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1. 发明授权

US06416988B1 Beta-1,3-galactosyltransferase homologs 失效
标题翻译： β-1,3-半乳糖基转移酶同系物
公开(公告)号：US06416988B1
公开(公告)日：2002-07-09
申请号：US09459133
申请日：1999-12-10
申请人： Darrell C. Conklin , Gayle Yamamoto , Stephen R. Jaspers , Zeren Gao
发明人： Darrell C. Conklin , Gayle Yamamoto , Stephen R. Jaspers , Zeren Gao
IPC分类号： C12N910
CPC分类号： C12N9/1051
摘要： The present invention relates to polynucleotide and polypeptide molecules for znssp2, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp2 polypeptides.
摘要翻译：本发明涉及用于znssp2（半乳糖基转移酶家族的新成员）的多核苷酸和多肽分子。多肽和编码它们的多核苷酸是调节细胞 - 细胞相互作用和糖蛋白合成，并可用于递送和治疗。本发明还包括针对znssp2多肽的抗体。

2. 发明授权

US06361985B1 Beta-1,3-galactosyltransferase homolog, ZNSSP6 失效
标题翻译： β-1,3-半乳糖基转移酶同源物，ZNSSP6
公开(公告)号：US06361985B1
公开(公告)日：2002-03-26
申请号：US09482180
申请日：2000-01-12
申请人： Darrell C. Conklin , Gayle Yamamoto , Zeren Gao , Stephen R. Jaspers
发明人： Darrell C. Conklin , Gayle Yamamoto , Zeren Gao , Stephen R. Jaspers
IPC分类号： C12N910
CPC分类号： C12N9/1051
摘要： The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
摘要翻译：本发明涉及用于znssp6（半乳糖基转移酶家族的新成员）的多核苷酸和多肽分子。多肽和编码它们的多核苷酸是调节细胞 - 细胞相互作用和糖蛋白合成，并可用于递送和治疗。本发明还包括针对znssp6多肽的抗体。

3. 发明授权

US4675386A Monoclonal antibody methods and compositions specific for single antigens in antigen aggregates 失效
标题翻译：单克隆抗体方法和抗原聚集体中单抗原特异性的组合物
公开(公告)号：US4675386A
公开(公告)日：1987-06-23
申请号：US495728
申请日：1983-05-19
申请人： Ivor Royston , John Majda , Gayle Yamamoto
发明人： Ivor Royston , John Majda , Gayle Yamamoto
IPC分类号： C07K16/28 , A61K39/395 , C12N5/00 , C12N15/00 , C12P21/00
CPC分类号： C07K16/28 , Y10S435/948 , Y10S530/808
摘要： Methods and compositions are provided for producing monoclonal antibodies capable of distinguishing between antigenic aggregates, which are differentiated by one or a small number of antigenic determinants. The method involves immunization of a mammal to produce spleen cells which are fused with a cell line which is stable in vitro. The hybridized cells are then dispensed into culture wells at a density level which encourages the production of one colony per well. Autologous antigenic aggregates are employed for screening to distinguish the antibodies which discriminate between the antigenic aggregates. Particularly, mice are hyperimmunized with a homogeneous population of T-cells, the immunized mice killed and the spleens removed. The spleen cells are fused with mouse myeloma cells and the resulting hybrids plated at a relatively low density in culture wells. Plates containing fewer than 30% hybrid positive wells are found to have primarily one colony per well. The cell supernatants are screened against autologous T- and B-cells and hybrid antibodies which do not bind to the B-cells are specific for T-cells.
摘要翻译：提供了用于产生能够区分由一个或少数抗原决定簇分化的抗原性聚集体的单克隆抗体的方法和组合物。该方法包括免疫哺乳动物以产生与体外稳定的细胞系融合的脾细胞。然后将杂交的细胞以鼓励每孔产生一个菌落的密度水平分配到培养孔中。自体抗原聚集体用于筛选以鉴别鉴别抗原聚集体之间的抗体。特别地，用同样的T细胞群体对小鼠进行超免疫，免疫的小鼠被杀死，脾脏被去除。将脾细胞与小鼠骨髓瘤细胞融合，并将所得杂交体以相对较低的密度铺在培养孔中。发现含有少于30％混合阳性井的板块每孔主要有一个菌落。对自体T细胞和B细胞筛选细胞上清液，并且不结合B细胞的杂交抗体对T细胞是特异性的。

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