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1. 发明申请

WO2015191478A1 LIQUID DRUG CARTRIDGES AND ASSOCIATED DISPENSER 审中-公开
标题翻译：液体药盒及相关配药
公开(公告)号：WO2015191478A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/034746
申请日：2015-06-08
申请人： DANCE BIOPHARM INC.
发明人： STEDMAN, Benjamin , FINK, Jim , MOLLOY, Lisa , SANDER, Matt
IPC分类号： A61M11/00
CPC分类号： A61M11/007 , A61M5/3145 , A61M15/0005 , A61M15/0085 , A61M15/0086 , A61M2016/0021 , A61M2016/0027 , A61M2205/053 , A61M2205/502 , A61M2205/52 , A61M2205/75 , A61M2205/8206 , A61M2209/10
摘要： Liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a container for storing the liquid drug, an end cap having an ejection opening, a filter element, and a piston that is repositionable relative to the container to selectively eject a volume of liquid drug from the ejection opening. The filter element filters the liquid drug prior to ejection from the ejection opening. The liquid drug cartridge can be coupled with an inhaler that includes an aerosol generator. The aerosol generator includes a vibratable membrane onto which the liquid drug is ejected. The liquid drug is aerosolized by the vibration of the membrane for inhalation by a user.
摘要翻译：液体药物盒和相关联的吸入器用于递送另外一个单独剂量的雾化液体药物。药筒包括用于储存液体药物的容器，具有喷射口的端盖，过滤元件和可相对于容器重新定位的活塞，以从喷射口选择性地排出一定体积的液体药物。过滤元件在从喷射口排出之前过滤液体药物。液体药物盒可与包括气溶胶发生器的吸入器联接。气溶胶发生器包括可喷射液体药物的可振动膜。液体药物由用户的吸入膜的振动而雾化。

2. 发明申请

WO2016090291A1 INTEGRATION OF GLUCOSE DATA TO ADJUST INHALED INSULIN DOSE 审中-公开
标题翻译：葡萄糖数据的整合调整吸入胰岛素剂量
公开(公告)号：WO2016090291A1
公开(公告)日：2016-06-09
申请号：PCT/US2015/064070
申请日：2015-12-04
申请人： DANCE BIOPHARM, INC.
发明人： FINK, Jim , SHAWVER, Michael , MOLLOY, Lisa , STEDMAN, Ben
IPC分类号： A61M5/172
CPC分类号： A61M15/0066 , A61K9/0078 , A61K38/28 , A61M11/005 , A61M15/0021 , A61M15/0085 , A61M15/0091 , A61M2016/0021 , A61M2016/0039 , A61M2202/00 , A61M2205/3569 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2230/005 , A61M2230/201 , A61M2230/40
摘要： An insulin dispenser receives blood glucose readings wirelessly from a blood glucose monitor, and calculates an insulin dose based on the historical response of the particular patient to prior insulin doses. The insulin dispenser preferably nebulizes an insulin-containing fluid for inhalation by the patient.
摘要翻译：胰岛素分配器从血糖监测器无线地接收血糖读数，并且基于特定患者对先前胰岛素剂量的历史反应来计算胰岛素剂量。胰岛素分配器优选地喷雾含有胰岛素的流体以供患者吸入。

3. 发明申请

WO2015191481A1 SELF-PUNCTURING LIQUID DRUG CARTRIDGES AND ASSOCIATED DISPENSER 审中-公开
标题翻译：自我补液液体药盒及相关配方
公开(公告)号：WO2015191481A1
公开(公告)日：2015-12-17
申请号：PCT/US2015/034752
申请日：2015-06-08
申请人： DANCE BIOPHARM INC.
发明人： STEDMAN, Benjamin , FINK, Jim , MOLLOY, Lisa
IPC分类号： A61M5/315
CPC分类号： A61M11/007 , A61M5/3145 , A61M15/0005 , A61M15/0085 , A61M15/0086 , A61M2016/0021 , A61M2016/0027 , A61M2205/053 , A61M2205/502 , A61M2205/52 , A61M2205/75 , A61M2205/8206 , A61M2209/10
摘要： Self-puncturing liquid drug cartridges and an associated inhaler are used to deliver one more separate doses of an aerosolized liquid drug. A cartridge includes a needle assembly coupled to a drug container. The needle assembly includes a hollow needle and is reconfigurable from a first configuration to a second configuration upon insertion of the cartridge into the inhaler. In the first configuration, the hollow needle does not extend into the container. In the second configuration, the hollow needle extends into the container. The inhaler includes an aerosol generator that includes a vibratable membrane that aerosolizes liquid drug ejected from the cartridge for inhalation by a patient.
摘要翻译：自我穿刺液体药物药筒和相关联的吸入器用于递送另外一个单独剂量的雾化液体药物。药筒包括联接到药物容器的针组件。针组件包括中空针，并且在将药筒插入吸入器中时可从第一配置重新配置到第二配置。在第一构造中，中空针不延伸到容器中。在第二构造中，中空针延伸到容器中。吸入器包括气溶胶发生器，其包括可振动膜，其使从药筒喷出的液体药物雾化，由患者吸入。

4. 发明申请

WO2014172455A1 LIQUID DISPENSING AND METHODS FOR DISPENSING LIQUIDS 审中-公开
标题翻译：液体分配和分配液体的方法
公开(公告)号：WO2014172455A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034356
申请日：2014-04-16
申请人： DANCE BIOPHARM INC.
发明人： PATTON, John S. , PATTON, Ryan S. , MOLLOY, Lisa , FINK, Jim
IPC分类号： A61J1/20 , A61J1/22 , A61M15/00 , B65D83/42
CPC分类号： A61M15/0065 , A61M15/0085 , A61M2202/0468 , B05B11/0059
摘要： A dispenser for supplying a metered volume of a liquid medicament to an aerosolizing device. The dispenser may include a container having a proximal end and a distal end, wherein the container is configured to store a volume of liquid medicament. The dispenser may also include a dispensing mechanism coupled to the distal end of the container. The dispensing mechanism may have a distal end terminating in a tip through which the liquid medicament is dispensed. The dispensing mechanism operates to dispense a metered volume of the liquid medicament from the tip each time the dispensing mechanism is operated. The distal end of the dispensing mechanism includes an interface that interacts with a housing of an inhaler to limit an insertion depth of the tip into an opening the housing.
摘要翻译：一种用于将计量体积的液体药物供应到雾化装置的分配器。分配器可以包括具有近端和远端的容器，其中容器构造成存储一定体积的液体药物。分配器还可以包括联接到容器的远端的分配机构。分配机构可以具有终止于尖端的远端，液体药物通过该尖端被分配。分配机构用于每次分配机构操作时从尖端分配计量体积的液体药物。分配机构的远端包括与吸入器的壳体相互作用以将尖端的插入深度限制到壳体的开口中的界面。

5. 发明申请

WO2016003739A1 AEROSOLIZATION SYSTEM WITH FLOW RESTRICTOR AND FEEDBACK DEVICE 审中-公开
标题翻译：具有流量限制器和反馈装置的气化系统
公开(公告)号：WO2016003739A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/037505
申请日：2015-06-24
申请人： DANCE BIOPHARM INC.
发明人： FINK, Jim , MOLLOY, Lisa , MACLOUGHLIN, Ronan , LILLIS, Claire Elizabeth , CASEY, Michael Joseph , MULLINS, John Matthew , HYLAND, Kieran James , GREHAN, Joseph Martin
IPC分类号： B05B1/08
CPC分类号： A61M15/002 , A61M11/005 , A61M15/0021 , A61M15/0085 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2205/3331 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/584 , A61M2205/6018 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2206/11
摘要： In one aspect, embodiments of the present invention provide an aerosolization device for ensuring proper delivery of an aerosolized medication to a user's respiratory system. The aerosolization device may include a conduit, an aerosol generator, a restrictor disposed within the conduit, and an indicator mechanism. The conduit may include a mouthpiece end by which a user may cause inspiratory flow through the conduit. The aerosol generator may include a vibratable mesh. The restrictor may define a plurality of apertures disposed along an outer periphery of the restrictor configured to provide an increase in pressure differential that varies with an inspiratory flow rate within the conduit and to provide a relatively laminar flow downstream of the restrictor compared to upstream of the restrictor. The indicator mechanism may indicate to a user a state of a parameter of the inspiratory flow relative to a predefined desired range.
摘要翻译：在一个方面，本发明的实施例提供了一种用于确保将雾化药物正确递送到使用者的呼吸系统的雾化装置。雾化装置可以包括导管，气溶胶发生器，设置在导管内的限流器和指示器机构。导管可以包括接口端，用户可以通过该接口端引起吸气流过导管。气溶胶发生器可以包括可振动网。限流器可以限定沿着节流器的外周设置的多个孔，其被配置为提供随着管道内的吸气流速而变化的压差的增加，并且与限流器的上游相比提供了限流器下游的相对层流限流器。指示器机构可以向用户指示相对于预定义的期望范围的吸气流的参数的状态。

6. 发明申请

WO2016003738A1 LIQUID NEBULIZATION SYSTEMS AND METHODS 审中-公开
标题翻译：液体渗透系统和方法
公开(公告)号：WO2016003738A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/037502
申请日：2015-06-24
申请人： DANCE BIOPHARM INC.
发明人： FINK, Jim , MOLLOY, Lisa , MACLOUGHLIN, Ronan , LILLIS, Clair Elizabeth , CASEY, Michael Joseph , MULLINS, John Matthew , HYLAND, Kieran James , GREHAN, Joseph Martin , SMITH, Niall Scott
IPC分类号： B05B1/08
CPC分类号： A61M15/0021 , A61M11/005 , A61M15/002 , A61M15/0085 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2205/3331 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/582 , A61M2205/584 , A61M2205/6018 , A61M2205/6054 , A61M2205/6072 , A61M2205/8206 , A61M2206/11
摘要： Embodiments provide aerosolization device for providing aerosolized medicament to user. The aerosolization device includes conduit, aerosol generator, fluid receiving chamber, restrictor within the conduit, and indicator mechanism. Conduit has an inner wall and a mouthpiece end for causing an inspiratory flow. Aerosol generator includes a vibratable mesh laterally offset from the inner wall. Fluid receiving chamber receives liquid medicament. At least a portion of chamber is tapered such that liquid medicament is directed onto vibratable mesh for aerosolization. Restrictor defines a plurality of apertures that provide increases in pressure differential that vary with inspiratory flow rate within conduit and provide relatively laminar flow downstream of restrictor. Indicator mechanism indicates a state of flow parameters relative to a predefined range. Aerosol generator is configured to aerosolize at least a portion of liquid medicament only when flow parameters of the inspiratory flow are within range.
摘要翻译：实施例提供了用于向使用者提供气雾化药物的雾化装置。雾化装置包括导管，气溶胶发生器，流体接收室，导管内的限流器和指示器机构。导管具有用于引起吸气流动的内壁和接口端。气溶胶发生器包括从内壁横向偏移的可振动网。流体接收室接收液体药物。室的至少一部分是锥形的，使得液体药物被引导到用于雾化的可振动网。限制器限定多个孔，其提供随着管道内的吸气流速而变化的压差增加，并且在节流器下游提供相对层流。指示器机构指示相对于预定义范围的流量参数的状态。气溶胶发生器被配置成仅当吸气流量的流动参数在范围内时才雾化至少一部分液体药物。

7. 发明授权

EP2986268B1 LIQUID DISPENSING 有权
公开(公告)号：EP2986268B1
公开(公告)日：2019-05-22
申请号：EP14785659.5
申请日：2014-04-16
申请人： Dance Biopharm Inc.
发明人： PATTON, John S. , PATTON, Ryan S. , MOLLOY, Lisa , FINK, Jim
IPC分类号： A61J1/20 , A61J1/22 , A61M15/00 , B65D83/42 , B05B11/00

8. 发明公开

EP3164221A1 LIQUID NEBULIZATION SYSTEMS AND METHODS 有权
标题翻译：液体雾化系统和方法
公开(公告)号：EP3164221A1
公开(公告)日：2017-05-10
申请号：EP15814884.1
申请日：2015-06-24
申请人： Dance Biopharm Inc.
发明人： FINK, Jim , MOLLOY, Lisa , MACLOUGHLIN, Ronan , LILLIS, Clair Elizabeth , CASEY, Michael Joseph , MULLINS, John Matthew , HYLAND, Kieran James , GREHAN, Joseph Martin , SMITH, Niall Scott
IPC分类号： B05B1/08
摘要： Embodiments provide aerosolization device for providing aerosolized medicament to user. The aerosolization device includes conduit, aerosol generator, fluid receiving chamber, restrictor within the conduit, and indicator mechanism. Conduit has an inner wall and a mouthpiece end for causing an inspiratory flow. Aerosol generator includes a vibratable mesh laterally offset from the inner wall. Fluid receiving chamber receives liquid medicament. At least a portion of chamber is tapered such that liquid medicament is directed onto vibratable mesh for aerosolization. Restrictor defines a plurality of apertures that provide increases in pressure differential that vary with inspiratory flow rate within conduit and provide relatively laminar flow downstream of restrictor. Indicator mechanism indicates a state of flow parameters relative to a predefined range. Aerosol generator is configured to aerosolize at least a portion of liquid medicament only when flow parameters of the inspiratory flow are within range.
摘要翻译：实施例提供用于向使用者提供雾化药物的雾化装置。雾化装置包括导管，气溶胶发生器，流体接收室，导管内的限流器和指示器机构。导管有一个内壁和一个吸嘴端，用于引起吸气流。气溶胶发生器包括从内壁横向偏移的可振动网。流体接收室接收液体药物。腔室的至少一部分是锥形的，使得液体药剂被引导到可振动网上用于雾化。限流器限定多个孔，其提供随着管道内的吸气流率而变化的压差增大并且提供限流器下游的相对层流。指示器机制指示相对于预定范围的流量参数的状态。气溶胶发生器构造成仅当吸气流量的流量参数在范围内时才使至少一部分液体药剂雾化。

9. 发明授权

EP3151891B1 LIQUID DRUG CARTRIDGES AND ASSOCIATED DISPENSER 有权
公开(公告)号：EP3151891B1
公开(公告)日：2020-01-15
申请号：EP15806485.7
申请日：2015-06-08
申请人： Dance BioPharm Inc.
发明人： STEDMAN, Benjamin , FINK, Jim , MOLLOY, Lisa , SANDER, Matt
IPC分类号： A61M5/31 , A61M11/00 , A61M15/00

10. 发明公开

EP2986268A1 LIQUID DISPENSING AND METHODS FOR DISPENSING LIQUIDS 审中-公开
标题翻译：液体分配和液体分配方法
公开(公告)号：EP2986268A1
公开(公告)日：2016-02-24
申请号：EP14785659.5
申请日：2014-04-16
申请人： Dance Biopharm Inc.
发明人： PATTON, John S. , PATTON, Ryan S. , MOLLOY, Lisa , FINK, Jim
IPC分类号： A61J1/20 , A61J1/22 , A61M15/00 , B65D83/42
CPC分类号： A61M15/0065 , A61M11/005 , A61M15/0085 , A61M2202/0468 , A61M2207/00 , A61M2209/045 , B05B11/0037 , B05B11/00444 , B05B17/0646
摘要： A dispenser for supplying a metered volume of a liquid medicament to an aerosolizing device. The dispenser may include a container having a proximal end and a distal end, wherein the container is configured to store a volume of liquid medicament. The dispenser may also include a dispensing mechanism coupled to the distal end of the container. The dispensing mechanism may have a distal end terminating in a tip through which the liquid medicament is dispensed. The dispensing mechanism operates to dispense a metered volume of the liquid medicament from the tip each time the dispensing mechanism is operated. The distal end of the dispensing mechanism includes an interface that interacts with a housing of an inhaler to limit an insertion depth of the tip into an opening the housing.
摘要翻译：用于将计量体积的液体药剂供应到雾化装置的分配器。分配器可以包括具有近端和远端的容器，其中容器构造成存储一定体积的液体药物。分配器还可以包括联接到容器的远端的分配机构。分配机构可以具有终止于尖端的远端，液体药剂通过该尖端被分配。每次分配机构被操作时，分配机构操作以从尖端分配计量体积的液体药物。分配机构的远端包括界面，该界面与吸入器的壳体相互作用以限制尖端插入壳体的开口中的插入深度。

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