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1. 发明授权

US09274518B2 Industrial control energy object 有权
公开(公告)号：US09274518B2
公开(公告)日：2016-03-01
申请号：US13275983
申请日：2011-10-18
申请人： Ramdas M. Pai , David A. Vasko , David D. Brandt , Richard A. Morgan , David W. Siegler , Angel Sustaeta
发明人： Ramdas M. Pai , David A. Vasko , David D. Brandt , Richard A. Morgan , David W. Siegler , Angel Sustaeta
IPC分类号： G05B19/00 , G05B19/418 , H02J13/00
CPC分类号： G05B19/4186 , G05B2219/31414 , G05B2219/32021 , H02J13/0013 , Y02P70/161 , Y02P80/114 , Y02P90/14 , Y02P90/18 , Y02P90/185 , Y02P90/205
摘要： An energy object extension to an industrial protocol having a comprehensive suite of attributes, messages and services utilized for the monitoring and control of energy consuming or producing resources by a manufacturing automation application is provided. The energy object includes an identifier associated with an energy resource that is associated with a manufacturing automation application and an energy type associated with the energy resource. This includes a measurement characteristic associated with the energy resource to facilitate energy management by the manufacturing automation application.

2. 发明申请

US20130096727A1 INDUSTRIAL CONTROL ENERGY OBJECT 有权
标题翻译：工业控制能源对象
公开(公告)号：US20130096727A1
公开(公告)日：2013-04-18
申请号：US13275983
申请日：2011-10-18
申请人： David D. Brandt , David A. Vasko , Ramdas M. Pai , Richard A. Morgan , David W. Siegler , Angel Sustaeta
发明人： David D. Brandt , David A. Vasko , Ramdas M. Pai , Richard A. Morgan , David W. Siegler , Angel Sustaeta
IPC分类号： G05B15/00
CPC分类号： G05B19/4186 , G05B2219/31414 , G05B2219/32021 , H02J13/0013 , Y02P70/161 , Y02P80/114 , Y02P90/14 , Y02P90/18 , Y02P90/185 , Y02P90/205
摘要： An energy object extension to an industrial protocol having a comprehensive suite of attributes, messages and services utilized for the monitoring and control of energy consuming or producing resources by a manufacturing automation application is provided. The energy object includes an identifier associated with an energy resource that is associated with a manufacturing automation application and an energy type associated with the energy resource. This includes a measurement characteristic associated with the energy resource to facilitate energy management by the manufacturing automation application.
摘要翻译：提供了具有用于由制造自动化应用监视和控制能量消耗或生产资源的综合性属性，消息和服务的工业协议的能量对象扩展。能量对象包括与与制造自动化应用相关联的能量资源和与能量资源相关联的能量类型相关联的标识符。这包括与能量资源相关联的测量特性，以促进制造自动化应用的能量管理。

3. 发明授权

US09345748B2 Anti-SSX-2 T cell receptors and related materials and methods of use 有权
标题翻译：抗SSX-2 T细胞受体及相关材料及使用方法
公开(公告)号：US09345748B2
公开(公告)日：2016-05-24
申请号：US13820802
申请日：2011-09-14
申请人： Richard A. Morgan , Nachimuthu Chinnasamy , Dhanalakshmi Chinnasamy , Steven A. Rosenberg
发明人： Richard A. Morgan , Nachimuthu Chinnasamy , Steven A. Rosenberg
IPC分类号： A61K39/00 , A61K38/17 , C07K14/725 , A61K31/706 , A61K38/08 , A61K38/10 , C07K16/28
CPC分类号： A61K38/1774 , A61K31/706 , A61K38/08 , A61K38/10 , A61K38/177 , A61K39/39558 , C07K14/7051 , C07K16/2809 , C07K16/30 , C07K2319/00 , G01N33/57492
摘要： The invention provides an isolated or purified T cell receptor (TCR) having antigenic specificity for synovial sarcoma X Breakpoint (SSX)-2. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells. Further provided by the invention are antibodies, or an antigen binding portion thereof, and pharmaceutical compositions relating to the TCRs of the invention. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are further provided by the invention.
摘要翻译：本发明提供了对滑膜肉瘤X断裂点（SSX）-2具有抗原特异性的分离或纯化的T细胞受体（TCR）。本发明还提供了相关的多肽和蛋白质，以及相关的核酸，重组表达载体，宿主细胞和细胞群。本发明进一步提供的是抗体或其抗原结合部分，以及与本发明的TCR有关的药物组合物。通过本发明进一步提供了检测宿主中癌症存在的方法以及在宿主中治疗或预防癌症的方法。

4. 发明授权

US09266960B2 Anti-epidermal growth factor receptor variant III chimeric antigen receptors and use of same for the treatment of cancer 有权
标题翻译：抗表皮生长因子受体变体III嵌合抗原受体及其用途用于治疗癌症
公开(公告)号：US09266960B2
公开(公告)日：2016-02-23
申请号：US14110189
申请日：2012-03-21
申请人： Richard A. Morgan , Steven A. Rosenberg
发明人： Richard A. Morgan , Steven A. Rosenberg
IPC分类号： C07K16/32 , C07K14/705 , C07K14/725 , C07K16/28 , C07K16/30 , A61K39/00 , A61K38/00
CPC分类号： C07K16/32 , A61K38/00 , A61K48/00 , A61K2039/505 , C07K14/70503 , C07K14/7051 , C07K14/70517 , C07K14/70521 , C07K14/70575 , C07K14/70578 , C07K14/70596 , C07K16/2863 , C07K16/3053 , C07K2317/21 , C07K2319/00 , C07K2319/02 , C07K2319/03 , C07K2319/30 , C07K2319/70 , G01N33/57492 , G01N2333/71
摘要： The disclosure provides chimeric antigen receptors (CARs) comprising an antigen binding domain of human antibody 139, an extracellular hinge domain, a transmembrane domain, and an intracellular domain T cell receptor signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a host and methods of treating or preventing cancer in a host are also disclosed.
摘要翻译：本公开提供包含人抗体139的抗原结合结构域，细胞外铰链结构域，跨膜结构域和细胞内结构域T细胞受体信号结构域的嵌合抗原受体（CAR）。公开了核酸，重组表达载体，宿主细胞，细胞群，抗体或其抗原结合部分以及与CAR相关的药物组合物。还公开了检测宿主中癌症存在的方法和治疗或预防宿主中的癌症的方法。

5. 发明申请

US20100034834A1 MODIFIED T CELL RECEPTORS AND RELATED MATERIALS AND METHODS 有权
标题翻译：改良的T细胞受体及相关材料与方法
公开(公告)号：US20100034834A1
公开(公告)日：2010-02-11
申请号：US12443111
申请日：2007-09-26
申请人： Paul F. Robbins , Richard A. Morgan , Steven A. Rosenberg , Alan David Bennett
发明人： Paul F. Robbins , Richard A. Morgan , Steven A. Rosenberg , Alan David Bennett
IPC分类号： A61K39/395 , C07K16/30 , C12N15/11 , C12N15/00 , C12N5/10 , G01N33/53 , G01N33/574 , C12Q1/68
CPC分类号： G01N33/505 , A61K38/00 , C07K14/7051 , G01N33/5091
摘要： The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with no more than three amino acid substitutions, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expressed by CD4+ T cells and (ii) does not exhibit a decrease in antigen specificity when expressed by CD8+ T cells. Polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions related to the modified TCR also are part of the invention. Further, the invention is directed to methods of detecting a diseased cell in a host, methods of treating or preventing a disease in a host, and methods of identifying a candidate adoptive immunotherapy TCR.
摘要翻译：本发明涉及包含不超过三个氨基酸取代的野生型（WT）TCR的氨基酸序列的修饰的T细胞受体（TCR），其中与WT TCR相比，修饰的TCR（i ）当由CD4 + T细胞表达时具有增强的识别靶细胞的能力，和（ii）当由CD8 + T细胞表达时不显示抗原特异性的降低。多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体和与修饰的TCR相关的药物组合物也是本发明的一部分。此外，本发明涉及检测宿主中的病变细胞的方法，治疗或预防宿主疾病的方法，以及鉴定候选的过继性免疫治疗TCR的方法。

6. 发明授权

US5464904A Low-melting tetrafluoroethylene copolymer and its uses 失效
公开(公告)号：US5464904A
公开(公告)日：1995-11-07
申请号：US341046
申请日：1994-11-16
申请人： George R. Chapman, Jr. , Lewis E. Crenshaw , Rita S. McMinn , Richard A. Morgan , Donnan E. Priester , Charles W. Stewart , Robert E. Tarney
发明人： George R. Chapman, Jr. , Lewis E. Crenshaw , Rita S. McMinn , Richard A. Morgan , Donnan E. Priester , Charles W. Stewart , Robert E. Tarney
IPC分类号： C08F214/26 , C08L23/02 , C09D127/18 , C08F214/16 , C08F214/28
CPC分类号： C08F214/26 , C08F214/262 , C08L23/0815 , C09D127/18 , C08L27/18 , C08L27/20
摘要： Copolymers of tetrafluoroethylene (TFE) and hexafluoropropylene (HFP) having high HFP content and end-of-melting temperature, T.sub.m (end), as low as 200.degree. C. are disclosed. Exceptional performance as a processing aid in polyolefins results from having T.sub.m (end) of the TFE/HFP copolymer close to the processing temperature of the polyolefin. These TFE/HFP copolymers are soluble in fluorinated cyclic solvents. Copolymer/solvent systems copolymer at significant concentrations in selected solvents are fluid and stable at room temperature.

7. 发明授权

US4952636A Modified polytetrafluoroethylene resins and blends thereof 失效
公开(公告)号：US4952636A
公开(公告)日：1990-08-28
申请号：US431947
申请日：1989-11-06
申请人： Richard A. Morgan , Charles W. Stewart
发明人： Richard A. Morgan , Charles W. Stewart
IPC分类号： C08F214/26 , C08F259/08 , C08L27/18 , C08L51/06
CPC分类号： C08L27/18 , C08F214/26 , C08F259/08 , C08L51/06 , Y10S525/902
摘要： Dispersion-process-produced, non-melt-processible, particulate, core-shell, tetrafluoroethylene copolymer comprising recurring units of tetrafluoroethylene and modifying recurring units of at least one ethylenically unsaturated comonomer that is copolymerizable with the tetrafluoroethylene, the number of recurring units of comonomer in the shell being sufficient to enable the copolymer to compound uniformly with an elastomer or plastic without forming visible agglomerates, and blends thereof with elastomeric and plastic resins.

8. 发明授权

US4876492A Electronically commutated motor driven apparatus including an impeller in a housing driven by a stator on the housing 失效
标题翻译：电动换向马达驱动装置，其包括在由外壳上的定子驱动的壳体中的叶轮
公开(公告)号：US4876492A
公开(公告)日：1989-10-24
申请号：US160526
申请日：1988-02-26
申请人： Gene D. Lester , Richard A. Morgan , Harold B. Harms , John P. Barrett , Tsung K. Chang , Donald S. Cushing , Richard F. Broo , William M. Hood
发明人： Gene D. Lester , Richard A. Morgan , Harold B. Harms , John P. Barrett , Tsung K. Chang , Donald S. Cushing , Richard F. Broo , William M. Hood
IPC分类号： F01P7/16 , F04D3/02 , F04D13/06 , H02K5/12 , H02K5/128 , H02K7/14 , H02K29/00
CPC分类号： F04D13/06 , F01P7/164 , F04D3/02 , H02K5/12 , H02K7/14 , H02K5/128
摘要： An apparatus for pumping fluid such as an integral pump/motor is provided. A housing having an inlet and an outlet has a rotatable assembly including an impeller located within and adapted to rotate within the housing to move fluid through the housing from the inlet to the outlet. Secured to the exterior of the housing is a stationary assembly for applying an electromagnetic field through the housing to and around the impeller to rotate the impeller and thereby to cause it to move fluid through the housing.The apparatus is for use in a cooling system, such as a cooling system of an automobile engine, to pump fluid through the cooling system. A temperature sensor is provided for sensing the temperature of the fluid within the cooling system. An electronic control, responsive to the temperature sensor, supplies electrical power to stationary assembly.Also, a method of circulating fluid within a system, such as a cooling system of an automobile engine, is disclosed. An electromagnetic field is applied through a housing to and around a rotatable assembly including an impeller located in the housing thereby to axially rotate the impeller and cause it to move fluid through the housing.
摘要翻译：提供了一种用于泵送流体的装置，例如一体式泵/马达。具有入口和出口的壳体具有可旋转组件，其包括位于壳体内并适于在壳体内旋转的叶轮以将流体从入口移动到出口。安装在壳体外部的是固定的组件，用于将电磁场通过壳体施加到叶轮周围并绕叶轮旋转叶轮，从而使其将流体移动通过壳体。该装置用于诸如汽车发动机的冷却系统的冷却系统中以将流体泵送通过冷却系统。提供温度传感器用于感测冷却系统内的流体的温度。响应于温度传感器的电子控制器向固定组件提供电力。另外，公开了一种在诸如汽车发动机的冷却系统的系统内循环流体的方法。电磁场通过壳体施加到包括位于壳体中的叶轮的可旋转组件上并围绕其旋转，从而轴向地旋转叶轮并使其将流体移动通过壳体。

9. 发明授权

US09128080B2 Modified T cell receptors and related materials and methods 有权
标题翻译：改良T细胞受体及相关材料及方法
公开(公告)号：US09128080B2
公开(公告)日：2015-09-08
申请号：US13304841
申请日：2011-11-28
申请人： Paul F. Robbins , Richard A. Morgan , Steven A. Rosenberg
发明人： Paul F. Robbins , Richard A. Morgan , Steven A. Rosenberg
IPC分类号： C07H21/04 , G01N33/50 , C07K14/725 , A61K38/00
CPC分类号： G01N33/505 , A61K38/00 , C07K14/7051 , G01N33/5091
摘要： The invention is directed to a modified T cell receptor (TCR) comprising an amino acid sequence of a wild-type (WT) TCR with no more than three amino acid substitutions, wherein the modified TCR, as compared to the WT TCR, (i) has an enhanced ability to recognize target cells when expressed by CD4+ T cells and (ii) does not exhibit a decrease in antigen specificity when expressed by CD8+ T cells. Polypeptides, proteins, nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, and pharmaceutical compositions related to the modified TCR also are part of the invention. Further, the invention is directed to methods of detecting a diseased cell in a host, methods of treating or preventing a disease in a host, and methods of identifying a candidate adoptive immunotherapy TCR.
摘要翻译：本发明涉及包含不超过三个氨基酸取代的野生型（WT）TCR的氨基酸序列的修饰的T细胞受体（TCR），其中与WT TCR相比，修饰的TCR（i ）当由CD4 + T细胞表达时具有增强的识别靶细胞的能力，和（ii）当由CD8 + T细胞表达时不显示抗原特异性的降低。多肽，蛋白质，核酸，重组表达载体，宿主细胞，细胞群，抗体和与修饰的TCR相关的药物组合物也是本发明的一部分。此外，本发明涉及检测宿主中的病变细胞的方法，治疗或预防宿主疾病的方法，以及鉴定候选的过继性免疫治疗TCR的方法。

10. 发明授权

US07819053B2 Method and system for molding chocolate utilizing an air knife and products made 有权
标题翻译：使用气刀成型巧克力的方法和系统
公开(公告)号：US07819053B2
公开(公告)日：2010-10-26
申请号：US11410207
申请日：2006-04-25
申请人： John M. Kaiser , Dale R. Slesser , Dominic M. Diperna , Richard A. Morgan , Rick A. Floyd , Robert A. Parker , Robert Harvey
发明人： John M. Kaiser , Dale R. Slesser , Dominic M. Diperna , Richard A. Morgan , Rick A. Floyd , Robert A. Parker , Robert Harvey
IPC分类号： A23G1/21 , A23G1/26
CPC分类号： A23G3/007 , A23G3/0072 , A23G7/0093
摘要： Prior to cooling, an air knife is used to remove bubbles from confectionery-filled chocolates, preferably center-filled chocolates, deposited in a mold tray, preferably using a one-shot depositor. Using the method and apparatus, it is possible to manufacture novel confectionery products, including one-shot deposited caramel-filled dark chocolates.
摘要翻译：在冷却之前，使用气刀来从放置在模托盘中的糖果装满的巧克力，优选中心填充的巧克力中，优选地使用一次存放器去除气泡。使用该方法和装置，可以制造新的糖果产品，包括一次沉淀的焦糖填充的暗巧克力。

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