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1. 发明授权

US07067627B2 Schizophrenia associated genes, proteins and biallelic markers 失效
公开(公告)号：US07067627B2
公开(公告)日：2006-06-27
申请号：US10147603
申请日：2002-05-16
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C07K1/00 , A23J1/00
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.

2. 发明授权

US06476208B1 Schizophrenia associated genes, proteins and biallelic markers 失效
标题翻译：精神分裂症相关基因，蛋白质和双重标记物
公开(公告)号：US06476208B1
公开(公告)日：2002-11-05
申请号：US09539333
申请日：2000-03-30
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C07M2102
CPC分类号： C07K14/47 , A01K2217/075 , C12Q1/6883 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的倾向以及疾病诊断和预后的手段。

3. 发明授权

US07371811B2 Schizophrenia associated genes, proteins and biallelic markers 失效
标题翻译：精神分裂症相关基因，蛋白质和双重标记物
公开(公告)号：US07371811B2
公开(公告)日：2008-05-13
申请号：US11145703
申请日：2005-06-06
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： A61K38/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。

4. 发明申请

US20050260667A1 Schizophrenia associated genes, proteins and biallelic markers 失效
标题翻译：精神分裂症相关基因，蛋白质和双重标记物
公开(公告)号：US20050260667A1
公开(公告)日：2005-11-24
申请号：US11145703
申请日：2005-06-06
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C07H21/04 , C07K14/47 , C07K14/705 , C12N5/08 , C12N15/09 , C12Q1/68
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。

5. 发明申请

US20080182268A1 SCHIZOPHRENIA ASSOCIATED GENES, PROTEINS AND BIALLELIC MARKERS 审中-公开
标题翻译： SCHIZOPHRENIA相关基因，蛋白质和BIALLELIC标记
公开(公告)号：US20080182268A1
公开(公告)日：2008-07-31
申请号：US12056900
申请日：2008-03-27
申请人： DANIEL COHEN , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
发明人： DANIEL COHEN , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Bernard Bihain , Laurent Essioux
IPC分类号： C12Q1/68 , C07K14/00 , C07H21/00 , C40B40/06 , C12N15/63 , C12N5/10 , C07K16/00
CPC分类号： C12Q1/6883 , A01K2217/075 , C07K14/47 , C12Q2600/156
摘要： The invention concerns the human sbg1, g34665, sbg2, g35017 and g35018 genes, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the sbg1, g34665, sbg2, g35017 and g35018 genes and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人sbg1，g34665，sbg2，g35017和g35018基因，多核苷酸，多肽双重标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相情感障碍与双重标记和sbg1，g34665，sbg2，g35017和g35018基因和核苷酸序列之间建立的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。

6. 发明授权

US06555316B1 Schizophrenia associated gene, proteins and biallelic markers 失效
标题翻译：精神分裂症相关基因，蛋白质和双重标记物
公开(公告)号：US06555316B1
公开(公告)日：2003-04-29
申请号：US09679409
申请日：2000-10-03
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Laurent Essioux
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret , Laurent Essioux
IPC分类号： C12Q168
CPC分类号： C12Q1/6883 , C07K14/47 , C07K16/18 , C12Q2600/156 , C12Q2600/172
摘要： The invention concerns the human g35030 gene, polynucleotides, polypeptides biallelic markers, and human chromosome 13q31-q33 biallelic markers. The invention also concerns the association established between schizophrenia and bipolar disorder and the biallelic markers and the g35030 gene and nucleotide sequences. The invention provides means to identify compounds useful in the treatment of schizophrenia, bipolar disorder and related diseases, means to determine the predisposition of individuals to said disease as well as means for the disease diagnosis and prognosis.
摘要翻译：本发明涉及人g35030基因，多核苷酸，多肽双向标记和人染色体13q31-q33双重标记。本发明还涉及精神分裂症和双相障碍与双重标记和g35030基因和核苷酸序列之间的关联。本发明提供了鉴定用于治疗精神分裂症，双相性精神障碍和相关疾病的化合物的方法，用于确定个体对所述疾病的易感性以及疾病诊断和预后的手段。

7. 发明授权

US07189833B2 Prostate cancer gene 失效
标题翻译：前列腺癌基因
公开(公告)号：US07189833B2
公开(公告)日：2007-03-13
申请号：US09901484
申请日：2001-07-09
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
IPC分类号： C07H21/02
CPC分类号： C12N9/6445 , A01K2217/05 , A61K38/00 , C07K14/47 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to PG1, a gene associated with prostate cancer. The invention provides polynucleotides including biallelic markers derived from PG1 and from flanking genomic regions. Primers hybridizing to these biallelic markers and regions flanking are also provided. This invention provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and prostate cancer and between a haplotype and prostate cancer. The invention also relates to diagnostic methods of determining whether an individual is at risk for developing prostate cancer, and whether an individual suffers from prostate cancer as a result of a mutation in the PG1 gene.
摘要翻译：本发明涉及与前列腺癌相关的基因PG1。本发明提供了多核苷酸，其包括衍生自PG1和来自侧翼基因组区域的双重标记。还提供了与这些双重标记和侧翼区域杂交的引物。本发明提供了适用于对本发明的一种或多种双重标记的含有核酸的样品进行基因分型的多核苷酸和方法。此外，本发明提供了检测双重标记等位基因与前列腺癌之间以及单倍型与前列腺癌之间的统计学相关性的方法。本发明还涉及确定个体是否处于发展中的前列腺癌风险的诊断方法以及PG1基因突变导致个体患有前列腺癌的诊断方法。

8. 发明授权

US06346381B1 Prostate cancer gene 失效
标题翻译：前列腺癌基因
公开(公告)号：US06346381B1
公开(公告)日：2002-02-12
申请号：US09218207
申请日：1998-12-22
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
IPC分类号： C12Q168
CPC分类号： C07K14/47 , A01K2217/05 , A61K38/00 , C12Q1/6827 , C12Q1/6886 , C12Q2600/136 , C12Q2600/172
摘要： The present invention relates to PG1, a gene associated with prostate cancer. The invention provides polynucleotides including biallelic markers derived from PG1 and from flanking genomic regions. Primers hybridizing to these biallelic markers and regions flanking are also provided. This invention provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and prostate cancer and between a haplotype and prostate cancer. The invention also relates to diagnostic methods of determining whether an individual is at risk for developing prostate cancer, and whether an individual suffers from prostate cancer as a result of a mutation in the PG1 gene.
摘要翻译：本发明涉及与前列腺癌相关的基因PG1。本发明提供了多核苷酸，其包括衍生自PG1和来自侧翼基因组区域的双重标记。还提供了与这些双重标记和侧翼区域杂交的引物。本发明提供了适用于对本发明的一种或多种双重标记的含有核酸的样品进行基因分型的多核苷酸和方法。此外，本发明提供了检测双重标记等位基因与前列腺癌之间以及单倍型与前列腺癌之间的统计学相关性的方法。本发明还涉及确定个体是否处于发展中的前列腺癌风险的诊断方法以及PG1基因突变导致个体患有前列腺癌的诊断方法。

9. 发明授权

US5945522A Prostate cancer gene 失效
标题翻译：前列腺癌基因
公开(公告)号：US5945522A
公开(公告)日：1999-08-31
申请号：US996306
申请日：1997-12-22
申请人： Daniel Cohen , Ilya Chumakov , Marta Blumenfeld , Lydie Bougueleret
发明人： Daniel Cohen , Ilya Chumakov , Marta Blumenfeld , Lydie Bougueleret
IPC分类号： A61K38/00 , C07K14/47 , C12Q1/68 , C07H21/02 , C07H21/04
CPC分类号： C07K14/47 , C12Q1/6827 , C12Q1/6886 , A01K2217/05 , A61K38/00 , C12Q2600/136 , C12Q2600/172
摘要： The present invention relates to PG1, a gene associated with prostate cancer. The invention also relates to methods of determining whether an individual is at risk for developing prostate cancer at a later date or whether an individual suffers from prostate cancer as a result of a mutation in the PG1 gene.
摘要翻译：本发明涉及与前列腺癌相关的基因PG1。本发明还涉及确定个体是否处于晚期发展中的前列腺癌风险的方法，还是由于PG1基因突变导致个体患有前列腺癌的方法。

10. 发明授权

US06265546B1 Prostate cancer gene 失效
标题翻译：前列腺癌基因
公开(公告)号：US06265546B1
公开(公告)日：2001-07-24
申请号：US09338907
申请日：1999-06-23
申请人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
发明人： Daniel Cohen , Marta Blumenfeld , Ilya Chumakov , Lydie Bougueleret
IPC分类号： C07K100
CPC分类号： C12N9/6445 , A01K2217/05 , A61K38/00 , C07K14/47 , C12Q1/6827 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to PG1, a gene associated with prostate cancer. The invention provides polynucleotides including biallelic markers derived from PG1 and from flanking genomic regions. Primers hybridizing to these biallelic markers and regions flanking are also provided. This invention provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Further, the invention provides methods to detect a statistical correlation between a biallelic marker allele and prostate cancer and between a haplotype and prostate cancer. The invention also relates to diagnostic methods of determining whether an individual is at risk for developing prostate cancer, and whether an individual suffers from prostate cancer as a result of a mutation in the PG1 gene.
摘要翻译：本发明涉及与前列腺癌相关的基因PG1。本发明提供了多核苷酸，其包括衍生自PG1和来自侧翼基因组区域的双重标记。还提供了与这些双重标记和侧翼区域杂交的引物。本发明提供了适用于对本发明的一种或多种双重标记的含有核酸的样品进行基因分型的多核苷酸和方法。此外，本发明提供了检测双重标记等位基因与前列腺癌之间以及单倍型与前列腺癌之间的统计学相关性的方法。本发明还涉及确定个体是否处于发展中的前列腺癌风险的诊断方法以及PG1基因突变导致个体患有前列腺癌的诊断方法。

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