专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5246931A Carbocyclic nucleoside analogs 失效
标题翻译：碳环核苷类似物
公开(公告)号：US5246931A
公开(公告)日：1993-09-21
申请号：US694538
申请日：1991-05-01
申请人： Daniel W. Norbeck , Jacob J. Plattner , Terry J. Rosen , David L. Garmaise , Richard J. Pariza , Steven M. Hannick , Thomas J. Sowin
发明人： Daniel W. Norbeck , Jacob J. Plattner , Terry J. Rosen , David L. Garmaise , Richard J. Pariza , Steven M. Hannick , Thomas J. Sowin
IPC分类号： C07C215/42 , C07C271/18 , C07C271/20 , C07C271/24 , C07C275/50 , C07D213/69 , C07D239/46 , C07D239/54 , C07D251/16 , C07D253/065 , C07D471/04 , C07D473/00 , C07D487/04 , C07F7/18 , C07F9/6561
CPC分类号： C07D213/69 , C07C215/42 , C07C271/18 , C07C271/20 , C07C271/24 , C07C275/50 , C07D239/47 , C07D239/54 , C07D251/16 , C07D253/065 , C07D471/04 , C07D473/00 , C07D487/04 , C07F7/1856 , C07F9/65616 , C07C2101/04
摘要： A compound of the formula: ##STR1## wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, --CH.sub.2 OH or --OH; and G and D are independently selected from hydrogen, C.sub.1 to C.sub.10 alkyl, --OH, --CH.sub.2 OH, --CH.sub.2 OR.sub.20 wherein R.sub.20 is C.sub.1 to C.sub.6 alkyl, --CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is C.sub.1 to C.sub.10 alkyl, --CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 is the side chain of any of the naturally occurring amino acids and R.sub.23 is hydrogen or --C(O)CH(R.sub.24)(NH.sub.2) wherein a R.sub.24 is the side chain of any of the naturally occurring amino acids, --CH.sub.2 SH, --CH.sub.2 Cl, --CH.sub.2 F, --CH.sub.2 Br, --CH.sub.2 I, --C(O)H, --CH.sub.2 CN, --CH.sub.2 N.sub.3, --CH.sub.2 NR.sub.1 R.sub.2, --CO.sub.2 R.sub.1, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OR.sub.20 wherein R.sub.20 is as defined above, --CH.sub.2 CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is as defined above, --CH.sub.2 CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 and R.sub.23 are as defined above, --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2, --CH.sub.2 OPO.sub.3 H.sub.2, --OCH.sub.2 PO.sub.3 H.sub.2 and --CH.sub.2 CO.sub.2 R.sub.3 wherein R.sub.1 and R.sub.2 are independently selected from hydrogen and C.sub.1 to C.sub.10 alkyl and R.sub.3 is hydrogen, C.sub.1 to C.sub.10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.
摘要翻译：下式的化合物：其中A是嘌呤-9-基，嘌呤-9-基的杂环等价基，嘧啶-1-基或嘧啶-1-基的杂环等价基组; E是氢，-CH 2 OH或-OH; 并且G和D独立地选自氢，C1-C10烷基，-OH，-CH2OH，-CH2OR20，其中R20是C1-C6烷基，-CH2OC（O）R21，其中R21是C1-C10烷基，-CH2OC（O） CH（R22）（NHR23）其中R22是任何天然存在的氨基酸的侧链，R 23是氢或-C（O）CH（R 24）（NH 2），其中R 24是任何天然存在的氨基酸的侧链发生的氨基酸，-CH 2 SH，-CH 2 Cl，-CH 2 F，-CH 2 Br，-CH 2 I，-C（O）H，-CH 2 CN，-CH 2 N 3，-CH 2 NR 1 R 2，-CO 2 R 1，-CH 2 CH 2 OH，-CH 2 CH 2 OR 20，其中R 20如上定义， -CH 2 CH 2 OC（O）R 21，其中R 21如上定义，-CH 2 CH 2 OC（O）CH（R 22）（NHR 23）其中R 22和R 23如上定义，-CH 2 CH 2 PO 3 H 2，-CH 2 OPO 3 H 2，-OCH 2 PO 3 H 2和-CH 2 CO 2 R 3，其中R 1和R 2是独立地选自氢和C1至C10烷基，R3是氢，C1至C10烷基，羧基烷基或氨基烷基; 或其药学上可接受的盐。

2. 发明授权

US5153352A Process for preparation of intermediates of carbocyclic nucleoside analogs 失效
标题翻译：制备碳环核苷类似物的中间体的方法
公开(公告)号：US5153352A
公开(公告)日：1992-10-06
申请号：US570198
申请日：1990-08-20
申请人： Daniel W. Norbeck , Richard J. Pariza , Steven M. Hannick , Thomas J. Sowin
发明人： Daniel W. Norbeck , Richard J. Pariza , Steven M. Hannick , Thomas J. Sowin
IPC分类号： C07C215/42 , C07C271/18 , C07C271/20 , C07C271/24 , C07C275/50 , C07D213/69 , C07D239/46 , C07D239/54 , C07D251/16 , C07D253/065 , C07D471/04 , C07D473/00 , C07D487/04 , C07F7/18 , C07F9/6561
CPC分类号： C07D213/69 , C07C215/42 , C07C271/18 , C07C271/20 , C07C271/24 , C07C275/50 , C07D239/47 , C07D239/54 , C07D251/16 , C07D253/065 , C07D471/04 , C07D473/00 , C07D487/04 , C07F7/1856 , C07F9/65616 , C07C2101/04
摘要： A compound of the formula: ##STR1## wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, --CH.sub.2 OH or --OH; and G and D are independently selected from hydrogen, C.sub.1 to C.sub.10 alkyl, --OH, --CH.sub.2 OH, --CH.sub.2 OR.sub.20 wherein R.sub.20 is C.sub.1 to C.sub.6 alkyl, --CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is C.sub.1 to C.sub.10 alkyl, --CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 is the side chain of any of the naturally occuring amino acids and R.sub.23 is hydrogen or --C(O)CH(R.sub.24)(NH.sub.2) wherein R.sub.24 is the side chain of any of the naturally occuring amino acids, --CH.sub.1 SH, --Ch.sub.2 Cl, --Ch.sub.2 F, --CH.sub.2 Br, --CH.sub.2 I, --C(O)H, --CH.sub.2 CN, --CH.sub.2 N.sub.3, --CH.sub.2 NR.sub.1 R.sub.2, --CO.sub.2 R.sub.1, --CH.sub.2 CH.sub.2 OH, --CH.sub.2 CH.sub.2 OR.sub.20 wherein R.sub.20 is as defined above, --CH.sub.2 CH.sub.2 OC(O)R.sub.21 wherein R.sub.21 is as defined above, --CH.sub.2 CH.sub.2 OC(O)CH(R.sub.22)(NHR.sub.23) wherein R.sub.22 and R.sub.23 are as defined above, --CH.sub.2 CH.sub.2 PO.sub.3 H.sub.2, --Ch.sub.2 OPO.sub.3 H.sub.2, --OCH.sub.2 PO.sub.3 H.sub.2 and --CH.sub.2 CO.sub.2 R.sub.3 wherein R.sub.1 and R.sub.2 are independently selected from hydrogen and C.sub.1 to C.sub.10 alkyl and R.sub.3 is hydrogen, C.sub.1 to C.sub.10 alkyl, carboxyalkyl or aminoalkyl; or a pharmaceutically acceptable salt thereof.
摘要翻译：下式的化合物：其中A是嘌呤-9-基，嘌呤-9-基的杂环等价基，嘧啶-1-基或嘧啶-1-基的杂环等价基组; E是氢，-CH 2 OH或-OH; 并且G和D独立地选自氢，C1-C10烷基，-OH，-CH2OH，-CH2OR20，其中R20是C1-C6烷基，-CH2OC（O）R21，其中R21是C1-C10烷基，-CH2OC（O） CH（R22）（NHR23）其中R22是任何天然存在的氨基酸的侧链，R 23是氢或-C（O）CH（R 24）（NH 2），其中R 24是任何天然存在的氨基酸的侧链氨基酸，-CH1SH，-Ch2Cl，-Ch2F，-CH2Br，-CH2I，-C（O）H，-CH2CN，-CH2N3，-CH2NR1R2，-CO2R1，-CH2CH2OH，-CH2CH2OR20，其中R20如上定义， CH 2 CH 2 OC（O）R 21，其中R 21如上所定义，-CH 2 CH 2 OC（O）CH（R 22）（NHR 23）其中R 22和R 23如上定义，-CH 2 CH 2 PO 3 H 2，-Ch 2 OPO 3 H 2，-OCH 2 PO 3 H 2和-CH 2 CO 2 R 3，其中R 1和R 2独立地选自氢和C1至C10烷基，R3为氢，C1至C10烷基，羧基烷基或氨基烷基; 或其药学上可接受的盐。

3. 发明授权

US5597824A Analogs of oxetanyl purines and pyrimidines 失效
标题翻译：氧杂环丁烷嘌呤和嘧啶的类似物
公开(公告)号：US5597824A
公开(公告)日：1997-01-28
申请号：US904407
申请日：1992-06-25
申请人： Daniel W. Norbeck , Jacob J. Plattner , Terry J. Rosen
发明人： Daniel W. Norbeck , Jacob J. Plattner , Terry J. Rosen
IPC分类号： C07D405/04 , C07D473/34 , A61K31/495 , C07D239/02 , C07D403/00 , C07F9/02
CPC分类号： C07D405/04 , C07D473/34
摘要： A compound of the formula: ##STR1## wherein B is a purin-9-yl group or a heterocyclic isostere of a purin-9-yl group; or a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; A is --CH-- or A--G taken together is --C(.dbd.O)--, --C(.dbd.CH.sub.2)--, --C(OH)(CH.sub.2 OH)-- or ##STR2## and G and D are functional groups; or a pharmaceutically acceptable salt or ester thereof.
摘要翻译：下式的化合物：其中B是嘌呤-9-基或嘌呤-9-基的杂环等价基; 或嘧啶-1-基或嘧啶-1-基的杂环等价基; A是-CH-或A-G，它们一起是-C（= O） - ， - C（= CH2） - ， - C（OH）（CH2OH） - 或者IMA，G和D是官能团; 或其药学上可接受的盐或酯。

4. 发明授权

US07968707B2 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US07968707B2
公开(公告)日：2011-06-28
申请号：US11679227
申请日：2007-02-27
申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
IPC分类号： C07D219/04 , C07D291/06 , C07D243/04 , C07D265/12 , C07D413/12 , C07D239/02
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

5. 发明授权

US06472529B2 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US06472529B2
公开(公告)日：2002-10-29
申请号：US09837280
申请日：2001-04-18
申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
IPC分类号： C07D23332
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

6. 发明授权

US06313296B1 Retroviral protease inhibiting compounds 有权
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US06313296B1
公开(公告)日：2001-11-06
申请号：US09511390
申请日：2000-02-23
申请人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
发明人： Hing Leung Sham , Daniel W. Norbeck , Xiaoqi Chen , David A. Betebenner , Dale J. Kempf , Thomas R. Herrin , Gondi N. Kumar , Stephen L. Condon , Arthur J. Cooper , Daniel A. Dickman , Steven M. Hannick , Lawrence Kolaczkowski , Patricia A. Oliver , Daniel J. Plata , Peter J. Stengel , Eric J. Stoner , Jieh-Heh J. Tien , Jih-Hua Liu , Ketan M. Patel
IPC分类号： C07D23902
CPC分类号： C07D207/27 , C07D207/404 , C07D207/408 , C07D223/10 , C07D233/32 , C07D233/42 , C07D239/10 , C07D239/22 , C07D241/08 , C07D241/18 , C07D253/06 , C07D263/22 , C07D307/20 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： A compound of the formula: is disclosed as an HIV protease inhibitor. Methods and compositions for inhibiting an HIV infection are also disclosed.
摘要翻译：公开了下式的化合物作为HIV蛋白酶抑制剂。还公开了用于抑制HIV感染的方法和组合物。

7. 发明授权

US5545750A Retroviral protease inhibiting compounds 失效
标题翻译：逆转录病毒蛋白酶抑制化合物
公开(公告)号：US5545750A
公开(公告)日：1996-08-13
申请号：US409391
申请日：1995-03-23
申请人： Dale J. Kempf , Daniel W. Norbeck , John W. Erickson , Hing Leung Sham , Lynn M. Codacovi , Jacob J. Plattner
发明人： Dale J. Kempf , Daniel W. Norbeck , John W. Erickson , Hing Leung Sham , Lynn M. Codacovi , Jacob J. Plattner
IPC分类号： C07D295/18 , A61K31/00 , A61K31/10 , A61K31/12 , A61K31/135 , A61K31/15 , A61K31/165 , A61K31/195 , A61K31/335 , A61K31/40 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/535 , A61K31/54 , A61K38/00 , A61P31/12 , A61P37/04 , C07C31/125 , C07C33/18 , C07C33/26 , C07C33/46 , C07C39/12 , C07C43/164 , C07C43/174 , C07C43/205 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/313 , C07C43/315 , C07C45/00 , C07C45/29 , C07C45/56 , C07C45/59 , C07C45/62 , C07C45/67 , C07C45/74 , C07C49/04 , C07C49/12 , C07C49/17 , C07C49/175 , C07C49/20 , C07C49/215 , C07C49/233 , C07C49/24 , C07C49/255 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07C211/27 , C07C215/06 , C07C215/18 , C07C215/20 , C07C215/28 , C07C217/04 , C07C225/06 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/35 , C07C233/36 , C07C233/40 , C07C233/78 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/04 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/08 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/00 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/05 , C07C311/06 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/11 , C07C323/12 , C07C323/25 , C07C323/41 , C07C323/60 , C07C381/00 , C07D207/06 , C07D207/08 , C07D207/12 , C07D207/16 , C07D207/24 , C07D209/42 , C07D211/22 , C07D211/54 , C07D211/62 , C07D211/96 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/55 , C07D213/56 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/14 , C07D217/16 , C07D217/26 , C07D231/10 , C07D233/60 , C07D233/61 , C07D233/84 , C07D239/38 , C07D263/06 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/36 , C07D277/42 , C07D277/56 , C07D279/12 , C07D295/088 , C07D295/14 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/20 , C07D295/205 , C07D295/215 , C07D295/22 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D305/14 , C07D307/42 , C07D317/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07D521/00 , C07F7/02 , C07F9/30 , C07F9/32 , C07F9/53 , C07K5/02 , C07K5/06 , C07K5/062 , C07K5/078 , G07C215/18
CPC分类号： C07D207/08 , C07C211/27 , C07C215/18 , C07C215/20 , C07C215/28 , C07C229/08 , C07C229/26 , C07C229/34 , C07C233/36 , C07C233/40 , C07C235/10 , C07C235/12 , C07C235/34 , C07C235/78 , C07C237/10 , C07C237/20 , C07C237/22 , C07C239/10 , C07C239/18 , C07C239/20 , C07C247/10 , C07C251/40 , C07C271/20 , C07C271/22 , C07C271/34 , C07C275/16 , C07C275/24 , C07C311/03 , C07C311/13 , C07C311/18 , C07C317/10 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C33/46 , C07C381/00 , C07C43/164 , C07C43/1742 , C07C43/2055 , C07C43/215 , C07C43/23 , C07C43/30 , C07C43/315 , C07C45/004 , C07C45/29 , C07C45/567 , C07C45/59 , C07C45/62 , C07C45/673 , C07C45/74 , C07C53/134 , C07C69/34 , C07C69/65 , C07C69/732 , C07D207/24 , C07D209/42 , C07D211/62 , C07D213/30 , C07D213/40 , C07D213/42 , C07D213/56 , C07D213/70 , C07D213/81 , C07D213/82 , C07D215/16 , C07D217/16 , C07D217/26 , C07D231/12 , C07D233/56 , C07D233/84 , C07D239/38 , C07D249/08 , C07D263/32 , C07D277/24 , C07D277/28 , C07D277/36 , C07D277/42 , C07D277/56 , C07D295/088 , C07D295/15 , C07D295/155 , C07D295/185 , C07D295/205 , C07D295/215 , C07D295/26 , C07D303/04 , C07D303/22 , C07D303/36 , C07D303/48 , C07D307/42 , C07D317/12 , C07D413/12 , C07D417/12 , C07D487/04 , C07F9/3241 , C07F9/5333 , C07K5/021 , C07K5/06043 , C07K5/06052 , C07K5/06139 , A61K38/00 , C07C2101/14 , Y02P20/55
摘要： A retroviral protease inhibiting compound of the formulaA--X--Bor a pharmaceutically acceptable salt, prodrug or ester thereof, wherein X is a linking group;A is(1) substituted amino,(2) substituted carbonyl,(3) functionalized imino,(4) functionalized alkyl,(5) functionalized acyl,(6) functionalized heterocyclic or(7) functionalized (heterocyclic)alkyl; andB is(1) substituted carbonyl independently defined as herein,(2) substituted amino independently defined as herein,(3) functionalized imino independently defined as herein,(4) functionalized alkyl independently defined as herein,(5) functionalized acyl independently defined as herein,(6) functionalized heterocyclic independently defined as herein or(7) functionalized (heterocyclic)alkyl independently defined as herein.
摘要翻译：式A-X-Bor的逆转录病毒蛋白酶抑制化合物其药学上可接受的盐，前药或酯，其中X是连接基团; A是（1）取代氨基，（2）取代羰基，（3）官能化亚氨基，（4）官能化烷基，（5）官能化酰基，（6）官能化杂环或（7）官能化（杂环）烷基; 并且B是（1）独立地定义如本文中的取代的羰基，（2）如本文独立定义的取代的氨基，（3）如本文独立定义的官能化亚氨基，（4）如本文独立定义的官能化烷基，（5）独立定义的官能化酰基如本文所述，（6）本文独立定义的官能化杂环或（7）如本文独立定义的官能化（杂环）烷基。

8. 发明授权

US06168913A Coding combinatorial libraries with fluorine tags 失效
标题翻译：用氟标签编码组合库
公开(公告)号：US06168913A
公开(公告)日：2001-01-02
申请号：US08949987
申请日：1997-10-14
申请人： Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Warren S. Wade , David N. Whittern
发明人： Jill Edie Hochlowski , Thomas J. Sowin , Daniel W. Norbeck , Warren S. Wade , David N. Whittern
IPC分类号： C12Q100
CPC分类号： C40B50/16 , B01J2219/00576 , C07K1/047 , C40B99/00
摘要： The present invention relates to coding combinatorial chemical libraries synthesized on a plurality of solid supports by attaching “tags” that comprise fluorine containing compounds in combinations and/or ratios. The tags can be decoded while attached to the solid support by fluorine nuclear magnetic resonance spectroscopy to follow the reaction history of individual beads, and to determine the particular member of the library that is attached on the bead.
摘要翻译：本发明涉及通过以组合和/或比率附着包含含氟化合物的“标签”，在多个固体支持物上合成的组合化学文库编码。可以通过氟核磁共振光谱法附着到固体支持物上来对标签进行解码，以跟踪单个珠粒的反应历程，并确定附着在珠粒上的文库的特定成员。

10. 发明授权

US5541328A Process for the preparation of a substituted 2,5-diamino-3-hydroxyhexane 失效
标题翻译：制备取代的2,5-二氨基-3-羟基己烷的方法
公开(公告)号：US5541328A
公开(公告)日：1996-07-30
申请号：US415385
申请日：1995-04-03
申请人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao , David Scarpetti
发明人： Timothy L. Stuk , Michael S. Allen , Anthony R. Haight , Francis A. Kerdesky , Denton C. Langridge , M. Robert Leanna , Linda M. Lijewski , Laura Melcher , Howard E. Morton , Daniel W. Norbeck , Daniel S. Reno , Timothy A. Robbins , Hing L. Sham , Thomas J. Sowin , Jien-Heh J. Tien , Chen Zhao , David Scarpetti
IPC分类号： C07C213/00 , C07C215/28 , C07C225/16 , C07C227/18 , C07C229/36 , C07C231/12 , C07C233/35 , C07C251/40 , C07C255/27 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07D221/14 , C07C251/78 , C07C209/44 , C07C221/14
CPC分类号： C07D221/14 , C07C213/00 , C07C215/28 , C07C225/16 , C07C251/40 , C07C255/42 , C07C269/06 , C07C271/20 , C07D209/44 , C07B2200/07
摘要： A substantially pure compound of formula: ##STR1## wherein R.sub.6 and R.sub.7 are independently selected from ##STR2## wherein R.sub.a and R.sub.b are independently selected from hydrogen, loweralkyl and phenyl and R.sub.c, R.sub.d and R.sub.e are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and ##STR3## wherein the naphthyl ring is unsubstituted or substituted with one, two or three substitutents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; orR.sub.6 is as defined above and R.sub.7 is R.sub.7a OC(O)-- wherein R.sub.7a is loweralkyl; orR.sub.6 and R.sub.7 taken together with the nitrogen atom to which they are bonded are ##STR4## wherein R.sub.f, R.sub.g, R.sub.h and R.sub.l are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; andR.sub.g is hydrogen, loweralkyl or benzyl; or an acid addition salt thereof.
摘要翻译：（I）其中R a和R b独立地选自氢，低级烷基和苯基，R c，R d和R 10独立地选自氢，低级烷基，三氟甲基，烷氧基，卤素和苯基; （ii）其中萘基环是未取代的或被一个，两个或三个独立地选自低级烷基，三氟甲基，烷氧基和卤素的取代基取代; 或R 6如上所定义，且R 7为R 7aa（O） - ，其中R 7a为低级烷基; 或者R 6和R 7与它们所键合的氮原子一起是其中R f，R g，R h和R 1独立地选自氢，低级烷基，烷氧基，卤素和三氟甲基; R g为氢，低级烷基或苄基; 或其酸加成盐。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式