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1. 发明申请

US20050049542A1 Electroporation catheter with sensing capabilities 有权
标题翻译：具有感应能力的电穿孔导管
公开(公告)号：US20050049542A1
公开(公告)日：2005-03-03
申请号：US10647522
申请日：2003-08-25
申请人： Daniel Sigg , Daisy Cross , Jesus Casas-Bejar , Rodolfo Padua
发明人： Daniel Sigg , Daisy Cross , Jesus Casas-Bejar , Rodolfo Padua
IPC分类号： A61N1/05 , A61N1/30
CPC分类号： A61N1/327 , A61N1/0575
摘要： In general, the invention is directed to techniques for delivering macromolecules to a tissue site via electroporation. Particularly, a catheter detects contact between a distal end of the catheter and a target tissue site via a sensing electrode at the distal end of the catheter. The catheter delivers a fluid containing macromolecules to the tissue site upon detecting contact between the tissue site and the catheter. Concurrently or soon after delivery of the fluid, an electrical stimulus is applied to the tissue site. The electrical stimulus can be applied by the catheter or directly from a power supply, such as an implanted pulse generator. The electrical stimulus causes membranes of cells within the tissue site to destabilize, in turn, forming pores through which the macromolecules migrate into the cells of the tissue site.
摘要翻译：通常，本发明涉及通过电穿孔将大分子递送到组织部位的技术。特别地，导管通过导管远端处的感测电极来检测导管的远端与目标组织部位之间的接触。当检测到组织部位和导管之间的接触时，导管将含有大分子的流体递送到组织部位。流体同时或不久之后，电刺激被施加到组织部位。电刺激可以由导管或直接从诸如注入脉冲发生器的电源施加。电刺激导致组织部位内的细胞膜破坏稳定，反过来，形成孔，大分子通过这些孔迁移到组织部位的细胞中。

2. 发明申请

US20100196437A1 MEDICAL DEVICES HAVING A SURFACE INCLUDING A BIOLOGICALLY ACTIVE AGENT THEREIN 审中-公开
标题翻译：具有包括生物活性剂的表面的医疗装置
公开(公告)号：US20100196437A1
公开(公告)日：2010-08-05
申请号：US12759050
申请日：2010-04-13
申请人： Thomas Q. Dinh , Rodolfo Padua , Jesus Casas-Bejar
发明人： Thomas Q. Dinh , Rodolfo Padua , Jesus Casas-Bejar
IPC分类号： A61F2/02 , A61K9/14 , A61K31/713 , A61K38/00 , A61K48/00 , A61K38/16 , A61P43/00 , A61F2/82
CPC分类号： A61L27/54 , A61F2/91 , A61F2250/0067 , A61K47/6957 , A61K48/0041 , A61L27/34 , A61L27/56 , A61L29/085 , A61L29/146 , A61L29/16 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/258 , A61L2300/606 , A61L2300/62 , A61L2300/64 , C08L67/04
摘要： The present invention provides a medical device, and methods of preparing and using a medical device. The medical device has a surface including a biologically active agent therein. The methods are particularly useful for preparing, for example, coated stents having a biologically active agent within the coating.
摘要翻译：本发明提供一种医疗装置，以及医疗装置的制造和使用方法。医疗装置具有包括其中的生物活性剂的表面。该方法特别可用于制备例如在涂层内具有生物活性剂的涂层支架。

3. 发明申请

US20100196438A1 METHODS INCLUDING MEDICAL DEVICES HAVING A SURFACE INCLUDING A BIOLOGICALLY ACTIVE AGENT THEREIN 审中-公开
标题翻译：包括具有包括生物活性剂在内的表面的医疗装置的方法
公开(公告)号：US20100196438A1
公开(公告)日：2010-08-05
申请号：US12759110
申请日：2010-04-13
申请人： Thomas Q. Dinh , Rodolfo Padua , Jesus Casas-Bejar
发明人： Thomas Q. Dinh , Rodolfo Padua , Jesus Casas-Bejar
IPC分类号： A61F2/00 , A61K38/43 , A61K35/00 , A61K38/00 , A61K31/7088
CPC分类号： A61L27/54 , A61F2/91 , A61F2250/0067 , A61K47/6957 , A61K48/0041 , A61L27/34 , A61L27/56 , A61L29/085 , A61L29/146 , A61L29/16 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/258 , A61L2300/606 , A61L2300/62 , A61L2300/64 , C08L67/04
摘要： The present invention provides a medical device, and methods of preparing and using a medical device. The medical device has a surface including a biologically active agent therein. The methods are particularly useful for preparing, for example, coated stents having a biologically active agent within the coating.
摘要翻译：本发明提供一种医疗装置，以及医疗装置的制造和使用方法。医疗装置具有包括其中的生物活性剂的表面。该方法特别可用于制备例如在涂层内具有生物活性剂的涂层支架。

4. 发明授权

US07699832B2 Medical device having a surface including a biologically active agent therein, and methods 有权
标题翻译：具有包含生物活性剂的表面的医疗装置及其方法
公开(公告)号：US07699832B2
公开(公告)日：2010-04-20
申请号：US11138545
申请日：2005-05-26
申请人： Thomas Q Dinh , Rodolfo Padua , Jesus Casas-Bejar
发明人： Thomas Q Dinh , Rodolfo Padua , Jesus Casas-Bejar
IPC分类号： A61K9/22 , A61F2/00
CPC分类号： A61L27/54 , A61F2/91 , A61F2250/0067 , A61K47/6957 , A61K48/0041 , A61L27/34 , A61L27/56 , A61L29/085 , A61L29/146 , A61L29/16 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/258 , A61L2300/606 , A61L2300/62 , A61L2300/64 , C08L67/04
摘要： The present invention provides a medical device, and methods of preparing and using a medical device. The medical device has a surface including a biologically active agent therein. The methods are particularly useful for preparing, for example, coated stents having a biologically active agent within the coating.
摘要翻译：本发明提供一种医疗装置，以及医疗装置的制造和使用方法。医疗装置具有包括其中的生物活性剂的表面。该方法特别可用于制备例如在涂层内具有生物活性剂的涂层支架。

5. 发明申请

US20050271696A1 Medical device having a surface including a biologically active agent therein, and methods 有权
标题翻译：具有包含生物活性剂的表面的医疗装置及其方法
公开(公告)号：US20050271696A1
公开(公告)日：2005-12-08
申请号：US11138545
申请日：2005-05-26
申请人： Thomas Dinh , Rodolfo Padua , Jesus Casas-Bejar
发明人： Thomas Dinh , Rodolfo Padua , Jesus Casas-Bejar
IPC分类号： A61F2/00 , A61F2/90 , A61K38/47 , A61K47/48 , A61K48/00 , A61L27/34 , A61L27/54 , A61L27/56 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16
CPC分类号： A61L27/54 , A61F2/91 , A61F2250/0067 , A61K47/6957 , A61K48/0041 , A61L27/34 , A61L27/56 , A61L29/085 , A61L29/146 , A61L29/16 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/258 , A61L2300/606 , A61L2300/62 , A61L2300/64 , C08L67/04
摘要： The present invention provides a medical device, and methods of preparing and using a medical device. The medical device has a surface including a biologically active agent therein. The methods are particularly useful for preparing, for example, coated stents having a biologically active agent within the coating.
摘要翻译：本发明提供一种医疗装置，以及医疗装置的制造和使用方法。医疗装置具有包括其中的生物活性剂的表面。该方法特别可用于制备例如在涂层内具有生物活性剂的涂层支架。

6. 发明申请

US20100131043A1 Endoluminal Implants For Bioactive Material Delivery 审中-公开
标题翻译：用于生物活性物质输送的腔内植入物
公开(公告)号：US20100131043A1
公开(公告)日：2010-05-27
申请号：US12324193
申请日：2008-11-26
申请人： Jesus W. Casas , Amy C. Dearking , Rodolfo Padua , Molly Schiltgen , Jeffrey P. Walker
发明人： Jesus W. Casas , Amy C. Dearking , Rodolfo Padua , Molly Schiltgen , Jeffrey P. Walker
IPC分类号： A61F2/44
CPC分类号： A61M31/002 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/00 , A61M2025/0681
摘要： Disclosed herein are endoluminal implants for bioactive material delivery. The disclosed endoluminal implants come in the general forms of patches and sleeves and can deliver bioactive materials independently of other implantable medical devices such as stents.
摘要翻译：本文公开了用于生物活性物质输送的腔内植入物。所公开的腔内植入物具有贴片和袖子的一般形式，并且可以独立于其他可植入医疗装置（例如支架）递送生物活性材料。

7. 发明申请

US20060189564A1 Methods and sequences to suppress pro-inflamatory cytokine actions locally to treat pain 审中-公开
标题翻译：抑制炎性细胞因子作用于局部治疗疼痛的方法和序列
公开(公告)号：US20060189564A1
公开(公告)日：2006-08-24
申请号：US11388891
申请日：2006-03-24
申请人： Eric Burright , Rodolfo Padua , Peter Schroeder , Jennifer Christianson , Lisa Shafer
发明人： Eric Burright , Rodolfo Padua , Peter Schroeder , Jennifer Christianson , Lisa Shafer
IPC分类号： A61K48/00
CPC分类号： C12N15/1136 , A61K31/70 , A61K31/713 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N2800/2842
摘要： Disclosed herein are methods and sequences used to treat pain. Specifically, the methods and sequences include locally administering nucleic acid molecules that suppress the expression of amino acid sequences that encode for pro-inflammatory cytokines and their receptors to treat acute or neuropathic pain associated with sciatica.
摘要翻译：本文公开了用于治疗疼痛的方法和序列。具体地，所述方法和序列包括局部施用抑制编码促炎细胞因子及其受体的氨基酸序列的表达以治疗与坐骨神经痛相关的急性或神经性疼痛的核酸分子。

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