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1. 发明申请

US20070010952A1 Molecules comprising a calcineurin-like binding pocket and encoded data storage medium capable of graphically displaying them 审中-公开
标题翻译：包含钙调神经磷酸酶结合口袋的分子和能够图形显示它们的编码数据存储介质
公开(公告)号：US20070010952A1
公开(公告)日：2007-01-11
申请号：US11471290
申请日：2006-06-19
申请人： David Armistead , Matthew Fitzgibbon , Mark Fleming , James Griffith , Eunice Kim , Joseph Kim , Michael Sintchak , John Thomson , Keith Wilson
发明人： David Armistead , Matthew Fitzgibbon , Mark Fleming , James Griffith , Eunice Kim , Joseph Kim , Michael Sintchak , John Thomson , Keith Wilson
IPC分类号： G06F19/00 , C07K14/705
CPC分类号： C07K14/705 , C12N9/16
摘要： The present invention relates to crystallized molecules and molecular complexes which comprise the active site binding pocket or the FKBP12/FK506 binding pocket of calcineurin or close structural homologues to either binding pocket. This invention also relates to a data storage material encoded with the corresponding structure coordinates of those crystallized molecules or molecular complexes. Such data storage material is capable of displaying such molecules and molecular complexes as a graphical three-dimensional representation on a computer screen. In addition, this invention relates to methods of using the structure coordinates of those molecules or molecular complexes to solve the structure of homologous proteins. This invention also relates to methods of using the structure coordinates to screen and design compounds that bind to calcineurin or homologues thereof.
摘要翻译：本发明涉及结晶分子和分子复合物，其包含活性位点结合口袋或钙调神经磷酸酶的FKBP12 / FK506结合口袋或紧密结构同源物至结合口袋。本发明还涉及用这些结晶分子或分子复合物的对应结构坐标编码的数据存储材料。这样的数据存储材料能够在计算机屏幕上显示作为图形三维表示的分子和分子复合物。此外，本发明涉及使用这些分子或分子复合物的结构坐标来解决同源蛋白质结构的方法。本发明还涉及使用结构坐标来筛选和设计结合钙调神经磷酸酶或其同系物的化合物的方法。

2. 发明申请

US20050203114A1 Kinase inhibitors 失效
标题翻译：激酶抑制剂
公开(公告)号：US20050203114A1
公开(公告)日：2005-09-15
申请号：US11125614
申请日：2005-05-09
申请人： David Armistead , Jean Bemis , Lucian DiPietro , Stephanie Geuns-Meyer , Gregory Habgood , Joseph Kim , Joseph Nunes , Vinod Patel , Leticia Toledo-Sherman
发明人： David Armistead , Jean Bemis , Lucian DiPietro , Stephanie Geuns-Meyer , Gregory Habgood , Joseph Kim , Joseph Nunes , Vinod Patel , Leticia Toledo-Sherman
IPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61P1/04 , A61P3/00 , A61P3/10 , A61P9/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/08 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P35/00 , A61P35/02 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/14 , C07D417/14 , A61K31/513
CPC分类号： C07D401/14 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The invention relates to inhibitors of kinases, compositions comprising the inhibitors, and methods of using the inhibitors and inhibitor compositions. The inhibitors and compositions comprising them are useful for treating disease or disease symptoms. The invention also provides for methods of making kinase inhibitor compounds, methods of inhibiting kinase activity, and methods for treating disease or disease symptoms.
摘要翻译：本发明涉及激酶抑制剂，包含抑制剂的组合物，以及使用抑制剂和抑制剂组合物的方法。包含它们的抑制剂和组合物可用于治疗疾病或疾病症状。本发明还提供了制备激酶抑制剂化合物的方法，抑制激酶活性的方法，以及治疗疾病或疾病症状的方法。

3. 发明申请

US20070136016A1 System and methods for integrating authoring with complexity analysis for computing system operation procedures 有权
标题翻译：用于将创作与计算系统操作程序的复杂度分析相结合的系统和方法
公开(公告)号：US20070136016A1
公开(公告)日：2007-06-14
申请号：US11301813
申请日：2005-12-13
申请人： Aaron Brown , Joseph Kim
发明人： Aaron Brown , Joseph Kim
IPC分类号： G06F19/00
CPC分类号： G06F17/50 , G06Q10/04 , G06Q10/06
摘要： Techniques are disclosed for integrating complexity analysis with procedure authoring (design and/or documentation). By way of example, a technique for authoring a procedure associated with a computing system operation based on a complexity analysis associated with the operation and the computing system implementing the operation comprises the following steps/operations. A procedure associated with a computing system operation is generated, wherein the generated procedure represents a new procedure or an edited existing procedure. A structured representation of the generated procedure is extracted from the generated procedure. The structured representation of the generated procedure is analyzed to produce complexity analysis results, wherein at least a portion of the complexity analysis results are fed back to a procedure author for use in selectively altering the generated procedure. The technique may also further comprise generating documentation relating to the generated procedure from the structured representation of the generated procedure.
摘要翻译：公开了将复杂度分析与程序创作（设计和/或文档）集成的技术。作为示例，用于基于与操作相关联的复杂性分析来创建与计算系统操作相关联的过程的技术和实现该操作的计算系统包括以下步骤/操作。生成与计算系统操作相关联的过程，其中生成的过程表示新的过程或已编辑的现有过程。从生成的过程中提取生成过程的结构化表示。分析生成的过程的结构化表示以产生复杂性分析结果，其中复杂度分析结果的至少一部分被反馈给过程作者以用于选择性地改变生成的过程。该技术还可以进一步包括从生成的过程的结构化表示生成与所生成的过程有关的文档。

4. 发明申请

US20170290474A1 Hygienic Toilet Seat and Lid Assembly 审中-公开
公开(公告)号：US20170290474A1
公开(公告)日：2017-10-12
申请号：US15093640
申请日：2016-04-07
申请人： Joseph Kim
发明人： Joseph Kim
IPC分类号： A47K13/00
CPC分类号： A47K13/00
摘要： A toilet seat and toilet lid assembly is provided which prevents bodily waste from undesirably exiting flushing toilets and contaminating surrounding areas and surfaces. More particularly, the assembly comprises an annular toilet seat and a lid, hingedly attached to the seat. An underside of the lid is configured to closely mate with the opening formed in the seat. Prior to flushing a toilet, a user may pivotally close the assembly, which may be secured over a toilet bowl. When closed, a male protrusion in the lid may be closely mated with the opening in the seat to prevent contaminants within the toilet bowl from exiting such bowl when activating the toilet's flushing capability agitates water and waste contained therein.

5. 发明申请

US20070031867A1 Molecular/genetic aberrations in surgical margins of resected pancreatic cancer represents neoplastic disease that correlates with disease outcome 审中-公开
标题翻译：切除胰腺癌手术切缘的分子/遗传畸变代表与疾病预后相关的肿瘤性疾病
公开(公告)号：US20070031867A1
公开(公告)日：2007-02-08
申请号：US11475723
申请日：2006-06-27
申请人： Dave Hoon , Joseph Kim
发明人： Dave Hoon , Joseph Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118
摘要： The present invention relates to the detection of field cancerization by detection of aberrations in tumor target genes at the margins of resected tumors, and the use of such information to predict survival in cancer patients. Methods for treatment of cancer based thereon also are provided.
摘要翻译：本发明涉及通过检测在切除的肿瘤边缘的肿瘤靶基因中的像差的现场癌化检测，以及使用这种信息来预测癌症患者的存活。还提供了用于治疗癌症的方法。

6. 发明申请

US20060040956A1 Substituted alkylamine derivatives and methods of use 有权
公开(公告)号：US20060040956A1
公开(公告)日：2006-02-23
申请号：US11234713
申请日：2005-09-23
申请人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
发明人： Guoqing Chen , Jeffrey Adams , Jean Bemis , Shon Booker , Guolin Cai , Lucian Di Pietro , Celia Dominguez , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Michael Handley , Qi Huang , Joseph Kim , Tae-Seong Kim , Alexander Kiselyov , Xiaohu Ouyang , Vinod Patel , Leon Smith , Markian Stec , Andrew Tasker , Ning Xi , Shimin Xu , Chester Yuan , Michael Croghan
IPC分类号： A61K31/506 , C07D403/02
CPC分类号： C07D213/82 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/538 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/00 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.

7. 发明申请

US20050261313A1 Substituted alkylamine derivatives and methods of use 失效
标题翻译：取代的烷基胺衍生物和使用方法
公开(公告)号：US20050261313A1
公开(公告)日：2005-11-24
申请号：US11014184
申请日：2004-12-15
申请人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian DiPietro , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Gregory Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Babak Riahi , Joseph Kim , Ning Xi , Kevin Yang , Chester Yuan
发明人： Benny Askew , Jeffrey Adams , Shon Booker , Guoqing Chen , Lucian DiPietro , Daniel Elbaum , Julie Germain , Stephanie Geuns-Meyer , Gregory Habgood , Michael Handley , Qi Huang , Tae-Seong Kim , Aiwen Li , Nobuko Nishimura , Rana Nomak , Vinod Patel , Babak Riahi , Joseph Kim , Ning Xi , Kevin Yang , Chester Yuan
IPC分类号： A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4709 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P9/10 , A61P11/06 , A61P15/08 , A61P17/06 , A61P19/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/02 , C07D471/04 , C07D491/02 , C07D41/02 , C07D43/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04
摘要： Selected amines are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：选择的胺对于预防和治疗疾病如血管生成介导的疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

8. 发明申请

US20050245547A1 Compounds and methods of use 有权
标题翻译：化合物和使用方法
公开(公告)号：US20050245547A1
公开(公告)日：2005-11-03
申请号：US11042398
申请日：2005-01-24
申请人： Tae-Seong Kim , Jean-Christophe Harmange , David Bauer , Shon Booker , Yuan Cheng , Shimin Xu , Ning Xi , Joseph Kim , Andrew Tasker
发明人： Tae-Seong Kim , Jean-Christophe Harmange , David Bauer , Shon Booker , Yuan Cheng , Shimin Xu , Ning Xi , Joseph Kim , Andrew Tasker
IPC分类号： A61K31/47 , A61K31/4709 , A61K31/4745 , A61K31/517 , A61K31/519 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/02 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/02 , C07D495/04
CPC分类号： C07D495/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：所选化合物对于预防和治疗诸如HGF介导的疾病等疾病是有效的。本发明包括新颖的化合物，类似物，前药和药学上可接受的盐，用于预防和治疗疾病和其它疾病或涉及癌症等的病症的药物组合物和方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

9. 发明申请

US20050050076A1 System and method for carrying out legacy application transitions 失效
标题翻译：用于执行传统应用程序转换的系统和方法
公开(公告)号：US20050050076A1
公开(公告)日：2005-03-03
申请号：US10921451
申请日：2004-08-19
申请人： Tack Tong , Joseph Kim
发明人： Tack Tong , Joseph Kim
IPC分类号： G06F17/30 , G06F7/00 , G06F9/44 , G06F12/00 , G06F17/20
CPC分类号： G06F17/30297 , Y10S707/99931 , Y10S707/99953
摘要： A system and method for carrying out transitions from legacy to new applications includes the definition of relational database views to permit relational queries defined for a database having a legacy schema to be run against a database having a new schema. The relational database views for the database having a new schema are generated with reference to and by selection from a set of database views defined for possible schema changes. The post-transition display of legacy display pages is handled by the preferred embodiment through the use of a view registry that associates a defined display view with a legacy view engine and a legacy display page.
摘要翻译：用于执行从旧应用到新应用的转换的系统和方法包括关系数据库视图的定义，以允许为具有旧模式的数据库定义的关系查询针对具有新模式的数据库运行。参考并通过为可能的模式更改定义的一组数据库视图进行选择来生成具有新模式的数据库的关系数据库视图。遗留显示页面的过渡后显示由优选实施例通过使用将定义的显示视图与传统视图引擎和传统显示页面相关联的视图注册表来处理。

10. 发明申请

US20180245734A1 Attachment and Securement System 审中-公开
公开(公告)号：US20180245734A1
公开(公告)日：2018-08-30
申请号：US15443410
申请日：2017-02-27
申请人： Steve W. Kim , Joseph Kim , Eun-Jin Kim , Ki-Hyung Han
发明人： Steve W. Kim , Joseph Kim , Eun-Jin Kim , Ki-Hyung Han
IPC分类号： F16M13/02 , F16M11/14 , F16M11/40 , F16M11/04 , F16B1/00 , B60R11/02 , B60R7/10 , H04M1/04
CPC分类号： F16M13/022 , B60R11/02 , B60R2011/0057 , B60R2011/0059 , B60R2011/0078 , B60R2011/0089 , F16B2001/0035 , F16M11/041 , F16M11/14 , F16M11/40 , F16M13/00 , H04M1/04
摘要： An attachment and securement system that allows an item to be secured onto a surface or a structure, and to be selectively positioned. The system consists of a first assembly with a magnet and an interface, and a second assembly with a screw actuated clamp and a post that terminates at a circular metal head. The first assembly is attached to an item such as a mobile communication device, a computing device, apparel, or an apparel accessory. The item with the attached first assembly is then placed in contact with and magnetically adhered to the second assembly, which is attached to a surface or structure. The magnet secures the item to the second assembly, and the circular design of the metal head allows the head to rotate about the magnet, allowing the item to be selectively positioned.

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