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1. 发明申请

US20120238751A1 TRICYCLIC GYRASE INHIBITORS 有权
公开(公告)号：US20120238751A1
公开(公告)日：2012-09-20
申请号：US13496188
申请日：2012-03-14
申请人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
发明人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
IPC分类号： C07D487/04 , C07D471/10 , C07D487/08 , C07D471/08 , C07D487/10 , C07D491/048 , C07D491/056 , C07D487/14 , C07D471/14 , C07D471/04 , C07D498/04
CPC分类号： C07D487/04 , C07D487/14
摘要： Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.
摘要翻译：本文公开了具有式I结构的化合物及其药学上合适的盐，酯和前药，其可用作抗菌三环类回旋酶抑制剂。还考虑了相关的药物组合物，用途和制备化合物的方法。

2. 发明授权

US09732083B2 Tricyclic gyrase inhibitors 有权
公开(公告)号：US09732083B2
公开(公告)日：2017-08-15
申请号：US13496188
申请日：2012-03-14
申请人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
发明人： Daniel Bensen , Zhiyong Chen , John Finn , Thanh To Lam , Suk Joong Lee , Xiaoming Li , Douglas W. Phillipson , Leslie William Tari , Michael Trzoss , Junhu Zhang , Felice C. Lightstone , Toan B. Nguyen , Sergio E. Wong , Paul Aristoff , Michael Jung
IPC分类号： C07D487/04 , C07D487/14
CPC分类号： C07D487/04 , C07D487/14
摘要： Disclosed herein are compounds having the structure of Formula I and pharmaceutically suitable salts, esters, and prodrugs thereof that are useful as antibacterially effective tricyclic gyrase inhibitors.Related pharmaceutical compositions, uses and methods of making the compounds are also contemplated.

3. 发明申请

US20130079323A1 GYRASE INHIBITORS 有权
标题翻译： GYRASE抑制剂
公开(公告)号：US20130079323A1
公开(公告)日：2013-03-28
申请号：US13394985
申请日：2010-09-10
申请人： Christopher J. Creighton , Leslie William Tari , Zhiyong Chen , Mark Hilgers , Thanh To Lam , Xiaoming Li , Michael Trzoss , Junhu Zhang , John Finn , Daniel Bensen
发明人： Christopher J. Creighton , Leslie William Tari , Zhiyong Chen , Mark Hilgers , Thanh To Lam , Xiaoming Li , Michael Trzoss , Junhu Zhang , John Finn , Daniel Bensen
IPC分类号： C07D487/04 , C07D471/04 , C07D491/048 , C07D487/16 , C07D513/04
CPC分类号： C07D519/00 , C07D471/04 , C07D471/16 , C07D487/04 , C07D487/16 , C07D491/048 , C07D513/04
摘要： Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula (I), are disclosed: Formula (I), wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof.
摘要翻译：新型促旋酶抑制剂和相关组合物和方法可用于阻止细菌生长。公开了式（I）的化合物：式（I），其中Y是N或CH; Z为N或CR5; R5是H，含有0-2个选自O，S和N的杂原子的取代或未取代的烃基残基（1-3C），或是无机残基; L是O，S，NR7或CR8R9; R7是H或C1-3烷基; R 8和R 9各自独立地为H或C 1-3烷基; R2是H，含有0-10个选自O，S和N的杂原子的烃基残基（1-40℃），任选被无机残基取代; R4是H，无机残基或含有0-12个选自O，S和N的杂原子并含有0-10个无机残基的烃基残基（1-30C），其中R 5和R 4可以连接形成稠环; 并且R 6选自H，C 1-5烷基，C 2-5烯基，C 2-5炔基，卤代C 1-5烷基，卤素C 2-5烯基，卤代C 2-5炔基，C 1-5羟基烷基，C 1 -5烷基氯，C2-5烯基氯和C2-5炔基氯; 或其药学上可接受的盐，酯或前药。

4. 发明授权

US09481675B2 Gyrase inhibitors 有权
标题翻译：促旋酶抑制剂
公开(公告)号：US09481675B2
公开(公告)日：2016-11-01
申请号：US13394985
申请日：2010-09-10
申请人： Christopher J Creighton , Leslie William Tari , Zhiyong Chen , Mark Hilgers , Thanh To Lam , Xiaoming Li , Michael Trzoss , Junhu Zhang , John Finn , Daniel Bensen
发明人： Christopher J Creighton , Leslie William Tari , Zhiyong Chen , Mark Hilgers , Thanh To Lam , Xiaoming Li , Michael Trzoss , Junhu Zhang , John Finn , Daniel Bensen
IPC分类号： C07D487/04 , C07D519/00 , C07D471/04 , C07D487/16 , C07D491/048 , C07D513/04
CPC分类号： C07D519/00 , C07D471/04 , C07D471/16 , C07D487/04 , C07D487/16 , C07D491/048 , C07D513/04
摘要： Novel gyrase inhibitors and related compositions and methods are useful for impeding bacterial growth. Compounds of Formula I are disclosed: wherein Y is N or CH; Z is N or CR5; R5 is H, a substituted or unsubstituted hydrocarbyl residue (1-3C) containing 0-2 heteroatoms selected from O, S and N, or is an inorganic residue; L is O, S, NR7, or CR8R9; R7 is H or C1-3 alkyl; R8 and R9 are each independently H or C1-3 alkyl; R2 is H, a hydrocarbyl residue (1-40C) containing 0-10 heteroatoms selected from O, S and N optionally substituted with an inorganic residue; R4 is H, an inorganic residue, or a hydrocarbyl residue (1-30C) containing 0-12 heteroatoms selected from O, S and N and containing 0-10 inorganic residues, wherein R5 and R4 together may join to form a fused ring; and R6 is selected from the group consisting of H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, halo C1-5 alkyl, halo C2-5 alkenyl, halo C2-5 alkynyl, C1-5 hydroxyalkyl, C1-5 alkyl chloride, C2-5 alkenyl chloride, and C2-5 alkynyl chloride; or a pharmaceutically-acceptable salt, ester, or prodrug thereof.
摘要翻译：新型促旋酶抑制剂和相关组合物和方法可用于阻止细菌生长。公开了式（I）的化合物：式（I），其中Y是N或CH; Z为N或CR5; R5是H，含有0-2个选自O，S和N的杂原子的取代或未取代的烃基残基（1-3C），或是无机残基; L是O，S，NR7或CR8R9; R7是H或C1-3烷基; R 8和R 9各自独立地为H或C 1-3烷基; R2是H，含有0-10个选自O，S和N的杂原子的烃基残基（1-40℃），任选被无机残基取代; R4是H，无机残基或含有0-12个选自O，S和N的杂原子并含有0-10个无机残基的烃基残基（1-30C），其中R 5和R 4可以连接形成稠环; 并且R 6选自H，C 1-5烷基，C 2-5烯基，C 2-5炔基，卤代C 1-5烷基，卤素C 2-5烯基，卤代C 2-5炔基，C 1-5羟基烷基，C 1 -5烷基氯，C2-5烯基氯和C2-5炔基氯; 或其药学上可接受的盐，酯或前药。

5. 发明申请

US20120136014A1 DIHYDROFOLATE REDUCTASE INHIBITORS 有权
标题翻译：二氢叶酸还原酶抑制剂
公开(公告)号：US20120136014A1
公开(公告)日：2012-05-31
申请号：US13151683
申请日：2011-06-02
申请人： Zhiyong Chen , Christopher J. Creghton , Mark Cunningham , John Finn , Mark Hilgers , Michael Jung , Lucy Aguirre Kohnen , Thanh Lam , Xiaoming Li , Mark Stidham , Les Tari , Michael Trzoss , Junhu Zhang
发明人： Zhiyong Chen , Christopher J. Creghton , Mark Cunningham , John Finn , Mark Hilgers , Michael Jung , Lucy Aguirre Kohnen , Thanh Lam , Xiaoming Li , Mark Stidham , Les Tari , Michael Trzoss , Junhu Zhang
IPC分类号： A61K31/517 , C07D401/14 , C07D239/72 , A61P31/10 , A61P33/00 , A61P31/04 , A61P29/00 , C12N9/99 , C07D417/14
CPC分类号： C07D401/14 , C07D239/95 , C07D417/14
摘要： The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.
摘要翻译：本公开提供式I化合物或其药学上可接受的盐，其中R 5，R 6和Z如本文所述。本公开还提供其药物组合物; 和抑制DHFR活性的方法; 以及通过给予式I化合物治疗细胞增殖性疾病，自身免疫疾病，炎性疾病或细菌，真菌或寄生虫感染的方法。

6. 发明授权

US08835445B2 Dihydrofolate reductase inhibitors 有权
标题翻译：二氢叶酸还原酶抑制剂
公开(公告)号：US08835445B2
公开(公告)日：2014-09-16
申请号：US13151683
申请日：2011-06-02
申请人： Zhiyong Chen , Christopher J. Creighton , Mark Cunningham , John Finn , Mark Hilgers , Michael Jung , Lucy Aguirre Kohnen , Thanh Lam , Xiaoming Li , Mark Stidham , Les Tari , Michael Trzoss , Junhu Zhang
发明人： Zhiyong Chen , Christopher J. Creighton , Mark Cunningham , John Finn , Mark Hilgers , Michael Jung , Lucy Aguirre Kohnen , Thanh Lam , Xiaoming Li , Mark Stidham , Les Tari , Michael Trzoss , Junhu Zhang
IPC分类号： A01N43/54 , A61K31/517 , C07D239/72 , C07D401/00
CPC分类号： C07D401/14 , C07D239/95 , C07D417/14
摘要： The present disclosure provides compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein R5, R6 and Z are as described herein. The disclosure also provides pharmaceutical compositions thereof; and methods for inhibiting DHFR activity; and methods for treating cell proliferative diseases, autoimmune disease, inflammatory disease or bacterial, fungal or parasitic infection by administering a compound of Formula I.
摘要翻译：本公开提供式I化合物或其药学上可接受的盐，其中R 5，R 6和Z如本文所述。本公开还提供其药物组合物; 和抑制DHFR活性的方法; 以及通过给予式I化合物治疗细胞增殖性疾病，自身免疫疾病，炎性疾病或细菌，真菌或寄生虫感染的方法。

7. 发明申请

US20220066058A1 landslide Deep Displacement Remote Visual Monitoring System 有权
公开(公告)号：US20220066058A1
公开(公告)日：2022-03-03
申请号：US17092359
申请日：2020-11-09
申请人： Jianjun Gan , Jianhua Li , Xiaoming Li
发明人： Jianjun Gan , Jianhua Li , Xiaoming Li
IPC分类号： G01V1/00 , G01V1/20 , G01V1/34 , G08B21/10 , H04W4/90
摘要： The invention discloses a landslide deep displacement remote visual monitoring system, comprising monitoring system and transmitting system, the monitoring system comprises displacement sensor, the displacement sensor is arranged on chassis, anchor eyes are provided on the chassis, wire embedding hole is arranged at centroid of the chassis, multiple bracing wires are provided in the wire embedding hole, the transmitting system comprises a data acquisition unit, the data acquisition unit is arranged on the displacement sensor for collecting data thereof, the data acquisition unit is connected to a network transmission module, the network transmission module is connected to a data receiving module through the network, the data receiving module is also provided with network transmission module, the data receiving module is connected to computer, the computer displays the data through display screen.

8. 发明授权

US08924760B2 Scheduler with voltage management 有权
标题翻译：具有电压管理的调度器
公开(公告)号：US08924760B2
公开(公告)日：2014-12-30
申请号：US12655881
申请日：2010-01-08
申请人： Xiaoming Li , Surinderjit S. Dhaliwal
发明人： Xiaoming Li , Surinderjit S. Dhaliwal
IPC分类号： G06F1/32 , G06F9/48
CPC分类号： G06F1/3203 , G06F1/324 , G06F1/329 , G06F1/3296 , G06F9/4893 , Y02D10/126 , Y02D10/172 , Y02D10/24
摘要： There is provided a method of scheduler assisted power management for semiconductor devices. By accessing and analyzing workload data for tasks to be completed, a scheduler may provide finer grained control for determining and implementing an efficient power management policy. In this manner, tasks with completion deadlines can be allocated sufficient resources without wasteful power consumption resulting from ramping up of performance through overestimating of voltage or frequency increases. Additionally, power management may be planned for longer periods, rather than looking only at immediate data to be processed and constantly fluctuating voltage and frequency. In this manner, power management can run more smoothly and efficiently compared to conventional means of power management that ignore data from a scheduler when determining power management policy.
摘要翻译：提供了一种用于半导体器件的调度器辅助电源管理的方法。通过访问和分析要完成的任务的工作负载数据，调度器可以提供更精细的粒度控制以确定和实现有效的电力管理策略。以这种方式，具有完成期限的任务可以被分配足够的资源，而不会由于通过过高估计电压或频率增加而提高性能而导致浪费的功率消耗。此外，电源管理可能会计划更长的时间，而不是仅查看要处理的即时数据和不断波动的电压和频率。以这种方式，与在确定电源管理策略时忽略来自调度器的数据的电力管理的传统手段相比，功率管理可以更平稳和有效地运行。

9. 发明授权

US08618782B2 Means and associated methods for digitally controlling converter systems 有权
标题翻译：用于数字控制转换器系统的方法和相关方法
公开(公告)号：US08618782B2
公开(公告)日：2013-12-31
申请号：US13218355
申请日：2011-08-25
申请人： Xiaoming Li , Yunping Lang
发明人： Xiaoming Li , Yunping Lang
IPC分类号： G05F1/00
CPC分类号： H02M3/157 , H02M3/33515 , H02M2001/0012
摘要： The embodiments of the present invention illustrate a means for digitally controlling a converter system and associated method. Wherein the means for digitally controlling a converter system comprises a means for generating a digital error signal according to an output voltage of the converter system and a reference voltage, a means for generating a digital control signal according to a digital reference signal and the digital error signal, and a means for generating a PWM signal according to the digital control signal in order to control the converter system. The means for digitally controlling a converter system and associated method at least alleviate the problem of limit-cycle oscillation, and promote the performance of system transient response and accuracy.
摘要翻译：本发明的实施例示出了用于数字控制转换器系统和相关方法的装置。其中用于数字控制转换器系统的装置包括用于根据转换器系统的输出电压和参考电压产生数字误差信号的装置，用于根据数字参考信号和数字误差产生数字控制信号的装置信号，以及用于根据数字控制信号产生PWM信号以便控制转换器系统的装置。用于数字控制转换器系统和相关方法的手段至少减轻了极限循环振荡的问题，并提高了系统瞬态响应和精度的性能。

10. 发明申请

US20110173478A1 Scheduler with voltage management 有权
标题翻译：具有电压管理的调度器
公开(公告)号：US20110173478A1
公开(公告)日：2011-07-14
申请号：US12655881
申请日：2010-01-08
申请人： Xiaoming Li , Surinderjit S. Dhaliwal
发明人： Xiaoming Li , Surinderjit S. Dhaliwal
IPC分类号： G06F1/32 , G06F1/26 , G06F9/46
CPC分类号： G06F1/3203 , G06F1/324 , G06F1/329 , G06F1/3296 , G06F9/4893 , Y02D10/126 , Y02D10/172 , Y02D10/24
摘要： There is provided a method of scheduler assisted power management for semiconductor devices. By accessing and analyzing workload data for tasks to be completed, a scheduler may provide finer grained control for determining and implementing an efficient power management policy. In this manner, tasks with completion deadlines can be allocated sufficient resources without wasteful power consumption resulting from ramping up of performance through overestimating of voltage or frequency increases. Additionally, power management may be planned for longer periods, rather than looking only at immediate data to be processed and constantly fluctuating voltage and frequency. In this manner, power management can run more smoothly and efficiently compared to conventional means of power management that ignore data from a scheduler when determining power management policy.
摘要翻译：提供了一种用于半导体器件的调度器辅助电源管理的方法。通过访问和分析要完成的任务的工作负载数据，调度器可以提供更精细的粒度控制以确定和实现有效的电力管理策略。以这种方式，具有完成期限的任务可以被分配足够的资源，而不会由于通过过高估计电压或频率增加而提高性能而导致浪费的功率消耗。此外，电源管理可能会计划更长的时间，而不是仅查看要处理的即时数据和不断波动的电压和频率。以这种方式，与在确定电源管理策略时忽略来自调度器的数据的电力管理的传统手段相比，功率管理可以更平稳和有效地运行。

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