器主体中之后可访问。一种多纤维套管，包括限定端面的连接端，限定突出肩部的后非连接部分和位于肩部的表面上的整体参考基准，用于确定由端面限定的平面的角度，其中当所述套圈被接收在连接器主体内时，所述整体数据是可访问的。

9. 发明申请

US20070025668A1 Fiber optic cables and assemblies for fiber to the subscriber applications 有权
标题翻译：用于光纤到用户应用的光纤电缆和组件
公开(公告)号：US20070025668A1
公开(公告)日：2007-02-01
申请号：US11193516
申请日：2005-07-29
申请人： Jody Greenwood , David Dean , Kenneth Temple , Keith Lail
发明人： Jody Greenwood , David Dean , Kenneth Temple , Keith Lail
IPC分类号： G02B6/44
CPC分类号： G02B6/4404 , G02B6/4411 , G02B6/4433 , G02B6/4475 , G02B6/4494 , G02B6/4495
摘要： A fiber optic cable has at least one optical fiber, at least one strength member having a major strength member dimension, and a cable jacket. The cable jacket has two major surfaces that are generally flat and includes a cavity with a cavity minor dimension generally orientated with a minor dimension of the fiber optic cable, wherein the at least one optical fiber is disposed within the cavity. In one embodiment, the cavity minor dimension of the fiber optic cable is about the same size or larger than the strength member dimension that is generally aligned with a minor dimension of the cable, thereby allowing access to the cavity when the fiber optic cable is entered while inhibiting damage to the at least one optical fiber. Fiber optic cables of the present invention are also suitable as a portion of a cable assembly.
摘要翻译：光纤电缆具有至少一个光纤，至少一个具有主要强度元件尺寸的强度元件和电缆护套。电缆护套具有两个大体平坦的主表面，并且包括具有通常以光纤电缆的小尺寸定向的空腔次尺寸的空腔，其中至少一个光纤设置在空腔内。在一个实施例中，光纤电缆的空腔次尺寸大致或大于通常与电缆的较小尺寸对准的强度构件尺寸，从而当进入光纤电缆时允许进入空腔同时抑制至少一个光纤的损坏。本发明的光纤电缆也适合作为电缆组件的一部分。

10. 发明申请

US20060242725A1 Cell-specific molecule and method for importing DNA into osteoblast nuclei 有权
标题翻译：细胞特异性分子和将DNA导入成骨细胞核的方法
公开(公告)号：US20060242725A1
公开(公告)日：2006-10-26
申请号：US11410579
申请日：2006-04-24
申请人： Donna Strong , Thomas Linkhart , David Dean
发明人： Donna Strong , Thomas Linkhart , David Dean
IPC分类号： A61K48/00 , A01K67/027 , C12Q1/68 , C07H21/04
CPC分类号： A61K48/0058 , C07K14/4702 , C07K2319/09 , C12N15/85 , C12N2800/30 , C12N2830/001 , C12N2830/008 , C12N2830/15 , C12N2830/42 , C12N2830/85 , C12N2840/20
摘要： A plasmid, viral or linear DNA molecule containing a nucleic acid sequence derived from the promoter region of the hCol1α2 gene, which is selectively transported into the nuclei of cells in the osteoblast lineage. The sequence can be used independently as a nuclear entry sequence only, and/or as a nuclear entry sequence without regard to position, in a vector or linear DNA that directs gene expression and nuclear entry. The disclosure further includes a chimeric DNA sequence derived by the addition of osteoblast-specific enhancer sequences to the nuclear entry sequence/promoter sequence, to increase osteoblast-specific expression while retaining osteoblast-specific nuclear import. An enhancer sequence is derived from the promoter region of the human Core Binding Factor alpha 1 (Cbfa1/Runx2) gene. The Cbfa1/Runx2 promoter can be added to the sequence derived from, or alternatively, comprising the promoter region of the hCol1α2 gene. Also provided are methods of use of the novel sequences.
摘要翻译：含有源自hCol1alpha2基因的启动子区域的核酸序列的质粒，病毒或线性DNA分子，其被选择性地转运到成骨细胞谱系中的细胞核中。该序列可以独立地用作核进入序列，和/或作为指导基因表达和核进入的载体或线性DNA中不考虑位置的核进入序列。本公开还包括通过向核进入序列/启动子序列添加成骨细胞特异性增强子序列而衍生的嵌合DNA序列，以增加成骨细胞特异性表达，同时保留成骨细胞特异性核进入。增强子序列衍生自人核心结合因子α1（Cbfa1 / Runx2）基因的启动子区。可以将Cbfa1 / Runx2启动子加入到由hCol1alpha2基因的启动子区域衍生或替代地包含hCol1alpha2基因的启动子区域的序列中。还提供了使用新序列的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式