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1. 发明授权

US08628754B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率地传送大量治疗性气溶胶
公开(公告)号：US08628754B2
公开(公告)日：2014-01-14
申请号：US13334236
申请日：2011-12-22
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译：用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。颗粒能够携带。试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合试剂与颗粒混合并与颗粒共同传送。还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。还包括递送这些可呼吸组合物的方法。

2. 发明授权

US07556798B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
公开(公告)号：US07556798B2
公开(公告)日：2009-07-07
申请号：US09878146
申请日：2001-06-08
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/12 , A61K9/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

3. 发明申请

US20090068274A1 HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC MASS AEROSOL 审中-公开
标题翻译：高效治疗大剂量气溶胶的高效运输
公开(公告)号：US20090068274A1
公开(公告)日：2009-03-12
申请号：US12253449
申请日：2008-10-17
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/14 , A61P11/00
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译：用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。颗粒能够携带。试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合试剂与颗粒混合并与颗粒共同传送。还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。还包括递送这些可呼吸组合物的方法。

4. 发明授权

US06858199B1 High efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率输送大量治疗性气溶胶
公开(公告)号：US06858199B1
公开(公告)日：2005-02-22
申请号：US09591307
申请日：2000-06-09
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K31/198 , A61K31/46 , A61K31/56 , A61K38/27 , A61K38/28 , A61K39/395 , A61L9/04 , B05D7/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.
摘要翻译：在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒超过0.4g / cm 3并且输送至少约50％的质量的颗粒。在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。容器可具有至少0.37厘米3的体积。

5. 发明申请

US20120093893A1 Highly Efficient Delivery of a Large Therapeutic Mass Aerosol 有权
标题翻译：高效率地输送大型治疗性质量气溶胶
公开(公告)号：US20120093893A1
公开(公告)日：2012-04-19
申请号：US13334236
申请日：2011-12-22
申请人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batycky , Lloyd Johnston
IPC分类号： A61K9/14 , A61P11/00 , A61K31/192 , A61K31/137 , A61K31/138 , A61K31/198
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.
摘要翻译：用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。颗粒能够携带。试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合试剂与颗粒混合并与颗粒共同传送。还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。还包括递送这些可呼吸组合物的方法。

6. 发明授权

US07384649B2 Particulate compositions for pulmonary delivery 有权
标题翻译：用于肺部输送的颗粒组合物
公开(公告)号：US07384649B2
公开(公告)日：2008-06-10
申请号：US11633750
申请日：2006-12-05
申请人： Richard P. Batycky , David A. Edwards , Michael M. Lipp
发明人： Richard P. Batycky , David A. Edwards , Michael M. Lipp
IPC分类号： A61K9/50
CPC分类号： A61K9/0075 , A61K9/1694
摘要： This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (σ) is greater than 2, optimally greater than 3.
摘要翻译：本发明涉及用于将药物递送至肺部系统的改进的颗粒组合物。申请人公开了一种识别高分散性的空气动力学轻微颗粒的最佳形式的方法。本发明的颗粒通过在颗粒形成过程中产生塌陷的中空的球形药物颗粒（即祖细胞颗粒）制成，导致具有非常低的包膜密度的褶皱，薄壁的药物颗粒。此外，申请人已经发现，当表面积参数（σ）大于2，最佳大于3时，这些颗粒对于吸入的气溶胶是特别优选的。

7. 发明申请

US20080226730A1 PARTICLES FOR INHALATION HAVING RAPID RELEASE PROPERTIES 审中-公开
标题翻译：具有快速释放特性的吸入颗粒
公开(公告)号：US20080226730A1
公开(公告)日：2008-09-18
申请号：US11860302
申请日：2007-09-24
申请人： Jennifer L. Schmitke , Donghao Chen , Richard P. Batycky , David A. Edwards , Jeffrey S. Hrkach
发明人： Jennifer L. Schmitke , Donghao Chen , Richard P. Batycky , David A. Edwards , Jeffrey S. Hrkach
IPC分类号： A61K9/14 , A61K38/28
CPC分类号： A61K9/1617 , A61K9/0075 , A61K38/28 , A61K47/544
摘要： The invention generally relates to formulations having particles comprising phospholipids, bioactive agent and excipients and the pulmonary delivery thereof. Dry powder inhaled insulin formulations are disclosed. Improved formulations comprising DPPC, insulin and sodium citrate which are useful in the treatment of diabetes are disclosed. Also, the invention relates to a method of for the pulmonary delivery of a bioactive agent comprising administering to the respiratory tract of a patient in need of treatment, or diagnosis an effective amount of particles comprising a bioactive agent or any combination thereof in association, wherein release of the agent from the administered particles occurs in a rapid fashion.
摘要翻译：本发明一般涉及具有包含磷脂，生物活性剂和赋形剂以及其肺部递送的颗粒的制剂。公开了干粉吸入胰岛素制剂。公开了包含可用于治疗糖尿病的DPPC，胰岛素和柠檬酸钠的改进制剂。此外，本发明涉及一种用于肺部递送生物活性剂的方法，包括向需要治疗的患者的呼吸道施用或相关地诊断包含生物活性剂或其任何组合的有效量的颗粒，其中药剂从施用的颗粒的释放以快速方式发生。

8. 发明授权

US07182961B2 Particulate compositions for pulmonary delivery 有权
标题翻译：用于肺部输送的颗粒组合物
公开(公告)号：US07182961B2
公开(公告)日：2007-02-27
申请号：US10300657
申请日：2002-11-20
申请人： Richard P. Batycky , David A. Edwards , Michael M. Lipp
发明人： Richard P. Batycky , David A. Edwards , Michael M. Lipp
IPC分类号： A61K9/50
CPC分类号： A61K9/0075 , A61K9/1694
摘要： This invention concerns an improved particulate composition for delivering a drug to the pulmonary system. Applicants disclose a method of identifying an optimal form of aerodynamically light particles which are highly dispersible. The particles of the instant invention are made by creating hollow, spherical drug particles (i.e., progenitor particles) that collapse in the process of particle formation, leading to wrinkled, thin-walled drug particles of very low envelope density. Additionally, Applicants have found that such particles are especially optimal for inhaled aerosols when the surface area parameter (σ) is greater than 2, optimally greater than 3.
摘要翻译：本发明涉及用于将药物递送至肺部系统的改进的颗粒组合物。申请人公开了一种识别高分散性的空气动力学轻微颗粒的最佳形式的方法。本发明的颗粒通过在颗粒形成过程中产生塌陷的中空的球形药物颗粒（即祖细胞颗粒）制成，导致具有非常低的包膜密度的褶皱，薄壁的药物颗粒。此外，申请人已经发现，当表面积参数（σ）大于2，最佳大于3时，这些颗粒对于吸入的气溶胶是特别优选的。

9. 发明授权

US06921528B2 Highly efficient delivery of a large therapeutic mass aerosol 有权
标题翻译：高效率地传送大量治疗性气溶胶
公开(公告)号：US06921528B2
公开(公告)日：2005-07-26
申请号：US10681416
申请日：2003-10-08
申请人： David A. Edwards , Richard P. Batvcky , Lloyd Johnston
发明人： David A. Edwards , Richard P. Batvcky , Lloyd Johnston
IPC分类号： A61K9/12 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/72 , A61K31/137 , A61K31/198 , A61K31/46 , A61K31/56 , A61K38/27 , A61K38/28 , A61K39/395 , A61L9/04 , B05D7/14
CPC分类号： A61K9/14 , A61K9/0075 , A61K9/1617 , A61K31/198
摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.
摘要翻译：在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒超过0.4g / cm 3，并输送至少约50％的质量的颗粒。在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。容器可具有至少0.37厘米3的体积。

10. 发明申请

US20140377130A1 SYSTEMS, METHODS AND ARTICLES TO PROVIDE OLFACTORY SENSATIONS 审中-公开
标题翻译：系统，方法和提供OLFACTORY SENSATIONS的文章
公开(公告)号：US20140377130A1
公开(公告)日：2014-12-25
申请号：US14213683
申请日：2014-03-14
申请人： David A. Edwards , Rachel Diane Field , Amy Michelle Yin , Eyal Shahar
发明人： David A. Edwards , Rachel Diane Field , Amy Michelle Yin , Eyal Shahar
IPC分类号： G05B15/02 , A61L9/02 , A61L9/03
CPC分类号： G05B15/02 , A61L9/02 , A61L9/03 , A61L9/035 , A61L2209/133 , A61L2209/134 , H04M1/21
摘要： A scent release system includes scent cartridges containing temperature activated scent media. The scent cartridges may bear machine-readable identification that specifies which scent media are carried by the cartridge. The scent release system can be controlled by a timer to initiate a phase change of the scent media to selectively release one or more scents, followed by a reverse phase change to selectively stop release of the respective scents. A scent release system in conjunction with a mobile electronic device, such as a smart phone, allows sending and receiving scent messages. The scent release system can be built into a case for the mobile electronic device, eliminating the need for a separate unit. A private scent delivery device in the form of a headset can be worn by users of a scent release system or by scent message recipients.
摘要翻译：气味释放系统包括含有温度活化香味介质的香味盒。气味墨盒可以承载机器可读的识别，其指定墨盒所携带的香味介质。香味释放系统可以由定时器控制以启动香味介质的相变，以选择性地释放一种或多种香料，随后进行反向相变以选择性地停止释放相应的香味。与诸如智能电话的移动电子设备结合的气味释放系统允许发送和接收香味消息。气味释放系统可以内置在移动电子设备的外壳中，无需单独的单元。耳机形式的私人气味递送装置可以由气味释放系统的用户或香味消息接收者穿戴。

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