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1. 发明授权

US06320049B1 Alpha 1a adrenergic receptor antagonists 失效
标题翻译： Alpha 1a肾上腺素能受体拮抗剂
公开(公告)号：US06320049B1
公开(公告)日：2001-11-20
申请号：US09563203
申请日：2000-05-02
申请人： Daniel R. Sidler , Robert D. Larsen , Wenjie Li
发明人： Daniel R. Sidler , Robert D. Larsen , Wenjie Li
IPC分类号： C07D23922
CPC分类号： C07D239/22 , C07D401/04 , C07D401/14
摘要： This invention relates to crystalline pharmaceutically acceptable salts of an alpha 1a adrenergic receptor antagonist, Compound A, which are useful in the treatment of benign prostatic hyperplasia. Pharmaceutical compositions employing the crystalline salts, and processes for making and using the crystalline salts and pharmaceutical compositions of Compound A are also disclosed. This invention further relates to a process for obtaining enantiomerically pure intermediate useful for the synthesis of end product alpha 1a adrenergic receptor antagonists. The end product compounds are useful for the treatment of benign prostatic hyperplasia and for relaxing lower urinary tract tissue. The invention also relates to a process for preparing a class of dihydropyrimidinone compounds of which Compound A is a member, wherein the process involves deprotonating a dihydropyrimidinone compound and then coupling the deprotonated derivative with a primary amine.
摘要翻译：本发明涉及可用于治疗良性前列腺增生的α1α肾上腺素能受体拮抗剂，化合物A的结晶药学上可接受的盐。还公开了使用结晶盐的药物组合物，以及制备和使用化合物A的结晶盐和药物组合物的方法。本发明还涉及用于获得可用于合成终产物α1α肾上腺素能受体拮抗剂的对映体纯中间体的方法。最终产品化合物可用于治疗良性前列腺增生和放松下尿路组织。本发明还涉及一种制备其中化合物A为成员的一类二氢嘧啶酮化合物的方法，其中该方法包括使二氢嘧啶酮化合物去质子化，然后将去质子化衍生物与伯胺偶联。

2. 发明授权

US10277047B2 Multi-function car-mounted charger 有权
公开(公告)号：US10277047B2
公开(公告)日：2019-04-30
申请号：US15415470
申请日：2017-01-25
申请人： Wenjie Li
发明人： Wenjie Li
IPC分类号： H02J7/00 , B60Q3/88 , B60Q3/59 , B60Q3/74 , B60Q3/82 , B60Q3/35 , B60Q1/52 , B60Q3/275 , B60R16/02 , B60R16/03 , B60Q1/26 , B60Q1/24
摘要： A multi-function car-mounted charger comprises a main housing, a lighting housing, a power input portion, a main circuit, a rechargeable battery, a magnet, a power output portion and a lighting portion; the power input portion, the main circuit, the rechargeable battery, the magnet, and the power output portion are disposed in the main housing; the lighting portion is disposed in the lighting housing; the power input portion, the rechargeable battery, the power output portion, and the lighting portion are electrically connected with the main circuit respectively; the power input portion comprises a first electrode and a second electrode, both of which are electrically connected with the main circuit respectively; and the first electrode is provided with a cone body. The car-mounted charger is diverse in function and may be attracted onto a car shell through the magnet.

3. 外观设计

USD846495S1 Charger 有权
公开(公告)号：USD846495S1
公开(公告)日：2019-04-23
申请号：US29614917
申请日：2017-08-24
申请人： Wenjie Li
设计人： Wenjie Li

4. 发明授权

US08676253B2 Method and device for ranking frequencies 有权
标题翻译：多模多苗多待通信终端，以及用于仲裁接收冲突的仲裁方法和装置
公开(公告)号：US08676253B2
公开(公告)日：2014-03-18
申请号：US13574563
申请日：2011-05-24
申请人： Wenjie Li
发明人： Wenjie Li
IPC分类号： H04W88/02
CPC分类号： H04W88/06 , H04W8/183 , H04W68/00 , H04W76/40
摘要： An arbitration method and device for arbitrating receiving conflict in a multi-mode multi-SIM multi-standby communication terminal is provided. The method includes: determining if there are at least two cards to receive messages in a time cycle while all of the cards are in standby states, the time cycle being a radio frame of one card; identifying types of messages to be received by the at least two cards after determining there are at least two cards to receive messages in the time cycle, and the types of messages comprising paging message and broadcast message; determining if a receiving conflict occurs; and arbitrating based on the types of receiving conflicts and obtaining arbitration results after determining there is a receiving conflict. The arbitration results include: receiving a paging message preferentially; receiving the paging message with the longest paging period; and receiving the broadcast message with the highest priority.
摘要翻译：提供了一种仲裁方法和装置，用于仲裁多模多SIM多待通信终端中的接收冲突。该方法包括：当所有卡处于待机状态时，确定是否存在至少两个卡以在时间周期中接收消息，该时间周期是一个卡的无线电帧; 在确定在该时间周期中存在至少两个接收消息的卡以及包括寻呼消息和广播消息的消息的类型之后，识别由至少两张卡接收的消息的类型; 确定是否发生接收冲突; 并根据接收冲突的类型进行仲裁，并在确定接收冲突后获得仲裁结果。仲裁结果包括：优先接收寻呼消息; 以最长的寻呼周期接收寻呼消息; 并接收具有最高优先级的广播消息。

5. 发明授权

US07700262B2 Top coat material and use thereof in lithography processes 失效
标题翻译：面漆材料及其在光刻工艺中的应用
公开(公告)号：US07700262B2
公开(公告)日：2010-04-20
申请号：US12044004
申请日：2008-03-07
申请人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
发明人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
IPC分类号： G03F7/00 , G03F7/004
CPC分类号： G03F7/11 , G03F7/0046 , G03F7/2041 , Y10T428/3154
摘要： A top coat material for applying on top of a photoresist material is disclosed. The top coat material includes a polymer, which includes at least one fluorosulfonamide monomer unit having one of the following two structures: wherein: M is a polymerizable backbone moiety; Z is a linking moiety selected from the group consisting of —C(O)O—, —C(O)—, —OC(O)—, and —O—C(O)—C(O)—O—; R1 is selected from the group consisting of an alkylene, an arylene, a semi- or perfluorinated alkylene, and a semi- or perfluorinated arylene; p and q are 0 or 1; R2 is selected from the group consisting of hydrogen, fluorine, an alkyl group of 1 to 6 carbons, and a semi- or perfluorinated alkyl group of 1 to 6 carbons; n is an integer from 1 to 6; and R3 is selected from the group consisting of hydrogen, an alkyl, an aryl, a semi- or perfluorinated alkyl, and a semi- or perfluorinated aryl. The top coat material may be used in lithography processes, wherein the top coat material is applied on a photoresist layer. The top coat material is preferably soluble in aqueous alkaline developer. The top coat material is also preferably insoluble in water, and is therefore particularly useful in immersion lithography techniques using water as the imaging medium.
摘要翻译：公开了一种用于涂覆在光致抗蚀剂材料上的顶涂层材料。面漆材料包括聚合物，其包括至少一种具有以下两种结构之一的氟磺酰胺单体单元：其中：M是可聚合主链部分; Z是选自-C（O）O-，-C（O） - ， - OC（O） - 和-O-C（O）-C（O）-O-的连接部分; R1选自亚烷基，亚芳基，半或全氟亚烷基，以及半或全氟化亚芳基; p和q为0或1; R2选自氢，氟，1至6个碳的烷基和1至6个碳的半或全氟化烷基; n是1至6的整数; 并且R 3选自氢，烷基，芳基，半或全氟烷基和半或全氟芳基。面漆材料可以用在光刻工艺中，其中将顶涂层材料施加在光致抗蚀剂层上。顶涂层材料优选可溶于含水碱性显影剂。面漆材料也优选不溶于水，因此特别适用于使用水作为成像介质的浸渍光刻技术。

6. 发明申请

US20080166568A1 TOP COAT MATERIAL AND USE THEREOF IN LITHOGRAPHY PROCESSES 失效
公开(公告)号：US20080166568A1
公开(公告)日：2008-07-10
申请号：US12044004
申请日：2008-03-07
申请人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
发明人： Wenjie Li , Margaret C. Lawson , Pushkara Rao Varanasi
IPC分类号： B32B27/28
CPC分类号： G03F7/11 , G03F7/0046 , G03F7/2041 , Y10T428/3154
摘要： A top coat material for applying on top of a photoresist material is disclosed. The top coat material includes a polymer, which includes at least one fluorosulfonamide monomer unit having one of the following two structures: wherein: M is a polymerizable backbone moiety; Z is a linking moiety selected from the group consisting of —C(O)O—, —C(O)—, —OC(O)—, and —O—C(O)—C(O)—O—; R1 is selected from the group consisting of an alkylene, an arylene, a semi- or perfluorinated alkylene, and a semi- or perfluorinated arylene; p and q are 0 or 1; R2 is selected from the group consisting of hydrogen, fluorine, an alkyl group of 1 to 6 carbons, and a semi- or perfluorinated alkyl group of 1 to 6 carbons; n is an integer from 1 to 6; and R3 is selected from the group consisting of hydrogen, an alkyl, an aryl, a semi- or perfluorinated alkyl, and a semi- or perfluorinated aryl. The top coat material may be used in lithography processes, wherein the top coat material is applied on a photoresist layer. The top coat material is preferably soluble in aqueous alkaline developer. The top coat material is also preferably insoluble in water, and is therefore particularly useful in immersion lithography techniques using water as the imaging medium.

7. 发明授权

US07365202B2 Polymorphs of an androgen receptor modulator 失效
标题翻译：雄激素受体调节剂的多态性
公开(公告)号：US07365202B2
公开(公告)日：2008-04-29
申请号：US11633152
申请日：2006-12-04
申请人： Lushi Tan , Robert S. Meissner , Wenjie Li , James J. Perkins , Aaron S. Cote , Joyce Stellabott , Yuan-Hon Kiang
发明人： Lushi Tan , Robert S. Meissner , Wenjie Li , James J. Perkins , Aaron S. Cote , Joyce Stellabott , Yuan-Hon Kiang
IPC分类号： C07D221/18
CPC分类号： C07J73/005 , C07D471/04
摘要： Compounds of structural formula I are modulators of the androgen receptor (AR) in a tissue selective manner. These compounds are useful in the enhancement of weakened muscle tone and the treatment of conditions caused by androgen deficiency or which can be ameliorated by androgen administration, including osteoporosis, osteopenia, glucocorticoid-induced osteoporosis, periodontal disease, bone fracture, bone damage following bone reconstructive surgery, sarcopenia, frailty, aging skin, male hypogonadism, postmenopausal symptoms in women, atherosclerosis, hypercholesterolemia, hyperlipidemia, obesity, aplastic anemia and other hematopoietic disorders, inflammatory arthritis and joint repair, HIV-wasting, prostate cancer, benign prostatic hyperplasia (BPH), abdominal adiposity, metabolic syndrome, type II diabetes, cancer cachexia, Alzheimer's disease, muscular dystrophies, cognitive decline, sexual dysfunction, sleep apnea, depression, premature ovarian failure, and autoimmune disease, alone or in combination with other active agents.
摘要翻译：结构式I的化合物是以组织选择性方式的雄激素受体（AR）的调节剂。这些化合物可用于增强弱化肌张力和治疗由雄激素缺乏引起的疾病或可由雄激素给药改善的疾病，包括骨质疏松症，骨质减少，糖皮质激素诱导的骨质疏松症，牙周病，骨折，骨重建后的骨损伤手术，肌营养不良，虚弱，老化的皮肤，男性性腺机能减退，女性绝经后症状，动脉粥样硬化，高胆固醇血症，高脂血症，肥胖，再生障碍性贫血和其他造血障碍，炎性关节炎和关节修复，艾滋病毒消耗，前列腺癌，良性前列腺增生），腹部肥胖，代谢综合征，II型糖尿病，癌症恶病质，阿尔茨海默氏病，肌营养不良症，认知衰退，性功能障碍，睡眠呼吸暂停，抑郁症，卵巢早衰以及自身免疫性疾病，单独或与其它活性剂组合。

8. 发明授权

US07361765B2 Process for the preparation of CCR-2 antagonists 有权
标题翻译：制备CCR-2拮抗剂的方法
公开(公告)号：US07361765B2
公开(公告)日：2008-04-22
申请号：US10577587
申请日：2004-10-25
申请人： Dongwei Cai , Fred Fleitz , Min Ge , Scott Hoerrner , Gary Javadi , Mark Jensen , Robert Larsen , Wenjie Li , Dorian Nelson , Elizabeth Szumigala , Lihu Yang , Changyou Zhou
发明人： Dongwei Cai , Fred Fleitz , Min Ge , Scott Hoerrner , Gary Javadi , Mark Jensen , Robert Larsen , Wenjie Li , Dorian Nelson , Elizabeth Szumigala , Lihu Yang , Changyou Zhou
IPC分类号： C07D471/02
CPC分类号： C07C271/24 , C07C303/40 , C07C2601/10 , C07D207/327 , C07D401/04 , C07C311/20
摘要： The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt. The present invention additionally provides an efficient syntheses for the preparation of intermediates (3R)-3-methoxytetrahydro-4H-pyran-4-one; (1S,4S)-4-(2,5-dimethyl-1H-pyrrol-1-yl)-1-isopropylcyclopent-2-ene-1-carboxylic acid; and 3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine; and for the preparation of the precursor (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(tri-fluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine. The invention additionally resides in the superior properties of the succinate salt of ((1R,3S)-3-isopropyl-3-1{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine
摘要翻译：本发明提供了制备（（1R，3S）-3-异丙基-3 - {[3-（三氟甲基）-7,8-二氢-1,6-二氮杂萘-6（5H） ]羰基}环戊基）[（3S，4S）-3-甲氧基四氢-2H-吡喃-4-基]胺及其琥珀酸盐。本发明另外提供了制备中间体（3R）-3-甲氧基四氢-4H-吡喃-4-酮的有效合成方法; （1S，4S）-4-（2,5-二甲基-1H-吡咯-1-基）-1-异丙基环戊-2-烯-1-羧酸; 和3-（三氟甲基）-5,6,7,8-四氢-1,6-萘啶; 制备前体（3S，4S）-N - （（1S，4S）-4-异丙基-4 - {[3-（三氟甲基）-7,8-二氢-1,6-萘啶-2-基] （5H） - 基]羰基}环戊-2-烯-1-基）-3-甲氧基四氢-2H-吡喃-4-胺。本发明另外存在（（1R，3S）-3-异丙基-3-1 {[3-（三氟甲基）-7,8-二氢-1,6-二氮杂萘-6（5H））的琥珀酸盐的优异性质） - 基]羰基}环戊基）[（3S，4S）-3-甲氧基四氢-2H-吡喃-4-基]胺

9. 发明申请

US20080026315A1 FLUORINATED HALF ESTER OF MALEIC ANHYDRIDE POLYMERS FOR DRY 193 NM TOP ANTIREFLECTIVE COATING APPLICATION 失效
标题翻译：用于干燥193 NM顶级抗反射涂层应用的马来酸酐聚合物的氟化半酯
公开(公告)号：US20080026315A1
公开(公告)日：2008-01-31
申请号：US11425529
申请日：2006-06-21
申请人： Wu-Song S. Huang , Wenjie Li , Pushkara R. Varanasi
发明人： Wu-Song S. Huang , Wenjie Li , Pushkara R. Varanasi
IPC分类号： G03C1/00
CPC分类号： G03F7/091 , G03F7/0046 , G03F7/0752 , Y10S438/952
摘要： The present invention discloses a composition suitable for use as a top antireflective coating and barrier layer for 193 nm lithography. The inventive composition is soluble in aqueous base solutions and has low refractive index at 193 nm. The inventive composition comprises an aqueous base-soluble polymer having a backbone and a fluorinated half ester moiety. The fluorinated half ester moiety is pendant from the backbone. The present invention also discloses a method of forming a patterned layer on a substrate by using the inventive composition in lithography.
摘要翻译：本发明公开了适合用作193nm光刻的顶部抗反射涂层和阻挡层的组合物。本发明的组合物可溶于碱性水溶液中，并且在193nm具有低折射率。本发明的组合物包含具有主链和氟化半酯部分的水溶性基团可溶性聚合物。氟化半酯部分是从骨架侧挂。本发明还公开了通过在光刻中使用本发明的组合物在衬底上形成图案化层的方法。

10. 发明授权

US07235342B2 Negative photoresist composition including non-crosslinking chemistry 有权
标题翻译：负光致抗蚀剂组合物包括非交联化学
公开(公告)号：US07235342B2
公开(公告)日：2007-06-26
申请号：US10766058
申请日：2004-01-28
申请人： Wenjie Li , Pushkara R. Varanasi
发明人： Wenjie Li , Pushkara R. Varanasi
IPC分类号： G03F7/038 , G03F7/30
CPC分类号： G03F7/0382 , G03F7/0046 , Y10S430/106 , Y10S430/111 , Y10S430/115 , Y10S430/128
摘要： A negative photoresist composition and a method of patterning a substrate through use of the negative photoresist composition. The composition includes: a radiation sensitive acid generator; a hydroxy-containing additive; and a resist polymer derived from at least one first monomer. The resist polymer may be further derived from a second monomer having an aqueous base soluble moiety. The hydroxy-containing additive has the structure of Q—OH, where Q may include one or more cyclic structures. Q—OH may have a primary alcohol structure. The acid generator is adapted to generate an acid upon exposure to radiation. The resist polymer is adapted to chemically react with the additive in the presence of the acid to generate a non-crosslinking reaction product that is insoluble in an aqueous alkaline developer solution.
摘要翻译：负性光致抗蚀剂组合物和通过使用负性光致抗蚀剂组合物构图基板的方法。组合物包括：辐射敏感酸发生剂; 含羟基的添加剂; 和衍生自至少一种第一单体的抗蚀剂聚合物。抗蚀剂聚合物可以进一步衍生自具有碱性水溶性部分的第二单体。含羟基的添加剂具有Q-OH的结构，其中Q可以包括一个或多个环状结构。 Q-OH可以具有伯醇结构。酸产生器适于在暴露于辐射时产生酸。抗蚀剂聚合物适于在酸存在下与添加剂发生化学反应以产生不溶于碱性显影剂水溶液的非交联反应产物。

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