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1. 发明申请

US20120136334A1 Delivery of Two or More Medicaments Through a Single Dose Selection and Dispense Interface 有权
标题翻译：通过单剂量选择和分配接口交付两种或更多种药物
公开(公告)号：US20120136334A1
公开(公告)日：2012-05-31
申请号：US13375525
申请日：2010-06-01
申请人： Daneil Thomas De Sausmarez Lintell , Malcolm Stanley Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall , Jay Graham , Ross Douglas Laurie MacArthur , Michael James Heald , Christopher James Smith , Elliot Lucas Ortiz
发明人： Daneil Thomas De Sausmarez Lintell , Malcolm Stanley Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall , Jay Graham , Ross Douglas Laurie MacArthur , Michael James Heald , Christopher James Smith , Elliot Lucas Ortiz
IPC分类号： A61M5/31
CPC分类号： A61M5/2448 , A61M5/2455 , A61M5/31551 , A61M5/31561 , A61M5/3294 , A61M2005/1787 , A61M2005/3142
摘要： An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).
摘要翻译：一种用于共同递送具有药物输送装置（2）的两种药物（1,2）的注射系统，所述药物输送装置（7）包含含有第一药剂（1）并具有第二储存器（5,17,30）的主储存器，第二药物（2），其中药物递送装置（7）仅具有用于主储存器（11）的一个剂量设定器（12）并且自动确定第二药剂（2）的剂量。两种药物（1,2）都通过一个分配界面（3,16,21,31）进行输送。

2. 发明授权

US09592342B2 Delivery of two or more medicaments through a single dose selection and dispense interface 有权
标题翻译：通过单剂量选择和分配界面递送两种或更多种药物
公开(公告)号：US09592342B2
公开(公告)日：2017-03-14
申请号：US13375525
申请日：2010-06-01
申请人： Daniel Thomas De Sausmarez Lintell , Malcolm Stanley Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall , Jay Graham , Ross Douglas Laurie MacArthur , Michael James Heald , Christopher James Smith , Elliot Lucas Ortiz
发明人： Daniel Thomas De Sausmarez Lintell , Malcolm Stanley Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall , Jay Graham , Ross Douglas Laurie MacArthur , Michael James Heald , Christopher James Smith , Elliot Lucas Ortiz
IPC分类号： A61M5/31 , A61M5/24 , A61M5/32 , A61M5/315 , A61M5/178
CPC分类号： A61M5/2448 , A61M5/2455 , A61M5/31551 , A61M5/31561 , A61M5/3294 , A61M2005/1787 , A61M2005/3142
摘要： An injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (7) containing a primary reservoir (11) containing a first medicament (1) and having a secondary reservoir (5, 17, 30) containing a second medicament (2) where the drug delivery device (7) has only one dose setter (12) for the primary reservoir (11) and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface (3, 16, 21, 31).
摘要翻译：一种用于共同递送具有药物输送装置（2）的两种药物（1,2）的注射系统，所述药物输送装置（7）包含含有第一药剂（1）并具有第二储存器（5,17,30）的主储存器，第二药物（2），其中药物递送装置（7）仅具有用于主储存器（11）的一个剂量设定器（12）并且自动确定第二药剂（2）的剂量。两种药物（1,2）都通过一个分配界面（3,16,21,31）进行输送。

3. 发明申请

US20130253441A1 Drug Delivery Device and Method for Sequentially Delivering at Least Two Medicaments 审中-公开
标题翻译：药物递送装置和方法，用于连续递送至少两种药物
公开(公告)号：US20130253441A1
公开(公告)日：2013-09-26
申请号：US13989361
申请日：2011-11-28
申请人： Carmen Patricia Keating , Malcolm Stanley Boyd , David Martin Leak , David Sanders , Elizabeth Anne Marshall , David Aubrey Plumptre
发明人： Carmen Patricia Keating , Malcolm Stanley Boyd , David Martin Leak , David Sanders , Elizabeth Anne Marshall , David Aubrey Plumptre
IPC分类号： A61M5/19 , A61M5/315
CPC分类号： A61M5/19 , A61M5/31548
摘要： Various examples of a drug delivery device and corresponding method for sequentially delivering at least two medicaments via a single dispense interface are provided. In one example, the device includes a variable dose setting mechanism operably connected to a first cartridge containing a first medicament, a fixed dose setting mechanism operably connected to a second cartridge containing a second medicament, a dose setter for setting a user settable dose of the first medicament and a fixed dose of the second medicament, and a connecting feature for detachably connecting the variable dose setting mechanism to the fixed dose setting mechanism. During setting of the fixed dose of the second medicament, the rotationally driven variable dose setting mechanism and the fixed dose setting mechanism are connected via the connecting feature, however, during setting of the user settable dose of the first medicament, the rotationally driven variable dose setting mechanism and the fixed dose setting mechanism are not connected.
摘要翻译：提供了药物输送装置的各种实例以及通过单个分配界面顺序递送至少两种药物的相应方法。在一个示例中，该装置包括可操作地连接到包含第一药剂的第一药筒，可操作地连接到含有第二药物的第二药筒的固定剂量设定机构的可变剂量设定机构，用于设定用户可设定剂量的剂量设定器第一药剂和固定剂量的第二药剂，以及用于将可变剂量设定机构可拆卸地连接到固定剂量设定机构的连接特征。在第二药剂的固定剂量的设定期间，旋转驱动的可变剂量设定机构和固定剂量设定机构经由连接特征连接，然而，在第一药剂的用户可设定剂量的设定期间，旋转驱动的可变剂量固定剂量设定机构无法连接。

4. 发明授权

US09457142B2 Device and method for delivery of two or more drug agents 有权
标题翻译：用于递送两种或更多种药剂的装置和方法
公开(公告)号：US09457142B2
公开(公告)日：2016-10-04
申请号：US13509603
申请日：2010-11-29
申请人： Shane Alistair Day , Daniel Thomas De Sausmarez Lintell , Steven Wimpenny , Christopher Jones , Aidan Michael O'Hare , Barry Yates , Robert Veasey , Christopher James Smith , Malcolm Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall
发明人： Shane Alistair Day , Daniel Thomas De Sausmarez Lintell , Steven Wimpenny , Christopher Jones , Aidan Michael O'Hare , Barry Yates , Robert Veasey , Christopher James Smith , Malcolm Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall
IPC分类号： A61M37/00 , A61M5/142 , A61M5/172 , A61M5/19 , A61M5/20 , A61M5/315 , A61M5/24 , A61M5/31
CPC分类号： A61M5/19 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M5/20 , A61M5/24 , A61M5/31511 , A61M5/31525 , A61M5/31546 , A61M5/31583 , A61M5/3202 , A61M5/3294 , A61M5/3295 , A61M5/347 , A61M2005/2407 , A61M2005/2411 , A61M2005/2496 , A61M2005/3126 , A61M2005/31518 , A61M2005/31588 , A61M2205/14 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/6063 , A61M2205/6072 , A61M2205/8206
摘要： A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.
摘要翻译：构造成递送至少一剂两种或更多种药物的计算机化机电药物递送装置。该装置包括控制单元。机电驱动单元可操作地联接到控制单元和用于第一药剂的主容器和用于流体试剂的第二储存器，例如液体。第二种药物。操作员界面与控制单元通信。单个分配组件被配置为与初级和次级容器流体连通。操作面板的激活设定来自主贮存器的第一剂量，并且基于第一剂量和治疗剂量分布，该控制单元构造成确定流体试剂的剂量或范围。或者，控制单元确定或计算第三药剂的剂量或范围。此外，公开了一种用于药物输送装置的分配界面。

5. 发明申请

US20120330228A1 DEVICE AND METHOD FOR DELIVERY OF TWO OR MORE DRUG AGENTS 有权
标题翻译：用于递送两种或多种药物的装置和方法
公开(公告)号：US20120330228A1
公开(公告)日：2012-12-27
申请号：US13509603
申请日：2010-11-29
申请人： Shane Alistair Day , Daniel Thomas De Sausmarez Lintell , Steven Wimpenny , Christopher Jones , Aidan Michael O'Hare , Barry Yates , Robert Veasey , Christopher James Smith , Malcolm Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall
发明人： Shane Alistair Day , Daniel Thomas De Sausmarez Lintell , Steven Wimpenny , Christopher Jones , Aidan Michael O'Hare , Barry Yates , Robert Veasey , Christopher James Smith , Malcolm Boyd , David Martin Leak , Carmen Patricia Keating , David Sanders , Elizabeth Anne Marshall
IPC分类号： A61M37/00
CPC分类号： A61M5/19 , A61M5/14244 , A61M5/14248 , A61M5/1723 , A61M5/20 , A61M5/24 , A61M5/31511 , A61M5/31525 , A61M5/31546 , A61M5/31583 , A61M5/3202 , A61M5/3294 , A61M5/3295 , A61M5/347 , A61M2005/2407 , A61M2005/2411 , A61M2005/2496 , A61M2005/3126 , A61M2005/31518 , A61M2005/31588 , A61M2205/14 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2205/6063 , A61M2205/6072 , A61M2205/8206
摘要： A computerized electro-mechanical drug delivery device configured to deliver at least one dose of two or more medicaments. The device comprises a control unit. An electro-mechanical drive unit is operably coupled to the control unit and a primary reservoir for a first medicament and a secondary reservoir for a fluid agent, e.g. a second medicament. An operator interface is in communication with the control unit. A single dispense assembly is configured for fluid communication with the primary and the secondary reservoir. Activation of the operator panel sets a first dose from the primary reservoir and based on the first dose and a therapeutic dose profile, the control unit is configured to determine a dose or range of the fluid agent. Alternatively, the control unit determines or calculates a dose or range of a third medicament. Further, a dispense interface for use with a drug delivery device is disclosed.
摘要翻译：构造成递送至少一剂两种或更多种药物的计算机化机电药物递送装置。该装置包括控制单元。机电驱动单元可操作地联接到控制单元和用于第一药剂的主容器和用于流体试剂的第二储存器，例如液体。第二种药物。操作员界面与控制单元通信。单个分配组件被配置为与初级和次级容器流体连通。操作面板的激活设定来自主贮存器的第一剂量，并且基于第一剂量和治疗剂量分布，该控制单元构造成确定流体试剂的剂量或范围。或者，控制单元确定或计算第三药剂的剂量或范围。此外，公开了一种用于药物输送装置的分配界面。

6. 发明授权

US08651338B2 Delivery of two or more medicaments through a single dose selection and single dispense interface 有权
标题翻译：通过单剂量选择和单次分配界面递送两种或多种药物
公开(公告)号：US08651338B2
公开(公告)日：2014-02-18
申请号：US13375679
申请日：2010-06-01
申请人： David Martin Leak , Malcolm Stanley Boyd , David Aubrey Plumptre , Daniel Thomas De Sausmarez Lintell , Elizabeth Anne Marshall , Christopher Smith , Elliot Lucas Ortiz
发明人： David Martin Leak , Malcolm Stanley Boyd , David Aubrey Plumptre , Daniel Thomas De Sausmarez Lintell , Elizabeth Anne Marshall , Christopher Smith , Elliot Lucas Ortiz
IPC分类号： B65D88/54 , G01F11/00 , B67D7/70
CPC分类号： A61M5/31558 , A61M5/19 , A61M5/31553 , A61M5/31561 , A61M5/31583 , A61M5/31585 , A61M5/31593
摘要： A injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (10) containing a primary reservoir containing a first medicament (1) and that has a secondary reservoir containing a second medicament (2) where the drug delivery device (10) has only one dose setter (12) for the primary reservoir and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface.
摘要翻译：一种用于共同递送具有药物递送装置（10）的两种药物（1,2）的注射系统，所述药物递送装置（10）包含含有第一药物（1）的主储存器，并且具有含有第二药物（2）的第二储存器，输送装置（10）仅具有用于主储存器的一个剂量设定器（12），并且自动确定第二药剂（2）的剂量。两种药物（1,2）均通过一个分配界面进行输送。

7. 发明申请

US20120125951A1 Delivery of Two or More Medicaments Through a Single Dose Selection and Single Dispense Interface 有权
标题翻译：通过单剂量选择和单次分配接口交付两种或更多种药物
公开(公告)号：US20120125951A1
公开(公告)日：2012-05-24
申请号：US13375679
申请日：2010-06-01
申请人： David Martin Leak , Malcolm Stanley Boyd , David Aubrey Plumptre , Daniel Thomas De Sausmarez Lintell , Elizabeth Anne Marshall , Christopher Smith , Elliot Lucas Ortiz
发明人： David Martin Leak , Malcolm Stanley Boyd , David Aubrey Plumptre , Daniel Thomas De Sausmarez Lintell , Elizabeth Anne Marshall , Christopher Smith , Elliot Lucas Ortiz
IPC分类号： G01F11/00
CPC分类号： A61M5/31558 , A61M5/19 , A61M5/31553 , A61M5/31561 , A61M5/31583 , A61M5/31585 , A61M5/31593
摘要： A injection system for co-delivery of two medicaments (1, 2) having a drug delivery device (10) containing a primary reservoir containing a first medicament (1) and that has a secondary reservoir containing a second medicament (2) where the drug delivery device (10) has only one dose setter (12) for the primary reservoir and that automatically determines the dose of the second medicament (2). Both medicaments (1, 2) are delivered through a single dispense interface.
摘要翻译：一种用于共同递送具有药物递送装置（10）的两种药物（1,2）的注射系统，所述药物递送装置（10）包含含有第一药物（1）的主储存器，并且具有含有第二药物（2）的第二储存器，输送装置（10）仅具有用于主储存器的一个剂量设定器（12），并且自动确定第二药剂（2）的剂量。两种药物（1,2）均通过一个分配界面进行输送。

8. 发明申请

US20130253440A1 Drug Delivery Device 审中-公开
标题翻译：药物输送装置
公开(公告)号：US20130253440A1
公开(公告)日：2013-09-26
申请号：US13989355
申请日：2011-11-28
申请人： Christopher James Smith , Carmen Patricia Keating , David Martin Leak , Malcolm Stanley Boyd
发明人： Christopher James Smith , Carmen Patricia Keating , David Martin Leak , Malcolm Stanley Boyd
IPC分类号： A61M5/315
CPC分类号： A61M5/31545 , A61M5/19 , A61M5/24 , A61M5/3155 , A61M5/31565 , A61M2005/1787
摘要： A drug delivery device having a dose limiting system. The drug delivery device includes a first dose setting mechanism operably coupled to a primary reservoir holding a first medicament. The first dose setting mechanism includes a first dose setter and is a variable dose setting mechanism. The device further includes a second dose setting mechanism operably coupled to a secondary reservoir holding a second medicament, and the second dose setting mechanism includes a second dose setter. Still further, the device includes a dose limiting system. The dose limiting system operably couples the variable dose setting mechanism and the fixed dose setting mechanism. Further, the dose limiting system is configured to limit a settable amount of a dose of the second medicament a user can set using the second dose setter based on an amount of a variable dose that a user sets using the first dose setter.
摘要翻译：具有剂量限制系统的药物递送装置。药物递送装置包括可操作地连接到容纳第一药物的主储器的第一剂量设定机构。第一剂量设定机构包括第一剂量设定器，是可变剂量设定机构。该装置还包括第二剂量设定机构，该第二剂量设定机构可操作地连接到容纳第二药物的次级容器，并且第二剂量设定机构包括第二剂量设定器。此外，该装置包括剂量限制系统。剂量限制系统可操作地连接可变剂量设定机构和固定剂量设定机构。此外，剂量限制系统被配置为基于用户使用第一剂量设定器设定的可变剂量的量来限制使用者可以使用第二剂量设定器设定的第二药剂的可设定量。

9. 发明授权

US09089645B2 Drug delivery device 有权
标题翻译：给药装置
公开(公告)号：US09089645B2
公开(公告)日：2015-07-28
申请号：US13885322
申请日：2011-11-28
申请人： David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
发明人： David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
IPC分类号： A61M5/00 , A61M5/19 , A61M5/315 , A61M5/20 , A61M5/34 , A61M5/178 , A61M5/24
CPC分类号： A61M5/19 , A61M5/002 , A61M5/20 , A61M5/31545 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/31563 , A61M5/31575 , A61M5/31585 , A61M5/34 , A61M2005/1787 , A61M2005/202 , A61M2005/2474
摘要： A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.
摘要翻译：具有固定剂量设定机构的药物输送装置，具有偏置元件。药物递送装置包括第一剂量设定机构，其中第一剂量设定机构可操作地连接到容纳第一药剂的主贮存器。该装置还包括可操作地耦合到第一剂量设定机构的剂量设定器。该装置还包括第二剂量设定机构，其中第二剂量设定机构可操作地连接到容纳第二药剂的二级容器。第二剂量设定机构与第一剂量设定机构机械连接，第二剂量设定机构包括偏置元件。剂量设定器被配置为设置第一药剂的可变剂量并且在活化时自动设定固定剂量的第二药剂。另外，偏置元件构造成辅助分配第二药剂。

10. 发明申请

US20130267908A1 DRUG DELIVERY DEVICE 有权
标题翻译：药物递送装置
公开(公告)号：US20130267908A1
公开(公告)日：2013-10-10
申请号：US13885322
申请日：2011-11-28
申请人： David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
发明人： David Martin Leak , Malcolm Stanley Boyd , Carmen Patricia Keating
IPC分类号： A61M5/19
CPC分类号： A61M5/19 , A61M5/002 , A61M5/20 , A61M5/31545 , A61M5/31551 , A61M5/3156 , A61M5/31561 , A61M5/31563 , A61M5/31575 , A61M5/31585 , A61M5/34 , A61M2005/1787 , A61M2005/202 , A61M2005/2474
摘要： A drug delivery device having a fixed dose setting mechanism with a biasing element. The drug delivery device includes a first dose setting mechanism, where the first dose setting mechanism is operably coupled to a primary reservoir holding a first medicament. The device also includes a dose setter operably coupled to the first dose setting mechanism. The device further includes second dose setting mechanism, where the second dose setting mechanism is operably coupled to a secondary reservoir holding a second medicament. The second dose setting mechanism is mechanically linked to the first dose setting mechanism, and the second dose setting mechanism includes a biasing element. The dose setter is configured to set a variable dose of the first medicament and automatically set a fixed dose of the second medicament upon activation. In addition, the biasing element is configured to assist with dispense of the second medicament.
摘要翻译：具有固定剂量设定机构的药物输送装置，具有偏置元件。药物递送装置包括第一剂量设定机构，其中第一剂量设定机构可操作地连接到容纳第一药剂的主贮存器。该装置还包括可操作地耦合到第一剂量设定机构的剂量设定器。该装置还包括第二剂量设定机构，其中第二剂量设定机构可操作地连接到容纳第二药剂的二级容器。第二剂量设定机构与第一剂量设定机构机械连接，第二剂量设定机构包括偏置元件。剂量设定器被配置为设置第一药剂的可变剂量并且在活化时自动设定固定剂量的第二药剂。另外，偏置元件构造成辅助分配第二药剂。

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