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1. 发明申请

US20130030531A1 Radiolucent Spinal Fusion Cage 审中-公开
标题翻译：放射性可乐脊髓融合笼
公开(公告)号：US20130030531A1
公开(公告)日：2013-01-31
申请号：US13538559
申请日：2012-06-29
申请人： Darrel S. Brodke , Bret M. Berry , Ashok C. Khandkar , Ramaswamy Lakshminarayanan , Mahendra S. Rao
发明人： Darrel S. Brodke , Bret M. Berry , Ashok C. Khandkar , Ramaswamy Lakshminarayanan , Mahendra S. Rao
IPC分类号： A61F2/44
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的骨移植物用于人类植入，特别是例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱融合器。改进的脊柱融合器包括具有选定尺寸和形状以适应解剖空间的高强度生物相容性材料的基底块，以及类似于天然骨的受控孔隙。衬底块可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨向内生长和增强骨融合。植入后，融合笼提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于手术后监测的放射性。融合笼可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

2. 发明申请

US20110098818A1 Radiolucent spinal fusion cage 审中-公开
标题翻译：放射性可透性脊柱融合器
公开(公告)号：US20110098818A1
公开(公告)日：2011-04-28
申请号：US12800219
申请日：2010-05-10
申请人： Darrel S. Brodke , Bret M. Berry , Ashok C. Khandkar , Ramaswamy Lakshminarayanan , Mahendra S. Rao
发明人： Darrel S. Brodke , Bret M. Berry , Ashok C. Khandkar , Ramaswamy Lakshminarayanan , Mahendra S. Rao
IPC分类号： A61F2/44
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength biocompatible material having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block may be coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的骨移植物用于人类植入，特别是例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱融合器。改进的脊柱融合器包括具有选定尺寸和形状以适应解剖空间的高强度生物相容性材料的基底块，以及类似于天然骨的受控孔隙。衬底块可以涂覆有生物活性表面涂层材料，例如羟基磷灰石或磷酸钙，以促进骨向内生长和增强骨融合。植入后，融合笼提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于手术后监测的放射性。融合笼可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

3. 发明授权

US06790233B2 Radiolucent spinal fusion cage 有权
标题翻译：放射性可透性脊柱融合器
公开(公告)号：US06790233B2
公开(公告)日：2004-09-14
申请号：US10137108
申请日：2002-04-30
申请人： Darrel S. Brodke , Ashok C. Khandkar , Mahendra S. Rao , Ramaswamy Lakshminarayanan
发明人： Darrel S. Brodke , Ashok C. Khandkar , Mahendra S. Rao , Ramaswamy Lakshminarayanan
IPC分类号： A61F228
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved ceramic bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength ceramic having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block is coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的陶瓷骨移植物用于人类植入，特别是例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱融合器。改进的脊柱融合器包括具有选定的尺寸和形状以适应解剖空间的高强度陶瓷的基底块，以及类似于天然骨的受控孔隙。用生物活性表面涂层材料如羟基磷灰石或磷酸钙涂覆底物块以促进骨向内生长并增强骨融合。植入后，融合笼提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于手术后监测的放射性。融合笼可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

4. 发明申请

US20120330420A1 SPINAL FUSION IMPLANTS 审中-公开
标题翻译：脊柱融合植入物
公开(公告)号：US20120330420A1
公开(公告)日：2012-12-27
申请号：US13468278
申请日：2012-05-10
申请人： Darrel S. Brodke , Bret M. Berry , Ashok C. Khandkar , Ramaswamy Lakshminarayanan , Mahendra S. Rao
发明人： Darrel S. Brodke , Bret M. Berry , Ashok C. Khandkar , Ramaswamy Lakshminarayanan , Mahendra S. Rao
IPC分类号： A61F2/44
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/4455 , A61F2/446 , A61F2/4465 , A61F2/4611 , A61F2002/2835 , A61F2002/30013 , A61F2002/30018 , A61F2002/30029 , A61F2002/30056 , A61F2002/30166 , A61F2002/30179 , A61F2002/30785 , A61F2002/30789 , A61F2002/30808 , A61F2002/30812 , A61F2002/30904 , A61F2002/30911 , A61F2002/3092 , A61F2002/3093 , A61F2002/4475 , A61F2220/0025 , A61F2250/0019 , A61F2250/0023 , A61F2310/00179 , A61F2310/00203 , A61F2310/00239 , A61F2310/00299 , A61F2310/00317 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/38
摘要： An improved implant is provided for human implantation, such as a spinal implant for implantation into the intervertebral space between two adjacent vertebrae. Some embodiments include a substrate of high strength biocompatible material, such as doped silicon nitride ceramic for example. In some embodiments, the substrate may also include one or more regions of a controlled porosity analogous to natural bone. In other embodiments, the substrate may comprise the entire implant.
摘要翻译：提供用于人类植入的改进的植入物，例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱植入物。一些实施例包括高强度生物相容性材料的衬底，例如掺杂氮化硅陶瓷。在一些实施方案中，基底还可以包括类似于天然骨的受控孔隙的一个或多个区域。在其他实施例中，基底可以包括整个植入物。

5. 发明授权

US06846327B2 Radiolucent bone graft 有权
标题翻译：放射性可透性骨移植
公开(公告)号：US06846327B2
公开(公告)日：2005-01-25
申请号：US10137106
申请日：2002-04-30
申请人： Ashok C. Khandkar , Mahendra S. Rao
发明人： Ashok C. Khandkar , Mahendra S. Rao
IPC分类号： A61F2/00 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/38 , A61L27/56
CPC分类号： A61L27/3804 , A61F2/30767 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4611 , A61F2002/2835 , A61F2002/30011 , A61F2002/30016 , A61F2002/30064 , A61F2002/30153 , A61F2002/30158 , A61F2002/30166 , A61F2002/30179 , A61F2002/30224 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/30271 , A61F2002/3028 , A61F2002/30329 , A61F2002/30616 , A61F2002/30677 , A61F2002/30733 , A61F2002/30774 , A61F2002/30777 , A61F2002/30789 , A61F2002/3082 , A61F2002/30822 , A61F2002/30827 , A61F2002/3085 , A61F2002/30881 , A61F2002/30891 , A61F2002/30892 , A61F2002/30896 , A61F2002/3092 , A61F2002/30968 , A61F2002/4475 , A61F2002/4623 , A61F2002/4627 , A61F2002/4629 , A61F2002/4648 , A61F2220/0025 , A61F2230/0019 , A61F2230/0026 , A61F2230/0028 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0019 , A61F2250/0023 , A61F2310/00203 , A61F2310/00239 , A61F2310/00796 , A61F2310/00928 , A61F2310/0097 , A61F2310/00976 , A61L27/10 , A61L27/30 , A61L27/32 , A61L27/3608 , A61L27/365 , A61L27/3847 , A61L27/56 , A61L2430/02 , A61L2430/38
摘要： An improved ceramic bone graft is provided for human implantation, particularly such as a spinal fusion cage for implantation into the inter-vertebral space between two adjacent vertebrae. The improved spinal fusion cage includes a substrate block of high strength ceramic having a selected size and shape to fit the anatomical space, and a controlled porosity analogous to natural bone. The substrate block is coated with a bio-active surface coating material such as hydroxyapatite or a calcium phosphate to promote bone ingrowth and enhanced bone fusion. Upon implantation, the fusion cage provides a spacer element having a desired combination of mechanical strength together with osteoconductivity and osteoinductivity to promote bone ingrowth and fusion, as well as radiolucency for facilitated post-operative monitoring. The fusion cage may additionally carry one or more natural or synthetic therapeutic agents for further promoting bone ingrowth and fusion.
摘要翻译：提供改进的陶瓷骨移植物用于人类植入，特别是例如用于植入到两个相邻椎骨之间的椎间空间中的脊柱融合器。改进的脊柱融合器包括具有选定的尺寸和形状以适应解剖空间的高强度陶瓷的基底块，以及类似于天然骨的受控孔隙。用生物活性表面涂层材料如羟基磷灰石或磷酸钙涂覆底物块以促进骨向内生长并增强骨融合。植入后，融合笼提供了具有机械强度与骨传导性和骨诱导性的期望组合的间隔元件，以促进骨向内生长和融合，以及便于手术后监测的放射性。融合笼可另外携带一种或多种天然或合成治疗剂，用于进一步促进骨向内生长和融合。

6. 发明授权

US08709807B2 Method of isolating human neuroepithelial precursor cells from human fetal tissue 有权
标题翻译：从人胎儿组织中分离人神经上皮前体细胞的方法
公开(公告)号：US08709807B2
公开(公告)日：2014-04-29
申请号：US13435424
申请日：2012-03-30
申请人： Margot Mayer-Proschel , Mahendra S. Rao , Patrick A. Tresco , Darin J. Messina
发明人： Margot Mayer-Proschel , Mahendra S. Rao , Patrick A. Tresco , Darin J. Messina
IPC分类号： C12N5/08 , C12N5/0797
CPC分类号： A61K35/54 , A61K35/12 , C12N5/0623
摘要： A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
摘要翻译：通过培养成纤维细胞生长因子和雏鸡胚胎提取物中的人胎细胞和从培养的人胎儿细胞免疫进行分离，可以提供任何表达A2B5，NG2和eNCAM的细胞从人胎儿组织中分离人神经上皮前体细胞的方法。另外，提供将这些细胞移植到动物体内的方法。还提供了用这些人类神经上皮前体细胞移植的动物模型以及通过检测人特异性标志物监测动物模型中细胞的存活，增殖，分化和迁移的方法。

7. 发明授权

US06830927B2 Common neural progenitor for the CNS and PNS 失效
标题翻译： CNS和PNS的常见神经祖细胞
公开(公告)号：US06830927B2
公开(公告)日：2004-12-14
申请号：US09073881
申请日：1998-05-06
申请人： Mahendra S. Rao , Tahmina Mujtaba
发明人： Mahendra S. Rao , Tahmina Mujtaba
IPC分类号： C12N506
CPC分类号： C12N5/0661 , C12N5/0623 , C12N2501/113 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2506/08
摘要： A method of generating neural crest stem cells involves inducing neuroepithelial stem cells to differentiate in vitro into neural crest stem cells. Differentiation can be induced by replating the cells on laminin, withdrawing mitogens, or adding dorsalizing agents to the growth medium. Derivatives of the peripheral nervous system can be generated by inducing the neural crest stem cells to differentiate in vitro.
摘要翻译：产生神经嵴干细胞的方法包括诱导神经上皮干细胞体外分化为神经嵴干细胞。可以通过在层粘连蛋白上重复细胞，取出有丝分裂原或向生长培养基中加入背胶剂来诱导分化。通过诱导神经嵴干细胞体外分化可以产生外周神经系统的衍生物。

8. 发明授权

US06787353B1 Lineage-restricted neuronal precursors and methods of isolation 失效
标题翻译：谱系限制性神经元前体和分离方法
公开(公告)号：US06787353B1
公开(公告)日：2004-09-07
申请号：US09109858
申请日：1998-07-02
申请人： Mahendra S. Rao , Margot Mayer-Proschel , Anjali J. Kalyani
发明人： Mahendra S. Rao , Margot Mayer-Proschel , Anjali J. Kalyani
IPC分类号： C12N508
CPC分类号： C12N5/0623 , A61K35/12 , A61K48/00 , C12N2501/115 , C12N2501/13 , C12N2501/385
摘要： A self-renewing restricted stem cell population has been identified in developing (embryonic day 13.5) spinal cords that can differentiate into multiple neuronal phenotypes, but cannot differentiate into glial phenotypes. This neuronal-restricted precursor (NRP) expresses highly polysialated or embryonic neural cell adhesion molecule (E-NCAM) and is morphologically distinct from neuroepithelial stem cells (NEP cells) and spinal glial progenitors derived from embryonic day 10.5 spinal cord. NRP cells self renew over multiple passages in the presence of fibroblast growth factor (FGF) and neurotrophin 3 (NT-3) and express a characteristic subset of neuronal epitopes. When cultured in the presence of RA and the absence of FGF, NRP cells differentiate into GABAergic, glutaminergic, and cholinergic immunoreactive neurons. NRP cells can also be generated from multipotent NEP cells cultured from embryonic day 10.5 neural tubes. Clonal analysis shows that E-NCAM immunoreactive NRP cells arise from an NEP progenitor cell that generates other restricted CNS precursors. The NEP-derived E-NCAM immunoreactive cells undergo self renewal in defined medium and differentiate into multiple neuronal phenotypes in mass and clonal culture. Thus, a direct lineal relationship exists between multipotential NEP cells and more restricted neuronal precursor cells present in vivo at embryonic day 13.5 in the spinal cord. Methods for treating neurological diseases are also disclosed.
摘要翻译：在发育（胚胎期13.5）脊髓中已经鉴定出自我更新的限制性干细胞群，其可以分化成多个神经元表型，但不能分化成胶质表型。这种神经元限制性前体（NRP）表达高度多聚化或胚胎神经细胞粘附分子（E-NCAM），并且在形态学上与神经上皮干细胞（NEP细胞）和源自胚胎第10.5天脊髓的脊髓神经祖细胞不同。 NRP细胞在成纤维细胞生长因子（FGF）和神经营养因子3（NT-3）的存在下自我更新多次，并表达神经元表位的特征亚群。当在RA和无FGF的存在下培养时，NRP细胞分化为GABA能，谷氨酸能和胆碱能免疫反应性神经元。 NRP细胞还可以从从胚胎第10.5天神经管培养的多能NEP细胞产生。克隆分析表明，E-NCAM免疫反应性NRP细胞来自产生其他受限制的CNS前体的NEP祖细胞。 NEP衍生的E-NCAM免疫反应性细胞在限定的培养基中进行自我更新，并在大量和克隆培养中分化成多个神经元表型。因此，多潜能NEP细胞与脊髓中第13.5天体内存在的更多受限的神经元前体细胞之间存在直接的直线关系。还公开了治疗神经疾病的方法。

9. 发明申请

US20100015702A1 Generation, Characterization and Isolation of Neuroepithelial Stem Cells and Lineage Restricted Intermediate Precursor 审中-公开
标题翻译：神经上皮干细胞和谱系限制性中间体前体的产生，表征和分离
公开(公告)号：US20100015702A1
公开(公告)日：2010-01-21
申请号：US12568419
申请日：2009-09-28
申请人： Mahendra S. Rao , Margot Mayer-Proschel
发明人： Mahendra S. Rao , Margot Mayer-Proschel
IPC分类号： C12N5/00
CPC分类号： C12N5/0661 , C12N5/0623 , C12N2501/113 , C12N2501/115 , C12N2501/135 , C12N2501/155 , C12N2501/385 , C12N2506/08
摘要： Multipotent neuroepithelial stem cells and lineage-restricted oligodendrocyte-astrocyte precursor cells are described. The neuroepithelial stem cells are capable of self-renewal and of differentiation into neurons, astrocytes, and oligodendrocytes. The oligodendrocyte-astrocyte precursor cells are derived from neuroepithelial stem cells, are capable of self-renewal, and can differentiate into oligodendrocytes and astrocytes, but not neurons. Methods of generating, isolating, and culturing such neuroepithelial stem cells and oligodendrocyte-astrocyte precursor cells are also disclosed.
摘要翻译：描述了多能神经上皮干细胞和谱系限制性少突胶质细胞 - 星形胶质细胞前体细胞。神经上皮干细胞能够自我更新并分化为神经元，星形胶质细胞和少突胶质细胞。少突胶质细胞 - 星形胶质细胞前体细胞衍生自神经上皮干细胞，能够自我更新，并能分化为少突胶质细胞和星形胶质细胞，而不能分化为神经元。还公开了产生，分离和培养这种神经上皮干细胞和少突胶质细胞 - 星形胶质细胞前体细胞的方法。

10. 发明申请

US20090162330A1 Method of Isolating Human Neuroepithelial Precursor Cells from Human Fetal Tissue 有权
标题翻译：人类胎盘组织分离人神经上皮前体细胞的方法
公开(公告)号：US20090162330A1
公开(公告)日：2009-06-25
申请号：US12395677
申请日：2009-03-01
申请人： Margot Mayer-Proschel , Mahendra S. Rao , Patrick A. Tresco , Darin J. Messina
发明人： Margot Mayer-Proschel , Mahendra S. Rao , Patrick A. Tresco , Darin J. Messina
IPC分类号： A61K45/00 , G01N33/53 , A61P25/28
CPC分类号： A61K35/54 , A61K35/12 , C12N5/0623
摘要： A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing A2B5, NG2 and eNCAM is provided. In addition, methods for transplanting these cells into an animal are provided. Animals models transplanted with these human neuroepithelial precursor cells and methods for monitoring survival, proliferation, differentiation and migration of the cells in the animal model via detection of human specific markers are also provided.
摘要翻译：通过培养成纤维细胞生长因子和雏鸡胚胎提取物中的人胎细胞和从培养的人胎儿细胞免疫进行分离，可以提供任何表达A2B5，NG2和eNCAM的细胞从人胎儿组织中分离人神经上皮前体细胞的方法。另外，提供将这些细胞移植到动物体内的方法。还提供了用这些人类神经上皮前体细胞移植的动物模型以及通过检测人特异性标志物监测动物模型中细胞的存活，增殖，分化和迁移的方法。

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