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1. 发明申请

US20090268548A1 MICROFLUIDIC SYSTEMS, DEVICES AND METHODS FOR REDUCING DIFFUSION AND COMPLIANCE EFFECTS AT A FLUID MIXING REGION 审中-公开
标题翻译：微流体系统，用于减少流体混合区域的扩散和合并效应的装置和方法
公开(公告)号：US20090268548A1
公开(公告)日：2009-10-29
申请号：US11719523
申请日：2006-08-10
申请人： Daniel M. Hartmann , Joshua T. Nevill , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Daniel M. Hartmann , Joshua T. Nevill , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： B01F15/02 , B21D51/16
CPC分类号： B01F13/0059 , B01F5/0646 , B01F5/0647 , Y10T29/494
摘要： Microfluidic Systems, Devices and Methods for Reducing Diffusion and Compliance Effects at a Fluid Mixing Region. According to one embodiment, a microfluidic device is provided for combining fluids in a mixing region. The microfluidic device can include a fluid mixing region connected to a first and second microscale channel. The microscale channels can advance fluids to the fluid mixing region. The microscale channels can include constricted flow portions. According to another embodiment, the microscale channels can be connected to waste channels for removing fluid diffused into one of the channels from the other channel. According to yet another embodiment, a microfluidic system is provided for controlling the flow of fluids through the microscale channels for reducing or eliminating diffusion between the channels.
摘要翻译：微流体系统，用于减少流体混合区域的扩散和依从性效应的装置和方法。根据一个实施例，提供了用于在混合区域中组合流体的微流体装置。微流体装置可以包括连接到第一和第二微量通道的流体混合区域。微量通道可以将流体推进到流体混合区域。微型通道可以包括收缩的流动部分。根据另一个实施例，微型通道可以连接到废物通道，用于从另一个通道去除扩散到一个通道中的流体。根据又一个实施例，提供了一种微流体系统，用于控制流经微量通道的流体，以减少或消除通道之间的扩散。

2. 发明申请

US20090142198A1 APPARATUS AND METHOD FOR HANDLING FLUIDS AT NANO-SCALE RATES 有权
标题翻译：用于处理纳米尺度流体的装置和方法
公开(公告)号：US20090142198A1
公开(公告)日：2009-06-04
申请号：US11719518
申请日：2006-08-10
申请人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
IPC分类号： F04B49/06 , F04B35/04 , A61M1/00
CPC分类号： F04B19/006 , B01J2219/0081 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , F04B9/02 , F04B23/06 , G01N2035/00158
摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
摘要翻译：以纳米级速率处理流体的装置和方法。线性位移泵产生低至nl / mm范围的非脉动液体流速。泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。微流体互连装置可以联接到枪管。这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置在与泵的桶或桶相对的一侧与导热体接触。

3. 发明申请

US20090140170A1 MICROFLUIDIC SYSTEMS, DEVICES AND METHODS FOR REDUCING BACKGROUND AUTOFLUORESCENCE AND THE EFFECTS THEREOF 审中-公开
标题翻译：微流体系统，减少背景自动化的装置和方法及其效果
公开(公告)号：US20090140170A1
公开(公告)日：2009-06-04
申请号：US11719526
申请日：2006-08-10
申请人： Joshua T. Nevill , Eric T. Espenhahn , Daniel M. Hartmann , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Joshua T. Nevill , Eric T. Espenhahn , Daniel M. Hartmann , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： H05B33/00 , G01J1/58
CPC分类号： B01L3/502707 , B01L3/502715 , B01L2200/12 , B01L2300/0816 , B01L2300/0822 , B01L2300/0887 , B01L2300/12 , G01N21/6428 , G01N21/6458
摘要： According to one embodiment, a microfluidic system and method is disclosed for reducing autofluorescence. The microfluidic system can include a light source for generating an excitation light. The microfluidic system can also include a microscope having an objective for focusing the excitation light on a fluid inside a microfluidic channel of a microfluidic chip. Further, the microfluidic system can include a detector for rejecting out-of-focus light emitted from the microfluidic chip.
摘要翻译：根据一个实施方案，公开了用于减少自发荧光的微流体系统和方法。微流体系统可以包括用于产生激发光的光源。微流体系统还可以包括具有将激发光聚焦在微流体芯片的微流体通道内的流体的目的的显微镜。此外，微流体系统可以包括用于拒绝从微流控芯片发射的离焦光的检测器。

4. 发明申请

US20090145576A1 MICROFLUID BASED APPARATUS AND METHOD FOR THERMAL REGULATION AND NOISE REDUCTION 审中-公开
标题翻译：基于微流控的装置和用于热调节和噪声减少的方法
公开(公告)号：US20090145576A1
公开(公告)日：2009-06-11
申请号：US11719520
申请日：2006-08-10
申请人： David W. Wyrick , Daniel M. Hartmann , Joshua T. Nevill , Mehul Patell , Michael G. Pollack , Gregory A. Votaw , Hugh C. Crenshaw
发明人： David W. Wyrick , Daniel M. Hartmann , Joshua T. Nevill , Mehul Patell , Michael G. Pollack , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： F28F27/00 , B01J19/00
CPC分类号： B01L3/502715 , B01J19/0093 , B01J2219/00783 , B01J2219/00822 , B01J2219/00831 , B01J2219/00873 , B01J2219/00891 , B01J2219/0095 , B01J2219/00961 , B01L3/502707 , B01L3/50273 , B01L3/565 , B01L7/00 , B01L9/527 , B01L2200/147 , B01L2300/1822 , B01L2300/1827 , B01L2400/0487 , F28F3/02
摘要： An actively temperature regulated microfluidic chip assembly includes a first thermally conductive body, a second thermally conductive body attached to the first thermally conductive body, a microfluidic chip encapsulated between the first and second thermally conductive bodies, and a temperature regulating element mounted to the first thermally conductive body for adding heat to or alternately removing heat from the chip. The temperature of the chip and thus the liquid contained and/or flowing therein can be regulated by measuring the temperature of the liquid and operating the temperature regulating element to establish a thermal gradient toward or alternately away from the liquid based on the measured temperature and in comparison with a desired set point temperature.
摘要翻译：主动温度调节的微流体芯片组件包括第一导热体，连接到第一导热体的第二导热体，封装在第一和第二导热体之间的微流体芯片，以及安装在第一导热体上的温度调节元件导电体，用于向芯片加热或交替地从芯片中去除热量。可以通过测量液体的温度和操作温度调节元件来调节芯片的温度，从而使其中含有和/或流过的液体的温度基于测量的温度和/或在与所需设定点温度进行比较。

5. 发明授权

US08021130B2 Apparatus and method for handling fluids at nano-scale rates 有权
标题翻译：用于处理纳米级流体的装置和方法
公开(公告)号：US08021130B2
公开(公告)日：2011-09-20
申请号：US11719518
申请日：2006-08-10
申请人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
发明人： Gregory A. Votaw , Charles A. Buckner , Daniel M. Hartmann , William Karsh , Frank Anthony Montefusco , Joshua T. Nevill , Mehul Patel , David W. Wyrick , Hugh C. Crenshaw
IPC分类号： F04B17/00
CPC分类号： F04B19/006 , B01J2219/0081 , B01J2219/00891 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0896 , B01L2400/0478 , B82Y30/00 , F04B9/02 , F04B23/06 , G01N2035/00158
摘要： Apparatus and Method for Handling Fluids at Nano-Scale Rates. A linear displacement pump produces non-pulsatile liquid flow rates as low as the nl/mm range. The pump includes a servo motor, a gear reduction, a lead screw, a linear stage, a barrel, and a plunger extending into the barrel and coupled to the stage. A microfluidic interconnect device can be coupled to the barrel. One or more of these pumps can be disposed in a thermally controlled pump assembly that includes a pump housing, a thermally conductive body disposed in the housing and including first and second opposing sides, and a temperature regulating element such as a thermoelectric device disposed in thermal contact with the thermally conductive body on a side thereof opposite to the barrel or barrels of the pumps.
摘要翻译：以纳米级速率处理流体的装置和方法。线性位移泵产生低至nl / mm范围的非脉动液体流速。泵包括伺服电动机，齿轮减速器，导螺杆，线性平台，筒体和延伸到筒体中并联接到平台的柱塞。微流体互连装置可以联接到枪管。这些泵中的一个或多个可以设置在热控泵组件中，其包括泵壳体，设置在壳体中并包括第一和第二相对侧的导热体，以及温度调节元件，例如热电装置在与泵的桶或桶相对的一侧与导热体接触。

6. 发明申请

US20090053814A1 MICROFLUIDIC APPARATUS AND METHOD FOR SAMPLE PREPARATION AND ANALYSIS 审中-公开
标题翻译：微流化装置和样品制备和分析方法
公开(公告)号：US20090053814A1
公开(公告)日：2009-02-26
申请号：US11719513
申请日：2006-08-10
申请人： Mehul Patel , Daniel M. Hartmann , Joshua T. Nevill , Katya M. Prince , David G. Tew , Sara H. Thrall , Gregory A. Votaw , Hugh C. Crenshaw
发明人： Mehul Patel , Daniel M. Hartmann , Joshua T. Nevill , Katya M. Prince , David G. Tew , Sara H. Thrall , Gregory A. Votaw , Hugh C. Crenshaw
IPC分类号： G01N31/00 , B01J19/00 , G01N21/64
CPC分类号： G05D11/136 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01F15/0404 , B01F15/042 , B01L3/50273 , B01L3/502738 , B01L3/565 , B01L7/52 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , F04B19/006 , G01N2035/00158 , G05D7/0694 , Y10T436/10
摘要： The pumps (Pn) are operated to transport individual reagent streams into the chip in a non-pulsatile, laminar flow regime at low flow rates permitting lows grading from 0 to as little as 5 nl/min with a precision of 0.1 nl/min. In the chip (MFC), the reagent streams are merged and the reagents mixed to form a reaction product. The reaction product can be measured at one or more detection points defined in the chip. Concentration gradients are continuously varied by continuously varying the flow rates respectively produced by the pumps according to predetermined flow velocity profiles.
摘要翻译：操作泵（Pn）以低流速以非脉动，层流状态将各个试剂流输送到芯片中，允许以0.1nl / min的精度从0降至低至5nl / min。在芯片（MFC）中，将试剂流合并，将试剂混合形成反应产物。可以在芯片中定义的一个或多个检测点处测量反应产物。通过根据预定的流速分布连续改变由泵产生的流量，浓度梯度连续变化。

7. 发明申请

US20090147253A1 MICROFLUIDIC CHIP APPARATUSES, SYSTEMS AND METHODS HAVING FLUIDIC AND FIBER OPTIC INTERCONNECTIONS 有权
标题翻译：具有流体和光纤互联的微流控芯片设备，系统和方法
公开(公告)号：US20090147253A1
公开(公告)日：2009-06-11
申请号：US11719527
申请日：2006-08-10
申请人： Daniel M. Hartmann , Joshua T. Nevill , Pang-Jen Craig Kung , Kenneth I. Pettigrew , Brian Herbert Warrington , Hugh C. Crenshaw
发明人： Daniel M. Hartmann , Joshua T. Nevill , Pang-Jen Craig Kung , Kenneth I. Pettigrew , Brian Herbert Warrington , Hugh C. Crenshaw
IPC分类号： G01N21/01 , B23P17/04 , B01J19/00
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , G01N2021/0346 , G02B6/10 , G02B6/1228 , G02B6/305 , G02B6/3636 , G02B6/3644 , G02B6/3652 , G02B6/3688 , G02B6/3692 , G02B6/3696 , Y10T29/49885
摘要： Microfluidic Chip Apparatuses, Systems, and Methods having Fluidic and Fiber Optic Interconnections. According to one embodiment, apparatuses and methods are provided for connecting a light-guiding conduit to a microfluidic channel. First and second substrates with first surfaces can be provided, wherein the first surfaces of the first and second substrates form a microfluidic channel and a connection channel when the first surfaces are positioned together, and wherein the connection channel extends from an edge of the first surface of the first or second substrate to the microfluidic channel. The apparatus and method can also include bonding the first surfaces of the first and second substrates to form the microfluidic channel and the connection channel. A light-guiding conduit can be inserted into the connection channel such that the light-guiding conduit connects to the microfluidic channel and filling an area between the light-guiding conduit and the connection channel for forming a liquid-tight seal between the light-guiding conduit and the connection channel.
摘要翻译：具有流体和光纤互连的微流控芯片设备，系统和方法。根据一个实施例，提供了用于将导光管连接到微流体通道的装置和方法。可以提供具有第一表面的第一和第二基底，其中第一和第二基底的第一表面在第一表面位于一起时形成微流体通道和连接通道，并且其中连接通道从第一表面的边缘延伸的第一或第二基底到微流体通道。该装置和方法还可以包括粘合第一和第二基底的第一表面以形成微流体通道和连接通道。导光管可以插入连接通道中，使得导光管连接到微流体通道并且填充导光管和连接通道之间的区域，以在导光管之间形成液密密封导管和连接通道。

8. 发明申请

US20090139576A1 MICROFLUIDIC SYSTEMS, DEVICES AND METHODS FOR REDUCING NOISE GENERATED BY MECHANICAL INSTABILITIES 审中-公开
标题翻译：微流体系统，减少由机械性不稳定产生的噪音的装置和方法
公开(公告)号：US20090139576A1
公开(公告)日：2009-06-04
申请号：US11719524
申请日：2006-08-10
申请人： Hugh C. Crenshaw , Jennifer Colonell , Daniel M. Hartmann , Joshua T. Nevill , David W. Wyrick
发明人： Hugh C. Crenshaw , Jennifer Colonell , Daniel M. Hartmann , Joshua T. Nevill , David W. Wyrick
IPC分类号： G05D11/03 , B81B7/04
CPC分类号： B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , Y10T137/0329 , Y10T137/86131 , Y10T137/87249
摘要： Microfluidic Systems, Devices and Methods for Reducing Noise Generated by Mechanical Instabilities. According to one embodiment, a microfluidic device is provided for reducing noise in a fluid mix. The microfluidic device can include microscale channels for passage of fluids to a mixing junction. The mixing channel can be adapted to combine the fluids into a common fluid flow. The microfluidic device can also include a connector channel including first and second ends. The first end of the connector channel can be connected to the mixing junction. The microfluidic device can also include an expansion channel having connection to the second end of the connector channel. The expansion channel can be adapted for passage of the fluid mix through the expansion channel to reduce concentration gradient noise of the fluid mix by dispersion of the fluid mix as the fluid mix passes through the expansion channel.
摘要翻译：微流控系统，降低机械不稳定噪声的设备和方法。根据一个实施例，提供了用于减少流体混合物中的噪声的微流体装置。微流体装置可以包括用于将流体通过混合结的微量通道。混合通道可适于将流体组合成公共的流体流。微流体装置还可以包括包括第一端和第二端的连接器通道。连接器通道的第一端可以连接到混合连接点。微流体装置还可以包括具有连接到连接器通道的第二端的扩张通道。膨胀通道可适于使流体混合物通过膨胀通道，以在流体混合物通过膨胀通道时通过流体混合物的分散来减小流体混合物的浓度梯度噪声。

9. 发明授权

US07933012B2 Microfluidic chip apparatuses, systems and methods having fluidic and fiber optic interconnections 有权
标题翻译：具有流体和光纤互连的微流控芯片装置，系统和方法
公开(公告)号：US07933012B2
公开(公告)日：2011-04-26
申请号：US11719527
申请日：2006-08-10
申请人： Daniel M. Hartmann , Joshua T. Nevill , Pang-Jen Craig Kung , Kenneth I. Pettigrew , Brian Herbert Warrington , Hugh C. Crenshaw
发明人： Daniel M. Hartmann , Joshua T. Nevill , Pang-Jen Craig Kung , Kenneth I. Pettigrew , Brian Herbert Warrington , Hugh C. Crenshaw
IPC分类号： G01N1/10
CPC分类号： B01L3/502715 , B01L2200/12 , B01L2300/0654 , B01L2300/0816 , G01N2021/0346 , G02B6/10 , G02B6/1228 , G02B6/305 , G02B6/3636 , G02B6/3644 , G02B6/3652 , G02B6/3688 , G02B6/3692 , G02B6/3696 , Y10T29/49885
摘要： According to one embodiment, apparatuses and methods are provided for connecting a light-guiding conduit to a microfluidic channel. First and second substrates with first surfaces can be provided, wherein the first surfaces of the first and second substrates form a microfluidic channel and a connection channel when the first surfaces are positioned together, and wherein the connection channel extends from an edge of the first surface of the first or second substrate to the microfluidic channel. The apparatus and method can also include bonding the first surfaces of the first and second substrates to form the microfluidic channel and the connection channel. A light-guiding conduit can be inserted into the connection channel such that the light-guiding conduit connects to the microfluidic channel and filling an area between the light-guiding conduit and the connection channel for forming a liquid-tight seal between the light-guiding conduit and the connection channel.
摘要翻译：根据一个实施例，提供了用于将导光管连接到微流体通道的装置和方法。可以提供具有第一表面的第一和第二基底，其中第一和第二基底的第一表面在第一表面位于一起时形成微流体通道和连接通道，并且其中连接通道从第一表面的边缘延伸的第一或第二基底到微流体通道。该装置和方法还可以包括粘合第一和第二基底的第一表面以形成微流体通道和连接通道。导光管可以插入连接通道中，使得导光管连接到微流体通道并且填充导光管和连接通道之间的区域，以在导光管之间形成液密密封导管和连接通道。

10. 发明授权

US07771630B2 Precise fabrication of polymer microlens arrays 有权
标题翻译：聚合物微透镜阵列的精确制造
公开(公告)号：US07771630B2
公开(公告)日：2010-08-10
申请号：US09792236
申请日：2001-02-23
申请人： Daniel M. Hartmann , Sadik C. Esener , Osman Kibar
发明人： Daniel M. Hartmann , Sadik C. Esener , Osman Kibar
IPC分类号： B29D11/00
CPC分类号： G02B3/0018 , B29D11/00365 , B82Y10/00 , B82Y40/00 , G02B3/0012 , G02B3/0056 , G03F7/0002 , Y10T156/10
摘要： High performance microlens arrays are fabricated by (i) depositing liquid on the hydrophilic domains of substrates of patterned wettability by either (a) condensing liquid on the domains or (b) withdrawing the substrate from a liquid solution and (ii) optionally curing the liquid to form solid microlenses. The f-number (f#) of formed microlenses is controlled by adjusting liquid viscosity, surface tension, density, and index of refraction, as well as the surface free energies of the hydrophobic and hydrophilic areas. The f-number of formed microlenses is also adjustable by controlling substrate dipping angle and withdrawal speed, the array fill factor and the number of dip coats used. At an optimum withdrawal speed f# is minimized and array uniformity is maximized. At this optimum, arrays of f/3.48 microlenses were fabricated using one dip-coat with uniformity better than Δf/f˜±3.8% while multiple dip-coats permit production of f/1.38 microlens arrays and uniformity better than Δf/f˜±5.9%. Average f#s are reproducible to within 3.5%. The method is adaptable and extendible to precision parallel fabrication of (i) microlenses precisely sized, aligned and spatially positioned to various small light sources and optical fiber ends, (ii) conductive bump bonds on substrate pads, and (iii) conductive bonds between corresponding domains on separate perpendicular substrates, all of which are self-aligned.
摘要翻译：通过以下步骤制造高性能微透镜阵列：（i）通过（a）将液体冷凝在畴上，或（b）从液体溶液中取出基底和（ii）任选地固化液体，使液体沉积在具有图案化润湿性的基底的亲水区域上以形成固体微透镜。通过调节液体粘度，表面张力，密度和折射率以及疏水和亲水区域的表面自由能来控制形成的微透镜的f数（f＃）。形成的微透镜的f数也可以通过控制衬底浸渍角度和抽出速度，阵列填充因子和所用浸涂层的数量来调节。在最佳退出速度f＃被最小化并且阵列均匀性最大化。在这个最佳条件下，使用一种比Dgr; f / f〜±3.8％更好的浸渍涂层制造f / 3.48微透镜阵列，而多个浸涂层允许生产f / 1.38微透镜阵列，并且均匀度优于＆Dgr; f /f〜cooper5.9%。平均f＃s可重复到3.5％以内。该方法适用于和可扩展以精确并行制造（i）精确尺寸，对准和空间定位于各种小光源和光纤端的微透镜，（ii）衬底焊盘上的导电凸块接合，以及（iii）相应的导电键分离的垂直基底上的结构域都是自对准的。

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