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1. 发明申请

US20090299190A1 Ultrasound Molecular Sensors and Uses Thereof 失效
标题翻译：超声波分子传感器及其用途
公开(公告)号：US20090299190A1
公开(公告)日：2009-12-03
申请号：US12224928
申请日：2007-03-05
申请人： David Burns , David Troiani , Jonathan Dion
发明人： David Burns , David Troiani , Jonathan Dion
IPC分类号： A61B8/00 , C07K16/00 , C07K14/00 , C07H21/00 , C07H1/00 , A61K39/395 , A61K38/00 , A61K31/7088 , A61K31/70
CPC分类号： A61K49/226 , A61B8/0866 , A61B8/481
摘要： The present invention relates to the use of polymers as contrast agents for ultrasounds. The idea is to have a molecular imprint in the polymer that is specific for a given molecule or analyte. When that molecule binds to the polymer it induces a conformational change that results in an increase in the ultrasound signal, referred to as a target-bound state. The method can also be used for example for quantitative measurements of analytes.
摘要翻译：本发明涉及聚合物作为超声造影剂的用途。这个想法是在聚合物中具有特定于给定分子或分析物的分子印迹。当该分子与聚合物结合时，其诱导构象变化，导致超声信号的增加，称为靶结合状态。该方法也可用于例如分析物的定量测量。

2. 发明授权

US08366625B2 Ultrasound molecular sensors and uses thereof 失效
标题翻译：超声分子传感器及其用途
公开(公告)号：US08366625B2
公开(公告)日：2013-02-05
申请号：US12224928
申请日：2007-03-05
申请人： David Burns , David Troiani , Jonathan Dion
发明人： David Burns , David Troiani , Jonathan Dion
IPC分类号： A61B8/14
CPC分类号： A61K49/226 , A61B8/0866 , A61B8/481
摘要： The present invention relates to the use of polymers as contrast agents for ultrasounds. The idea is to have a molecular imprint in the polymer that is specific for a given molecule or analyte. When that molecule binds to the polymer it induces a conformational change that results in an increase in the ultrasound signal, referred to as a target-bound state. The method can also be used for example for quantitative measurements of analytes.
摘要翻译：本发明涉及聚合物作为超声造影剂的用途。这个想法是在聚合物中具有特定于给定分子或分析物的分子印迹。当该分子与聚合物结合时，其诱导构象变化，导致超声信号的增加，称为靶结合状态。该方法也可用于例如分析物的定量测量。

3. 发明申请

US20120197545A1 DETERMINATION OF FRACTIONAL COMPOSITIONS USING NONLINEAR SPECTROPHONOMETRY 审中-公开
标题翻译：使用非线性光谱测定法确定部分成分
公开(公告)号：US20120197545A1
公开(公告)日：2012-08-02
申请号：US13322489
申请日：2010-05-28
申请人： David Burns , Jonathan Dion
发明人： David Burns , Jonathan Dion
IPC分类号： G06F19/00 , G01N31/00
CPC分类号： G01N29/036 , G01N29/46 , G01N2291/011 , G01N2291/0224
摘要： Applicants have discovered new methods and apparatuses for determining the fractional composition of a component in a multi-component mixture using multivariate statistical analysis of the ultrasonic frequency profile. Applicants show the use of ultrasonic spectrophonometry to determine the fractional composition of a component in a 3-component solvent mixture comprising water, ethanol and methanol as well as determination of the fractional composition of certain contaminants in water. Applicants provide a method of determining a fractional composition of a component in a multi-component mixture comprising pulsing a mixture with a source of ultrasounds, detecting “non-linear” ultrasonic spectral data propagating through the mixture and computing the fractional composition of the component.
摘要翻译：申请人已经发现了使用超声波频率分布的多变量统计分析来确定多组分混合物中组分的分数组成的新方法和装置。申请人显示使用超声波分光光度法来测定包含水，乙醇和甲醇的3组分溶剂混合物中组分的分数组成，以及测定水中某些污染物的分数组成。申请人提供了一种确定多组分混合物中组分的分数组成的方法，包括将脉冲与超声波源混合，检测通过混合物传播的“非线性”超声频谱数据并计算组分的分数组成。

4. 发明申请

US20110178402A1 ULTRASONIC MEASUREMENT OF pH IN FLUIDS 审中-公开
标题翻译：超声波测量流体中的pH
公开(公告)号：US20110178402A1
公开(公告)日：2011-07-21
申请号：US13057567
申请日：2009-08-04
申请人： David Hugh Burns , Jonathan Dion , Michiko Kato
发明人： David Hugh Burns , Jonathan Dion , Michiko Kato
IPC分类号： A61B8/00 , C12Q1/02 , G01N29/02 , G01N33/00 , G06F19/00
CPC分类号： G01N29/46 , G01N29/032 , G01N2291/02491 , G01N2291/02809
摘要： The present invention pertains to new methods and apparatuses for the determination of pH of a fluid. Applicants have discovered that ultrasonic spectrophonometry (the study and measurement of acoustic spectra) can be used to distinguish conformational changes of albumin and red blood cells in response to pH. In accordance with the present invention, there is provided a method of determining the pH of a fluid based on a pH-dependent conformation of at least one fluid constituent comprising subjecting the fluid to an ultrasonic pulse; detecting ultrasonic spectral data of the fluid constituent resulting from the ultrasonic pulse; wherein the spectral data varies with pH; and then calculating pH from the spectral data.
摘要翻译：本发明涉及用于测定流体pH的新方法和装置。申请人已经发现，超声波分光光度法（声谱的研究和测量）可用于区分白蛋白和红血细胞响应于pH的构象变化。根据本发明，提供了一种基于至少一种流体成分的pH依赖性构象确定流体pH的方法，该方法包括使流体经受超声波脉冲; 检测由超声脉冲产生的流体成分的超声光谱数据; 其中光谱数据随pH而变化; 然后从光谱数据计算pH。

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