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1. 发明申请

US20100087853A1 COMPOSITIONS AND METHODS FOR USE OF ALGINATE DURAL SEALANTS 审中-公开
标题翻译：用于治疗ALGINATE DURAL SEALANTS的组合物和方法
公开(公告)号：US20100087853A1
公开(公告)日：2010-04-08
申请号：US12480133
申请日：2009-06-08
申请人： Daryl A. Kipke , Timothy A. Becker , Justin C. Williams , Rio J. Vetter
发明人： Daryl A. Kipke , Timothy A. Becker , Justin C. Williams , Rio J. Vetter
IPC分类号： A61B17/03
CPC分类号： A61L24/0015 , A61L24/08 , A61L2300/41 , C08L5/04
摘要： The present invention comprises compositions and methods for use of an alginate dural sealant in conjunction with mammalian neurosurgical procedures, including but not limited to, the implantation of neuroprosthetic devices.
摘要翻译：本发明包括与哺乳动物神经外科手术结合使用藻酸盐硬脑膜封闭剂的组合物和方法，包括但不限于神经假体装置的植入。

2. 发明申请

US20130030352A1 NEUROMODULATION TRANSFECTION SYSTEM WITH ACTIVE FLUID DELIVERY 有权
标题翻译：具有活性流体输送的神经网络转移系统
公开(公告)号：US20130030352A1
公开(公告)日：2013-01-31
申请号：US13557536
申请日：2012-07-25
申请人： John P. Seymour , KC Kong , Rio J. Vetter
发明人： John P. Seymour , KC Kong , Rio J. Vetter
IPC分类号： A61M37/00
CPC分类号： A61N5/0622 , A61B5/04001 , A61B5/4839 , A61B5/6868 , A61B2562/0209 , A61B2562/046 , A61N1/0529 , A61N1/0551 , A61N1/327 , A61N2005/0612 , A61N2005/063 , A61N2005/0651 , A61N2005/067
摘要： A neural interface array including an optical waveguide, a thin film electrode array associated with the optical waveguide, the thin film electrode array having a plurality of electrodes, and a fluid delivery channel attached to at least one of the optical waveguide and the thin film electrode array. Also disclosed are methods for optical stimulation and a neural interface system with active fluid delivery.
摘要翻译：一种神经接口阵列，包括光波导，与光波导相关联的薄膜电极阵列，具有多个电极的薄膜电极阵列，以及附着到光波导和薄膜电极中的至少一个的流体输送通道数组。还公开了用于光学刺激的方法和具有活性流体递送的神经界面系统。

3. 发明授权

US08332046B2 Neural interface system 有权
标题翻译：神经界面系统
公开(公告)号：US08332046B2
公开(公告)日：2012-12-11
申请号：US12848828
申请日：2010-08-02
申请人： David J. Anderson , Rio J. Vetter , Jamille F. Hetke , Daryl R. Kipke
发明人： David J. Anderson , Rio J. Vetter , Jamille F. Hetke , Daryl R. Kipke
IPC分类号： A61N1/05
CPC分类号： A61B5/04001 , A61N1/0534 , A61N1/0539 , Y10T29/49204
摘要： A neural interface system including an electrode array and a carrier that supports the electrode array, in which the electrode array includes a substrate rolled into a three-dimensional shape, a plurality of conductive traces patterned on the substrate and adapted to transmit electrical signals, and a plurality of elliptically shaped, externally facing electrode sites coupled to the plurality of conductive traces that electrically communicate with their surroundings. The plurality of electrodes are arranged in a triangular lattice circumferentially around and axially along the carrier, and the substrate includes an edge that extends axially along the carrier and is constrained between a first axial row portion of the plurality of electrode sites and a second axial row portion of the plurality of electrode sites adjacent to the first axial row portion.
摘要翻译：一种神经接口系统，包括支撑电极阵列的电极阵列和载体，其中电极阵列包括滚动成三维形状的基底，在基底上图案化并适于透射电信号的多个导电迹线，以及耦合到与其周围环境电连通的多个导电迹线的多个椭圆形的外部对置的电极位置。所述多个电极沿着所述载体围绕并且轴向地布置成三角形晶格，并且所述基板包括沿着所述载体轴向延伸并且被约束在所述多个电极位置的第一轴向行部分和第二轴向行多个电极位置的与第一轴向行部分相邻的部分。

4. 发明申请

US20090102068A1 SYSTEM AND METHOD TO MANUFACTURE AN IMPLANTABLE ELECTRODE 有权
标题翻译：制造可植入电极的系统和方法
公开(公告)号：US20090102068A1
公开(公告)日：2009-04-23
申请号：US12130828
申请日：2008-05-30
申请人： David S. Pellinen , Jamille Farraye Hetke , Daryl R. Kipke , K. C. Kong , Rio J. Vetter , Mayurachat Gulari
发明人： David S. Pellinen , Jamille Farraye Hetke , Daryl R. Kipke , K. C. Kong , Rio J. Vetter , Mayurachat Gulari
IPC分类号： H01L23/28 , H01L21/00
CPC分类号： H01L23/49541 , A61N1/05 , H01L21/561 , H01L23/293 , H01L23/3185 , H01L2924/0002 , H01L2924/3025 , H01L2924/00
摘要： The method of the preferred embodiments includes the steps of providing a base having a frame portion and a center portion; building a preliminary structure coupled to the base; removing a portion of the preliminary structure to define a series of devices and a plurality of bridges; removing the center portion of the base such that the frame portion defines an open region, wherein the plurality of bridges suspend the series of devices in the open region defined by the frame; and encapsulating the series of devices. The method is preferably designed for the manufacture of semiconductor devices, and more specifically for the manufacture of encapsulated implantable electrodes. The method, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译：优选实施例的方法包括提供具有框架部分和中心部分的基部的步骤; 建立与基地相结合的初步结构; 去除所述初步结构的一部分以限定一系列装置和多个桥; 移除所述基座的中心部分使得所述框架部分限定开放区域，其中所述多个桥将所述一系列装置悬挂在由所述框架限定的开放区域中; 并封装了一系列设备。该方法优选地设计用于制造半导体器件，更具体地设计用于制造封装的可植入电极。然而，该方法可以替代地在任何合适的环境中用于任何合适的原因。

5. 发明授权

US10493297B2 Neuromodulation transfection system with passive fluid delivery 有权
公开(公告)号：US10493297B2
公开(公告)日：2019-12-03
申请号：US13557555
申请日：2012-07-25
申请人： John P. Seymour , KC Kong , Rio J. Vetter
发明人： John P. Seymour , KC Kong , Rio J. Vetter
IPC分类号： A61B5/04 , A61N1/05 , A61N5/06 , C12N15/87 , A61N1/32 , A61N5/067 , A61N1/36
CPC分类号： A61N5/0622 , C12N15/87 , A61B5/04001 , A61N1/05 , A61N1/327 , A61N1/36121 , A61N2005/063 , A61N2005/067 , A61N2005/0612 , A61N2005/0651 , Y10T29/49204
摘要： An implantable optical electrode having a thin film electrode array including a plurality of electrodes, a light source associated with the thin film electrode array, and a passive bioactive agent delivery module associated with the thin film electrode array. Also disclosed are methods of manufacturing the array and a neural interface system with passive fluid delivery.

6. 发明授权

US08498720B2 Implantable electrode and method of making the same 有权
标题翻译：可植入电极及其制造方法
公开(公告)号：US08498720B2
公开(公告)日：2013-07-30
申请号：US12396107
申请日：2009-03-02
申请人： David S. Pellinen , Mayurachat Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
发明人： David S. Pellinen , Mayurachat Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61B5/04001 , A61B2562/0209 , A61N1/0529 , A61N1/0551 , H05K1/0393 , H05K1/113 , H05K3/4644 , H05K2201/09781 , H05K2201/2072 , Y10T29/49117
摘要： The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that is connected to both the conductor and the insulating element. The anchor is mechanically interlocked with at least one of the conductor and the insulator.
摘要翻译：优选实施例的可植入电极系统包括导体，耦合到导体的互连件，绝缘体互连件的绝缘体以及连接到导体和绝缘元件两者的锚固件。锚固体与导体和绝缘体中的至少一个机械地互锁。

7. 发明授权

US08224417B2 Guide tube for an implantable device system 有权
标题翻译：可植入装置系统的导管
公开(公告)号：US08224417B2
公开(公告)日：2012-07-17
申请号：US12253796
申请日：2008-10-17
申请人： Rio J. Vetter
发明人： Rio J. Vetter
IPC分类号： A61B5/0478 , A61N1/05
CPC分类号： A61N1/0534 , A61N1/0551 , A61N1/36082
摘要： The implantable device system of the preferred embodiments includes a guide tube, a first electrical subsystem, and a second electrical subsystem. The first electrical subsystem is connected to the second electrical subsystem. The guide tube functions to facilitate the insertion of at least one first electrical subsystem and is adapted to allow the first electrical subsystem(s) to move freely with the tissue, allowing the placement of the first electrical subsystem without disconnecting the second electrical subsystem. The implantable device system may be implanted into the brain, spinal cord, peripheral nerve, muscle, or any other suitable anatomical location. The guide tube of the system, however, may be alternatively used in any suitable environment and for any suitable reason.
摘要翻译：优选实施例的可植入装置系统包括导管，第一电子系统和第二电子系统。第一电子系统连接到第二电子系统。引导管用于促进至少一个第一电气子系统的插入，并且适于允许第一电气子系统与组织自由移动，允许第一电气子系统的放置而不断开第二电子系统。可植入装置系统可植入大脑，脊髓，周围神经，肌肉或任何其它合适的解剖学位置。然而，系统的引导管可以替代地在任何合适的环境中用于任何合适的原因。

8. 发明申请

US20120078188A1 NEURAL DRUG DELIVERY SYSTEM WITH FLUIDIC THREADS 有权
标题翻译：具有流体螺纹的神经药物输送系统
公开(公告)号：US20120078188A1
公开(公告)日：2012-03-29
申请号：US13236973
申请日：2011-09-20
申请人： Jamille F. Hetke , Daryl R. Kipke , Rio J. Vetter
发明人： Jamille F. Hetke , Daryl R. Kipke , Rio J. Vetter
IPC分类号： A61M5/00
CPC分类号： A61M25/007 , A61M2025/0058 , A61M2210/1003
摘要： A neural drug delivery system with fluidic threads implantable into tissue, including: a plurality of fluid delivery conduits configured to transport fluid and having an array of fluid delivery ports through which the fluid is selectively released; a plurality of port gates each including a mesh structure coupled to a corresponding fluid delivery port and coated with an electroactive polymer; a voltage source providing a conductive signal; and an interconnect network that carries the conductive signal to the port gates. In response of the electroactive polymer to the conductive signal, each port gate is selectively operable between a closed mode that prevents transfer of fluid through its corresponding fluid delivery port to the tissue, and an open mode that allows transfer of the fluid through its corresponding fluid delivery port to the tissue.
摘要翻译：一种具有可植入组织中的流体线的神经药物递送系统，包括：多个流体输送导管，其构造成输送流体并具有流体选择性释放的流体排放口阵列; 多个端口门，每个端口门均包括耦合到相应的流体输送端口并涂覆有电活性聚合物的网状结构; 提供导电信号的电压源; 以及将导电信号传送到端口门的互连网络。响应于电活性聚合物对导电信号的响应，每个端口门可选择性地在封闭模式之间操作，该闭合模式防止流体通过其相应的流体输送端口传递到组织，以及允许流体通过其相应流体传递的开放模式输送端口到组织。

9. 发明申请

US20090118806A1 THREE-DIMENSIONAL SYSTEM OF ELECTRODE LEADS 有权
标题翻译：电极引线三维系统
公开(公告)号：US20090118806A1
公开(公告)日：2009-05-07
申请号：US12253803
申请日：2008-10-17
申请人： Rio J. Vetter , Daryl R. Kipke , Jamille F. Helke
发明人： Rio J. Vetter , Daryl R. Kipke , Jamille F. Helke
IPC分类号： A61N1/05
CPC分类号： A61B5/0478 , A61B5/04001 , A61N1/0534 , A61N1/0551
摘要： The electrode lead system of a preferred embodiment includes a series of first electrical subsystems; a guiding element that positions the series of first electrical subsystems in a three dimensional arrangement within body tissue; a second electrical subsystem; and at least one connector that couples the first electrical subsystems to the second electrical subsystem. The electrode lead system of another preferred embodiment includes a series of electrode arrays; a guide tube that facilitates implantation of electrode arrays within body tissue and temporarily contains the series of electrode arrays; and a guiding element that provides a bias on the series of electrode arrays such that (a) when contained by the guide tube, the first electrical subsystems maintain a substantially singular path within body tissue, and (b) when not contained by the guide tube, the first electrical subsystems diverge along more than one path into a three dimensional arrangement within body tissue.
摘要翻译：优选实施例的电极引线系统包括一系列第一电子子系统; 引导元件，其将所述一系列第一电子系统定位在身体组织内的三维排列中; 第二电子系统; 以及将第一电子系统耦合到第二电子系统的至少一个连接器。另一个优选实施例的电极引线系统包括一系列电极阵列; 引导管，其有助于将电极阵列植入体内组织并暂时包含一系列电极阵列; 以及引导元件，其在所述一系列电极阵列上提供偏置，使得（a）当由所述引导管容纳时，所述第一电子系统在所述主体组织内保持基本上奇异的路径，以及（b）当所述引导管未被所述导管，第一电子子系统沿着多于一条的路径发散成体内组织内的三维排列。

10. 发明授权

US08954144B2 Hybrid clustered neural interface system 有权
标题翻译：混合聚类神经接口系统
公开(公告)号：US08954144B2
公开(公告)日：2015-02-10
申请号：US13524989
申请日：2012-06-15
申请人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
发明人： David Anderson , Daryl R. Kipke , Jamille Hetke , Rio J. Vetter , Kc Kong , John Seymour
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/0531 , Y10T29/49147
摘要： An apparatus comprises a flexible substrate. The flexible substrate includes a first substrate surface, a surface electrode array that includes a plurality of electrodes disposed on the first substrate surface, one or more flexible neural probes substantially orthogonal to the first substrate surface and insertable into biological tissue, and a penetrating electrode array that includes a plurality of electrodes formed on the one or more flexible neural probes, wherein electrodes of the surface electrode array and the penetrating electrode array are configured to one or both of receive a neural signal from a neural signal source and provide electrical stimulation energy to a neural stimulation target.
摘要翻译：一种装置包括柔性基板。柔性基板包括第一基板表面，包括设置在第一基板表面上的多个电极的表面电极阵列，基本上与第一基板表面正交并可插入到生物组织中的一个或多个柔性神经探针，以及穿透电极阵列其包括形成在所述一个或多个柔性神经探针上的多个电极，其中所述表面电极阵列和所述穿透电极阵列的电极被配置为接收来自神经信号源的神经信号中的一个或两个，并将电刺激能量提供给神经刺激目标。

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