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1. 发明授权

US09039997B2 Microfluidic devices with removable cover and methods of fabrication and application 有权
标题翻译：具有可拆卸盖的微流体装置和制造和应用的方法
公开(公告)号：US09039997B2
公开(公告)日：2015-05-26
申请号：US13499879
申请日：2010-09-29
申请人： David Cohen , Andrew May , Martin Pieprzyk , Brian Fowler , Kim Huat Lee , Jun Yan , Ming Fang Zhou , Seng Beng Ng
发明人： David Cohen , Andrew May , Martin Pieprzyk , Brian Fowler , Kim Huat Lee , Jun Yan , Ming Fang Zhou , Seng Beng Ng
IPC分类号： B01L99/00 , B01L3/00 , B01L9/00 , B01L7/00 , G01N1/40
CPC分类号： B01L3/5027 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/12 , B01L2300/045 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , G01N1/405
摘要： The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.
摘要翻译：本发明包括具有微型空腔的微流体系统，其可以被可移除的盖覆盖，其中可移除的盖允许微加工腔的至少一部分开口被操作者暴露或直接访问。微流体系统包括在可包括PDMS的弹性体层中形成的腔室，流动和控制通道。可移除的盖包括通过粘合剂层结合到弹性体层的热塑性基底膜。当可移除的盖被剥离时，室至少部分地打开以允许从室中取样。该室可能在PCR反应内部形成大分子晶体或产生内含物。本发明还包括通过使用可移除盖制造弹性体层中的通孔的方法。本发明还包括用于剥离可剥离盖或诸如集成式加热器撒布机的可移除部件的方法和装置。

2. 发明申请

US20120195810A1 MICROFLUIDIC DEVICES WITH REMOVABLE COVER AND METHODS OF FABRICATION AND APPLICATION 失效
标题翻译：具有可拆卸盖的微流体装置以及制造和应用方法
公开(公告)号：US20120195810A1
公开(公告)日：2012-08-02
申请号：US13499879
申请日：2010-09-09
申请人： David Cohen , Andrew May , Martin Pieprzyk , Brian Fowler , Kim Huat Lee , Jun Yan , Ming Fang Zhou , Seng Beng Ng
发明人： David Cohen , Andrew May , Martin Pieprzyk , Brian Fowler , Kim Huat Lee , Jun Yan , Ming Fang Zhou , Seng Beng Ng
IPC分类号： B01L3/00 , B32B38/00
CPC分类号： B01L3/5027 , B01L3/502738 , B01L7/52 , B01L9/527 , B01L2200/12 , B01L2300/045 , B01L2300/0887 , B01L2300/123 , B01L2400/0655 , G01N1/405
摘要： The present invention includes microfluidic systems having a microfabricated cavity that may be covered with a removable cover, where the removable cover allows at least part of the opening of the microfabricated cavity to be exposed or directly accessed by an operator. The microfluidic systems comprise chambers, flow and control channels formed in elastomeric layers that may comprise PDMS. The removable cover comprises a thermoplastic base film bonded to an elastomer layer by an adhesive layer. When the removable cover is peeled off, the chamber is at least partially open to allow sample extraction from the chamber. The chamber may have macromolecular crystals formed inside or resulting contents from a PCR reaction. The invention also includes a method for making vias in elastomeric layers by using the removable cover. The invention further includes methods and devices for peeling the peelable cover or a removable component such as Integrated Heater Spreader.
摘要翻译：本发明包括具有微型空腔的微流体系统，其可以被可移除的盖覆盖，其中可移除的盖允许微加工腔的至少一部分开口被操作者暴露或直接访问。微流体系统包括在可包括PDMS的弹性体层中形成的腔室，流动和控制通道。可移除的盖包括通过粘合剂层结合到弹性体层的热塑性基底膜。当可移除的盖被剥离时，室至少部分地打开以允许从室中取样。该室可能在PCR反应内部形成大分子晶体或产生内含物。本发明还包括通过使用可移除盖制造弹性体层中的通孔的方法。本发明还包括用于剥离可剥离盖或诸如集成式加热器撒布机的可移除部件的方法和装置。

3. 发明授权

US08058630B2 Microfluidic devices and methods 有权
标题翻译：微流体装置和方法
公开(公告)号：US08058630B2
公开(公告)日：2011-11-15
申请号：US12688462
申请日：2010-01-15
申请人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
发明人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC分类号： G01N21/64
CPC分类号： G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
摘要： Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
摘要翻译：本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。提供了减少使用微流体装置期间的混合时间的方法。微流控装置和相关的制造方法具有提高的制造产率。提供改进的装置和相关系统用于向微流体装置提供受控的压力。提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。微流控装置和相关方法提供了改进的样品与试剂混合比控制。微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。提供了用于改进微流体装置的荧光成像的方法和系统。

4. 发明授权

US08389960B2 Microfluidic devices and methods 有权
标题翻译：微流体装置和方法
公开(公告)号：US08389960B2
公开(公告)日：2013-03-05
申请号：US13295028
申请日：2011-11-11
申请人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
发明人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC分类号： G01N21/64
CPC分类号： G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
摘要： Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
摘要翻译：本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。提供了减少使用微流体装置期间的混合时间的方法。微流控装置和相关的制造方法具有提高的制造产率。提供改进的装置和相关系统用于向微流体装置提供受控的压力。提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。微流控装置和相关方法提供了改进的样品与试剂混合比控制。微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。提供了用于改进微流体装置的荧光成像的方法和系统。

5. 发明申请

US20120261007A1 MICROFLUIDIC DEVICES AND METHODS 有权
标题翻译：微流体装置和方法
公开(公告)号：US20120261007A1
公开(公告)日：2012-10-18
申请号：US13295028
申请日：2011-11-11
申请人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
发明人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC分类号： F16K31/12
CPC分类号： G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
摘要： Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
摘要翻译：本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。提供了减少使用微流体装置期间的混合时间的方法。微流控装置和相关的制造方法具有提高的制造成品率。提供改进的装置和相关系统用于向微流体装置提供受控的压力。提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。微流控装置和相关方法提供了改进的样品与试剂混合比控制。微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。提供了用于改进微流体装置的荧光成像的方法和系统。

6. 发明申请

US20100230613A1 MICROFLUIDIC DEVICES AND METHODS 有权
标题翻译：微流体装置和方法
公开(公告)号：US20100230613A1
公开(公告)日：2010-09-16
申请号：US12688462
申请日：2010-01-15
申请人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
发明人： Martin Pieprzyk , Geoff Facer , Timothy Woudenberg , Brian Fowler
IPC分类号： G01J1/58
CPC分类号： G01N1/28 , B01L3/502738 , B01L7/52 , B01L2200/16 , B01L2300/0867 , B01L2300/0874 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , B33Y80/00 , C12Q1/686 , G01N21/05 , G01N21/6452 , G01N2021/0346 , Y10T137/7793 , Y10T436/2575
摘要： Embodiments of the present invention provide improved microfluidic devices and related apparatus, systems, and methods. Methods are provided for reducing mixing times during use of microfluidic devices. Microfluidic devices and related methods of manufacturing are provided with increased manufacturing yield rates. Improved apparatus and related systems are provided for supplying controlled pressure to microfluidic devices. Methods and related microfluidic devices are provided for reducing dehydration of microfluidic devices during use. Microfluidic devices and related methods are provided with improved sample to reagent mixture ratio control. Microfluidic devices and systems are provided with improved resistance to compression fixture pressure induced failures. Methods and systems for conducting temperature controlled reactions using microfluidic devices are provided that reduce condensation levels within the microfluidic device. Methods and systems are provided for improved fluorescent imaging of microfluidic devices.
摘要翻译：本发明的实施例提供了改进的微流体装置和相关装置，系统和方法。提供了减少使用微流体装置期间的混合时间的方法。微流控装置和相关的制造方法具有提高的制造产率。提供改进的装置和相关系统用于向微流体装置提供受控的压力。提供了方法和相关的微流体装置，用于在使用过程中减少微流体装置的脱水。微流控装置和相关方法提供了改进的样品与试剂混合比控制。微流体装置和系统具有改进的抗压缩夹具压力引起的故障的阻力。提供了使用微流体装置进行温度控制反应的方法和系统，其减少微流体装置内的冷凝水平。提供了用于改进微流体装置的荧光成像的方法和系统。

7. 发明授权

US09074204B2 Nucleic acid encoding reactions 有权
标题翻译：核酸编码反应
公开(公告)号：US09074204B2
公开(公告)日：2015-07-07
申请号：US13476911
申请日：2012-05-21
申请人： Megan Anderson , Peilin Chen , Brian Fowler , Robert C. Jones , Fiona Kaper , Ronald Lebofsky , Andrew May
发明人： Megan Anderson , Peilin Chen , Brian Fowler , Robert C. Jones , Fiona Kaper , Ronald Lebofsky , Andrew May
IPC分类号： C12Q1/68 , C12N15/10 , C12N15/65 , C12N15/66
CPC分类号： C12Q1/6855 , C12N15/10 , C12N15/1065 , C12N15/65 , C12N15/66 , C12Q1/686 , C12Q1/6874
摘要： Described herein are methods useful for incorporating one or more adaptors and/or nucleotide tag(s) and/or barcode nucleotide sequence(s) one, or typically more, target nucleotide sequences. In particular embodiments, nucleic acid fragments having adaptors, e.g., suitable for use in high-throughput DNA sequencing are generated. In other embodiments, information about a reaction mixture is encoded into a reaction product. Also described herein are methods and kits useful for amplifying one or more target nucleic acids in preparation for applications such as bidirectional nucleic acid sequencing. In particular embodiments, methods of the invention entail additionally carrying out bidirectional DNA sequencing. Also described herein are methods for encoding and detecting and/or quantifying alleles by primer extension.
摘要翻译：本文所描述的方法可用于掺入一个或多个衔接子和/或核苷酸标签和/或条形码核苷酸序列，一个或多个靶核苷酸序列。在具体实施方案中，产生具有适配器（例如适合用于高通量DNA测序）的核酸片段。在其它实施方案中，关于反应混合物的信息被编码成反应产物。本文还描述了可用于扩增一种或多种靶核酸以准备应用如双向核酸测序的方法和试剂盒。在具体实施方案中，本发明的方法还需要进行双向DNA测序。本文还描述了通过引物延伸来编码和检测和/或定量等位基因的方法。

8. 发明授权

US07974380B2 Method and system for crystallization and X-ray diffraction screening 有权
$Method and system for crystallization and X-ray diffraction screening$
标题翻译：用于结晶和X射线衍射筛选的方法和系统
公开(公告)号：US07974380B2
公开(公告)日：2011-07-05
申请号：US12118185
申请日：2008-05-09
申请人： Brian Fowler , Andrew May
发明人： Brian Fowler , Andrew May
IPC分类号： G01N23/20
CPC分类号： G01N23/20025
摘要： An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
摘要翻译：集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。第一结构被配置为提供通过多个通道的一种或多种材料的流动。集成流体回路还包括耦合到衬底层的第二结构。第二结构包括被配置为接收致动压力的多个控制通道。集成流体回路的特征在于厚度小于1.5mm。

9. 发明申请

US20120021523A1 METHOD AND SYSTEM FOR CRYSTALLIZATION AND X-RAY DIFFRACTION SCREENING 有权
标题翻译：用于结晶和X射线衍射筛选的方法和系统
公开(公告)号：US20120021523A1
公开(公告)日：2012-01-26
申请号：US13168041
申请日：2011-06-24
申请人： Brian Fowler , Andrew May
发明人： Brian Fowler , Andrew May
IPC分类号： G01N23/20
CPC分类号： G01N23/20025
摘要： An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
摘要翻译：集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。第一结构被配置为提供通过多个通道的一种或多种材料的流动。集成流体回路还包括耦合到衬底层的第二结构。第二结构包括被配置为接收致动压力的多个控制通道。集成流体回路的特征在于厚度小于1.5mm。

10. 发明申请

US20090147918A1 METHOD AND SYSTEM FOR CRYSTALLIZATION AND X-RAY DIFFRACTION SCREENING 有权
标题翻译：用于结晶和X射线衍射筛选的方法和系统
公开(公告)号：US20090147918A1
公开(公告)日：2009-06-11
申请号：US12118185
申请日：2008-05-09
申请人： Brian Fowler , Andrew May
发明人： Brian Fowler , Andrew May
IPC分类号： G01N23/207
CPC分类号： G01N23/20025
摘要： An integrated fluidic circuit includes a substrate layer and a first structure coupled to the substrate layer and including a plurality of channels. The first structure is configured to provide for flow of one or more materials through the plurality of channels. The integrated fluidic circuit also includes a second structure coupled to the substrate layer. The second structure includes a plurality of control channels configured to receive an actuation pressure. The integrated fluidic circuit is characterized by a thickness of less than 1.5 mm.
摘要翻译：集成流体回路包括衬底层和耦合到衬底层并且包括多个通道的第一结构。第一结构被配置为提供通过多个通道的一种或多种材料的流动。集成流体回路还包括耦合到衬底层的第二结构。第二结构包括被配置为接收致动压力的多个控制通道。集成流体回路的特征在于厚度小于1.5mm。

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