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1. 发明授权

US09038919B2 Formation and control of fluidic species 有权
标题翻译：流体物种的形成和控制
公开(公告)号：US09038919B2
公开(公告)日：2015-05-26
申请号：US11246911
申请日：2005-10-07
申请人： Darren Roy Link , David A. Weitz , Manuel Marquez-Sanchez , Zhengdong Cheng
发明人： Darren Roy Link , David A. Weitz , Manuel Marquez-Sanchez , Zhengdong Cheng
IPC分类号： B05B5/057 , B01F5/06 , B01F13/00 , B01J2/04 , B05B5/03 , B05B7/06
CPC分类号： B01L3/502784 , B01F5/0682 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2215/0431 , B01J2/04 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2300/0867 , B01L2400/02 , B01L2400/0415 , B01L2400/0424 , B05B5/03 , B05B7/061
摘要： This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.
摘要翻译：本发明一般涉及用于形成和/或控制流体物质的系统和方法，以及由这些系统和方法生产的制品。在一些情况下，本发明涉及独特的流体通道，系统，控制和/或限制及其组合。在某些实施方案中，本发明允许流体流（其可以是连续的或不连续的，即液滴）以各种尺度形成和/或组合，包括微流体尺度。在一组实施例中，流体流可以从通道产生，其中流体流的横截面尺寸小于通道的横截面尺寸，例如通过使用结构元件，其它流体和/或应用外场等。在某些情况下，可能产生泰勒锥。在另一组实施例中，可以以某种方式操纵流体流，例如以产生管（其可以是中空或固体），液滴，嵌套管或液滴，管或液滴阵列，管的网格等。在一些情况下，使用本发明的某些实施方案产生的液滴可能被充电或基本上带电，这可能允许它们进一步操作，例如使用外部应用场。这种操作的非限制性实例包括产生带电液滴，聚集液滴（特别是微量级），同步液滴形成，使液滴中的分子对齐等。在一些情况下，液滴和/或流体流可包括胶体，细胞，治疗剂等。

2. 发明授权

US08765485B2 Electronic control of fluidic species 有权
标题翻译：流体物种的电子控制
公开(公告)号：US08765485B2
公开(公告)日：2014-07-01
申请号：US11360845
申请日：2006-02-23
申请人： Darren Roy Link , David A. Weitz , Galder Cristobal-Azkarate , Zhengdong Cheng , Keunho Ahn
发明人： Darren Roy Link , David A. Weitz , Galder Cristobal-Azkarate , Zhengdong Cheng , Keunho Ahn
IPC分类号： G01N1/10 , G01N35/08 , B01F13/00 , B01L3/00
CPC分类号： B01L3/5027 , B01F5/0256 , B01F5/0646 , B01F5/0655 , B01F5/0682 , B01F5/0689 , B01F13/0069 , B01F13/0071 , B01F13/0074 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00862 , B01L3/0241 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L3/502792 , B01L3/5088 , B01L2200/0636 , B01L2200/0652 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , B01L2400/0487 , C12Q2563/159 , C12Q2565/629 , G01N15/10 , G01N15/14 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/149 , Y10S436/807 , Y10T436/118339 , Y10T436/2525 , Y10T436/2575
摘要： Various aspects of the present invention relates to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets.
摘要翻译：本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。一方面，本发明涉及使用例如电场，机械改变，中间流体等的添加来制造由液体包围的流体液滴的系统和方法。本发明还涉及用于根据本发明的另一方面，例如通过电荷和/或偶极相互作用来熔融液滴。在一些情况下，液滴的融合可引发或确定反应。在另一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。实例包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如，流体位移）来对液滴进行分类。

3. 发明申请

US20060163385A1 Formation and control of fluidic species 有权
公开(公告)号：US20060163385A1
公开(公告)日：2006-07-27
申请号：US11246911
申请日：2005-10-07
申请人： Darren Link , David Weitz , Manuel Marquez-Sanchez , Zhengdong Cheng
发明人： Darren Link , David Weitz , Manuel Marquez-Sanchez , Zhengdong Cheng
IPC分类号： B05B7/06
CPC分类号： B01L3/502784 , B01F5/0682 , B01F13/0062 , B01F13/0071 , B01F13/0076 , B01F2215/0431 , B01J2/04 , B01L3/502715 , B01L3/50273 , B01L2200/0673 , B01L2300/0867 , B01L2400/02 , B01L2400/0415 , B01L2400/0424 , B05B5/03 , B05B7/061
摘要： This invention generally relates to systems and methods for the formation and/or control of fluidic species, and articles produced by such systems and methods. In some cases, the invention involves unique fluid channels, systems, controls, and/or restrictions, and combinations thereof. In certain embodiments, the invention allows fluidic streams (which can be continuous or discontinuous, i.e., droplets) to be formed and/or combined, at a variety of scales, including microfluidic scales. In one set of embodiments, a fluidic stream may be produced from a channel, where a cross-sectional dimension of the fluidic stream is smaller than that of the channel, for example, through the use of structural elements, other fluids, and/or applied external fields, etc. In some cases, a Taylor cone may be produced. In another set of embodiments, a fluidic stream may be manipulated in some fashion, for example, to create tubes (which may be hollow or solid), droplets, nested tubes or droplets, arrays of tubes or droplets, meshes of tubes, etc. In some cases, droplets produced using certain embodiments of the invention may be charged or substantially charged, which may allow their further manipulation, for instance, using applied external fields. Non-limiting examples of such manipulations include producing charged droplets, coalescing droplets (especially at the microscale), synchronizing droplet formation, aligning molecules within the droplet, etc. In some cases, the droplets and/or the fluidic streams may include colloids, cells, therapeutic agents, and the like.

4. 发明申请

US20070003442A1 Electronic control of fluidic species 有权
标题翻译：流体物种的电子控制
公开(公告)号：US20070003442A1
公开(公告)日：2007-01-04
申请号：US11360845
申请日：2006-02-23
申请人： Darren Link , David Weitz , Galder Cristobal-Azkarate , Zhengdong Cheng , Keunho Ahn
发明人： Darren Link , David Weitz , Galder Cristobal-Azkarate , Zhengdong Cheng , Keunho Ahn
IPC分类号： B01L3/00
CPC分类号： B01L3/5027 , B01F5/0256 , B01F5/0646 , B01F5/0655 , B01F5/0682 , B01F5/0689 , B01F13/0069 , B01F13/0071 , B01F13/0074 , B01F13/0076 , B01J19/0093 , B01J2219/00783 , B01J2219/00862 , B01L3/0241 , B01L3/502761 , B01L3/502776 , B01L3/502784 , B01L3/502792 , B01L3/5088 , B01L2200/0636 , B01L2200/0652 , B01L2200/0673 , B01L2300/0864 , B01L2300/0867 , B01L2300/161 , B01L2400/0415 , B01L2400/0439 , B01L2400/0487 , C12Q2563/159 , C12Q2565/629 , G01N15/10 , G01N15/14 , G01N15/1459 , G01N15/1484 , G01N2015/1006 , G01N2015/1081 , G01N2015/149 , Y10S436/807 , Y10T436/118339 , Y10T436/2525 , Y10T436/2575
摘要： Various aspects of the present invention relate to the control and manipulation of fluidic species, for example, in microfluidic systems. In one aspect, the invention relates to systems and methods for making droplets of fluid surrounded by a liquid, using, for example, electric fields, mechanical alterations, the addition of an intervening fluid, etc. In some cases, the droplets may each have a substantially uniform number of entities therein. For example, 95% or more of the droplets may each contain the same number of entities of a particular species. In another aspect, the invention relates to systems and methods for dividing a fluidic droplet into two droplets, for example, through charge and/or dipole interactions with an electric field. The invention also relates to systems and methods for fusing droplets according to another aspect of the invention, for example, through charge and/or dipole interactions. In some cases, the fusion of the droplets may initiate or determine a reaction. In a related aspect of the invention, systems and methods for allowing fluid mixing within droplets to occur are also provided. In still another aspect, the invention relates to systems and methods for sorting droplets, e.g., by causing droplets to move to certain regions within a fluidic system. Examples include using electrical interactions (e.g., charges, dipoles, etc.) or mechanical systems (e.g., fluid displacement) to sort the droplets. In some cases, the fluidic droplets can be sorted at relatively high rates, e.g., at about 10 droplets per second or more. Another aspect of the invention provides the ability to determine droplets, or a component thereof, for example, using fluorescence and/or other optical techniques (e.g., microscopy), or electric sensing techniques such as dielectric sensing.
摘要翻译：本发明的各个方面涉及流体物质的控制和操作，例如在微流体系统中。一方面，本发明涉及使用例如电场，机械改变，中间流体等的添加来制造由液体包围的流体液滴的系统和方法。在一些情况下，液滴可以各自具有其中的实体数量基本一致。例如，95％或更多的液滴可以各自包含相同数量的特定物种的实体。另一方面，本发明涉及用于将流体液滴分成两个液滴的系统和方法，例如通过与电场的电荷和/或偶极相互作用。本发明还涉及根据本发明另一方面的用于熔融液滴的系统和方法，例如通过电荷和/或偶极相互作用。在一些情况下，液滴的融合可引发或确定反应。在本发明的相关方面，还提供了允许在液滴内进行流体混合的系统和方法。在另一方面，本发明涉及用于分选液滴的系统和方法，例如通过使液滴移动到流体系统内的某些区域。实例包括使用电相互作用（例如电荷，偶极子等）或机械系统（例如，流体位移）来对液滴进行分类。在一些情况下，流体液滴可以以相对较高的速率进行分选，例如每秒约10个液滴或更多。本发明的另一方面提供了例如使用荧光和/或其他光学技术（例如显微镜）或诸如电介质感测的电传感技术来确定液滴或其组分的能力。

5. 发明申请

US20220195275A1 Biocompatible Oil Herders and Methods of Use 有权
公开(公告)号：US20220195275A1
公开(公告)日：2022-06-23
申请号：US17687405
申请日：2022-03-04
申请人： Zhengdong Cheng , Roshan Sebastian , Lecheng Zhang , Dali Huang , Minxiang Zeng , Abhijeet Shinde , Qingsheng Wang
发明人： Zhengdong Cheng , Roshan Sebastian , Lecheng Zhang , Dali Huang , Minxiang Zeng , Abhijeet Shinde , Qingsheng Wang
IPC分类号： C09K3/32 , C08B37/00 , C02F1/68 , E02B15/08
摘要： Provided herein are oil herding agents, for example, a biocompatible non-ionic functionalized polysaccharide konjac glucomannan radiation-induced degraded konjac glucomannan. Also provided is a method for containing the spread of an oil spill on a water surface at a low water temperature utilizing the oil herding agent. In addition there is provided a method for preparing an oil herder, a radiation-induced degraded konjac glucomannan prepared by the method and a method for increasing a slick thickness ratio of an oil slick on a water surface utilizing the prepared oil herder.

6. 发明授权

US06839137B2 Asphaltene aggregation in petroleum oil mixtures determined by small angle light scattering 有权
标题翻译：沥青质聚集在石油混合物中由小角度光散射确定
公开(公告)号：US06839137B2
公开(公告)日：2005-01-04
申请号：US10458811
申请日：2003-06-10
申请人： Thomas G. Mason , James C. Sung , Zhengdong Cheng , Eric B. Sirota , Michael Siskin
发明人： Thomas G. Mason , James C. Sung , Zhengdong Cheng , Eric B. Sirota , Michael Siskin
IPC分类号： G01N21/49 , G01N21/51 , G01N33/28 , G01N21/00
CPC分类号： G01N21/51 , G01N33/2835
摘要： The present invention includes a method to determine if asphaltenes are soluble or insoluble in a solution. The solution may be a petroleum oil, a mixture of petroleum oils, petroleum derived oils and mixtures or similar combinations in a solvent. The invention includes the steps of illuminating the solution with a laser, measuring the small angle scattered light as a function of angle away from the laser beam, and determining if the asphaltenes are soluble or insoluble in the solution.

7. 发明申请

US20150299240A1 AMPHIPHILIC NANOSHEETS AND METHODS OF MAKING THE SAME 有权
标题翻译：大分子纳米材料及其制备方法
公开(公告)号：US20150299240A1
公开(公告)日：2015-10-22
申请号：US14624974
申请日：2015-02-18
申请人： Zhengdong Cheng , Andres F. MEJIA , Agustin DIAZ , Abraham CLEARFIELD , Mahboobul S. MANNAN , Ya-Wen CHANG
发明人： Zhengdong Cheng , Andres F. MEJIA , Agustin DIAZ , Abraham CLEARFIELD , Mahboobul S. MANNAN , Ya-Wen CHANG
IPC分类号： C07F19/00
CPC分类号： C07F19/005 , C01B25/26 , C01B25/372 , C01B32/20 , C01B32/225 , C01B33/26 , C01P2002/82 , C01P2002/85 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/24
摘要： In some embodiments, the present invention provides amphiphilic nanosheets that comprise lamellar crystals with at least two regions: a first hydrophilic region, and a second hydrophobic region. In some embodiments, the amphiphilic nanosheets of the present invention also comprise a plurality of functional groups that are appended to the lamellar crystals. In some embodiments, the functional groups are hydrophobic functional groups that are appended to the second region of the lamellar crystals. In some embodiments, the lamellar crystals comprise α-zirconium phosphates. Additional embodiments of the present invention pertain to methods of making the aforementioned amphiphilic nanosheets. Such methods generally comprise appending one or more functional groups to a stack of lamellar crystals; and exfoliating the stack of lamellar crystals for form the amphiphilic nanosheets.
摘要翻译：在一些实施方案中，本发明提供了包含具有至少两个区域的层状晶体的两亲性纳米片：第一亲水区域和第二疏水区域。在一些实施方案中，本发明的两亲性纳米片还包含附着到层状晶体的多个官能团。在一些实施方案中，官能团是附着到层状晶体的第二区域的疏水官能团。在一些实施方案中，层状晶体包含磷酸α-锆。本发明的另外的实施方案涉及制备上述两亲性纳米片的方法。这样的方法通常包括将一个或多个官能团附加到层状晶体的堆叠中; 并剥离层叠晶体的叠层以形成两亲性纳米片。

8. 发明授权

US08986641B1 Amphiphilic nanosheets and methods of making the same 有权
标题翻译：两亲纳米片及其制作方法
公开(公告)号：US08986641B1
公开(公告)日：2015-03-24
申请号：US13848669
申请日：2013-03-21
申请人： Zhengdong Cheng , Andres F. Mejia , Agustin Diaz , Abraham Clearfield , Mahboobul S Mannan , Ya-Wen Chang
发明人： Zhengdong Cheng , Andres F. Mejia , Agustin Diaz , Abraham Clearfield , Mahboobul S Mannan , Ya-Wen Chang
IPC分类号： C01B25/26 , C01B25/37 , C01B39/02 , C01G33/00 , C01G23/00 , C01B33/26 , C01B31/04 , B01J19/10
CPC分类号： C07F19/005 , C01B25/26 , C01B25/372 , C01B32/20 , C01B32/225 , C01B33/26 , C01P2002/82 , C01P2002/85 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2004/24
摘要： In some embodiments, the present invention provides amphiphilic nanosheets that comprise lamellar crystals with at least two regions: a first hydrophilic region, and a second hydrophobic region. In some embodiments, the amphiphilic nanosheets of the present invention also comprise a plurality of functional groups that are appended to the lamellar crystals. In some embodiments, the functional groups are hydrophobic functional groups that are appended to the second region of the lamellar crystals. In some embodiments, the lamellar crystals comprise α-zirconium phosphates. Additional embodiments of the present invention pertain to methods of making the aforementioned amphiphilic nanosheets. Such methods generally comprise appending one or more functional groups to a stack of lamellar crystals; and exfoliating the stack of lamellar crystals for form the amphiphilic nanosheets.
摘要翻译：在一些实施方案中，本发明提供了包含具有至少两个区域的层状晶体的两亲性纳米片：第一亲水区域和第二疏水区域。在一些实施方案中，本发明的两亲性纳米片还包含附着到层状晶体的多个官能团。在一些实施方案中，官能团是附着到层状晶体的第二区域的疏水官能团。在一些实施方案中，层状晶体包含磷酸α-锆。本发明的另外的实施方案涉及制备上述两亲性纳米片的方法。这样的方法通常包括将一个或多个官能团附加到层状晶体的堆叠中; 并剥离层叠晶体的叠层以形成两亲性纳米片。

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