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    • 7. 发明申请
    • Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein
    • 三维体外脊髓模型及其分析物质分布的方法
    • US20050106545A1
    • 2005-05-19
    • US10957359
    • 2004-10-01
    • Kenneth HeruthMark LentMichael Hegland
    • Kenneth HeruthMark LentMichael Hegland
    • G09B23/28G09B23/30G09B23/34
    • G09B23/34B33Y50/00B33Y80/00G09B23/30
    • An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticum of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
    • 人体脊柱体外模型装置及其中物质分布模式的检测和分析方法。 在一个实施例中,模型设备包括定义通道的柱体,该通道基本上模拟成年人脊柱的尺寸,形状和结构。 还包括可以位于和锚定在通道内的绳索结构。 帘线结构基本上模仿成年人脊髓的尺寸,形状和结构。 例如,绳索结构可以包括类似神经根,齿状韧带和人脊柱的隔膜的连接元件。 模型装置的通道可以填充有模拟脑脊液(CSF)的第一流体,并且可以将含有药物(或模拟药物)的第二流体引入通道中,之后药物在通道内的分布 可以分析。
    • 9. 发明授权
    • Three-dimensional in-vitro spinal models and methods of analyzing substance distribution therein
    • 三维体外脊髓模型及其分析物质分布的方法
    • US07403883B2
    • 2008-07-22
    • US10957359
    • 2004-10-01
    • Kenneth T. HeruthMark S. LentMichael Hegland
    • Kenneth T. HeruthMark S. LentMichael Hegland
    • G06G7/58
    • G09B23/34B33Y50/00B33Y80/00G09B23/30
    • An in-vitro model apparatus of a human spine and methods for detecting and analyzing substance distribution patterns therein. In one embodiment, the model apparatus includes a column body defining a passageway that substantially mimics the size, shape, and structure of an adult human spinal canal. Also included is a cord structure that may be located and anchored within the passageway. The cord structure substantially mimics the size, shape, and structure of an adult human spinal cord. For example, the cord structure may include connecting elements that resemble nerve roots, dentate ligaments, and the septum posticum of a human spine. The passageway of the model apparatus may be filled with a first fluid that simulates cerebro-spinal fluid (CSF), and a second fluid containing a drug (or simulated drug) may be introduced into the passageway, after which the drug's distribution within the passageway may be analyzed.
    • 人体脊柱体外模型装置及其中物质分布模式的检测和分析方法。 在一个实施例中,模型设备包括定义通道的柱体,该通道基本上模拟成年人脊柱的尺寸,形状和结构。 还包括可以位于和锚定在通道内的绳索结构。 帘线结构基本上模仿成年人脊髓的尺寸,形状和结构。 例如,绳索结构可以包括类似神经根,齿状韧带和人脊柱的隔膜的连接元件。 模型装置的通道可以填充有模拟脑脊液(CSF)的第一流体,并且可以将含有药物(或模拟药物)的第二流体引入通道中,之后药物在通道内的分布 可以分析。