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1. 发明授权

US08005526B2 Biologically integrated electrode devices 有权
标题翻译：生物集成电极装置
公开(公告)号：US08005526B2
公开(公告)日：2011-08-23
申请号：US11512479
申请日：2006-08-30
申请人： David C. Martin , Sarah Richardson-Burns , Donghwan Kim , Jeffrey L. Hendricks , Laura Povlich , Mohamad Reza Abidian , Matthew Meier
发明人： David C. Martin , Sarah Richardson-Burns , Donghwan Kim , Jeffrey L. Hendricks , Laura Povlich , Mohamad Reza Abidian , Matthew Meier
IPC分类号： A61B5/04 , A61N1/05
CPC分类号： A61B5/0408 , A61B2562/0217 , A61B2562/125 , A61N1/05
摘要： Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.
摘要翻译：提供具有增强的生物相容性和仿生特征的生物电极。进一步提供制造和使用生物电极的方法。一种生物集成生物电极装置和方法，用于使用包括第一导电基底和生物成分的生物电极检测电子信号。生物电极还包括导电聚合物，其电耦合第一导电基底和生物组分以限定生物电极。生物电极可以在导电基底和生物组分和导电聚合物之间传输或接收电信号。

2. 发明申请

US20110257504A1 BIOLOGICALLY INTEGRATED ELECTRODE DEVICES 审中-公开
标题翻译：生物集成电极装置
公开(公告)号：US20110257504A1
公开(公告)日：2011-10-20
申请号：US13085060
申请日：2011-04-12
申请人： Jeffrey L. Hendricks , Sarah Richardson-Burns , David C. Martin
发明人： Jeffrey L. Hendricks , Sarah Richardson-Burns , David C. Martin
IPC分类号： A61B5/04 , A61N1/362 , A61N1/36 , A61N1/39 , A61F11/04 , A61F9/08 , C08G75/06 , A61K38/43 , A61K47/34 , A61K31/7088 , A61K38/02 , A61K35/00 , A61K35/34 , A61K35/30 , A61K35/12 , A61K35/28 , C12N5/071 , B32B3/10 , H01B1/12 , A61N1/05
CPC分类号： A61B5/0408 , A61B2562/0217 , A61B2562/125 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0536 , Y10T428/24355
摘要： Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.
摘要翻译：提供具有增强的生物相容性和仿生特征的生物电极。进一步提供制造和使用生物电极的方法。一种生物集成生物电极装置和方法，用于使用包括第一导电基底和生物成分的生物电极检测电子信号。生物电极还包括导电聚合物，其电耦合第一导电基底和生物组分以限定生物电极。生物电极可以在导电基底和生物组分和导电聚合物之间传输或接收电信号。

3. 发明授权

US09084546B2 Co-electrodeposited hydrogel-conducting polymer electrodes for biomedical applications 有权
标题翻译：用于生物医学应用的共电沉积的水凝胶导电聚合物电极
公开(公告)号：US09084546B2
公开(公告)日：2015-07-21
申请号：US12755070
申请日：2010-04-06
申请人： Sarah Richardson-Burns , Jeffrey L. Hendricks , David C. Martin , Andrew Sereno , Zachary King , Edward Jan
发明人： Sarah Richardson-Burns , Jeffrey L. Hendricks , David C. Martin , Andrew Sereno , Zachary King , Edward Jan
IPC分类号： C23C28/00 , C25D11/00 , A61B5/0408 , A61N1/05
CPC分类号： G01N27/3272 , A61B5/04 , A61B5/0408 , A61B2562/0217 , A61B2562/125 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/0541 , A61N1/0543 , A61N1/056 , B29C35/02 , B29C67/02 , B29K2039/00 , B29K2995/0005 , B29L2031/34 , B29L2031/7546 , C23C28/00 , G01N27/327 , H01B1/127
摘要： Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.
摘要翻译：提供具有增强的生物相容性和仿生特征的生物电极。进一步提供制造和使用生物电极的方法。一种生物集成生物电极装置和方法，用于使用包括第一导电基底和生物成分的生物电极检测电子信号。生物电极还包括导电聚合物，其电耦合第一导电基底和生物组分以限定生物电极。生物电极可以在导电基底和生物组分和导电聚合物之间传输或接收电信号。

4. 发明申请

US20110087315A1 CO-ELECTRODEPOSITED HYDROGEL-CONDUCTING POLYMER ELECTRODES FOR BIOMEDICAL APPLICATIONS 有权
标题翻译：用于生物医学应用的共电极导电聚合物电极
公开(公告)号：US20110087315A1
公开(公告)日：2011-04-14
申请号：US12755070
申请日：2010-04-06
申请人： Sarah Richardson-Burns , Jeffrey L. Hendricks , David C. Martin , Andrew Sereno , Zachary King , Edward Jan
发明人： Sarah Richardson-Burns , Jeffrey L. Hendricks , David C. Martin , Andrew Sereno , Zachary King , Edward Jan
IPC分类号： A61N1/05 , B05D5/12 , C25D5/10 , C23C28/04
CPC分类号： G01N27/3272 , A61B5/04 , A61B5/0408 , A61B2562/0217 , A61B2562/125 , A61N1/05 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/0541 , A61N1/0543 , A61N1/056 , B29C35/02 , B29C67/02 , B29K2039/00 , B29K2995/0005 , B29L2031/34 , B29L2031/7546 , C23C28/00 , G01N27/327 , H01B1/127
摘要： Bioelectrodes having enhanced biocompatible and biomimetic features are provided. Methods of making and using the bioelectrodes are further provided. A biologically integrated bioelectrode device and method for detecting electronic signals using a bioelectrode comprising a first electrically conductive substrate and a biological component. The bioelectrode also comprises a conductive polymer electrically coupling the first electrically conductive substrate and the biological component to define a bioelectrode. The bioelectrode can transmit or receive an electrical signal between the electrically conductive substrate and the biological component and conductive polymer.
摘要翻译：提供具有增强的生物相容性和仿生特征的生物电极。进一步提供制造和使用生物电极的方法。一种生物集成生物电极装置和方法，用于使用包括第一导电基底和生物成分的生物电极检测电子信号。生物电极还包括导电聚合物，其电耦合第一导电基底和生物组分以限定生物电极。生物电极可以在导电基底和生物组分和导电聚合物之间传输或接收电信号。

5. 发明申请

US20090292325A1 HYBRID BIOELECTRICAL INTERFACE DEVICE 审中-公开
标题翻译：混合生物界面装置
公开(公告)号：US20090292325A1
公开(公告)日：2009-11-26
申请号：US12432343
申请日：2009-04-29
申请人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbancheck , Daryl A. Kipke , Sarah Richardson-Burns , David C. Martin
发明人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbancheck , Daryl A. Kipke , Sarah Richardson-Burns , David C. Martin
IPC分类号： A61N1/00
CPC分类号： A61F2/72 , A61F2250/0001 , A61L27/34 , A61L27/3675 , A61N1/05 , A61N1/0543 , A61N1/0551 , A61N1/36125
摘要： A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a means to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).
摘要翻译：混合生物电接口（HBI）装置可以是可植入装置，其包括可操作以经由电子或离子传递电荷的非生物成分; 与神经组织接触的生物组分，生物组分来自生物学，生物衍生的或生物功能化的材料; 共轭聚合物组分共同提供长寿命地将活体神经组织与电子装置接合以延长持续时间（例如大于10年）的手段。在一些实施方案中，共轭聚合物为神经系统和电子设备（例如机器人假肢，视网膜植入物，微芯片）之间的电荷转移和信号转导提供功能性电接口。

6. 发明授权

US09044347B2 Hybrid bioelectrical interface device 有权
标题翻译：混合生物电接口装置
公开(公告)号：US09044347B2
公开(公告)日：2015-06-02
申请号：US13586350
申请日：2012-08-15
申请人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbanchek , Daryl R. Kipke , Sarah Richardson-Burns , David C. Martin , Eugene D. Daneshvar
发明人： Paul S. Cederna , Brent M. Egeland , Mohammad Reza Abidian , Antonio Peramo , Melanie G. Urbanchek , Daryl R. Kipke , Sarah Richardson-Burns , David C. Martin , Eugene D. Daneshvar
IPC分类号： A61B5/04 , A61F2/72 , A61N1/05 , A61L27/34 , A61L27/36 , A61N1/36
CPC分类号： A61F2/72 , A61F2250/0001 , A61L27/34 , A61L27/3675 , A61N1/05 , A61N1/0543 , A61N1/0551 , A61N1/36125
摘要： A hybrid bioelectrical interface (HBI) device can be an implantable device comprising an abiotic component operable to transmit charge via electrons or ions; a biological component interfacing with the neural tissue, the biological component being sourced from biologic, biologically-derived, or bio-functionalized material; and a conjugated polymer component that together provide a way to chronically interface living neural tissue with electronic devices for extended durations (e.g. greater than 10 years). In some embodiments, conjugated polymers provide a functional electrical interface for charge transfer and signal transduction between the nervous system and an electronic device (e.g. robotic prosthetic limb, retinal implant, microchip).
摘要翻译：混合生物电接口（HBI）装置可以是可植入装置，其包括可操作以经由电子或离子传递电荷的非生物成分; 与神经组织接触的生物组分，生物组分来自生物学，生物衍生的或生物功能化的材料; 共轭聚合物组分一起提供了一种使活体神经组织与电子设备长期接触延长持续时间（例如大于10年）的方式。在一些实施方案中，共轭聚合物为神经系统和电子设备（例如机器人假肢，视网膜植入物，微芯片）之间的电荷转移和信号转导提供功能性电接口。

7. 发明授权

US08513321B2 Dual cure coating compositions, methods of coating a substrate, and related coated substrates 有权
标题翻译：双重固化涂料组合物，涂布基材的方法和相关的涂布基材
公开(公告)号：US08513321B2
公开(公告)日：2013-08-20
申请号：US12940317
申请日：2010-11-05
申请人： David C. Martin , Brian K. Rearick , Christina A. Winters , Mary Ann Fuhry , Cynthia Kutchko
发明人： David C. Martin , Brian K. Rearick , Christina A. Winters , Mary Ann Fuhry , Cynthia Kutchko
IPC分类号： C08F2/52 , C08F2/42 , C08J3/28
CPC分类号： C09D4/00
摘要： Disclosed herein are dual cure coating compositions that include (a) a melamine-group containing polyethylenically unsaturated compound and (b) an acrylate-containing compound different from (a), wherein the acrylate-containing compound is present at a level sufficient to provide a cured coating layer having a glass transition temperature of 100° C. or below and a crosslink density of 20.0 mmoles/cc or below. Also disclosed are related multi-component composite coatings, coated substrates, and methods for coating a substrate.
摘要翻译：本文公开了双重固化涂料组合物，其包含（a）含三聚氰胺基团的多烯属不饱和化合物和（b）不同于（a）的含丙烯酸酯化合物，其中含丙烯酸酯化合物的含量足以提供玻璃化转变温度为100℃以下，交联密度为20.0毫摩尔/ cc以下的固化涂层。还公开了相关的多组分复合涂层，涂覆的基底和用于涂覆基底的方法。

8. 发明申请

US20120178893A1 SUBSTITUTED 3,4-PROPYLENEDIOXYTHIOPHENE MONOMERS AND 3,4-PROPYLENEDIOXYTHIOPHENE-BASED CROSSLINKERS AND POLYMERS THEREOF 失效
标题翻译：取代的3,4-丙烯基二甲苯单体和基于3,4-丙烯二氧基聚苯乙烯的交联剂及其聚合物
公开(公告)号：US20120178893A1
公开(公告)日：2012-07-12
申请号：US13215321
申请日：2011-08-23
申请人： David C. Martin , Kathleen E. Feldman
发明人： David C. Martin , Kathleen E. Feldman
IPC分类号： C08G75/06 , C08G77/28 , C07F7/18 , C07D495/04 , C07H15/26
CPC分类号： C07D495/04 , C08G61/126 , C08G2261/1424 , C08G2261/145 , C08G2261/44
摘要： Substituted 3,4-propylenedioxythiophene monomers may be prepared by reacting 3-allyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine or 3,3-diallyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine with a thiol having a hydrocarbyl moiety optionally containing one or more heteroatom-containing functional groups under radical addition conditions under radical addition conditions. Such monomers may be used in homo- or copolymerization processes to obtain thiophene-type polymers containing substituents (which may bear functional groups such as silane, thiol, hydroxyl, carboxylic acid, amine, sugar groups, polyoxyalkylene, and the like). Crosslinkers useful for introducing crosslinking into thiophene-type polymers may be prepared by reacting 3-allyl-3,4-dihydro-2H-thieno[3,4-b][1,4]dioxepine with a compound having two or more thiol groups under radical addition conditions.
摘要翻译：取代的3,4-亚丙二氧基噻吩单体可以通过使3-烯丙基-3,4-二氢-2H-噻吩并[3,4-b] [1,4]二氧杂环庚三烯或3,3-二烯丙基-3,4-二氢 -2H-噻吩并[3,4-b] [1,4]二氧杂环庚烯与在自由基加成条件下具有任选含有一个或多个含杂原子的官能团的烃基部分的硫醇。这些单体可用于均聚或共聚方法以获得含有取代基（可含有官能团如硅烷，硫醇，羟基，羧酸，胺，糖基，聚氧化烯等）的噻吩型聚合物。用于将交联引入噻吩型聚合物中的交联剂可以通过使3-烯丙基-3,4-二氢-2H-噻吩并[3,4-b] [1,4]二氧杂环庚烯与具有两个或更多个硫醇基的化合物根本添加条件。

9. 发明授权

US07708908B2 Carboxylic acid-modified EDOT for bioconjugation 有权
标题翻译：用于生物共轭的羧酸改性的EDOT
公开(公告)号：US07708908B2
公开(公告)日：2010-05-04
申请号：US12038138
申请日：2008-02-27
申请人： Jinsang Kim , Jae Cheol Cho , Laura K. Povlich , David C. Martin
发明人： Jinsang Kim , Jae Cheol Cho , Laura K. Povlich , David C. Martin
IPC分类号： H01B1/12 , C08G75/00 , C07D333/10 , G01N31/00
CPC分类号： C07D495/04
摘要： An electroconductive carboxylic acid functionalized monomer corresponding to Formula (I), wherein A represents a hydrogen or a carboxyl group. Polymerized monomers of Formula (I) conjugated with a biomolecule result in conjugated PEDOT polymers of Formula (III) wherein A is a hydrogen or a carboxylic acid group and B is a biomolecule selected from the group consisting of a peptide, a protein, a lipid, a carbohydrate and a polynucleotide. The biomolecule conjugated polymers can be disposed onto an electrically conductive substrate wherein the substrate has a first layer of PEDOT polymerized on a surface of the substrate and a second layer of biomolecule conjugated PEDOT polymer of Formula (III) polymerized on the first layer of PEDOT. The first and second layers form a charge transport material in electrical communication with the conductive substrate. The electrically conductive substrate further comprises a dopant.
摘要翻译：对应于式（I）的导电羧酸官能化单体，其中A表示氢或羧基。与生物分子缀合的式（I）的聚合单体导致式（III）的共轭PEDOT聚合物，其中A是氢或羧酸基团，B是选自肽，蛋白质，脂质的生物分子，碳水化合物和多核苷酸。生物分子共轭聚合物可以设置在导电基底上，其中基底具有在基底表面上聚合的第一层PEDOT和在第一层PEDOT上聚合的式（III）的生物分子共轭PEDOT聚合物的第二层。第一和第二层形成与导电基底电连通的电荷传输材料。导电衬底还包括掺杂剂。

10. 发明授权

US5888618A Fire-resistant, retroreflective structure 失效
标题翻译：耐火，回射结构
公开(公告)号：US5888618A
公开(公告)日：1999-03-30
申请号：US756391
申请日：1996-11-26
申请人： David C. Martin
发明人： David C. Martin
IPC分类号： B32B3/10 , B32B3/18 , B32B3/26 , B32B27/08 , B32B27/18 , B32B27/30 , G02B5/124 , B32B5/30
CPC分类号： G02B5/124 , B32B3/10 , B32B3/18 , Y10S428/92 , Y10S428/921 , Y10T428/24479 , Y10T428/24521 , Y10T428/2457 , Y10T428/31507 , Y10T428/3158 , Y10T428/31797 , Y10T428/31917 , Y10T428/3192 , Y10T428/31928
摘要： A fire-resistant retroreflective structure having an array of rigid retroreflective elements and a method for making the structure are disclosed. The retroreflective structure is formed of an array of rigid retroreflective elements having a first side and a second side. A transparent polymeric film is attached to the first side of the array of rigid retroreflective elements. A transparent fire-resistant outerlayer is attached to the transparent polymeric film. A flame-retardant layer is placed proximate to the second side of the array of rigid retroreflective elements. A fire-resistant polymer underlayer is attached to the flame-retardant layer. The five resistant polymer underlayer can be bonded to the transparent polymeric film through the array of rigid retroreflective elements and the flame-retardant layer.
摘要翻译：公开了具有刚性回射元件阵列的耐火逆反射结构和制造该结构的方法。回射结构由具有第一侧和第二侧的刚性回射元件的阵列形成。透明聚合物膜连接到刚性回射元件阵列的第一侧。透明耐火外层附着在透明聚合物膜上。将阻燃层放置成靠近刚性回射元件阵列的第二侧。耐火聚合物底层附着在阻燃层上。五个耐电聚合物底层可以通过刚性回射元件阵列和阻燃层结合到透明聚合物膜上。

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