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2. 发明申请

US20070270383A1 Prodrugs of HIV protease inhibitors 有权
标题翻译： HIV蛋白酶抑制剂的前药
公开(公告)号：US20070270383A1
公开(公告)日：2007-11-22
申请号：US11170197
申请日：2005-06-29
申请人： David DeGoey , William Flosi , David Grampovnik , Larry Klein , Dale Kempf , Xiu Wang
发明人： David DeGoey , William Flosi , David Grampovnik , Larry Klein , Dale Kempf , Xiu Wang
IPC分类号： A61K31/675 , A61P31/18 , C07F9/09
CPC分类号： A61K45/06 , A61K31/661 , A61K2300/00
摘要： A compound of the formula is disclosed as a prodrug of an HIV protease inhibitor. Methods and compositions for inhibiting HIV protease activity and treating HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂的前药。还公开了用于抑制HIV蛋白酶活性和治疗HIV感染的方法和组合物。

3. 发明申请

US20050131042A1 HIV protease inhibiting compounds 审中-公开
标题翻译： HIV蛋白酶抑制化合物
公开(公告)号：US20050131042A1
公开(公告)日：2005-06-16
申请号：US10733915
申请日：2003-12-11
申请人： Charles Flentge , Hui-Ju Chen , David DeGoey , William Flosi , David Grampovnik , Peggy Huang , Dale Kempf , Larry Klein , Allan Krueger , Darold Madigan , John Randolph , Minghua Sun , Ming Yeung , Chen Zhao
发明人： Charles Flentge , Hui-Ju Chen , David DeGoey , William Flosi , David Grampovnik , Peggy Huang , Dale Kempf , Larry Klein , Allan Krueger , Darold Madigan , John Randolph , Minghua Sun , Ming Yeung , Chen Zhao
IPC分类号： A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07C311/17 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
CPC分类号： C07D471/04 , A61K31/175 , A61K31/18 , A61K31/195 , A61K31/277 , A61K31/4168 , A61K31/65 , A61K45/06 , C07D213/30 , C07D213/40 , C07D213/78 , C07D233/32 , C07D233/72 , C07D277/28 , C07D277/46 , C07D277/48 , C07D307/20 , C07D307/42 , C07D401/06 , C07D403/06 , C07D403/10 , C07D405/06 , C07D405/10 , C07D409/06 , C07D417/06 , C07D417/14 , C07D493/04 , A61K2300/00
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

4. 发明申请

US20050159469A1 HIV protease inhibiting compounds 有权
公开(公告)号：US20050159469A1
公开(公告)日：2005-07-21
申请号：US11010177
申请日：2004-12-10
申请人： John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
发明人： John Randolph , Hui-Ju Chen , David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Peggy Huang , Douglas Hutchinson , Dale Kempf , Larry Klein , Ming Yeung
IPC分类号： A61K31/4166 , A61K31/4178 , C07C243/24 , C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D43/02
CPC分类号： C07C271/22 , C07D401/06 , C07D401/14 , C07D403/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

5. 发明申请

US20050131017A1 HIV protease inhibiting compounds 审中-公开
公开(公告)号：US20050131017A1
公开(公告)日：2005-06-16
申请号：US10733946
申请日：2003-12-11
申请人： David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein
发明人： David DeGoey , Charles Flentge , William Flosi , David Grampovnik , Dale Kempf , Larry Klein
IPC分类号： C07D213/30 , C07D213/40 , C07D401/06 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04 , A61K31/4709 , A61K31/427 , A61K31/4439 , C07D417/02 , C07D43/02
CPC分类号： C07D401/06 , C07D213/30 , C07D213/40 , C07D401/12 , C07D401/14 , C07D417/06 , C07D417/14 , C07D471/04 , C07D493/04
摘要： A compound of the formula is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.

6. 发明申请

US20070197558A1 ANTI-VIRAL COMPOUNDS 有权
标题翻译：反虚构化合物
公开(公告)号：US20070197558A1
公开(公告)日：2007-08-23
申请号：US11613825
申请日：2006-12-20
申请人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号： A61K31/519 , C07D498/02 , C07D487/02
CPC分类号： C07D487/04 , C07D471/04 , C07D475/06 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
摘要翻译：公开了有效抑制丙型肝炎病毒（“HCV”）或其他病毒复制的化合物。本发明还涉及包含这些化合物的组合物，这些化合物与其它抗病毒剂或治疗剂的共同配制或共同给药，用于合成这些化合物的方法和中间体，以及使用这些化合物治疗 HCV或其他病毒感染。

7. 发明申请

US20070232627A1 ANTI-VIRAL COMPOUNDS 有权
公开(公告)号：US20070232627A1
公开(公告)日：2007-10-04
申请号：US11613810
申请日：2006-12-20
申请人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
发明人： David Betebenner , David DeGoey , Clarence Maring , Allan Krueger , Nobuhiko Iwasaki , Todd Rockway , Curt Cooper , David Anderson , Pamela Donner , Brian Green , Dale Kempf , Dachun Liu , Keith McDaniel , Darold Madigan , Christopher Motter , John Pratt , Jason Shanley , Michael Tufano , Rolf Wagner , Rong Zhang , Akhteruzzaman Molla , Hongmei Mo , Tami Pilot-Matias , Sherie Masse , Robert Carrick , Wenping He , Liangjun Lu , David Grampovnik
IPC分类号： A61K31/519 , A61K31/4375 , C07D239/70 , C07D471/02 , C12N7/06
CPC分类号： C07D471/04 , C07D495/04 , C07D513/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.

8. 发明申请

US20060199851A1 Novel compounds that are useful for improving pharmacokinetics 有权
标题翻译：可用于改善药代动力学的新型化合物
公开(公告)号：US20060199851A1
公开(公告)日：2006-09-07
申请号：US11366172
申请日：2006-03-02
申请人： Dale Kempf , Charles Flentge , John Randolph , Peggy Huang , Larry Klein
发明人： Dale Kempf , Charles Flentge , John Randolph , Peggy Huang , Larry Klein
IPC分类号： A61K31/427 , A61K31/426 , C07D417/02 , C07D277/38
CPC分类号： C07D277/30 , A61K31/426 , A61K31/427 , A61K45/06 , C07C53/18 , C07D213/30 , C07D231/12 , C07D233/64 , C07D263/32 , C07D277/24 , C07D277/38 , C07D277/587 , C07D333/16 , C07D417/04
摘要： Novel compounds of formula 1 or a pharmaceutically acceptable salt thereof inhibit cytochrome P450 monooxygenase.
摘要翻译：新的式1化合物或其药学上可接受的盐抑制细胞色素P450单加氧酶。

9. 发明申请

US20130299010A1 WATER CONTROL FIXTURE HAVING BYPASS VALVE 有权
标题翻译：带旁路阀的水控制件
公开(公告)号：US20130299010A1
公开(公告)日：2013-11-14
申请号：US13944729
申请日：2013-07-17
申请人： Ken Lum , Dale Kempf
发明人： Dale Kempf , Ken Lum
IPC分类号： F24D17/00
CPC分类号： F24D17/0078 , E03B7/045 , E03B7/09 , F16K31/002 , G05D23/022 , G05D23/134 , Y02A20/411 , Y10T137/6416 , Y10T137/6497
摘要： A water control fixture includes a fixture body in fluid communication with a pressurized supply of hot water and a pressurized supply of cold water. The fixture body interconnects the supply of hot water and the supply of cold water. The fixture body has a spout outlet configured to dispense water from the fixture body. At least one operating valve is coupled to the fixture body for controlling a flow of water to the spout outlet. A bypass valve is disposed in the fixture body for controlling a recirculating flow of water through the fixture body. The bypass valve blocks and permits recirculating flow from the supply of hot water to the supply of cold water based on a temperature of the water.
摘要翻译：水控夹具包括与加压供水的热水和加压供水的冷水流体连通的固定体。夹具主体将热水供应和冷水供应相互连接。夹具本体具有喷出口，其配置成从夹具本体分配水。至少一个操作阀连接到夹具本体上，用于控制到喷口出口的水流。旁通阀设置在固定体内，用于控制通过夹具本体的水的循环流动。旁通阀阻挡并允许基于水的温度从热水供应到冷水供应的循环流动。

10. 发明申请

US20130180611A1 WATER CONTROL FIXTURE HAVING AUXILIARY FUNCTIONS 审中-公开
标题翻译：具有辅助功能的水控制件
公开(公告)号：US20130180611A1
公开(公告)日：2013-07-18
申请号：US13552348
申请日：2012-07-18
申请人： Ken Lum , Dale Kempf
发明人： Ken Lum , Dale Kempf
IPC分类号： E03B7/04
CPC分类号： E03B7/04 , E03B1/048 , E03B7/045 , F24D17/00 , F24D17/0094 , Y10T137/6497 , Y10T137/86815 , Y10T137/87249
摘要： A water control fixture includes a housing having a plurality of ports defining a hot water inlet port, a cold water port, a fixture outlet port, and an auxiliary port. A flow control unit is configured to be selectively positioned in fluid communication with different combinations of the plurality of ports, wherein the flow control unit has a main passage in fluid communication with the hot water inlet port, the cold water port, and the fixture outlet port. The flow control unit controls the flow of water from the hot water inlet port and the cold water port to the fixture outlet port. The flow control unit has an auxiliary passage in fluid communication with the auxiliary port and at least one of the hot water inlet port, the cold water port, and the fixture outlet port to perform an auxiliary function.
摘要翻译：一种水控制器具包括具有限定热水入口端口的多个端口的壳体，冷水端口，固定器出口端口和辅助端口。流量控制单元被配置为选择性地定位成与多个端口的不同组合流体连通，其中流量控制单元具有与热水入口端口，冷水端口和固定出口流体连通的主通道港口。流量控制单元控制从热水入口和冷水端口到固定器出口的水流。流量控制单元具有与辅助端口和热水入口端口，冷水端口和固定器出口端口中的至少一个流体连通的辅助通道，以执行辅助功能。

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