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1. 发明授权

US5679810A Linear oligomeric polychelant compounds 失效
标题翻译：线性低聚聚合物化合物
公开(公告)号：US5679810A
公开(公告)日：1997-10-21
申请号：US480056
申请日：1995-06-07
申请人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
发明人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
IPC分类号： A61K49/06 , C07F15/00 , C07F3/08
CPC分类号： A61K49/06
摘要： Linear oligomer polychelant compounds and chelates formed therewith have alternating chelant and linker moieties bound together by amide or ester moieties. The compounds have between 3 and 100 chelant moieties, at least one of which complexes a paramagnetic metal ion. The polychelants and especially their paramagnetic metal polychelates are particularly suitable for diagnostic imaging.
摘要翻译：由此形成的线型低聚物聚合物和螯合物具有通过酰胺或酯部分结合在一起的交替螯合剂和连接部分。化合物具有3至100个螯合剂部分，其中至少一种与顺磁性金属离子复合。多层，特别是它们的顺磁性金属聚合物特别适用于诊断成像。

2. 发明授权

US5446145A Polychelant compounds 失效
标题翻译：聚合物化合物
公开(公告)号：US5446145A
公开(公告)日：1995-08-29
申请号：US86996
申请日：1993-07-07
申请人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
发明人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
IPC分类号： A61K49/00 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D241/06 , C07D257/02 , C07D295/185 , C07D403/14 , C07F9/6524 , C07F19/00 , C07D225/02
CPC分类号： C07D241/06 , A61K49/0002 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D257/02 , C07D295/185 , C07D403/14 , C07F19/005 , C07F9/6524
摘要： There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.
摘要翻译：公开了多层金属螯合剂和由此形成的螯合物的聚合物化合物。复合物，特别是它们的顺磁金属，重金属或放射性金属聚合物特别适用于诊断成像，重金属解毒或放射治疗。聚合物具有直链或支链低聚结构，其包含交替的螯合剂和通过酰胺或酯部分连接在一起的接头部分，其羰基与螯合剂部分相邻，每个聚合物包含至少两个能够络合金属离子的所述螯合剂部分。

3. 发明授权

US5281704A Polychelant compounds 失效
标题翻译：聚合物化合物
公开(公告)号：US5281704A
公开(公告)日：1994-01-25
申请号：US468107
申请日：1990-01-19
申请人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
发明人： David B. Love , William C. Dow , Richard J. Himmelsbach , Alan D. Watson , Scott M. Rocklage
IPC分类号： A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D241/06 , C07D257/02 , C07D295/185 , C07F19/00 , C07H15/12 , C07H19/02 , C07H23/00
CPC分类号： C07D241/06 , A61K49/06 , C07C237/06 , C07C237/10 , C07C237/12 , C07D257/02 , C07D295/185 , C07F19/005
摘要： There are disclosed polychelant compounds, that is multi-site metal chelating agents, and chelates formed therewith. The polychelants and especially their paramagnetic metal, heavy metal or radioactive metal polychelates are particularly suitable for use in diagnostic imaging, heavy metal detoxification or radiotherapy. The polychelants have a linear or branched oligomeric structure comprising alternating chelant and linker moieties bound together by amide or ester moieties the carbonyl groups whereof being adjacent the chelant moieties, each polychelant comprising at least two said chelant moieties capable of complexing a metal ion.
摘要翻译：公开了多层金属螯合剂和由此形成的螯合物的聚合物化合物。复合物，特别是它们的顺磁金属，重金属或放射性金属聚合物特别适用于诊断成像，重金属解毒或放射治疗。聚合物具有直链或支链低聚结构，其包含交替的螯合剂和通过酰胺或酯部分连接在一起的接头部分，其羰基与螯合剂部分相邻，每个聚合物包含至少两个能够络合金属离子的所述螯合剂部分。

4. 发明申请

US20100297778A1 Conjugate Having Cleavable Linking Agent 审中-公开
标题翻译：具有可切换链接代理的共轭体
公开(公告)号：US20100297778A1
公开(公告)日：2010-11-25
申请号：US12468939
申请日：2009-05-20
申请人： John G. Konrath , Jeffrey A. Moore , Richard J. Himmelsbach
发明人： John G. Konrath , Jeffrey A. Moore , Richard J. Himmelsbach
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： G01N33/54333 , G01N33/582
摘要： A method and reagent that can be used to eliminate the signal caused by non-specific binding of a labeled conjugate, e.g., a specific binding member attached to a label, to a solid phase, e.g., a magnetic microparticle. The method and the reagent involve the use of a cleavable linking agent to link the label to the specific binding member that specifically binds to the analyte. The use of a cleavable linking agent would allow the release of the label from the specific binding member from the complex comprising the magnetic microparticle, analyte, and labeled conjugate into solution. After the release of the label, the magnetic microparticles having any label non-specifically bound thereto, are removed from the reaction mixture. Only the label, e.g., acridinium, from the labeled conjugate would remain in the elution well. The conjugate that is non-specifically bound through interaction between the label and the solid phase, e.g., a magnetic particle, would remain bound to the solid phase, and would subsequently be removed from the elution well when the solid phase is removed from the elution well and transferred to another well the introduction of additional reagent(s).
摘要翻译：可用于消除由标记的缀合物（例如附着于标记物的特异性结合构件）与固相例如磁性微粒的非特异性结合引起的信号的方法和试剂。该方法和试剂包括使用可切割的连接剂将标记物与特异性结合分析物结合的特异性结合成员连接。使用可切割交联剂将允许从包含磁性微粒，分析物和标记的缀合物的络合物中将标记从特异性结合成员释放到溶液中。剥离标签后，从反应混合物中除去具有非特异性结合的标记的磁性微粒。只有来自标记的缀合物的标记（例如吖啶鎓）将保留在洗脱井中。通过标记和固相（例如磁性颗粒）之间的相互作用非特异性结合的缀合物将保持与固相结合，并且随后在从洗脱液中除去固相时从洗脱孔中除去并转移到另一个井，引入额外的试剂。

5. 发明授权

US5869651A Hydrazide derivatives of polyamides and their medical use as chelating agents 失效
标题翻译：聚酰胺的酰肼衍生物及其作为螯合剂的医疗用途
公开(公告)号：US5869651A
公开(公告)日：1999-02-09
申请号：US190143
申请日：1994-08-08
申请人： Richard J. Himmelsbach , P.ang.l Rongved , Jo Klaveness , Per Strande , Harald Dugstad
发明人： Richard J. Himmelsbach , P.ang.l Rongved , Jo Klaveness , Per Strande , Harald Dugstad
IPC分类号： A61K51/00 , C07C243/34 , C07C259/06 , C07C311/31 , C07C317/28 , C07D257/02 , C07D259/00 , C07F5/00 , C07F9/24 , C07F9/6524 , C09K3/00 , C07D498/08 , C07F15/02
CPC分类号： C07C243/34 , C07C259/06 , C07D257/02
摘要： The invention relates to certain substituted derivatives of aminopolycarboxylic acids and metal chelates thereof. The compounds are particularly suitable for use as diagnostic agent. For example, the compounds can be used as radiodiagnostic agents, detoxification agents and contrast agents for diagnostic imaging processes. In particular, the high relaxivity paramagnetic metal chelates of substituted aminopolycarboxylic acids are especially suited for use as magnetic resonance imaging contrast agents.
摘要翻译： PCT No.PCT / EP92 / 01598 Sec。 371日期1994年8月8日 102（e）日期1994年8月8日PCT提交1992年7月16日PCT公布。公开号WO93 / 08045 日期：1993年2月4日本发明涉及某些取代的氨基多羧酸衍生物及其金属螯合物。该化合物特别适合用作诊断剂。例如，化合物可用作诊断成像过程的放射诊断剂，解毒剂和造影剂。特别地，取代的氨基多羧酸的高弛豫顺磁性金属螯合物特别适合用作磁共振成像造影剂。

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