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1. 发明申请

US20050038379A1 Microfluidic device for drug delivery 有权
标题翻译：用于药物输送的微流体装置
公开(公告)号：US20050038379A1
公开(公告)日：2005-02-17
申请号：US10762664
申请日：2004-01-22
申请人： David Beebe , Michael MacDonald , David Eddington , Glennys Mensing
发明人： David Beebe , Michael MacDonald , David Eddington , Glennys Mensing
IPC分类号： A61M5/14 , A61M5/142 , A61M5/145 , A61M5/168 , A61M31/00
CPC分类号： A61M5/141 , A61M5/14248 , A61M5/14586 , A61M5/16881 , A61M2005/1726
摘要： A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.
摘要翻译：提供了用于将药物递送给个体的微流体装置。微流体装置包括限定用于在其中接收药物的储存器的主体。阀将储存器互连到可插入个人皮肤的输出针。压力源将药物从储存器推向针。所述阀可在关闭位置之间移动，所述关闭位置防止药物从所述贮存器流到所述输出针，以及打开位置，以允许所述药物从所述储存器流动到所述输出针，以响应于所述生理流体中的预定条件个人

2. 发明申请

US20050058714A1 Dispenser for the selective release of microparticles 审中-公开
标题翻译：用于选择性释放微粒的分配器
公开(公告)号：US20050058714A1
公开(公告)日：2005-03-17
申请号：US10663126
申请日：2003-09-16
申请人： David Beebe , Glennys Mensing , David Eddington
发明人： David Beebe , Glennys Mensing , David Eddington
IPC分类号： A61K9/14 , A61M31/00
CPC分类号： A61M31/002
摘要： A microparticle storage and delivery device is provided for allowing an individual to selectively dispense a dosage of a microparticle. The device includes a hydrogel string loaded with a plurality of dosages of the microparticle and a storage container for receiving the string. The storage container has a first open end and a second opposite end. A biasing structure urges the string toward the open end of the storage container and an actuator selectively engages the string to urge a dosage of the microparticle from the open end of the storage container.
摘要翻译：提供了一种微粒储存和递送装置，用于允许个体选择性地分配微粒的剂量。该装置包括装载有多个微粒剂量的水凝胶柱和用于接收绳索的储存容器。存储容器具有第一开口端和第二相对端。偏压结构将琴弦推向存储容器的开口端，并且致动器选择性地接合琴弦以从存储容器的开口端推动剂量的微粒。

3. 发明授权

US08501462B2 Insert device for multiwell plate 有权
标题翻译：多孔板插入装置
公开(公告)号：US08501462B2
公开(公告)日：2013-08-06
申请号：US12527897
申请日：2008-02-27
申请人： David Eddington , Ki-Hwan Nam , Shawn C. Oppegard
发明人： David Eddington , Ki-Hwan Nam , Shawn C. Oppegard
IPC分类号： C12M1/12 , C12M1/00
CPC分类号： C12M29/04 , C12M23/12 , C12M23/24 , C12M23/34 , C12M25/04 , C12M29/06 , C12M29/10
摘要： An assembly comprises a multiwell test plate having a plurality of wells having an opening and a base surface, an insert plate having a plurality of inserts positioned to align with a corresponding one of the wells whereby the insert plate can be nested with the multiwell plate. Each of the inserts includes a supply port arranged for flow communication with a supply source, an exhaust port, a bottom portion having a plurality of channels extending between the supply port and the exhaust port, and a gas permeable membrane covering the bottom portion. Each of the inserts is sized to position the gas permeable membrane a desired distance from the base surface of the multiwell test plate when the multiwell test plate and the insert plate are coupled to one another.
摘要翻译：组件包括多孔测试板，其具有多个具有开口和底面的孔，插入板具有多个插入件，定位成与相应的一个孔对准，由此插入板可以与多孔板嵌套。每个插入件包括布置成与供应源流动连通的供应端口，排气口，具有在供应口和排气口之间延伸的多个通道的底部，以及覆盖底部的透气膜。当多孔试验板和插入板彼此连接时，每个插入件的尺寸设定成将透气膜定位在距离多孔试验板的基面的期望距离处。

4. 发明申请

US20100112690A1 INSERT DEVICE FOR MULTIWELL PLATE 有权
标题翻译：多层板的插入设备
公开(公告)号：US20100112690A1
公开(公告)日：2010-05-06
申请号：US12527897
申请日：2008-02-27
申请人： David Eddington
发明人： David Eddington
IPC分类号： C12M1/12 , B32B38/00 , C12N5/00
CPC分类号： C12M29/04 , C12M23/12 , C12M23/24 , C12M23/34 , C12M25/04 , C12M29/06 , C12M29/10
摘要： An assembly comprises a multiwell test plate having a plurality of wells having an opening and a base surface, an insert plate having a plurality of inserts positioned to align with a corresponding one of the wells whereby the insert plate can be nested with the multiwell plate. Each of the inserts includes a supply port arranged for flow communication with a supply source, an exhaust port, a bottom portion having a plurality of channels extending between the supply port and the exhaust port, and a gas permeable membrane covering the bottom portion. Each of the inserts is sized to position the gas permeable membrane a desired distance from the base surface of the multiwell test plate when the multiwell test plate and the insert plate are coupled to one another.
摘要翻译：组件包括多孔测试板，其具有多个具有开口和底面的孔，插入板具有多个插入件，定位成与相应的一个孔对准，由此插入板可以与多孔板嵌套。每个插入件包括布置成与供应源流动连通的供应端口，排气口，具有在供应口和排气口之间延伸的多个通道的底部，以及覆盖底部的透气膜。当多孔试验板和插入板彼此连接时，每个插入件的尺寸设定成将透气膜定位在距离多孔试验板的基面的期望距离处。

5. 发明申请

US20120077246A1 Methods and Devices for Capturing Circulating Tumor Cells 审中-公开
标题翻译：捕获循环肿瘤细胞的方法和装置
公开(公告)号：US20120077246A1
公开(公告)日：2012-03-29
申请号：US13265916
申请日：2010-04-23
申请人： Seungpyo Hong , David Eddington , Ja Hye Myung , Cari Launiere
发明人： Seungpyo Hong , David Eddington , Ja Hye Myung , Cari Launiere
IPC分类号： C12N11/00 , B01L3/00
CPC分类号： G01N33/574
摘要： A method of capturing a Circulating Tumor Cell (CTC) from a sample includes introducing a sample into a microfluidic device having a cell capture surface and a flow modification surface under conditions that allow a CTC to bind to a cell rolling-inducing agent and a capturing agent disposed on the cell capture surface. The flow modification surface induces a rotational flow within the sample as it flows through the microfluidic device.
摘要翻译：从样品捕获循环肿瘤细胞（CTC）的方法包括将样品引入到具有细胞捕获表面和流动修饰表面的微流体装置中，该条件允许CTC结合细胞转导诱导剂和捕获药剂置于细胞捕获表面上。流动修饰表面在样品流过微流体装置时会引起样品内的旋转流动。

6. 发明申请

US20060160066A1 Cellular microarrays for screening differentiation factors 有权
标题翻译：用于筛选分化因子的细胞微阵列
公开(公告)号：US20060160066A1
公开(公告)日：2006-07-20
申请号：US11336131
申请日：2006-01-19
申请人： Sangeeta Bhatia , Christopher Flaim , David Eddington
发明人： Sangeeta Bhatia , Christopher Flaim , David Eddington
IPC分类号： C12Q1/00 , C12M1/34
CPC分类号： G01N33/5023 , B01J19/0046 , B01J2219/00317 , B01J2219/00367 , B01J2219/00378 , B01J2219/00387 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , B01J2219/00691 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00743 , B01L3/5027 , B01L3/5085 , B01L2300/0636 , B01L2300/0829 , B82Y30/00 , C12M25/14 , C12M41/46 , G01N33/5008 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/5032 , G01N33/5064 , G01N33/5067 , G01N33/507
摘要： Provided is a microarray platform for the culture of cells atop combinatorial matrix mixtures; enabling the study of differentiation in response to a multitude of microenvironments in parallel.
摘要翻译：提供了用于组合基质混合物上的细胞培养的微阵列平台; 使得能够并行地响应多种微环境的分化研究。

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