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1. 发明授权

US6093725A Frangible compounds for pathogen inactivation 失效
公开(公告)号：US6093725A
公开(公告)日：2000-07-25
申请号：US3115
申请日：1998-01-06
申请人： David Cook , John E. Merritt , Aileen Nerio , Henry Rapoport , Adonis Stassinopoulos , Susan Wollowitz , Jan Matejovic
发明人： David Cook , John E. Merritt , Aileen Nerio , Henry Rapoport , Adonis Stassinopoulos , Susan Wollowitz , Jan Matejovic
IPC分类号： A61L2/00 , A61M1/02 , B01J20/28 , C07D219/10 , C07D405/12 , C07D493/04 , C07F9/64 , A61K31/44 , C07D219/08
CPC分类号： C07D405/12 , A61L2/0082 , A61L2/0088 , A61M1/0209 , B01J20/28 , C07D219/10 , C07D493/04 , C07F9/64
摘要： Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.

2. 发明授权

US06514987B1 Frangible compounds for pathogen inactivation 有权
标题翻译：用于病原体灭活的易碎化合物
公开(公告)号：US06514987B1
公开(公告)日：2003-02-04
申请号：US09610652
申请日：2000-07-02
申请人： David Cook , John E. Merritt , Aileen Nerio , Henry Rapoport , Adonis Stassinopoulos , Susan Wollowitz , Jan Matejovic , William A. Denny
发明人： David Cook , John E. Merritt , Aileen Nerio , Henry Rapoport , Adonis Stassinopoulos , Susan Wollowitz , Jan Matejovic , William A. Denny
IPC分类号： A61K3144
CPC分类号： C07D405/12 , A61L2/0082 , A61M1/0209 , B01J20/28 , C07D219/10 , C07D493/04 , C07F9/64
摘要： Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to treat materials intended for in vitro or in vivo use, such as clinical testing or transfusion. The compounds are designed to specifically bind to and react with nucleic acid, and then to degrade to form breakdown products. The degradation reaction is preferably slower than the reaction with nucleic acid.
摘要翻译：描述了用于灭活材料中的病原体的化合物和方法，包括用于灭活生物材料如红细胞制剂和血浆中的病原体的组合物和方法。化合物和方法可以用于治疗用于体外或体内使用的物质，例如临床试验或输血。该化合物被设计成与核酸特异性结合并与其反应，然后降解以形成分解产物。降解反应优选比与核酸的反应更慢。

3. 发明授权

US5559250A Treating red blood cell solutions with anti-viral agents 失效
标题翻译：用抗病毒剂治疗红细胞溶液
公开(公告)号：US5559250A
公开(公告)日：1996-09-24
申请号：US464471
申请日：1995-06-05
申请人： David Cook , Susan Wollowitz , Aileen Nerio
发明人： David Cook , Susan Wollowitz , Aileen Nerio
IPC分类号： C12Q1/00 , A61K31/47 , A61K31/473 , A61K35/16 , A61L2/00 , A61P31/12 , C07D219/12 , C07D219/14 , C07D493/04 , C12N1/20 , C12N5/06 , C12N5/08 , C12N7/04 , C12N7/06 , C12Q1/68
CPC分类号： C07D493/04 , A61L2/0088 , C07D219/12 , C12N7/00 , C12N2730/10163 , C12N2740/16063 , C12N2795/18163
摘要： Novel compounds for photodecontaminating biological material which are compatible with clinical testing, in that they do not interfere with serum analytes.
摘要翻译：用于光临化生物材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

4. 发明授权

US6143490A Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety 失效
标题翻译：用具有芥末和核酸结合部分的化合物治疗血液或血液制品
公开(公告)号：US6143490A
公开(公告)日：2000-11-07
申请号：US476842
申请日：1995-06-07
申请人： David Cook , Susan Wollowitz , Aileen Nerio
发明人： David Cook , Susan Wollowitz , Aileen Nerio
IPC分类号： C12Q1/00 , A61K31/47 , A61K31/473 , A61K35/16 , A61L2/00 , A61P31/12 , C07D219/12 , C07D219/14 , C07D493/04 , C12N1/20 , C12N5/06 , C12N5/08 , C12N7/04 , C12N7/06 , C12Q1/68 , A01N1/02
CPC分类号： C07D493/04 , A61L2/0088 , C07D219/12 , C12N7/00 , C12N2730/10163 , C12N2740/16063 , C12N2795/18163
摘要： Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
摘要翻译：描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。该技术处理大量人血清而不损害检测结果。还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

5. 发明授权

US06410219B1 Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid binding group 失效
标题翻译：用具有芥末，氮基或氮丙啶基团的化合物和核酸结合基团处理血液或血液制品
公开(公告)号：US06410219B1
公开(公告)日：2002-06-25
申请号：US09539226
申请日：2000-03-30
申请人： David Cook , Susan Wollowitz , Aileen Nerio
发明人： David Cook , Susan Wollowitz , Aileen Nerio
IPC分类号： A01N102
CPC分类号： C07D493/04 , A61K35/16 , A61L2/0088 , A61L2/18 , C07D219/12 , C12N7/00 , C12N7/04 , C12N2730/10163 , C12N2740/16063 , C12N2795/18163
摘要： Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
摘要翻译：描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。该技术处理大量人血清而不损害检测结果。还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

6. 发明授权

US06177441B1 Treating red blood cell solutions with anti-viral agents 失效
标题翻译：用抗病毒剂治疗红细胞溶液
公开(公告)号：US06177441B1
公开(公告)日：2001-01-23
申请号：US09012702
申请日：1998-01-23
申请人： David Cook , Susan Wollowitz , Aileen Nerio
发明人： David Cook , Susan Wollowitz , Aileen Nerio
IPC分类号： A61K3144
CPC分类号： A61K31/473 , A61K31/37 , A61K31/396 , A61K31/4025 , A61K31/496 , A61K31/5415 , A61L2/0082 , A61M1/3687
摘要： Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results.
摘要翻译：描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。该技术处理大量人血清而不损害检测结果。

7. 发明授权

US06171777B2 Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety 失效
标题翻译：用具有芥末和核酸结合部分的化合物治疗血液或血液制品
公开(公告)号：US06171777B2
公开(公告)日：2001-01-09
申请号：US08486821
申请日：1995-06-07
申请人： David Cook , Susan Wollowitz , Aileen Nerio
发明人： David Cook , Susan Wollowitz , Aileen Nerio
IPC分类号： A01N102
CPC分类号： C07D493/04 , A61K35/16 , A61L2/0088 , A61L2/18 , C07D219/12 , C12N7/00 , C12N7/04 , C12N2730/10163 , C12N2740/16063 , C12N2795/18163
摘要： Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes.
摘要翻译：描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。该技术处理大量人血清而不损害检测结果。还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。

8. 发明授权

US5691132A Method for inactivating pathogens in red cell compositions using quinacrine mustard 失效
标题翻译：使用喹吖啶芥末灭活红细胞组合物中病原体的方法
公开(公告)号：US5691132A
公开(公告)日：1997-11-25
申请号：US338040
申请日：1994-11-14
申请人： Susan Wollowitz , David Cook , Aileen Nerio
发明人： Susan Wollowitz , David Cook , Aileen Nerio
IPC分类号： C12Q1/00 , A61K31/47 , A61K31/473 , A61K35/16 , A61L2/00 , A61P31/12 , C07D219/12 , C07D219/14 , C07D493/04 , C12N1/20 , C12N5/06 , C12N5/08 , C12N7/04 , C12N7/06 , C12Q1/68 , A01N1/02 , A01N63/00 , A01N43/42
CPC分类号： C07D493/04 , A61L2/0088 , C07D219/12 , C12N7/00 , C12N2730/10163 , C12N2740/16063 , C12N2795/18163
摘要： Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques handle large volumes of human serum without impairing the testing results. Novel compounds for photodecontaminating biological material are also contemplated which are compatible with clinical testing, in that they do not interfere with serum analytes. In particular, quinacrine mustard is used to inactivate pathogens in red cell compositions with retention of red cell function.
摘要翻译：描述了用于治疗材料中病原体的方法和组合物，包括在临床实验室中加工之前对人体流体进行净化的方法以及在体内使用之前对血液制品进行净化的方法。该技术处理大量人血清而不损害检测结果。还考虑了用于光生化材料的新型化合物，其与临床测试相容，因为它们不干扰血清分析物。特别地，奎纳克林芥末用于灭活具有红细胞功能的红细胞组合物中的病原体。

9. 发明授权

US06709810B2 Methods for quenching pathogen inactivators in biological materials 有权
标题翻译：在生物材料中淬灭病原体灭活剂的方法
公开(公告)号：US06709810B2
公开(公告)日：2004-03-23
申请号：US09912031
申请日：2001-07-23
申请人： David Cook , Adonis Stassinopoulos
发明人： David Cook , Adonis Stassinopoulos
IPC分类号： A01N102
CPC分类号： A61L2/0088
摘要： Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. Biological materials which may be treated include whole blood, red blood cells, blood plasma, and platelets. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.
摘要翻译：提供了用于猝灭病原体灭活化合物在生物材料中的不希望的副反应的方法。在一个具体实施方案中，提供了用于猝灭病原体灭活化合物的不希望的副反应的方法，其包括可亲电子基团或能够形成亲电基团的官能团。在该实施方案中，用病原体灭活化合物和猝灭剂处理材料，其中猝灭剂包含能够与亲电子基团共价反应的亲核官能团。病原体灭活化合物上的亲电基团优选为非自由基阳离子基团。在一个实施方案中，病原体灭活化合物包括核酸结合配体和芥子基团，其中芥末基团能够在原位反应形成亲电子基团。优选的猝灭剂是硫醇，如谷胱甘肽。可以治疗的生物材料包括全血，红细胞，血浆和血小板。该方法允许在病原体灭活期间抑制含红细胞的材料中的红细胞的修饰。

10. 发明授权

US06270952B1 Methods for quenching pathogen inactivators in biological materials 失效
标题翻译：在生物材料中淬灭病原体灭活剂的方法
公开(公告)号：US06270952B1
公开(公告)日：2001-08-07
申请号：US09110776
申请日：1998-07-06
申请人： David Cook , Adonis Stassinopoulos
发明人： David Cook , Adonis Stassinopoulos
IPC分类号： A01N102
CPC分类号： A61L2/0088
摘要： Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functional group which is, or which is capable of forming, an electrophilic group. In this embodiment, the material is treated with the pathogen inactivating compound and a quencher, wherein the quencher comprises a nucleophilic functional group that is capable of covalently reacting with the electrophilic group. The electrophilic group on the pathogen inactivating compound is preferably a non-radical cationic group. In one embodiment, the pathogen inactivating compound includes a nucleic acid binding ligand and a mustard group, wherein the mustard group is capable of reacting in situ to form the electrophilic group. Preferred quenchers are thiols, such as glutathione. Biological materials which may be treated include whole blood, red blood cells, blood plasma, and platelets. The methods permit inhibition of the modification of red blood cells in red blood cell containing materials during pathogen inactivation.
摘要翻译：提供了用于猝灭病原体灭活化合物在生物材料中的不希望的副反应的方法。在一个具体实施方案中，提供了用于猝灭病原体灭活化合物的不希望的副反应的方法，其包括可亲电子基团或能够形成亲电基团的官能团。在该实施方案中，用病原体灭活化合物和猝灭剂处理材料，其中猝灭剂包含能够与亲电子基团共价反应的亲核官能团。病原体灭活化合物上的亲电基团优选为非自由基阳离子基团。在一个实施方案中，病原体灭活化合物包括核酸结合配体和芥子基团，其中芥末基团能够在原位反应形成亲电子基团。优选的猝灭剂是硫醇，如谷胱甘肽。可以治疗的生物材料包括全血，红细胞，血浆和血小板。该方法允许在病原体灭活期间抑制含红细胞的材料中的红细胞的修饰。

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