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1. 发明授权

US08106244B2 Process for production of delta-9-tetrahydrocannabinol 有权
标题翻译：生产delta-9-四氢大麻酚的方法
公开(公告)号：US08106244B2
公开(公告)日：2012-01-31
申请号：US13108651
申请日：2011-05-16
申请人： David C. Burdick , Steven J. Collier , Betina Biolatto , Harold Meckler
发明人： David C. Burdick , Steven J. Collier , Betina Biolatto , Harold Meckler
IPC分类号： C07C35/18
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.
摘要翻译：本发明涉及一种制备δ-9-四氢大麻酚化合物或其衍生物的方法，包括在有效制备δ-9-四氢大麻酚化合物或其衍生物的条件下，用有机铝基路易斯酸催化剂处理第一中间体化合物。本发明的另一方面涉及制备大麻二醇或大麻二酸化合物的方法，包括在金属三氟甲磺酸酯催化剂存在下，在有效形成大麻二醇或大麻二醇化合物的条件下使第一起始化合物与第二起始化合物反应。本发明还涉及下式化合物：其中R 8，R 9和R 10相同或不同且独立地选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的杂芳基，或卤素，其中R 1，R 2和R 3定义如下。

2. 发明申请

US20110263878A1 PROCESS FOR PRODUCTION OF DELTA-9-TETRAHYDROCANNABINOL 有权
标题翻译：生产DELTA-9-四氢胞嘧啶的方法
公开(公告)号：US20110263878A1
公开(公告)日：2011-10-27
申请号：US13108651
申请日：2011-05-16
申请人： David C. BURDICK , Steven J. Collier , Betina Biolatto , Harold Meckler
发明人： David C. BURDICK , Steven J. Collier , Betina Biolatto , Harold Meckler
IPC分类号： C07D311/80 , C07C315/00 , C07F9/02 , C07C381/00 , C07F7/02 , C07C43/18
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.
摘要翻译：本发明涉及一种制备δ-9-四氢大麻酚化合物或其衍生物的方法，包括在有效制备δ-9-四氢大麻酚化合物或其衍生物的条件下，用有机铝基路易斯酸催化剂处理第一中间体化合物。本发明的另一方面涉及制备大麻二醇或大麻二酸化合物的方法，包括在金属三氟甲磺酸酯催化剂存在下，在有效形成大麻二醇或大麻二醇化合物的条件下使第一起始化合物与第二起始化合物反应。本发明还涉及下式化合物：其中R 8，R 9和R 10相同或不同且独立地选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的杂芳基，或卤素，其中R 1，R 2和R 3定义如下。

3. 发明授权

US07674922B2 Process for production of delta-9-tetrahydrocannabinol 失效
标题翻译：生产delta-9-四氢大麻酚的方法
公开(公告)号：US07674922B2
公开(公告)日：2010-03-09
申请号：US11529147
申请日：2006-09-28
申请人： David C. Burdick , Steven J. Collier , Frédéric Jos , Betina Biolatto , Bernhard J. Paul , Harold Meckler , Mark A. Helle , Alicia J. Habershaw
发明人： David C. Burdick , Steven J. Collier , Frédéric Jos , Betina Biolatto , Bernhard J. Paul , Harold Meckler , Mark A. Helle , Alicia J. Habershaw
IPC分类号： C07D311/80 , C07C39/18
CPC分类号： C07C29/00 , C07C37/16 , C07C67/343 , C07C2601/16 , C07C35/16 , C07C39/23 , C07C69/94
摘要： The present invention relates to a process for preparation of a delta-9-tetrahydrocannabinol compound or derivative thereof involving treating a first intermediate compound with an organoaluminum-based Lewis acid catalyst, under conditions effective to produce the delta-9-tetrahydrocannabinol compound or derivative thereof. Another aspect of the present invention relates to a process for preparation of a cannabidiol or cannabidiolate compound involving reacting a first starting compound with a second starting compound in the presence of a metal triflate catalyst, under conditions effective to form the cannabidiol or cannabidiolate compound. The present invention also relates to a compound of the formula: where R8, R9, and R10 are the same or different and independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or halo, with R1, R2, and R3 defined herein.
摘要翻译：本发明涉及一种制备δ-9-四氢大麻酚化合物或其衍生物的方法，包括在有效制备δ-9-四氢大麻酚化合物或其衍生物的条件下，用有机铝基路易斯酸催化剂处理第一中间体化合物。本发明的另一方面涉及制备大麻二醇或大麻二酸化合物的方法，包括在金属三氟甲磺酸酯催化剂存在下，在有效形成大麻二醇或大麻二醇化合物的条件下使第一起始化合物与第二起始化合物反应。本发明还涉及下式化合物：其中R 8，R 9和R 10相同或不同且独立地选自H，取代或未取代的烷基，取代或未取代的芳基，取代或未取代的杂芳基，或卤素，其中R 1，R 2和R 3定义如下。

4. 发明授权

US08334266B2 Process for and intermediates in the preparation of canfosfamide and its salts 有权
标题翻译：用于制备卡非司酮及其盐的方法和中间体
公开(公告)号：US08334266B2
公开(公告)日：2012-12-18
申请号：US13429065
申请日：2012-03-23
申请人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernandez Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
发明人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernandez Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
IPC分类号： A61K38/07 , C07K38/06
CPC分类号： C07K5/0205 , A61K38/00 , C07F9/2408 , C07F9/2458 , C07K5/0215 , C07K5/0606 , C07K5/06191
摘要： A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
摘要翻译：一种在制备头孢噻吩及其盐的过程和中间体。一些中间体具有抗癌活性。

5. 发明申请

US20120238772A1 PROCESS FOR AND INTERMEDIATES IN THE PREPARATION OF CANFOSFAMIDE AND ITS SALTS 有权
标题翻译：在制备氰氟虫及其盐的过程和中间体
公开(公告)号：US20120238772A1
公开(公告)日：2012-09-20
申请号：US13429065
申请日：2012-03-23
申请人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernández Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
发明人： William A. Boulanger , Steven J. Collier , Stephen A. Eastham , Dennis L. Edie , Ronan Y. Guevel , Pedro E. Hernández Abad , R. Jason Herr , Hans J. Kjaersgaard , Harold Meckler , Robert E. Polomski , Steven R. Schow , Pavel E. Zhichkin
IPC分类号： C07F9/24 , C07C323/59
CPC分类号： C07K5/0205 , A61K38/00 , C07F9/2408 , C07F9/2458 , C07K5/0215 , C07K5/0606 , C07K5/06191
摘要： A process for and intermediates in the preparation of canfosfamide and its salts. Some of the intermediates have anticancer activity.
摘要翻译：一种在制备头孢噻吩及其盐的过程和中间体。一些中间体具有抗癌活性。

6. 发明授权

US09040262B2 Biocatalysts for ezetimibe synthesis 有权
标题翻译：用于依泽替米贝合成的生物催化剂
公开(公告)号：US09040262B2
公开(公告)日：2015-05-26
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
IPC分类号： C12P17/10 , C12N9/04 , C12N1/15 , C07H21/04 , C07K14/47 , C12P17/14 , A61K38/00
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.
摘要翻译：本公开涉及可用于制备依泽替米贝的非天然存在的多肽，编码多肽的多核苷酸以及使用多肽的方法。

7. 发明申请

US20140199735A1 BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF 有权
标题翻译：用于制备精氨酸的生物化学方法及其类似物
公开(公告)号：US20140199735A1
公开(公告)日：2014-07-17
申请号：US14110964
申请日：2012-04-12
申请人： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
发明人： Anupam Gohel , Derek Smith , Brian Wong , Joly Sukumaran , Wan Lin Yeo , Steven J. Collier , Scott Novick
IPC分类号： C12P17/10
CPC分类号： C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
摘要翻译：本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。

8. 发明申请

US20130302859A1 Engineered imine reductases and methods for the reductive animation of ketone and amine compounds. 有权
标题翻译：酮和胺化合物的还原动力的工程亚胺还原酶和方法。
公开(公告)号：US20130302859A1
公开(公告)日：2013-11-14
申请号：US13890944
申请日：2013-05-09
申请人： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
发明人： CHEN Haibin , Steven J. Collier , Jovana NAZOR , Joly SUKUMARAN , Derek SMITH , Jeffrey C. MOORE , Gregory HUGHES , Jacob JANEY , Gjalt HUISMAN , Scott NOVICK , Nicholas AGARD , Oscar ALVIZO , Gregory COPE , Wan Lin YEO , Stephanie NG
IPC分类号： C12N9/00
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译：本公开提供了具有亚胺还原酶活性的工程改造的多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法产品化合物。

9. 发明申请

US20130052699A1 BIOCATALYSTS FOR EZETIMIBE SYNTHESIS 有权
公开(公告)号：US20130052699A1
公开(公告)日：2013-02-28
申请号：US13695856
申请日：2011-05-04
申请人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
发明人： Michael Crowe , Oscar Alvizo , Behnaz Behrouzian , Yong Koy Bong , Steven J. Collier , Anupam Gohel , Jagadeesh Mavinahalli , Naga Modukuru , Emily Mundorff , Derek Smith , Shiwei Song , Wan Lin Yeo
IPC分类号： C12N9/04 , C12N5/10 , C07H21/04 , C12N1/15 , C12N1/19 , C12N15/63 , C12P17/10 , C12N1/21
CPC分类号： C12N9/0006 , A61K38/00 , C07K14/47 , C12P17/10 , C12P17/14 , C12Y101/00 , C12Y101/01184
摘要： The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

10. 发明授权

US08796002B2 Polypeptides for a ketoreductase-mediated stereoselective route to alpha chloroalcohols 有权
标题翻译：用于酮还原酶介导的对α-氯代醇的立体选择性途径的多肽
公开(公告)号：US08796002B2
公开(公告)日：2014-08-05
申请号：US13378618
申请日：2010-06-22
申请人： Yong Koy Bong , Michael Vogel , Steven J. Collier , Vesna Mitchell , Jagadeesh Mavinahalli
发明人： Yong Koy Bong , Michael Vogel , Steven J. Collier , Vesna Mitchell , Jagadeesh Mavinahalli
IPC分类号： C12N9/04 , C12P7/22 , C12P17/02 , C12N9/02 , C12P21/00
CPC分类号： C12N9/0006 , C12N9/0008 , C12P7/28 , C12P13/02 , C12P17/02 , C12Y101/01184
摘要： The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of α chloroalcohols from α chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.
摘要翻译：本公开涉及工程化酮还原酶多肽及其用于从α-氯代酮制备α-氯代醇的用途。还提供了编码工程化酮还原酶多肽和能够表达工程化酮还原酶多肽的宿主细胞的多核苷酸。

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