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1. 发明申请

US20060065677A1 Laterally-actuated dispenser with one-way valve for storing and dispensing metered amounts of substances 有权
标题翻译：具有用于存储和分配计量的物质的单向阀的侧向致动的分配器
公开(公告)号：US20060065677A1
公开(公告)日：2006-03-30
申请号：US11237599
申请日：2005-09-27
申请人： Daniel Py , Julian Chan , David Fellows , Eric Hartman , Bing He
发明人： Daniel Py , Julian Chan , David Fellows , Eric Hartman , Bing He
IPC分类号： B67D5/40
CPC分类号： B65D83/0094 , A45D34/04 , A45D2200/055 , A45D2200/056 , A61M35/003 , B05B11/00416 , B05B11/3015 , B05B11/3032 , B05B11/3033 , B05B11/3094 , B65B1/04 , B65D83/0033 , G01F11/025 , G01F11/08
摘要： A dispenser for dispensing a substance, such as a pharmaceutical, ophthalmic, dermatological, cosmeceutical, cosmetic or other product, has a body defining a variable-volume storage chamber for storing the product. A dispensing portion of the dispenser is connected with the body and defines a bore coupled in fluid communication with the storage chamber for receiving substance therefrom, and an outlet aperture coupled in fluid communication with the bore. A one-way valve of the dispenser includes an axially-extending valve seat and an axially-extending flexible valve cover seated on the valve seat and defining a normally-closed, axially-extending seam therebetween forming a fluid-tight seal between the valve cover and valve seat. The flexible valve cover is movable relative to the valve seat and the seam is connectable in fluid communication with the outlet aperture to allow the passage of substance through the seam and out of the dispenser. The dispenser further comprises an actuator and piston assembly including a piston receivable within the bore, a manually-engageable actuator connected to the piston for moving the piston between first and second positions relative to the bore to dispense substance within the bore through the outlet aperture, and an integral, dome-shaped spring coupled to at least one of the piston and the actuator for biasing the piston in a direction from one of the first and second positions toward the other.
摘要翻译：用于分配物质（例如药物，眼科，皮肤病学，药妆，化妆品或其他产品）的分配器具有限定用于存储产品的可变容积储存室的主体。分配器的分配部分与主体连接并且限定了与储存室流体连通以接收物质的孔以及与孔流体连通的出口孔。分配器的单向阀包括轴向延伸的阀座和位于阀座上的轴向延伸的柔性阀盖，并且在其间限定一个常闭的轴向延伸的接缝，形成在阀盖之间的流体密封和阀座。柔性阀盖可相对于阀座移动，并且接缝可与出口孔流体连通以允许物质通过接缝并从分配器中通过。分配器还包括致动器和活塞组件，其包括可接收在孔内的活塞，连接到活塞的可手动接合的致动器，用于相对于孔移动活塞在第一和第二位置之间，以通过出口孔分配孔内的物质，以及联接到所述活塞和所述致动器中的至少一个的整体的圆顶形弹簧，用于沿从所述第一位置和所述第二位置之一向另一个方向偏压所述活塞。

2. 发明申请

US20070095857A1 Container and one-way valve assembly for strong and dispensing substances, and related method 有权
公开(公告)号：US20070095857A1
公开(公告)日：2007-05-03
申请号：US11588968
申请日：2006-10-26
申请人： Daniel Py , Miles Flamenbaum , Eric Hartman , Nathaniel Houle
发明人： Daniel Py , Miles Flamenbaum , Eric Hartman , Nathaniel Houle
IPC分类号： B67D5/00
CPC分类号： B65D51/227 , B65D47/205 , B65D2251/0025 , B65D2251/0093
摘要： A device for storing and dispensing a substance includes a container having a body defining therein a storage chamber for receiving and storing the substance. The container includes a first passageway that is in fluid communication with the storage chamber of the body and defines a flow path therebetween. The container also includes a pierceable wall located on an opposite side of the first passageway relative to the storage chamber, and a first threaded connecting portion located at one end of the body for connecting another component thereto. The device also includes a one-way valve assembly that includes a valve body including a body base defining a second passageway and a piercing portion mounted within the valve body and engageable with the pierceable wall of the container. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall and the first passageway of the container is in fluid communication with the second passageway of the valve body for allowing the flow of substance from the storage chamber therethrough. The valve assembly includes a second threaded connecting portion that is threadedly connectable to the first threaded connecting portion of the container for fixedly securing the valve assembly to the container when the valve assembly and container are located in the second position. A manually-engageable and removable member is disposed intermediate the valve body and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed. The valve assembly includes a valve seat and at least one flow aperture extending through the valve body adjacent to the valve seat and in fluid communication with the second passageway for receiving the substance from the storage chamber there through.

3. 发明申请

US20060231519A1 Container closure with overlying needle penetrable and thermally resealable portion and underlying portion compatible with fat containing liquid product, and related method 有权
公开(公告)号：US20060231519A1
公开(公告)日：2006-10-19
申请号：US11339966
申请日：2006-01-25
申请人： Daniel Py , Norbert Assion , Nathaniel Houle , Debashis Sahoo , M. Willey , Eric Hartman
发明人： Daniel Py , Norbert Assion , Nathaniel Houle , Debashis Sahoo , M. Willey , Eric Hartman
IPC分类号： B65D53/00 , B65D51/00 , B65D43/18
CPC分类号： B65B55/10 , B65B3/003 , B65B7/2842 , B65B51/22 , B65B55/025 , B65D51/002 , B65D51/18 , B65D2251/0015 , B65D2251/0078
摘要： A container and method are provided for storing fat containing liquid products, such as infant or baby formula, or other milk-based products. The container includes a body defining a storage chamber for receiving the aseptic fat containing liquid product, and a first aperture in fluid communication with the storage chamber. The body does not leach more than a predetermined amount of leachables into the fat containing liquid product and does not undesirably alter a taste profile of the fat containing liquid product. A container closure assembly includes a stopper receivable within the first aperture for hermetically sealing the storage chamber. The stopper includes a first material portion defining an internal surface in fluid communication with the storage chamber forming at least most of the surface area of the container closure that can contact any fat containing liquid product within the storage chamber and that does not leach more than a predetermined amount of leachables into the fat containing liquid product or undesirably alter a taste profile of the fat containing liquid product. A second material portion of the stopper either (i) overlies the first material portion and cannot contact any product within the storage chamber, or (ii) forms a substantially lesser surface area of the container closure that can contact any product within the storage chamber in comparison to the first material portion. The second material portion is needle penetrable for filling the storage chamber with product, and a resulting needle aperture formed in the second material portion is thermally resealable such as by the application of laser energy to seal the product within the storage chamber. A sealing portion of the container closure is engageable with the body prior to needle filling the storage chamber to thereby form a substantially dry hermetic seal between the container closure and body.

4. 发明申请

US20080235166A1 TRAINING A MODEL OF A NON-LINEAR PROCESS 有权
标题翻译：培养非线性过程的模型
公开(公告)号：US20080235166A1
公开(公告)日：2008-09-25
申请号：US12112750
申请日：2008-04-30
申请人： Bijan Sayyar-Rodsari , Edward Plumer , Eric Hartman , Kadir Liano , Celso Axelrud
发明人： Bijan Sayyar-Rodsari , Edward Plumer , Eric Hartman , Kadir Liano , Celso Axelrud
IPC分类号： G06F15/18
CPC分类号： G05B13/048 , G05B13/042 , G05B17/02
摘要： System and method for modeling a nonlinear process. A combined model for predictive optimization or control of a nonlinear process includes a nonlinear approximator, coupled to a parameterized dynamic or static model, operable to model the nonlinear process. The nonlinear approximator receives process inputs, and generates parameters for the parameterized dynamic model. The parameterized dynamic model receives the parameters and process inputs, and generates predicted process outputs based on the parameters and process inputs, where the predicted process outputs are useable to analyze and/or control the nonlinear process. The combined model may be trained in an integrated manner, e.g., substantially concurrently, by identifying process inputs and outputs (I/O), collecting data for process I/O, determining constraints on model behavior from prior knowledge, formulating an optimization problem, executing an optimization algorithm to determine model parameters subject to the determined constraints, and verifying the compliance of the model with the constraints.
摘要翻译：用于建模非线性过程的系统和方法。用于非线性过程的预测优化或控制的组合模型包括耦合到参数化动态或静态模型的非线性近似器，可操作以对非线性过程建模。非线性近似器接收过程输入，并为参数化动态模型生成参数。参数化动态模型接收参数和过程输入，并根据参数和过程输入生成预测过程输出，其中预测过程输出可用于分析和/或控制非线性过程。组合模型可以通过识别过程输入和输出（I / O），收集过程I / O的数据，确定来自先验知识的模型行为的约束，制定优化问题，以基本上同时的方式进行训练，执行优化算法以确定受限于确定的模型参数，并验证模型与约束的一致性。

5. 发明申请

US20070198104A1 CONTROLLING A NON-LINEAR PROCESS WITH VARYING DYNAMICS USING NON-LINEAR MODEL PREDICTIVE CONTROL 有权
标题翻译：使用非线性模型预测控制来控制具有变化动力学的非线性过程
公开(公告)号：US20070198104A1
公开(公告)日：2007-08-23
申请号：US11678634
申请日：2007-02-26
申请人： Bijan Sayyarrodsari , Eric Hartman , Celso Axelrud , Kadir Liano
发明人： Bijan Sayyarrodsari , Eric Hartman , Celso Axelrud , Kadir Liano
IPC分类号： G05B13/02
CPC分类号： G05B13/042
摘要： The present invention provides a method for controlling nonlinear control problems within particle accelerators. This method involves first utilizing software tools to identify variable inputs and controlled variables associated with the particle accelerator, wherein at least one variable input parameter is a controlled variable. This software tool is further operable to determine relationships between the variable inputs and controlled variables. A control system that provides variable inputs to and acts on controller outputs from the software tools tunes one or more manipulated variables to achieve a desired controlled variable, which in the case of a particle accelerator may be realized as a more efficient collision.
摘要翻译：本发明提供了一种用于控制粒子加速器内的非线性控制问题的方法。该方法首先利用软件工具来识别与粒子加速器相关联的变量输入和控制变量，其中至少一个可变输入参数是受控变量。该软件工具进一步可操作以确定可变输入和受控变量之间的关系。向软件工具向控制器输出提供可变输入并作用于控制器输出的控制系统调整一个或多个操纵变量以实现期望的受控变量，其在粒子加速器的情况下可被实现为更有效的冲突。

6. 发明授权

US07184845B2 System and method of applying adaptive control to the control of particle accelerators with varying dynamics behavioral characteristics using a nonlinear model predictive control technology 有权
标题翻译：使用非线性模型预测控制技术对具有不同动力学行为特征的粒子加速器的控制应用自适应控制的系统和方法
公开(公告)号：US07184845B2
公开(公告)日：2007-02-27
申请号：US10731596
申请日：2003-12-09
申请人： Bijan Sayyarrodsari , Eric Hartman , Celso Axelrud , Kadir Liano
发明人： Bijan Sayyarrodsari , Eric Hartman , Celso Axelrud , Kadir Liano
IPC分类号： G05B13/02
CPC分类号： G05B13/042
摘要： The present invention provides a method for controlling nonlinear control problems within particle accelerators. This method involves first utilizing software tools to identify variable inputs and controlled variables associated with the particle accelerator, wherein at least one variable input parameter is a controlled variable. This software tool is further operable to determine relationships between the variable inputs and controlled variables. A control system that provides variable inputs to and acts on controller outputs from the software tools tunes one or more manipulated variables to achieve a desired controlled variable, which in the case of a particle accelerator may be realized as a more efficient collision.
摘要翻译：本发明提供了一种用于控制粒子加速器内的非线性控制问题的方法。该方法首先利用软件工具来识别与粒子加速器相关联的变量输入和控制变量，其中至少一个可变输入参数是受控变量。该软件工具进一步可操作以确定可变输入和受控变量之间的关系。向软件工具向控制器输出提供可变输入并作用于控制器输出的控制系统调整一个或多个操纵变量以实现期望的受控变量，其在粒子加速器的情况下可被实现为更有效的冲突。

7. 发明申请

US20050187643A1 Parametric universal nonlinear dynamics approximator and use 审中-公开
标题翻译：参数通用非线性动力学近似和使用
公开(公告)号：US20050187643A1
公开(公告)日：2005-08-25
申请号：US10842157
申请日：2004-05-10
申请人： Bijan Sayyar-Rodsari , Edward Plumer , Eric Hartman , Kadir Liano , Celso Axelrud
发明人： Bijan Sayyar-Rodsari , Edward Plumer , Eric Hartman , Kadir Liano , Celso Axelrud
IPC分类号： G05B13/02 , G05B13/04 , G05B17/02 , G06F15/18
CPC分类号： G05B13/048 , G05B13/042 , G05B17/02
摘要： System and method for modeling a nonlinear process. A combined model for predictive optimization or control of a nonlinear process includes a nonlinear approximator, coupled to a parameterized dynamic or static model, operable to model the nonlinear process. The nonlinear approximator receives process inputs, and generates parameters for the parameterized dynamic model. The parameterized dynamic model receives the parameters and process inputs, and generates predicted process outputs based on the parameters and process inputs, where the predicted process outputs are useable to analyze and/or control the nonlinear process. The combined model may be trained in an integrated manner, e.g., substantially concurrently, by identifying process inputs and outputs (I/O), collecting data for process I/O, determining constraints on model behavior from prior knowledge, formulating an optimization problem, executing an optimization algorithm to determine model parameters subject to the determined constraints, and verifying the compliance of the model with the constraints.
摘要翻译：用于建模非线性过程的系统和方法。用于非线性过程的预测优化或控制的组合模型包括耦合到参数化动态或静态模型的非线性近似器，可操作以对非线性过程建模。非线性近似器接收过程输入，并为参数化动态模型生成参数。参数化动态模型接收参数和过程输入，并根据参数和过程输入生成预测过程输出，其中预测过程输出可用于分析和/或控制非线性过程。组合模型可以通过识别过程输入和输出（I / O），收集过程I / O的数据，确定来自先验知识的模型行为的约束，制定优化问题，以基本上同时的方式进行训练，执行优化算法以确定受限于确定的模型参数，并验证模型与约束的一致性。

8. 发明申请

US20060249536A1 Device and method for dispensing a food product using a reclosable resilient valve 审中-公开
标题翻译：用于使用可重新闭合的弹性阀分配食物的装置和方法
公开(公告)号：US20060249536A1
公开(公告)日：2006-11-09
申请号：US11124145
申请日：2005-05-09
申请人： Eric Hartman , Bradley Feldman , Wendy Geiger
发明人： Eric Hartman , Bradley Feldman , Wendy Geiger
IPC分类号： B67D5/56
CPC分类号： B67D1/108 , B67D1/0004 , B67D1/0021 , B67D1/0051 , B67D2001/082
摘要： The present invention relates to a food dispensing device for dispensing a food product. The device includes a valve/cannula connection assembly that provides a reclosable resilient sealed connection to a food container. A cannula is received in a resilient valve to open the valve.
摘要翻译：本发明涉及一种用于分配食品的食物分配装置。该装置包括阀/套管连接组件，其提供与食物容器的可再闭合的弹性密封连接。套管被接纳在弹性阀中以打开阀门。

9. 发明授权

US06941301B2 Pre-processing input data with outlier values for a support vector machine 有权
标题翻译：使用支持向量机的异常值预处理输入数据
公开(公告)号：US06941301B2
公开(公告)日：2005-09-06
申请号：US10051266
申请日：2002-01-18
申请人： Bruce Ferguson , Eric Hartman
发明人： Bruce Ferguson , Eric Hartman
IPC分类号： G06E1/00 , G06F7/00 , G06F15/18 , G06F17/30 , G06K9/00
CPC分类号： G06K9/00503 , Y10S707/99934 , Y10S707/99936 , Y10S707/99943
摘要： A system and method for preprocessing input data to a support vector machine (SVM). The SVM is a system model having parameters that define the representation of the system being modeled, and operates in two modes: run-time and training. A data preprocessor preprocesses received data in accordance with predetermined preprocessing parameters, and outputs preprocessed data. The data preprocessor includes an input buffer for receiving and storing the input data. The input data may include one or more outlier values. A data filter detects and removes any outlier values in the input data, generating corrected input data. The filter may optionally replace the outlier values in the input data. An output device outputs the corrected data from the data filter as preprocessed data. The corrected data may be input to the SVM in training mode to train the SVM, and/or in run-time mode to generate control parameters and/or predictive output information.
摘要翻译：一种用于将输入数据预处理到支持向量机（SVM）的系统和方法。 SVM是具有定义正在建模的系统的表示的参数的系统模型，并且以运行时和训练两种模式运行。数据预处理器根据预定的预处理参数对接收到的数据进行预处理，并输出预处理数据。数据预处理器包括用于接收和存储输入数据的输入缓冲器。输入数据可以包括一个或多个异常值。数据滤波器检测和去除输入数据中的任何异常值，产生校正的输入数据。滤波器可以可选地替换输入数据中的异常值。输出装置将来自数据滤波器的校正数据作为预处理数据输出。校正数据可以在训练模式下输入到SVM，以训练SVM，和/或以运行时模式生成控制参数和/或预测输出信息。

10. 发明授权

US6047221A Method for steady-state identification based upon identified dynamics 失效
标题翻译：基于确定的动力学的稳态识别方法
公开(公告)号：US6047221A
公开(公告)日：2000-04-04
申请号：US943489
申请日：1997-10-03
申请人： Stephen Piche , James David Keeler , Eric Hartman , William D. Johnson , Mark Gerules , Kadir Liano
发明人： Stephen Piche , James David Keeler , Eric Hartman , William D. Johnson , Mark Gerules , Kadir Liano
IPC分类号： G05B23/02 , G05B13/02
CPC分类号： G05B17/02 , G05B13/048
摘要： A method for modeling a steady-state network in the absence of steady-state historical data. A steady-state neural network can be tied by impressing the dynamics of the system onto the input data during the training operation by first determining the dynamics in a local region of the input space, this providing a set of dynamic training data. This dynamic training data is then utilized to train a dynamic model, gain thereof then set equal to unity such that the dynamic model is now valid over the entire input space. This is a linear model, and the historical data over the entire input space is then processed through this model prior to input to the neural network during training thereof to remove the dynamic component from the data, leaving the steady-state component for the purpose of training. This provides a valid model in the presence of historical data that has a large content of dynamic behavior. A single dynamic model is required for each output variable in a multi-input multi-output steady-state model such that for each output there is a separate dynamic model required for pre-filtering. They are combined in a single network made up of multiple individual steady-state models for each output. The dynamic model can be identified utilizing a weighting factor for the gain to force the dynamic gain of the dynamic model to the steady-state gain by weighting the difference thereof during optimization of the dynamic model. The steady-state model is optimized utilizing gain constraints during the optimization procedure such that the gain of the network is prevented from exceeding the gain constraints.
摘要翻译：在没有稳态历史数据的情况下建模稳态网络的方法。稳态神经网络可以通过在训练操作期间通过首先确定输入空间的局部区域中的动力学来将系统的动力学压印到输入数据上，从而提供一组动态训练数据。然后利用该动态训练数据来训练动态模型，然后将其增益设置为等于1，使动态模型现在在整个输入空间上有效。这是一个线性模型，然后在整个输入空间中的历史数据在通过该模型输入到神经网络之前通过该模型进行处理，以在训练期间从数据中移除动态分量，将稳态分量留在目的训练。这在存在具有大量动态行为的历史数据的情况下提供了有效的模型。在多输入多输出稳态模型中，每个输出变量都需要单个动态模型，因此对于每个输出，都需要一个单独的动态模型来进行预滤波。它们组合在由每个输出的多个单独稳态模型组成的单个网络中。可以利用增益的加权因子来识别动态模型，以通过在动态模型的优化期间加权其差异来将动态模型的动态增益强制为稳态增益。在优化过程中利用增益约束优化稳态模型，使得网络的增益被阻止超过增益约束。

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