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1. 发明申请

US20100120716A1 MACROCYCLIC HEPATITIS C SERINE PROTEASE INHIBITORS AND USES THEREFOR 审中-公开
标题翻译：大环内酯类抗生素C丝氨酸蛋白酶抑制剂及其用途
公开(公告)号：US20100120716A1
公开(公告)日：2010-05-13
申请号：US12515941
申请日：2007-12-05
申请人： David A. Campbell , Michael E. Hepperle , David T. Winn , Juan M. Betancort
发明人： David A. Campbell , Michael E. Hepperle , David T. Winn , Juan M. Betancort
IPC分类号： A61K31/69 , C07D267/00 , C07D245/04 , A61P31/12
CPC分类号： C07F5/025
摘要： Macrocyclic inhibitors of Hepatitis C protease are provided, the inhibitors including a boronic acid or ester group, a macrocyclic ring of about 13 to 25 atoms including at least two amide linkages, a proline-analogous group, and a connecting segment joining moieties on either side of the proline-analogous group. Methods of making the HCV protease-inhibitory compounds, methods of using the compounds, formulations of the compounds, and pharmaceutical combinations including the compounds, are provided.
摘要翻译：提供丙型肝炎蛋白酶的大环抑制剂，所述抑制剂包括硼酸或酯基，约13至25个原子的大环，包括至少两个酰胺键，脯氨酸类似基团和连接部分连接任一侧的部分的脯氨酸类似组。提供制备HCV蛋白酶抑制化合物的方法，使用化合物的方法，化合物的制剂以及包括该化合物的药物组合。

2. 发明申请

US20100120661A1 HETEROCYCLIC BORONIC ACID COMPOUNDS 有权
标题翻译：杂环硼酸化合物
公开(公告)号：US20100120661A1
公开(公告)日：2010-05-13
申请号：US12692276
申请日：2010-01-22
申请人： David A. Campbell , David T. Winn , Juan M. Betancort
发明人： David A. Campbell , David T. Winn , Juan M. Betancort
IPC分类号： A61K38/28 , C07F5/02 , A61K31/69 , C12N9/99 , C07D205/02 , A61P3/10
CPC分类号： C07F5/025
摘要： Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH2)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
摘要翻译：提供二肽基肽酶IV（DPP-IV）抑制化合物，其具有式I：其中n为1至3; X为CH 2; S; O; CF 2或C（CH 2）2; Z是H; 卤素; 羟; （C 1-6）烷氧基; （C 1-12）烷基; （C3-12）环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R7单取代或独立地被二取代; 任选地，X与相邻的环碳一起形成稠合的环丙基; 并且任选地，含有X的环中的一个键是双键; CriRii，R1，R2，R3，R4和R5如本文所述。使用含有这些化合物的药物组合物中的式I化合物来描述制备这些化合物的方法，以及治疗糖尿病，特别是II型糖尿病和其它相关疾病的方法。含有这些化合物与其它抗糖尿病药物的组合的药物组合物也在本文中描述。

3. 发明授权

US07674913B2 Heterocyclic boronic acid compounds 失效
标题翻译：杂环硼酸化合物
公开(公告)号：US07674913B2
公开(公告)日：2010-03-09
申请号：US10514575
申请日：2004-11-12
申请人： David A. Campbell , David T. Winn , Juan M. Betancort
发明人： David A. Campbell , David T. Winn , Juan M. Betancort
IPC分类号： A61K31/69 , C07D403/12 , C07F5/02
CPC分类号： C07F5/025
摘要： Dipeptidyl peptidase IV (DPP-IV)-inhibiting compounds are provided that have formula I: wherein n is 1 to 3; X is CH2; S; O; CF2 or C(CH3)2; Z is H; halogen; hydroxyl; (C1-6)alkoxy; (C1-12)alkyl; (C3-12)cycloalkyl; phenyl; or heteroaryl; where the phenyl and heteroaryl groups are optionally mono- or independently plurisubstituted with R7; optionally, X together with an adjacent ring carbon and Z form a fused cyclopropyl; and optionally, one of the bonds in the ring containing X is a double bond; and CriRii, R1, R1, R3, R4 and R5 are as described herein. Methods for preparing these compounds, and methods for treating diabetes, especially Type II diabetes, and other related diseases are described using the compounds of formula I in pharmaceutical compositions which contain these compounds. Pharmaceutical compositions which contain combinations of these compounds with other antidiabetic agents are also described herein.
摘要翻译：提供二肽基肽酶IV（DPP-IV）抑制化合物，其具有式I：其中n为1至3; X为CH 2; S; O; CF 2或C（CH 3）2; Z是H; 卤素; 羟; （C 1-6）烷氧基; （C 1-12）烷基; （C3-12）环烷基; 苯基; 或杂芳基; 其中苯基和杂芳基任选被R7单取代或独立地被二取代; 任选地，X与相邻的环碳一起形成稠合的环丙基; 并且任选地，含有X的环中的一个键是双键; 和CriRii，R1，R1，R3，R4和R5如本文所述。使用含有这些化合物的药物组合物中的式I化合物来描述制备这些化合物的方法，以及治疗糖尿病，特别是II型糖尿病和其它相关疾病的方法。含有这些化合物与其它抗糖尿病药物的组合的药物组合物也在本文中描述。

4. 发明申请

US20060135553A1 Imidazole derivatives 审中-公开
标题翻译：咪唑衍生物
公开(公告)号：US20060135553A1
公开(公告)日：2006-06-22
申请号：US11262394
申请日：2005-10-28
申请人： David A. Campbell , Juan M. Betancort
发明人： David A. Campbell , Juan M. Betancort
IPC分类号： A61K31/4745 , A61K31/444 , C07D471/02 , C07D403/14
CPC分类号： C07D403/12 , C07D235/06 , C07D401/12
摘要： Certain imidazole-containing compounds are useful for treating and/or preventing of various disease conditions, by way of methodology for modulating tyrosine kinases and angiogenesis. Illustrative of such conditions are inflammatory diseases and diseases characterized by abnormal cellular proliferation.
摘要翻译：通过用于调节酪氨酸激酶和血管生成的方法，某些含咪唑化合物可用于治疗和/或预防各种疾病状况。这些病症的说明是炎性疾病和以细胞增殖异常为特征的疾病。

5. 发明申请

US20080182995A1 PYRROLIDINE COMPOUNDS AND METHODS FOR SELECTIVE INHIBITION OF DIPEPTIDYL PEPTIDASE-IV 有权
标题翻译：吡咯啉化合物和选择性抑制DIPEPTIDYL PEPTIDASE-IV的方法
公开(公告)号：US20080182995A1
公开(公告)日：2008-07-31
申请号：US11930337
申请日：2007-10-31
申请人： David A. Campbell , David T. Winn , Juan Manuel Betancort
发明人： David A. Campbell , David T. Winn , Juan Manuel Betancort
IPC分类号： C07F5/02 , C07D207/00
CPC分类号： C07F5/025
摘要： The present invention is directed to pyrrolidinylaminoacetyl pyrrolidine boronic acid compounds that display selective, potent dipeptidyl peptidase IV inhibitory activity. These compounds are useful for the treatment of disorders that can be regulated or normalized via inhibition of DPP-IV including those characterized by impaired glycemic control such as Diabetes Mellitus and related conditions. The compounds can be administered alone or with another medicament that displays pharmacological activity for treatment of these and other diseases.
摘要翻译：本发明涉及显示选择性，有效的二肽基肽酶IV抑制活性的吡咯烷基氨基乙酰基吡咯烷硼酸化合物。这些化合物可用于治疗可以通过抑制DPP-IV调节或归一化的疾病，包括那些以血糖控制受损为特征的糖尿病和相关病症。化合物可以单独施用或与另外一种显示用于治疗这些和其它疾病的药理活性的药物一起施用。

6. 发明授权

US4447190A Fluid pressure control in a gas turbine engine 失效
标题翻译：燃气涡轮发动机中的流体压力控制
公开(公告)号：US4447190A
公开(公告)日：1984-05-08
申请号：US438632
申请日：1982-11-02
申请人： David A. Campbell
发明人： David A. Campbell
IPC分类号： F01D5/08 , F01D5/18 , F01D25/12 , F02C7/28 , F01D11/06
CPC分类号： F02C7/28 , F01D25/12 , F01D5/08 , F01D5/18 , Y02T50/676
摘要： Air is bled from the compressor of a gas turbine engine and it is led to holes in the shanks of turbine blades, so as to cool the interiors of the blades during operation of the engine. Some of the air leaks radially outwards, to seal the gas annulus against hot gas leaks onto the face of the turbine disc. A reduced flow of cooling air is enabled at conditions other than engine full throttle. This however, starves the gas sealing air. The invention provides a back up supply, by putting the air through a plenum chamber and dividing it so that when cooling airflow is reduced, a further sealing air flow is provided in compensation therefore.
摘要翻译：空气从燃气涡轮发动机的压缩机排出，并且被引导到涡轮机叶片的柄部中的孔，以便在发动机运行期间冷却叶片的内部。一些空气径向向外泄漏，以密封气体环以防止热气体泄漏到涡轮盘的表面上。在除发动机全油门外的条件下，冷却空气的流量减少。然而，这使气体密封空气变空。本发明提供备用电源，通过将空气通过增压室并将其分开，使得当冷却气流减小时，因此提供另外的密封空气流。

7. 发明申请

US20090121372A1 Method and Apparatus for Pelletizing A Polymer Feed 审中-公开
标题翻译：聚合物进料造粒的方法和装置
公开(公告)号：US20090121372A1
公开(公告)日：2009-05-14
申请号：US12256973
申请日：2008-10-23
申请人： David A. Campbell , Patrick S. Byrne , Ramin Abhari , David R. Johnsrud , Jay L. Reimers
发明人： David A. Campbell , Patrick S. Byrne , Ramin Abhari , David R. Johnsrud , Jay L. Reimers
IPC分类号： B29B9/12 , B28B17/00
CPC分类号： B29B9/16 , B29B9/065 , B29B9/12 , B29B2009/165 , B29K2105/0097 , F26B3/08 , F26B5/08 , F26B17/00
摘要： A method and apparatus are described in which a polymer feed is pelletized by introducing the polymer feed to an extruder, removing heat from the polymer feed in the extruder, and extruding the polymer feed through a pelletizing die.
摘要翻译：描述了一种方法和装置，其中聚合物进料通过将聚合物进料引入挤出机而造粒，从挤出机中的聚合物进料中除去热量，并通过造粒模挤出聚合物进料。

8. 发明授权

US4348157A Air cooled turbine for a gas turbine engine 失效
标题翻译：用于燃气涡轮发动机的空气冷却涡轮机
公开(公告)号：US4348157A
公开(公告)日：1982-09-07
申请号：US85300
申请日：1979-10-16
申请人： David A. Campbell , Frederick W. W. Morley
发明人： David A. Campbell , Frederick W. W. Morley
IPC分类号： F02C7/18 , F01D5/08 , F02C7/28 , F01D5/18
CPC分类号： F01D5/081
摘要： An air cooled turbine which has cooling air provided through pre-swirl nozzles into an annulus formed between radially inner and outer seals and then into cooling air inlets to the turbine blading, has leakage air deflector means to prevent the leakage flow from the inner to outer seal interfering with the cooling air flow. The deflector means may comprise leakage flow inlets adjacent the inner seal, channels extending radially and cooperating with the turbine rotor to provide passages for the leakage flow to a location radially outboard of the cooling air inlets to the turbine blading, and open portions through which the cooling air can flow to the cooling air inlets. The channel outlets of the deflector may be arranged so that some of the leakage flow can be directed to cool a less critical part of the turbine blading the remaining leakage flow being directed radially outboard of the cooling air inlets to a more critical part of the turbine blading which are arranged to receive the normal cooling air flow.
摘要翻译：一种空气冷却涡轮机，其具有通过预旋喷嘴提供的冷却空气，形成在径向内部和外部密封件之间的环形空间中，然后进入到涡轮叶片的冷却空气入口中，具有泄漏空气导流装置，以防止从内部到外部的泄漏流动密封件干扰冷却空气流动。导流装置可以包括邻近内部密封件的泄漏流入口，径向延伸并与涡轮机转子配合的通道，以提供通向泄漏流的通道，该通道用于流向涡轮叶片的冷却空气入口径向外侧的位置，冷却空气可以流到冷却空气入口。偏转器的通道出口可以被布置成使得一些泄漏流可以被引导以冷却涡轮叶片的不太关键的部分，将剩余的泄漏流径向排出到冷却空气入口的外侧到涡轮机的更关键部分布置成接收正常冷却空气流的叶片。

9. 发明申请

US20100323988A1 SOLID CITRATE AND TARTRATE SALTS OF DPP-IV INHIBITORS 有权
标题翻译： DPP-IV抑制剂的固体柠檬酸盐和盐酸盐
公开(公告)号：US20100323988A1
公开(公告)日：2010-12-23
申请号：US12439140
申请日：2007-08-23
申请人： Zhen-Ping Wu , David A. Campbell , Julie M. Cherrington
发明人： Zhen-Ping Wu , David A. Campbell , Julie M. Cherrington
IPC分类号： A61K31/69 , C07F5/02 , A61P3/08 , A61P3/10 , A61P5/50
CPC分类号： C07F5/025
摘要： This invention relates to DPP-IV inhibitory citrate or tartrate salts of pyrrolidinylaminoacetyl pyrrolid acid compounds that are physically and chemically stable, substantially non-deliquescent solids under ambient conditions.
摘要翻译：本发明涉及物理和化学稳定的，在环境条件下基本上非潮解固体的吡咯烷基氨基乙酰基吡咯烷酸化合物的DPP-IV抑制柠檬酸盐或酒石酸盐。

10. 发明授权

US06307101B1 Inhibitors of metalloproteases, pharmaceutical compositions comprising same and methods of their use 失效
标题翻译：金属蛋白酶抑制剂，包含其的药物组合物及其使用方法
公开(公告)号：US06307101B1
公开(公告)日：2001-10-23
申请号：US09271801
申请日：1999-03-17
申请人： David A. Campbell , Dinesh V. Patel , Xiao-Yi Xiao
发明人： David A. Campbell , Dinesh V. Patel , Xiao-Yi Xiao
IPC分类号： C07C23300
CPC分类号： C07C323/60 , C07C2601/14 , C07K5/06043 , C07K5/06095
摘要： Disclosed are novel inhibitors of metalloproteases, in particular matrix metalloproteases. The disclosed inhibitors are mercaptoketone and mercaptoalcohol compounds which are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, for example, arthropathy, dermatological conditions, bone resorption, inflammatory diseases, and tumor invasion and in the promotion of wound healing.
摘要翻译：公开了金属蛋白酶，特别是基质金属蛋白酶的新型抑制剂。所公开的抑制剂是巯基酮和巯基醇化合物，其可用于治疗或控制涉及组织分解的疾病状态或病症的方法，例如关节病，皮肤病学条件，骨吸收，炎性疾病和肿瘤侵袭以及促进的伤口愈合。

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