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    • 4. 发明授权
    • Process for preparing epoxides
    • 环氧化物的制备方法
    • US6031115A
    • 2000-02-29
    • US109856
    • 1998-07-02
    • David BellMichael FedouloffGillian Turner
    • David BellMichael FedouloffGillian Turner
    • C07D493/04C07D319/14C07D491/00
    • C07D493/04
    • A process for preparing compounds of formula (B) wherein:one of A.sub.1 ' or A.sub.2 ' represents hydrogen and the other represents a group CF.sub.3 --Y-- wherein Y represents --CF.sub.2 --, >C.dbd.O, or --CH(OH)--, or A.sub.1 ' and A.sub.2 ' are groups convertible to A.sub.1 and A.sub.2 respectively.Y.sub.1 represents --O--, --CH.sub.2 -- or NR.sup.O wherein R.sup.O is hydrogen, alkyl or alkylcarbonyl; R.sub.1 and R.sub.2 independently represent hydrogen or alkyl; orR.sub.1 and R.sub.2 together represent a C.sub.2-7 polymethylene moiety;R.sub.3 represents hydrogen, hydroxy, alkoxy or acyloxy and R.sub.4 is hydrogen or R.sub.3 and R.sub.4 together represent a bond;which process comprises reacting a compound of formula (C): ##STR1## wherein the variable A.sub.1 ', A.sub.2 ', Y.sub.1, R.sub.1 and R.sub.2 are as defined above, in the presence of an oxygen source and a chiral catalyst as defined in WO/91/14694.
    • 一种制备式(B)化合物的方法,其中:A1'或A2'之一表示氢,另一个表示基团CF 3 -Y-,其中Y表示-CF 2 - ,> C = O或-CH(OH) ,或A1'和A2'分别是可转换为A1和A2的组。 Y1表示-O-,-CH2-或NRO,其中RO是氢,烷基或烷基羰基; R1和R2独立地表示氢或烷基; 或R 1和R 2一起表示C2-7多亚甲基部分; R3表示氢,羟基,烷氧基或酰氧基,R4表示氢或R3和R4一起表示键; 该方法包括在WO / 91/14694中定义的氧源和手性催化剂的存在下使式(C)的化合物:其中变量A1',A2',Y1,R1和R2如上所定义。 。
    • 5. 发明申请
    • Bladder-based cuff for measuring physiological parameters and method of measuring physiological parameters using same
    • 用于测量生理参数的膀胱袖带和使用其测量生理参数的方法
    • US20050096552A1
    • 2005-05-05
    • US10695441
    • 2003-10-29
    • Perry LawDouglas CoxDavid MillerDavid Bell
    • Perry LawDouglas CoxDavid MillerDavid Bell
    • A61B5/022A61B5/024A61B5/02
    • A61B5/02233A61B5/02241A61B5/02422
    • A cuff for measuring volume and change in volume of a body appendage includes a hollow, rigid tube having an inner surface; and a bladder having an inner surface and an outer surface, the ends of the bladder being sealed to the ends of the tube to create an enclosed internal volume between the inner surface of the bladder and the inner surface of the tube and an external volume defined by the outer surface of the bladder and surrounded by the internal volume, the bladder having a normal, relaxed state, in which the internal volume is filled with a fluid and a retracted state in which the fluid is evacuated from the internal volume. Two stiffener ribs placed on the inner surface of the bladder, parallel to each other and to the lengthwise axis of the tube at diametrically opposite positions. A plurality of emitters and detectors arranged in a linear array are embedded in one of the ribs, so as to emit and detect light through the bladder. A fluid port extending through the tube and communicating with the internal volume, through which the internal volume can be filled with or emptied of the fluid.
    • 用于测量身体附件的体积和体积变化的袖带包括具有内表面的中空刚性管; 以及具有内表面和外表面的囊,所述囊的端部被密封到所述管的端部,以在所述囊的内表面和所述管的内表面之间产生封闭的内部容积,并且限定了外部容积 通过膀胱的外表面并被内部体积包围,气囊具有正常的松弛状态,其中内部容积填充有流体和从内部空间排出流体的缩回状态。 两个加强肋布置在囊的内表面上,在直径相对的位置处彼此平行并且与管的纵向轴线平行。 布置成线性阵列的多个发射器和检测器嵌入其中一个肋中,以便通过膀胱发射和检测光。 流体端口延伸穿过管并与内部容积连通,内部容积可以通过该容积填充或排空流体。