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1. 发明专利

JP2008237750A Method for evaluating respirator sensitization nature 有权
标题翻译：评估呼吸机感光度自然的方法
公开(公告)号：JP2008237750A
公开(公告)日：2008-10-09
申请号：JP2007085784
申请日：2007-03-28
申请人： Daicel Chem Ind Ltd , Kagoshima Univ , ダイセル化学工業株式会社 , 国立大学法人鹿児島大学
发明人： UEMORI KENJI , YAMAGISHI MANABU , AOYAMA KIMIHARU
IPC分类号： A61B10/00
摘要： PROBLEM TO BE SOLVED: To provide a sensitization nature evaluation method of easily and objectively evaluating the strength of a respirator sensitization nature at the time when chemical substances and natural substances directly reach a trachea or a lung.
SOLUTION: The sensitization nature evaluation method is to relatively evaluate the strength of the respirator sensitization nature by quantifying the respirator sensitization symptoms, and after a known respirator sensitization substance and a test substance are directly administrated in a trachea of a small animal with different concentrations, the respirator sensitization symptoms induced in the trachea or the lung of the small animal are quantitively measured with at least a method chosen from the scoring of histological findings, measurement of allergic inflammation cell number, quantification of cytokine, and quantification of antibodies, and then the obtained measurement results are relatively compared between the test substance and the standard substance to determine the respirator sensitization nature of the test substance.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种致敏性评估方法，其在化学物质和天然物质直接到达气管或肺部时容易客观地评估呼吸机致敏性的强度。敏感性评价方法是通过量化呼吸器敏化症状来相对评价呼吸机致敏性的强度，在将已知的呼吸器敏化物质和试验物质直接施用于小动物的气管中后，使用至少一种选自组织学发现评估，过敏性炎症细胞数量测定，细胞因子定量和抗体定量的方法定量测量小动物气管或肺中诱发的呼吸器致敏症状，然后将测试物质与标准物质进行相对比较，从而确定测试物质的呼吸器敏化性质。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2006136432A Method for evaluating respirator sensitization nature 有权
标题翻译：评估呼吸机感光度自然的方法
公开(公告)号：JP2006136432A
公开(公告)日：2006-06-01
申请号：JP2004327125
申请日：2004-11-10
申请人： Daicel Chem Ind Ltd , Kagoshima Univ , ダイセル化学工業株式会社 , 国立大学法人鹿児島大学
发明人： YAMASHITA KUNIHIKO , YAMAGISHI MANABU , AOYAMA KIMIHARU
IPC分类号： A61B5/08
摘要： PROBLEM TO BE SOLVED: To provide a sensitization nature evaluation method easily and quantitatively evaluating a respirator sensitization nature at the time when chemical substances, natural substances or others directly reach a trachea or a lung using small animals. SOLUTION: The sensitization nature evaluation method is characterized by that a living body section in the trachea or the lung is evaluated by directly administering a sample of 100 μl or less per one time into the trachea of the small animals of a body weight of 70 g or less. In the sensitization nature evaluation method, it is preferable to directly administering the sample inside of the trachea at the stage of sensitization and/or the stage of induction. Mouses may be used as the small animals. In the method of the invention, the mouth is opened using a mouth opening holding means capable of holding the mouth opening condition of the small animal, a sample administering means is inserted from the mouth of the small animal, and the sample is directly administered inside of the trachea through a pharyngeal portion. COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了在化学物质，天然物质或其它物质直接通过小动物直接到达气管或肺部时，提供致敏性评价方法，容易且定量地评价呼吸器致敏性。敏感性评价方法的特征在于，通过将每次100μl以下的样品直接施用到体重小的动物的气管中来评价气管或肺中的活体部分为70g以下。在敏化性评价方法中，优选在致敏阶段和/或诱导阶段直接给予气管内的样品。鼠标可能被用作小动物。在本发明的方法中，使用能够保持小动物的开口状态的开口保持装置打开口，从小动物的口插入样本给药装置，并将样品直接内部的气管通过咽部。版权所有（C）2006，JPO＆NCIPI

3. 发明专利

JP2006136348A Endotracheal sample administration aid for small animal 有权
标题翻译：用于小动物的内部样品管理辅助
公开(公告)号：JP2006136348A
公开(公告)日：2006-06-01
申请号：JP2004325878
申请日：2004-11-10
申请人： Daicel Chem Ind Ltd , Kagoshima Univ , ダイセル化学工業株式会社 , 国立大学法人鹿児島大学
发明人： YAMAGISHI MANABU , AOYAMA KIMIHARU
IPC分类号： A61D7/00 , A61C17/08 , A61D15/00 , A61M31/00
摘要： PROBLEM TO BE SOLVED: To provide an endotracheal sample administration aid for a small animal, capable of being safely inserted into the oral cavity of the small animal and directly administering a prescribed quantity of a sample to the trachea.
SOLUTION: This endotracheal sample administration aid for the small animal is the endotracheal sample administration aid used when the sample is administered from inside the oral cavity of the small animal to the entrance of the trachea. The endotracheal sample administration aid is characterized by a mouth opener in the shape of a truncated cone with both ends opened for keeping the mouth of the small animal in the opened state by inserting a small-diameter end into the mouth of the small animal, a saliva removing means for removing the saliva from inside the oral cavity of the small animal, and a light source for illuminating the inside of the oral cavity of the small animal. The endotracheal sample administration aid for the small animal may also have an enlarged observation means permitting enlarged observation of the entrance of the trachea in the oral cavity of the small animal.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为小动物提供气管内样品给药辅助剂，能够安全地插入小动物的口腔中，并直接向气管施用规定量的样品。解决方案：小型动物的气管内样品给药辅助剂是当样本从小动物的口腔内进入气管入口时使用的气管内样品给药辅助剂。气管内样品给药辅助剂的特征在于开口器的形状为截头圆锥形，其两端开口，用于通过将小直径端插入小动物的口中来保持小动物的嘴部处于打开状态，用于从小动物的口腔内部排出唾液的唾液去除装置和用于照射小动物口腔内部的光源。用于小动物的气管内样品给药辅助剂也可以具有扩大的观察装置，允许在小动物的口腔中扩大观察气管入口。版权所有（C）2006，JPO＆NCIPI

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