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1. 发明授权

US06442279B1 Acoustic conditioner 有权
标题翻译：声学调理器
公开(公告)号：US06442279B1
公开(公告)日：2002-08-27
申请号：US09687799
申请日：2000-10-13
申请人： David A. Preves , Robert L. Millier , Lawrence T. Hagen , Ning Shen
发明人： David A. Preves , Robert L. Millier , Lawrence T. Hagen , Ning Shen
IPC分类号： H03G700
CPC分类号： H04R25/502 , H04R25/356
摘要： An acoustic conditioning apparatus. The mechanism includes an attenuator to limit excessive noise levels. The attenuator includes a circuit for compressing an output sound pressure level below a desired level, such as 90 dBA over an eight-hour period. The mechanism also includes an amplifier for conditioning ambient sound level in accordance with the normal needs of a hearing impaired person using the conditioning apparatus. Additionally included is a switch in an electrical circuit to enable selection of attenuation of excessive noise levels or normal amplification. The switch can be controlled either manually by means of a toggle on a housing enclosing the various components, or automatically in response to the sensed noise level.
摘要翻译：声音调节装置。该机构包括一个衰减器以限制过高的噪音水平。衰减器包括用于将输出声压级压缩到低于期望水平的电路，例如在八小时内的90dBA。该机构还包括用于根据使用调节装置的听障人士的正常需要来调节环境声级的放大器。另外包括电路中的开关，以便能够选择过大噪声电平或正常放大的衰减。可以通过在包围各种部件的外壳上的肘节手动地控制开关，或者响应于感测到的噪声水平而自动地控制开关。

2. 发明授权

US06359992B1 Acoustics conditioner 失效
标题翻译：声学护发素
公开(公告)号：US06359992B1
公开(公告)日：2002-03-19
申请号：US08795545
申请日：1997-02-06
申请人： David A. Preves , Robert L. Millier , Lawrence T. Hagen , Ning Shen
发明人： David A. Preves , Robert L. Millier , Lawrence T. Hagen , Ning Shen
IPC分类号： H04R2500
CPC分类号： H04R25/502 , H04R25/356
摘要： An acoustic conditioning apparatus. The mechanism includes an attenuator to limit excessive noise levels. The attenuator includes a circuit for compressing an output sound pressure level below a desired level, such as 90 dBA over an eight-hour period. The mechanism also includes an amplifier for conditioning ambient sound level in accordance with the normal needs of a hearing impaired person using the conditioning apparatus. Additionally included is a switch in an electrical circuit to enable selection of attenuation of excessive noise levels or normal amplification. The switch can be controlled either manually by means of a toggle on a housing enclosing the various components, or automatically in response to the sensed noise level.
摘要翻译：声音调节装置。该机构包括一个衰减器以限制过高的噪音水平。衰减器包括用于将输出声压级压缩到低于期望水平的电路，例如在八小时内的90dBA。该机构还包括用于根据使用调节装置的听障人士的正常需要来调节环境声级的放大器。另外包括电路中的开关，以便能够选择过大噪声电平或正常放大的衰减。可以通过在包围各种部件的外壳上的肘节手动地控制开关，或者响应于感测到的噪声水平而自动地控制开关。

3. 发明授权

US09453062B2 Glucose dependent insulinotropic polypeptide analogs, pharmaceutical compositions and use thereof 有权
标题翻译：葡萄糖依赖性促胰岛素多肽类似物，药物组合物及其用途
公开(公告)号：US09453062B2
公开(公告)日：2016-09-27
申请号：US14125061
申请日：2012-06-08
申请人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
发明人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
IPC分类号： A61K38/22 , A61K38/00 , A61K38/28 , A61K38/26 , A61K38/16 , A61P3/04 , A61P3/10 , A61P7/12 , A61P19/10 , C07K14/605 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , C07K14/575 , C07K14/00
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu- A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译：本发明提供衍生自GIP（1-29，SEQ ID NO：1）的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性，并且包含由下式I表示的氨基酸序列： Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu- A27-A28-A29-Y。本发明还提供了包含GIP类似物及其用途的药物组合物。

4. 发明申请

US20140162945A1 GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE ANALOGS, PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 有权
标题翻译：葡萄糖依赖性胰岛素多肽类似物，药物组合物及其用途
公开(公告)号：US20140162945A1
公开(公告)日：2014-06-12
申请号：US14125061
申请日：2012-06-08
申请人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
发明人： Tao Ma , Shusen Xu , Zhijun Liu , Bo Zhang , Ning Shen , Hai Yang , Wei Zhang , Yuhua Li , Sunghwan Moon , Maengsup Kim
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A61K38/00 , A61K38/16 , A61K38/22 , C07K14/00 , C07K14/605
摘要： The present invention provides a GIP analog, which is derived from GIP (1-29, SEQ ID NO: 1), has both GLP-1 agonist activity and GIPR stimulation activity, and comprises an amino acid sequence represented by the following formula I: Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp-Leu-A27-A28-A29-Y. The present invention also provides a pharmaceutical composition comprising the GIP analog and use thereof.
摘要翻译：本发明提供衍生自GIP（1-29，SEQ ID NO：1）的GIP类似物具有GLP-1激动剂活性和GIPR刺激活性，并且包含由下式I表示的氨基酸序列： Tyr-A2-A3-Gly-Thr-Phe-A7-Ser-Asp-Tyr-Ser-A12-A13-A14-A15-Lys-A17-A18-A19-A20-A21-A22-A23-A24-Trp- Leu-A27-A28-A29-Y。本发明还提供了包含GIP类似物及其用途的药物组合物。

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