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1. 发明申请

US20050032065A1 Methods of prognosis of prostate cancer 审中-公开
标题翻译：前列腺癌预后的方法
公开(公告)号：US20050032065A1
公开(公告)日：2005-02-10
申请号：US10603505
申请日：2003-06-24
申请人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
发明人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , Y02A90/26
摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.
摘要翻译：本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。

2. 发明申请

US20070099197A1 Methods of prognosis of prostate cancer 审中-公开
标题翻译：前列腺癌预后的方法
公开(公告)号：US20070099197A1
公开(公告)日：2007-05-03
申请号：US11365745
申请日：2006-02-28
申请人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
发明人： Daniel Afar , Susan Henshall , Jordan Hiller , David Mack , Robert Sutherland
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158 , Y02A90/26
摘要： The present invention applies classical survival analysis to genome-wide gene expression profiles of prostate cancers and preoperative prostate-specific antigen levels from prostate cancer patient, to identify prognostic markers of disease relapse that provide additional predictive value relative to prostate-specific antigen concentration. The present invention provides a method of determining prognosis of prostate cancer and predicting prostate cancer outcome of a patient. The method comprises the steps of first establishing the threshold value of at least one prognostic gene of prostate cancer. Then, the amount of the prognostic gene from a prostate tissue of a prostate cancer patient is determined. The amount of the prognostic gene present in that patient is compared with the established threshold value of the prognostic gene, whereby the prognostic outcome of the patient is determined.
摘要翻译：本发明将经典生存分析应用于前列腺癌患者的前列腺癌基因组全基因表达谱和术前前列腺特异性抗原水平，以鉴定提供相对于前列腺特异性抗原浓度的额外预测值的疾病复发的预后标志物。本发明提供一种确定前列腺癌的预后并预测患者的前列腺癌预后的方法。该方法包括首先建立至少一种前列腺癌预后基因的阈值的步骤。然后，确定来自前列腺癌患者的前列腺组织的预后基因的量。将该患者中存在的预后基因的量与预后基因的既定阈值进行比较，从而确定患者的预后结果。

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