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1. 发明申请

US20130143794A1 POLYPEPTIDES FOR TREATING AND/OR LIMITING INFLUENZA INFECTION 失效
标题翻译：用于治疗和/或限制流感病毒感染的多肽
公开(公告)号：US20130143794A1
公开(公告)日：2013-06-06
申请号：US13813356
申请日：2011-08-03
申请人： David Baker , Timothy A. Whitehead , Sarel Fleishman
发明人： David Baker , Timothy A. Whitehead , Sarel Fleishman
IPC分类号： C07K14/00
CPC分类号： C07K7/08 , A61K38/00 , A61K38/10 , A61K38/16 , C07K14/00 , C07K14/001 , G01N33/53 , G01N33/56983 , G01N2333/11 , G01N2469/10
摘要： The present invention provides polypeptides according to the general formulas disclosed herein, which recognize and are strong binders to Influenza A hemagglutinin and can be used, for example, to treat and/or limit development of an influenza infection. The present invention further provides isolated nucleic acids encoding the polypeptides of the invention, recombinant expression vectors comprising the nucleic acids encoding the polypeptides of the invention operatively linked to a suitable control sequence, and recombinant host cells comprising the recombinant expression vectors of the invention. The present invention also provides antibodies that selectively bind to the polypeptides of the invention, and pharmaceutical compositions comprising one or more polypeptides according to the invention and a pharmaceutically acceptable carrier. Additionally, the present invention provides methods for treating and/or limiting an influenza infection, methods for diagnosing an influenza infection, or monitoring progression of an influenza infection, methods for identifying candidate influenza vaccines, and methods for identifying candidate compounds for treating, limiting, and/or diagnosing influenza infection.
摘要翻译：本发明提供了根据本文公开的通式的多肽，其识别并且是甲型流感血凝素的强粘合剂，并且可以用于例如治疗和/或限制流感感染的发展。本发明还提供了编码本发明多肽的分离的核酸，包含编码可操作地连接到合适的控制序列的本发明的多肽的核酸的重组表达载体和包含本发明的重组表达载体的重组宿主细胞。本发明还提供了选择性结合本发明的多肽的抗体，以及包含一种或多种本发明多肽和药学上可接受的载体的药物组合物。另外，本发明提供了用于治疗和/或限制流感感染的方法，用于诊断流感感染的方法或监测流感感染的进展，用于鉴定候选流感疫苗的方法，以及用于鉴定候选化合物的方法，用于治疗，限制，和/或诊断流感感染。

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