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1. 发明申请

US20120211084A1 MULTIPLE EMULSIONS CREATED USING JETTING AND OTHER TECHNIQUES 审中-公开
公开(公告)号：US20120211084A1
公开(公告)日：2012-08-23
申请号：US13388596
申请日：2010-09-01
申请人： David A. Weitz , Julian W.P. Thiele , Adam R. Abate
发明人： David A. Weitz , Julian W.P. Thiele , Adam R. Abate
IPC分类号： F17D1/00
CPC分类号： B01F3/0807 , B01F13/0062 , B01F13/0084 , B01F2003/0838 , B01F2215/045 , B01F2215/0459 , Y10T137/0318 , Y10T137/85938
摘要： The present invention generally relates to emulsions, and more particularly, to multiple emulsions. In one aspect, multiple emulsions are formed by urging a fluid into a channel, e.g., by causing the fluid to enter the channel as a “jet.” Side channels can be used to encapsulate the fluid with a surrounding fluid. In some cases, multiple fluids may flow through a channel collinearly before multiple emulsion droplets are formed. The fluidic channels may also, in certain embodiments, include varying degrees of hydrophilicity or hydrophobicity. As examples, the fluidic channel may be relatively hydrophilic upstream of an intersection (or other region within the channel) and relatively hydrophobic downstream of the intersection, or vice versa. In some cases, the average cross-sectional dimension may change, e.g., at an intersection. For instance, the average cross-sectional dimension may increase at the intersection. Surprisingly, a relatively small increase in dimension, in combination with a change in hydrophilicity of the fluidic channel, may delay droplet formation of a stream of collinearly-flowing multiple fluids under certain flow conditions; accordingly, the point at which multiple emulsion droplets are formed can be readily controlled within the fluidic channel. In some cases, the multiple droplet may be formed from the collinear flow of fluids at (or near) a single location within the fluidic channel. In addition, unexpectedly, systems such as those described herein may be used to encapsulate fluids in single or multiple emulsions that are difficult or impossible to encapsulate using other techniques, such as fluids with low surface tension, viscous fluids, or viscoelastic fluids. Other aspects of the invention are generally directed to methods of making and using such systems, kits involving such systems, emulsions created using such systems, or the like.

2. 发明申请

US20120167410A1 SPRAY DRYING TECHNIQUES 审中-公开
标题翻译：喷雾干燥技术
公开(公告)号：US20120167410A1
公开(公告)日：2012-07-05
申请号：US13330793
申请日：2011-12-20
申请人： Adam R. Abate , Julian W.P. Thiele , David A. Weitz , Christian Holtze , Maike Windbergs
发明人： Adam R. Abate , Julian W.P. Thiele , David A. Weitz , Christian Holtze , Maike Windbergs
IPC分类号： F26B21/00 , F26B3/02
CPC分类号： B01D1/18 , A61K31/58 , F26B3/12
摘要： The present invention generally relates to microfluidics, and to spray drying and other drying techniques. In some aspects, an article containing one or more channels or microfluidic channels is used to mix one or more fluids prior to spray drying. The mixing may occur immediately before the fluids are expelled through a nozzle or other opening into a drying region of the spray dryer. In one set of embodiments, for example, a first fluid is exposed to a second fluid, then the fluids are exposed to air or other gases before being expelled through a nozzle. In certain instances, the first fluid may contain a dissolved species that may precipitate upon exposure to the second fluid; such precipitation may occur immediately before expulsion through a nozzle or other opening, thereby resulting in controlled precipitation as part of the spray drying process.
摘要翻译：本发明一般涉及微流体，以及喷雾干燥和其它干燥技术。在一些方面，使用含有一种或多种通道或微流体通道的制品在喷雾干燥之前混合一种或多种流体。在流体通过喷嘴或其它开口排出到喷雾干燥器的干燥区域之前，混合可能发生。在一组实施例中，例如，第一流体暴露于第二流体，然后在通过喷嘴排出之前将流体暴露于空气或其它气体。在某些情况下，第一流体可以含有在暴露于第二流体时可能沉淀的溶解物质; 这样的沉淀可以在通过喷嘴或其他开口排出之前立即发生，从而导致作为喷雾干燥过程的一部分的受控沉淀。

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