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    • 2. 发明授权
    • Biological air filter
    • 生物空气过滤器
    • US08707619B2
    • 2014-04-29
    • US12682353
    • 2008-10-08
    • David A. EdwardsMathieu Lehanneur
    • David A. EdwardsMathieu Lehanneur
    • A01G9/02
    • A01G9/02A01G7/00B01D53/85B01D2257/2064B01D2257/502B01D2257/70B01D2257/7027B01D2259/4508F24F2003/1653F24F2006/005Y02A50/2359
    • A novel apparatus for the treatment, e.g., cleaning, humidifying, filtration and/or detoxifying, of ambient air incorporates a plant, soil, roots and a water reservoir to allow for effective filtration of air over an extended period of time. In particular, the device is designed with an air impeller system such that external “dirty” air is circulated within the device in the proximity of the plant, soil, roots and/or water reservoir, thereby removing impurities, toxins and other undesirable chemicals from the air. The apparatus and methods of the present invention are readily applicable to a number of applications where air treatment is desired, e.g., household use. Moreover, by incorporating a plant system, the apparatus serves not only a functional but an aesthetic purpose as well.
    • 用于治疗,例如清洁,加湿,过滤和/或解毒环境空气的新型装置包括植物,土壤,根部和水贮存器,以允许在长时间内有效地过滤空气。 特别地,该装置设计有空气叶轮系统,使得外部“脏”空气在装置内在植物,土壤,根部和/或水储存器附近循环,从而从杂质,毒素和其他不期望的化学物质中除去 空气。 本发明的装置和方法可以容易地应用于需要空气处理的许多应用,例如家用。 此外,通过结合植物系统,该装置不仅起到功能性的作用,而且起到美学的作用。
    • 9. 发明授权
    • Aerodynamically light particles for pulmonary drug delivery
    • 用于肺部药物递送的空气动力学轻微颗粒
    • US06977087B2
    • 2005-12-20
    • US10090418
    • 2002-03-01
    • David A. EdwardsGiovannia CaponettiJeffrey S. HrkachNoah LotanJustin HanesAbdell Aziz Ben-JebriaRobert S. Langer
    • David A. EdwardsGiovannia CaponettiJeffrey S. HrkachNoah LotanJustin HanesAbdell Aziz Ben-JebriaRobert S. Langer
    • A61K9/00A61K9/14A61K9/16A61K31/56A61K31/568A61K38/28
    • A61K9/0075A61K9/1647A61K31/56A61K31/568A61K38/28
    • Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear α-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.
    • 提供用于递送至肺系统的改善的空气动力学轻微颗粒,以及其制备和给药方法。 在优选的实施方案中,空气动力学轻微颗粒由可生物降解的材料制成,并且振实密度小于0.4g / cm 3,质量平均直径在5μm和30μm之间。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如,颗粒可以由官能化的聚酯接枝共聚物形成,所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚(氨基酸)侧链上的直链α-羟基酸聚酯主链组成 集团在聚酯骨干。 在一个实施方案中,具有大平均直径(例如大于5μm)的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。 空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂,并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。