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1. 发明授权

US07937153B2 Electrode with increased stability and method of manufacturing the same 有权
标题翻译：增加稳定性的电极及其制造方法
公开(公告)号：US07937153B2
公开(公告)日：2011-05-03
申请号：US11820744
申请日：2007-06-19
申请人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/0543 , A61N1/36046
摘要： An implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. An implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.
摘要翻译：具有增加的稳定性的可植入电极具有聚集结构，其中电极的表面被包括充满棒或柱的开口的材料覆盖。具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

2. 发明授权

US10159832B2 Electrode with increased stability and method of manufacturing the same 有权
公开(公告)号：US10159832B2
公开(公告)日：2018-12-25
申请号：US11924763
申请日：2007-10-26
申请人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
IPC分类号： C25D5/02 , A61N1/05 , A61N1/36
摘要： The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention further provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer.

3. 发明申请

US20080268134A1 ELECTRODE WITH INCREASED STABILITY AND METHOD OF MANUFACTURING THE SAME 审中-公开
标题翻译：具有增加的稳定性的电极及其制造方法
公开(公告)号：US20080268134A1
公开(公告)日：2008-10-30
申请号：US11924763
申请日：2007-10-26
申请人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Jerry Ok , Neil Hamilton Talbot , Brian V. Mech , James Singleton Little , Robert J. Greenberg
IPC分类号： H01M4/04
CPC分类号： A61N1/0543 , A61N1/36046
摘要： The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts.The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material.The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer.The present invention provides A method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.
摘要翻译：本发明提供具有增加的稳定性的可植入电极，其具有聚集结构，其中电极的表面被包括填充有棒或柱的开口的材料覆盖。本发明提供了具有增加的稳定性的可植入电极，其中电极的表面包括填充有用导电或绝缘材料填充的棒的网状网格。本发明提供一种具有增加的稳定性的电极的制造方法，包括：在基底层上沉积金属层; 在金属层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 去除留下空间的光致抗蚀剂层; 并用聚合物填充空间。本发明提供了一种制造具有增加的稳定性的电极的方法，包括：在基底层上沉积金属层; 在金属层上施加聚合物层; 在聚合物层上施加光致抗蚀剂层; 图案化提供开口的光致抗蚀剂层; 用金属电镀开口; 并除去光致抗蚀剂层。

4. 发明授权

US08180460B2 Flexible circuit electrode array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US08180460B2
公开(公告)日：2012-05-15
申请号：US11934627
申请日：2007-11-02
申请人： Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Nevsmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

5. 发明申请

US20120192416A1 Flexible Circuit Electrode Array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US20120192416A1
公开(公告)日：2012-08-02
申请号：US13422892
申请日：2012-03-16
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： H05K3/46 , H05K3/42 , H05K3/02
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

6. 发明申请

US20080221653A1 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路阵列
公开(公告)号：US20080221653A1
公开(公告)日：2008-09-11
申请号：US12044830
申请日：2008-03-07
申请人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
发明人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543 , A61N1/36046
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

7. 发明授权

US10188853B2 Flexible circuit electrode array with a drum stress relief 有权
公开(公告)号：US10188853B2
公开(公告)日：2019-01-29
申请号：US12044830
申请日：2008-03-07
申请人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
发明人： Rajat Agrawal , Robert J. Greenberg , Mark S. Humayun , James Singleton Little , Brian V. Mech , Jordan Matthew Neysmith , Neil Hamilton Talbot , Dao Min Zhou
IPC分类号： A61N1/05 , A61N1/36
摘要： The present invention is a flexible circuit electrode array with a polymer base layer, metal traces deposited on the polymer base layer, including electrodes suitable to stimulate neural tissue, a polymer top layer deposited on the polymer base layer and the metal traces, and a soft polymer filling a void through both the polymer base layer and polymer top layer, the soft polymer forming drum stress relief around an attachment point.

8. 发明授权

US09314615B2 Method of making a flexible circuit electrode array 有权
标题翻译：制造柔性电路电极阵列的方法
公开(公告)号：US09314615B2
公开(公告)日：2016-04-19
申请号：US13422892
申请日：2012-03-16
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： H05K3/02 , H05K3/10 , A61N1/05 , A61N1/36 , H05K1/11 , H05K3/00 , H05K3/38 , H05K3/46
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适合于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

9. 发明申请

US20080288037A1 Flexible Circuit Electrode Array 有权
标题翻译：柔性电路电极阵列
公开(公告)号：US20080288037A1
公开(公告)日：2008-11-20
申请号：US11934627
申请日：2007-11-02
申请人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
发明人： Jordan Matthew Neysmith , Neil Hamilton Talbot , James Singleton Little , Brian V. Mech , Robert J. Greenberg , Qingfang Yao , Dao Min Zhou
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：一种具有多于一层金属迹线的柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的多于一层由聚合物层隔开的金属痕迹层，包括适于刺激神经组织的电极; 以及沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激特别有用，用于创建人造视觉，人工耳蜗刺激以创建人造听觉或皮质刺激许多目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。

10. 发明申请

US20100147702A1 Process for Cathodic Protection of Electrode Material 有权
标题翻译：电极材料阴极保护工艺
公开(公告)号：US20100147702A1
公开(公告)日：2010-06-17
申请号：US12708358
申请日：2010-02-18
申请人： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
IPC分类号： C23F13/00
CPC分类号： C23F13/00 , A61N1/05 , A61N1/08 , C23F13/02
摘要： The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode. The negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
摘要翻译：本发明涉及对电极或电极材料进行阴极保护的方法，其中负电极施加在电极上。负偏压通过不对称电流脉冲获得。通过执行具有较高振幅的负相来获得非对称电流脉冲。通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相脉冲宽度大于阳极相。通过脉冲串获得更宽的脉冲宽度。

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