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1. 发明授权

US07449338B2 Tests for the rapid evaluation of ischemic states and kits 有权
标题翻译：检测缺血状态和试剂盒的快速评估
公开(公告)号：US07449338B2
公开(公告)日：2008-11-11
申请号：US10319263
申请日：2002-12-13
申请人： David Bar-Or , Edward Lau , James V. Winkler , Gary Fagan , Hollie Wayment
发明人： David Bar-Or , Edward Lau , James V. Winkler , Gary Fagan , Hollie Wayment
IPC分类号： G01N33/48
CPC分类号： G01N33/6842 , C07K14/765 , G01N33/68
摘要： The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
摘要翻译：本发明涉及用于检测缺血状态的快速方法和用于这些方法的试剂盒。基于检测和定量缺血事件发生的血清蛋白白蛋白变化的存在的方法，提供了一种快速测试和定量缺血的方法; 用于检测和定量这种改变的方法包括评估和定量循环白蛋白的钴结合能力，分析和测量血清白蛋白结合外源钴的能力，检测和测量纯化白蛋白样品中内源性铜的存在，以及使用在缺血事件之后发生的血清白蛋白改变形式的特异性免疫测定。本发明还教导了通过测量缺血事件后出现的白蛋白N末端衍生物检测和测量缺血事件，包括缺乏一至四个N-末端氨基酸的截短的白蛋白物质或具有乙酰化N-末端的白蛋白 Asp残基。

2. 发明申请

US20050142613A1 Test for the rapid evaluation of ischemic states and kits 审中-公开
标题翻译：测试缺血状态和试剂盒的快速评估
公开(公告)号：US20050142613A1
公开(公告)日：2005-06-30
申请号：US11033766
申请日：2005-01-12
申请人： David Bar-Or , Edward Lau , James Winkler , Gary Fagan , Hollie Wayment
发明人： David Bar-Or , Edward Lau , James Winkler , Gary Fagan , Hollie Wayment
IPC分类号： G01N33/68 , G01N33/53 , C07K14/765
CPC分类号： G01N33/6842 , G01N33/683
摘要： The present invention relates to rapid methods for the detection of ischemic states and to kits for use in such methods. Provided for is a rapid method of testing for and quantifying ischemia based upon methods of detecting and quantifying the existence of an alteration of the serum protein albumin which occurs following an ischemic event; methods for detecting and quantifying this alteration include evaluating and quantifying the cobalt binding capacity of circulating albumin, analysis and measurement of the ability of serum albumin to bind exogenous cobalt, detection and measurement of the presence of endogenous copper in a purified albumin sample and use of an immunological assay specific to the altered form of serum albumin which occurs following an ischemic event. Also taught by the present invention is the detection and measurement of an ischemic event by measuring albumin N-terminal derivatives that arise following an ischemic event, including truncated albumin species lacking one to four N-terminal amino acids or albumin with an acetylated N-terminal Asp residue.
摘要翻译：本发明涉及用于检测缺血状态的快速方法和用于这些方法的试剂盒。基于检测和定量缺血事件发生的血清蛋白白蛋白变化的存在的方法，提供了一种快速测试和定量缺血的方法; 用于检测和定量这种改变的方法包括评估和定量循环白蛋白的钴结合能力，分析和测量血清白蛋白结合外源钴的能力，检测和测量纯化白蛋白样品中内源性铜的存在，以及使用在缺血事件之后发生的血清白蛋白改变形式的特异性免疫测定。本发明还教导了通过测量缺血事件后出现的白蛋白N末端衍生物检测和测量缺血事件，包括缺乏一至四个N-末端氨基酸的截短的白蛋白物质或具有乙酰化N-末端的白蛋白 Asp残基。

3. 发明授权

US07063782B2 Electrochemical detection of ischemia 有权
公开(公告)号：US07063782B2
公开(公告)日：2006-06-20
申请号：US10304610
申请日：2002-11-26
申请人： Hollie Wayment , Gary Fagan , Peter A. Crosby , Shannon George
发明人： Hollie Wayment , Gary Fagan , Peter A. Crosby , Shannon George
IPC分类号： G01N27/327
CPC分类号： G01N33/5438 , G01N27/49 , G01N33/6887 , G01N2333/765
摘要： The subject invention comprises electrochemical methods and devices for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes are used to measure the current or potential difference of non-sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.

4. 发明申请

US20060191788A1 Electrochemical detection of ischemia 审中-公开
公开(公告)号：US20060191788A1
公开(公告)日：2006-08-31
申请号：US11415929
申请日：2006-05-01
申请人： Hollie Wayment , Gary Fagan , Peter Crosby , Shannon George
发明人： Hollie Wayment , Gary Fagan , Peter Crosby , Shannon George
IPC分类号： G01N33/487
CPC分类号： G01N33/5438 , G01N27/49 , G01N33/6887 , G01N2333/765
摘要： The subject invention comprises electrochemical methods and devices for in vitro detection of an ischemic event in a patient sample. Following addition of a known amount of a transition metal ion to the patient sample, electrodes are used to measure the current or potential difference of non-sequestered transition metal ion in the sample. The amount of non-sequestered transition metal ion in the sample reflects the degree of modification to albumin that is the result of an ischemic event.

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