专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100291680A1 METHODS AND COMPOSITIONS FOR INHIBITION OF MEMBRANE FUSION-ASSOCIATED EVENTS, INCLUDING HIV TRANSMISSION 审中-公开
标题翻译：用于抑制膜融合相关事件的方法和组合物，包括HIV传播
公开(公告)号：US20100291680A1
公开(公告)日：2010-11-18
申请号：US12791983
申请日：2010-06-02
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway, JR. , Alphonse J. Langlois
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway, JR. , Alphonse J. Langlois
IPC分类号： C12N5/02 , C07K14/005 , C07K14/16 , C07K14/155 , C07K14/135 , C07K14/115 , C07K14/02 , C07K14/11 , C07K14/05
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID NO:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID NO：1）肽以及DP178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

2. 发明授权

US06440656B1 Methods for the inhibition of respiratory syncytial virus transmission 失效
标题翻译：抑制呼吸道合胞病毒传播的方法
公开(公告)号：US06440656B1
公开(公告)日：2002-08-27
申请号：US08255208
申请日：1994-06-07
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway, Jr.
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway, Jr.
IPC分类号： C12Q170
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , C12N2710/16222 , C12N2730/10122 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , Y10S435/974 , Y10S530/826
摘要： Fusion of the viral envelope, or infected cell membranes with uninfected cell membranes, is an essential step in the viral life cycle. Recent studies involving the human immunodeficiency virus type 1 (HIV-1) demonstrated that synthetic peptides (designated DP-107 and DP-178) derived from potential helical regions of the transmembrane (TM) protein, gp41, were potent inhibitors of viral fusion and infection. A computerized antiviral searching technology (C.A.S.T.) that detects related structural motifs (e.g., ALLMOTI5, 107×178×4, and PLZIP) in other viral proteins was employed to identify similar regions in the respiratory syncytial virus (RSV). Several conserved heptad repeat domains that are predicted to form coiled-coil structures with antiviral activity were identified in the RSV genome. Synthetic peptides of 16 to 39 amino acids derived from these regions were prepared and their antiviral activities assessed in a suitable in vitro screening assay. These peptides proved to be potent inhibitors of RSV fusion. Based upon their structural and functional equivalence to the known HIV-1 inhibitors DP-107 and DP-178, these peptides should provide a novel approach to the development of targeted therapies for the treatment of RSV infections.
摘要翻译：病毒包膜或感染细胞膜与未感染细胞膜的融合是病毒生命周期中必不可少的一步。最近涉及人类免疫缺陷病毒1型（HIV-1）的研究表明，衍生自跨膜（TM）蛋白gp41的潜在螺旋区域的合成肽（称为DP-107和DP-178）是病毒融合的有效抑制剂，感染。采用在其他病毒蛋白中检测相关结构基序（例如，ALLMOTI5,107x178x4和PLZIP）的计算机化抗病毒检索技术（C.A.S.T.）来鉴定呼吸道合胞病毒（RSV）中的相似区域。在RSV基因组中鉴定了预测形成具有抗病毒活性的卷曲螺旋结构的几个保守的七肽重复结构域。制备衍生自这些区域的16至39个氨基酸的合成肽，并在合适的体外筛选测定中评估其抗病毒活性。这些肽被证明是RSV融合的有效抑制剂。基于它们与已知的HIV-1抑制剂DP-107和DP-178的结构和功能等同性，这些肽应提供开发用于治疗RSV感染的靶向治疗的新方法。

3. 发明授权

US07122190B2 Fusion proteins comprising DP-178 and other viral fusion inhibitor peptides useful for treating aids 失效
标题翻译：包含DP-178和用于治疗辅助剂的其它病毒融合抑制剂肽的融合蛋白
公开(公告)号：US07122190B2
公开(公告)日：2006-10-17
申请号：US10267748
申请日：2002-10-09
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway , Alphonse J. Langlois
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway , Alphonse J. Langlois
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1细胞gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽以及DP178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

4. 发明授权

US06479055B1 Methods for inhibition of membrane fusion-associated events, including respiratory syncytial virus transmission 失效
标题翻译：抑制膜融合相关事件的方法，包括呼吸道合胞病毒传播
公开(公告)号：US06479055B1
公开(公告)日：2002-11-12
申请号：US08470896
申请日：1995-06-06
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway , Alphonse J. Langlois
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild , Shawn O'Lin Barney , Dennis Michael Lambert , Stephen Robert Petteway , Alphonse J. Langlois
IPC分类号： A61K39145
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-viral activity. In particular, the invention relates to methods of using such peptides as inhibitory of respiratory syncytial virus (“RSV”) transmission to uninfected cells. The peptides used in the methods of the invention are homologs of the DP-178 and DP-107 peptides, peptides corresponding to amino acid residues 638 to 673, and to amino acid residues 558 to 595, respectively, of the HIV-1LAI transmembrane protein (TM) gp41.
摘要翻译：本发明涉及显示出有力的抗病毒活性的肽。特别地，本发明涉及使用这种肽抑制呼吸道合胞病毒（“RSV”）传播至未感染细胞的方法。在本发明方法中使用的肽分别是HIV-1LAI跨膜蛋白质的DP-178和DP-107肽的同系物，对应于氨基酸残基638至673的氨基酸残基558至595的氨基酸残基（TM）gp41。

5. 发明授权

US06824783B1 Methods for inhibition of membrane fusion-associated events, including HIV transmission 失效
标题翻译：抑制膜融合相关事件的方法，包括HIV传播
公开(公告)号：US06824783B1
公开(公告)日：2004-11-30
申请号：US08487266
申请日：1995-06-07
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild
IPC分类号： A61K3921
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽，以及DP178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

6. 发明授权

US6133418A Synthetic peptide inhibitors of HIV transmission 失效
标题翻译： HIV传播的合成肽抑制剂
公开(公告)号：US6133418A
公开(公告)日：2000-10-17
申请号：US554616
申请日：1995-11-06
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild
IPC分类号： G01N33/566 , A61K38/00 , A61K38/16 , A61K39/00 , A61K39/12 , A61P31/12 , C07K5/083 , C07K5/087 , C07K5/09 , C07K5/093 , C07K5/103 , C07K5/107 , C07K5/113 , C07K5/117 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/02 , C07K14/05 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/125 , C07K14/13 , C07K14/135 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , C07K17/08 , C07K17/10 , C12N15/11 , C12N15/62 , C12N15/63 , C12Q1/00 , C12Q1/70 , G01N33/53 , G01N33/569
CPC分类号： C07K14/005 , C07K14/21 , C07K14/22 , C07K14/285 , C07K14/31 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0815 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , A61K2039/525 , A61K38/00 , A61K39/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , Y10S435/974 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID:1) ptide corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1LAI gp41蛋白的氨基酸638至673的DP-178（SEQ ID：1），以及DP-178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

7. 发明授权

US07273614B2 Nucleic acids encoding DP-178 and other viral fusion inhibitor peptides useful for treating aids 失效
标题翻译：编码DP-178的核酸和用于治疗辅助物质的其他病毒融合抑制剂肽
公开(公告)号：US07273614B2
公开(公告)日：2007-09-25
申请号：US10267682
申请日：2002-10-09
申请人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild
发明人： Dani Paul Bolognesi , Thomas James Matthews , Carl T. Wild
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/525 , A61K2039/555 , A61K2039/60 , A61K2039/6031 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0817 , C07K5/0819 , C07K5/1008 , C07K5/101 , C07K5/1013 , C07K5/1016 , C07K5/1021 , C07K5/1024 , C07K14/21 , C07K14/22 , C07K14/245 , C07K14/285 , C07K14/31 , C07K2319/00 , C12N7/00 , C12N2710/16222 , C12N2730/10122 , C12N2740/13022 , C12N2740/14022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2740/17022 , C12N2760/16122 , C12N2760/18022 , C12N2760/18122 , C12N2760/18422 , C12N2760/18522 , C12N2760/18622 , C12N2760/18722 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , Y10S530/826
摘要： The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP178 (SEQ ID:1) peptide corresponding to amino acids 638 to 673 of the HIV-1LAI gp41 protein, and fragments, analogs and homologs of DP178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
摘要翻译：本发明涉及显示出有力的抗逆转录病毒活性的肽。本发明的肽包含对应于HIV-1细胞gp41蛋白的氨基酸638至673的DP178（SEQ ID：1）肽以及DP178的片段，类似物和同系物。本发明还涉及这样的肽的用途，例如抑制人和非人类逆转录病毒，特别是HIV，向未感染细胞的传播。

8. 发明申请

US20100221264A1 Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein 有权
标题翻译：通过破坏病毒衣壳间隔肽1蛋白的加工来抑制HIV-1复制
公开(公告)号：US20100221264A1
公开(公告)日：2010-09-02
申请号：US12498157
申请日：2009-07-06
申请人： Karl Salzwedel , Feng Li , Carl T. Wild , Graham P. Allaway , Eric O. Freed
发明人： Karl Salzwedel , Feng Li , Carl T. Wild , Graham P. Allaway , Eric O. Freed
IPC分类号： A61K39/395 , A61K31/655 , A61K38/16 , A61P31/18 , A61K31/56
CPC分类号： A61K45/06 , A61K31/56 , C07K14/005 , C12N2740/16043 , C12N2740/16222 , G01N2333/161 , A61K2300/00
摘要： Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to the Gag proteolytic cleavage site rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.
摘要翻译：公开了通过破坏来自CA-间隔肽1（SP1）蛋白前体（p25）的病毒Gag衣壳（CA）蛋白（p24））的加工来抑制HIV-1复制。含有Gag p25蛋白突变的氨基酸序列，突变导致二甲基琥珀酰桦树酸或二甲基琥珀酰基桦木醇处理p25至p24的抑制作用降低，编码这种突变序列的多核苷酸和选择性结合这种突变序列的抗体是也包括在内。包括抑制，抑制化合物的方法和发现靶向HIV Gag蛋白的蛋白水解加工的抑制性化合物的方法。在一个实施方案中，这样的化合物通过结合Gag蛋白水解切割位点而不是蛋白酶抑制HIV蛋白酶与Gag的相互作用。在另一个实施方案中，在Gag蛋白水解切割位点区域中含有突变的病毒或重组蛋白质可用于筛选测定以鉴定靶向蛋白水解加工的化合物。

9. 发明申请

US20080233559A1 Inhibition of HIV-1 Replication by Disruption of the Processing of the Viral Capsid-Spacer Peptide 1 Protein 审中-公开
标题翻译：通过破坏病毒衣壳间隔肽1蛋白的加工来抑制HIV-1复制
公开(公告)号：US20080233559A1
公开(公告)日：2008-09-25
申请号：US11962315
申请日：2007-12-21
申请人： Karl SALZWEDEL , Feng Li , Carl T. Wild , Graham P. Allaway , Eric O. Freed
发明人： Karl SALZWEDEL , Feng Li , Carl T. Wild , Graham P. Allaway , Eric O. Freed
IPC分类号： C12Q1/70
CPC分类号： A61K31/215 , A61K31/56 , A61K31/567 , A61K45/06 , C07K14/005 , C12N2740/16043 , C12N2740/16222 , G01N33/56988 , G01N2333/161 , A61K2300/00
摘要： Inhibition of HIV-1 replication by disrupting the processing of the viral Gag capsid (CA) protein (p24) from the CA-spacer peptide 1 (SP1) protein precursor (p25) is disclosed. Amino acid sequences containing a mutation in the Gag p25 protein, with the mutation resulting in a decrease in the inhibition of processing of p25 to p24 by dimethylsuccinyl betulinic acid or dimethylsuccinyl betulin, polynucleotides encoding such mutated sequences and antibodies that selectively bind such mutated sequences are also included. Methods of inhibiting, inhibitory compounds and methods of discovering inhibitory compounds that target proteolytic processing of the HIV Gag protein are included. In one embodiment, such compounds inhibit the interaction of the HIV protease enzyme with Gag by binding to Gag rather than to the protease enzyme. In another embodiment, viruses or recombinant proteins that contain mutations in the region of the Gag proteolytic cleavage site can be used in screening assays to identify compounds that target proteolytic processing.
摘要翻译：公开了通过破坏来自CA-间隔肽1（SP1）蛋白前体（p25）的病毒Gag衣壳（CA）蛋白（p24））的加工来抑制HIV-1复制。含有Gag p25蛋白突变的氨基酸序列，突变导致二甲基琥珀酰桦树酸或二甲基琥珀酰基桦木醇处理p25至p24的抑制作用降低，编码这种突变序列的多核苷酸和选择性结合这种突变序列的抗体是也包括在内。包括抑制，抑制化合物的方法和发现靶向HIV Gag蛋白的蛋白水解加工的抑制性化合物的方法。在一个实施方案中，这些化合物通过结合Gag而不是蛋白酶抑制HIV蛋白酶与Gag的相互作用。在另一个实施方案中，在Gag蛋白水解切割位点区域中含有突变的病毒或重组蛋白质可用于筛选测定以鉴定靶向蛋白水解加工的化合物。

10. 发明授权

US06573078B1 Compounds which inhibit HIV replication 失效
标题翻译：抑制HIV复制的化合物
公开(公告)号：US06573078B1
公开(公告)日：2003-06-03
申请号：US08464003
申请日：1995-06-02
申请人： Carl T. Wild , Thomas J. Matthews , Dani P. Bolognesi
发明人： Carl T. Wild , Thomas J. Matthews , Dani P. Bolognesi
IPC分类号： C12N508
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16122 , C12N2760/16022 , C12N2760/18522 , Y10S530/806
摘要： This invention relates to human immunodeficiency virus (HIV) protein fragments which have antiviral activity, and particularly relates to HIV peptides derived from the HIV transmembrane glycoprotein (gp41) which inhibit HIV-induced cell-cell fusion. This invention further relates to methods for the inhibition of enveloped viral infection, and to methods that modulate biochemical processes which involve coiled coil peptide interactions.
摘要翻译：本发明涉及具有抗病毒活性的人类免疫缺陷病毒（HIV）蛋白质片段，特别涉及抑制HIV诱导的细胞 - 细胞融合的HIV跨膜糖蛋白（gp41）的HIV肽。本发明还涉及抑制包膜病毒感染的方法，以及调节涉及卷曲螺旋肽相互作用的生化过程的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式