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1. 发明申请

US20110029069A1 Bioactive Material Coating Method And Tube 有权
标题翻译：生物活性材料涂层方法和管
公开(公告)号：US20110029069A1
公开(公告)日：2011-02-03
申请号：US12866235
申请日：2009-01-19
申请人： Dae-Joong Kim , In-Su Baek , Jong-Sang Park , Hye-Yeong Nam , Chengzhe Bai
发明人： Dae-Joong Kim , In-Su Baek , Jong-Sang Park , Hye-Yeong Nam , Chengzhe Bai
IPC分类号： A61F2/01 , B05D7/00
CPC分类号： A61L27/507 , A61L27/16 , A61L27/54 , A61L27/56 , A61L2300/416 , A61L2420/02 , A61M1/3655 , C08L27/18
摘要： A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.
摘要翻译：公开了一种用于涂覆生物活性材料和涂覆有生物活性材料的结构的方法。生物活性物质涂布方法包括：将作为生物活性物质生产的涂布溶液溶解在具有内腔的结构内的混合溶剂中; 以及在所述结构的内表面和外表面中的至少一个上以不同的浓度涂覆所述生物活性材料。将混合溶剂与具有不同特征的两种或更多种溶剂混合。可以减少血管和炎症的窒息的发生。肌成纤维细胞的大小的增加不被抑制。将药物溶解在混合溶剂中时，制成涂布溶液，混合溶剂作为极性溶剂和非极性溶剂以一定的比例混合。

2. 发明授权

US08075940B2 Bioactive material coating method and tube 有权
标题翻译：生物活性材料涂层方法和管
公开(公告)号：US08075940B2
公开(公告)日：2011-12-13
申请号：US12866235
申请日：2009-01-19
申请人： Dae-Joong Kim , In-Su Baek , Jong-Sang Park , Hye-Yeong Nam , Chengzhe Bai
发明人： Dae-Joong Kim , In-Su Baek , Jong-Sang Park , Hye-Yeong Nam , Chengzhe Bai
IPC分类号： A61L33/00
CPC分类号： A61L27/507 , A61L27/16 , A61L27/54 , A61L27/56 , A61L2300/416 , A61L2420/02 , A61M1/3655 , C08L27/18
摘要： A method for coating bioactive material and a structured coated with a bioactive material are disclosed. The bioactive material coating method includes: flowing a coating solution, produced as a bioactive material is dissolved in a mixed solvent, inside a structure having a lumen; and coating the bioactive material on at least one of inner and outer surfaces of the structure, with different concentrations. The mixed solvent is mixed with two or more solvents having different features. The occurrence of the strangulation of blood vessels and inflammation can be reduced. An increase in the size of the myofibroblast is not suppressed. The coating solution is produced as a medication is dissolved in a mixed solvent, where the mixed solvent is produced as a polar solvent and a nonpolar solvent are mixed with each other at a certain ratio.
摘要翻译：公开了一种用于涂覆生物活性材料和涂覆有生物活性材料的结构的方法。生物活性物质涂布方法包括：将作为生物活性物质生产的涂布溶液溶解在具有内腔的结构内的混合溶剂中; 以及在所述结构的内表面和外表面中的至少一个上以不同的浓度涂覆所述生物活性材料。将混合溶剂与具有不同特征的两种或更多种溶剂混合。可以减少血管和炎症的窒息的发生。肌成纤维细胞的大小的增加不被抑制。将药物溶解在混合溶剂中时，制成涂布溶液，混合溶剂是作为极性溶剂制备混合溶剂，非极性溶剂以一定比例混合。

3. 发明授权

US08399044B2 Method for coating medication on medical article 有权
标题翻译：医疗用品涂药方法
公开(公告)号：US08399044B2
公开(公告)日：2013-03-19
申请号：US12809054
申请日：2010-01-21
申请人： Jong-Sang Park , Dae-Joong Kim , In-Su Baek , Chengzhe Bai
发明人： Jong-Sang Park , Dae-Joong Kim , In-Su Baek , Chengzhe Bai
IPC分类号： A61F13/00 , A61F13/02 , A61K9/28 , A61K9/70 , A61B17/04 , A61B17/10 , A61L17/00 , A61M31/00 , B01J13/00 , B05D3/00 , B32B19/00 , D02G3/00
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/40 , Y10T428/29 , Y10T428/2913
摘要： A method for coating medication for a medical product is disclosed. A technique for coating gel in a viscous semisolid state is provided to facilitate coating of medication. Coating of medication on an article can be facilitated using gel, and coating of medication on an article such as an article made of silk and an article made of polypropylene can be further facilitated.
摘要翻译：公开了一种用于医疗产品的药物涂布方法。提供用于涂覆粘性半固体状态的凝胶的技术以便于涂覆药物。可以使用凝胶来促进制品上的药物涂层，并且可以进一步促进在诸如由丝制品制成的制品和由聚丙烯制成的制品上涂敷药物。

4. 发明申请

US20110183064A1 Method For Coating Medication On Medical Article 有权
标题翻译：医疗用涂料用药方法
公开(公告)号：US20110183064A1
公开(公告)日：2011-07-28
申请号：US12809054
申请日：2010-01-21
申请人： Jong-Sang Park , Dae-Joong Kim , In-Su Baek , Chengzhe Bai
发明人： Jong-Sang Park , Dae-Joong Kim , In-Su Baek , Chengzhe Bai
IPC分类号： A61B17/04
CPC分类号： A61B17/06166 , A61B2017/00526 , A61B2017/00893 , A61L17/005 , A61L17/145 , A61L2300/40 , Y10T428/29 , Y10T428/2913
摘要： A method for coating medication for a medical product is disclosed. A technique for coating gel in a viscous semisolid state is provided to facilitate coating of medication. Coating of medication on an article can be facilitated using gel, and coating of medication on an article such as an article made of silk and an article made of polypropylene can be further facilitated.
摘要翻译：公开了一种用于医疗产品的药物涂布方法。提供用于涂覆粘性半固体状态的凝胶的技术以便于涂覆药物。可以使用凝胶来促进制品上的药物涂层，并且可以进一步促进在诸如由丝制品制成的制品和由聚丙烯制成的制品上涂敷药物。

5. 发明申请

US20080317814A1 Tube for Connecting Marteriovenous and Interposition for Medical Operation 审中-公开
标题翻译：用于连接医疗手术的绝食和间接管
公开(公告)号：US20080317814A1
公开(公告)日：2008-12-25
申请号：US12094022
申请日：2005-11-17
申请人： Dae-Joong Kim , Chul-Soo Gim , Jai-Young Ko , Jong-Sang Park , Tae-Gun Kwon , Byung-Ha Lee , Woo-Kyung Lee , Hye-Yeong Nam , Hyun-Jung Lim
发明人： Dae-Joong Kim , Chul-Soo Gim , Jai-Young Ko , Jong-Sang Park , Tae-Gun Kwon , Byung-Ha Lee , Woo-Kyung Lee , Hye-Yeong Nam , Hyun-Jung Lim
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/06 , A61L29/16 , A61L2300/416
摘要： Disclosed herein are a tube for arteriovenous anastomosis useful in hemodialysis patients and an insert for use in medicinal operation in the body. The tube or the insert are repetitively treated with a medicament on the surface thereof, which provides stable communication between an artery and a vein of a patient under hemodialysis and can greatly reduce stenosis at arteriovenous connections by releasing the medicament at a suitable rate over a prolonged period of time.
摘要翻译：本文公开了用于血液透析患者的动静脉吻合管和用于体内药物操作的插入物。管或插入物在其表面上用药物重复地处理，其在血液透析下提供患者的动脉和静脉之间的稳定连通，并且可以通过在延长的时间内以合适的速率释放药物来大大减少动静脉连接处的狭窄一段的时间。

6. 发明授权

US07915360B2 Supported catalyst for olefin polymerization using transition metal compound having phenylene-bridge, method for preparing the same, and method for preparing polyolefin using the same 有权
标题翻译：使用具有亚苯基桥的过渡金属化合物进行烯烃聚合的负载催化剂，其制备方法以及使用其制备聚烯烃的方法
公开(公告)号：US07915360B2
公开(公告)日：2011-03-29
申请号：US12312823
申请日：2007-11-15
申请人： Dae-Sik Hong , Ki-Soo Lee , Yong-Gyu Han , Heon-Yong Kwon , Jong-Sang Park , Joon-Hee Cho , Seon-Kyoung Kim , Choong-Hoon Lee , Eun-Jung Lee , Seung-Whan Jung , Ki-Su Ro
发明人： Dae-Sik Hong , Ki-Soo Lee , Yong-Gyu Han , Heon-Yong Kwon , Jong-Sang Park , Joon-Hee Cho , Seon-Kyoung Kim , Choong-Hoon Lee , Eun-Jung Lee , Seung-Whan Jung , Ki-Su Ro
IPC分类号： C08F4/6592 , C08F4/642 , B01J31/22
CPC分类号： C08F210/16 , C08F4/65904 , C08F4/65912 , C08F2420/02 , Y10S526/943 , C08F4/6592 , C08F4/65916 , C08F210/14 , C08F2500/12 , C08F2500/03
摘要： The present invention provides a new supported catalyst for olefin polymerization prepared by reacting a novel transition metal compound on a cocatalyst-supported support, in which the transition metal compound is coordinated with a monocyclopentadienyl ligand to which an amido-quinoline group is introduced, a method for preparing the same, and a method for preparing a polyolefin using the same. The transition metal catalyst compound used in the present invention is configured such that an amido group is linked in a cyclic form via a phenylene bridge. Thus, a pentagon ring structure of the transition metal compound is stably maintained, so that monomers easily approach the transition metal compound and the reactivity is also high. Accordingly, if the supported catalyst for olefin polymerization prepared according to the present invention is applied to the copolymerization of ethylene and monomers having large steric hindrance in a slurry or a gas phase process, a linear, a linear, high molecular weight polyolefin having a very low density of 0.900 to 0.970 g/cc or less can be obtained.
摘要翻译：本发明提供了一种用于烯烃聚合的新型负载催化剂，其通过使新型过渡金属化合物在助催化剂负载的载体上反应制备，其中过渡金属化合物与引入酰胺基 - 喹啉基团的单环戊二烯基配体配位，以及制备使用该聚烯烃的聚烯烃的方法。本发明中使用的过渡金属催化剂化合物被配置成使得酰胺基通过亚苯基桥连接成环状。因此，稳定地维持过渡金属化合物的五角环结构，使得单体容易接近过渡金属化合物，反应性也高。因此，如果将根据本发明制备的用于烯烃聚合的负载型催化剂用于在浆料或气相方法中乙烯与具有大的空间位阻的单体的共聚合，则具有极性的直链，直链，高分子量的聚烯烃可以得到0.900〜0.970g / cc以下的低密度。

7. 发明申请

US20100093959A1 SUPPORTED CATALYST FOR OLEFIN POLLYMERIZATION USING TRANSITION METAL COMPOUND HAVING THENYLENE-BRIDGE, METHOD FOR PREPARING THE SAME, AND METHOD FOR PREPARING POLYOLEFINGUSINGTHED SAME 有权
标题翻译：使用具有亚戊基桥的过渡金属化合物的烯烃聚合的支持催化剂，其制备方法和制备聚烯烃的方法
公开(公告)号：US20100093959A1
公开(公告)日：2010-04-15
申请号：US12312823
申请日：2007-11-15
申请人： Dae-Sik Hong , Ki-Soo Lee , Yong-Gyu Han , Heon-Yong Kwon , Jong-Sang Park , Joon-Hee Cho , Seon-Kyoung Kim , Choong-Hoon Lee , Eun-Jung Lee , Seung-Whan Jung , Ki-Su Ro
发明人： Dae-Sik Hong , Ki-Soo Lee , Yong-Gyu Han , Heon-Yong Kwon , Jong-Sang Park , Joon-Hee Cho , Seon-Kyoung Kim , Choong-Hoon Lee , Eun-Jung Lee , Seung-Whan Jung , Ki-Su Ro
IPC分类号： C08F4/6592 , B01J31/14 , B01J37/00
CPC分类号： C08F210/16 , C08F4/65904 , C08F4/65912 , C08F2420/02 , Y10S526/943 , C08F4/6592 , C08F4/65916 , C08F210/14 , C08F2500/12 , C08F2500/03
摘要： The present invention provides a new supported catalyst for olefin polymerization prepared by reacting a novel transition metal compound on a cocatalyst-supported support, in which the transition metal compound is coordinated with a monocyclopentadienyl ligand to which an amido-quinoline group is introduced, a method for preparing the same, and a method for preparing a polyolefin using the same. The transition metal catalyst compound used in the present invention is configured such that an amido group is linked in a cyclic form via a phenylene bridge. Thus, a pentagon ring structure of the transition metal compound is stably maintained, so that monomers easily approach the transition metal compound and the reactivity is also high. Accordingly, if the supported catalyst for olefin polymerization prepared according to the present invention is applied to the copolymerization of ethylene and monomers having large steric hindrance in a slurry or a gas phase process, a linear, a linear, high molecular weight polyolefin having a very low density of 0.900 to 0.970 g/cc or less can be obtained.
摘要翻译：本发明提供了一种用于烯烃聚合的新型负载催化剂，其通过使新型过渡金属化合物在助催化剂负载的载体上反应制备，其中过渡金属化合物与引入酰胺基 - 喹啉基团的单环戊二烯基配体配位，以及制备使用该聚烯烃的聚烯烃的方法。本发明中使用的过渡金属催化剂化合物被配置成使得酰胺基通过亚苯基桥连接成环状。因此，稳定地维持过渡金属化合物的五角环结构，使得单体容易接近过渡金属化合物，反应性也高。因此，如果将根据本发明制备的用于烯烃聚合的负载型催化剂用于在浆料或气相方法中乙烯与具有大的空间位阻的单体的共聚合，则具有极性的直链，直链，高分子量的聚烯烃可以得到0.900〜0.970g / cc以下的低密度。

8. 发明授权

US08431660B2 Non-metallocene catalysts having tetrazol group for olefin polymerization and polymerizing method of olefin using the same 有权
标题翻译：具有用于烯烃聚合的四唑基的非茂金属催化剂和使用其的烯烃的聚合方法
公开(公告)号：US08431660B2
公开(公告)日：2013-04-30
申请号：US12746441
申请日：2008-12-05
申请人： Heon-Yong Kwon , Nicola Maggiarosa , Ki-Soo Lee , Min-Seok Cho , Jong-Sang Park , Joon-Hee Cho , Yong-Ho Lee , Byung-Ryul Lee , Seon-Kyoung Kim , Dae-Sik Hong
发明人： Heon-Yong Kwon , Nicola Maggiarosa , Ki-Soo Lee , Min-Seok Cho , Jong-Sang Park , Joon-Hee Cho , Yong-Ho Lee , Byung-Ryul Lee , Seon-Kyoung Kim , Dae-Sik Hong
IPC分类号： C08F4/64 , C08F4/76 , C08F4/52
CPC分类号： C08F10/02 , C07F7/003 , C08F110/02 , C08F210/16 , C08F4/642 , C08F2500/03 , C08F210/14 , C08F4/64075
摘要： The present invention provides a non-metallocene transition metal compound that is easily produced, includes a tetrazol group having the high polymerization activity and high temperature stability in the polymerization of olefins, and a catalytic composition that includes the transition metal compound and a cocatalyst. In addition, the present invention provides a method for efficiently producing an olefin homopolymer or copolymer by using the catalytic composition.
摘要翻译：本发明提供易于生产的非金属茂过渡金属化合物，包括在烯烃聚合中具有高聚合活性和高温稳定性的四唑基和包含过渡金属化合物和助催化剂的催化组合物。此外，本发明提供了通过使用催化剂组合物有效地制备烯烃均聚物或共聚物的方法。

9. 发明申请

US20100324321A1 AMINE BRIDGED METALLOCENE CATALYST, METHOD FOR PREPARING THEREOF AND METHOD FOR POLYMERIZING ETHYLENE-ALPHA OLEFIN COPOLYMER USING AMINE BRIDGED METALLOCENE CATALYST 有权
标题翻译：胺桥联金属催化剂，其制备方法和使用氨基桥联金属催化剂聚合乙烯-α-烯烃共聚物的方法
公开(公告)号：US20100324321A1
公开(公告)日：2010-12-23
申请号：US12865663
申请日：2009-01-30
申请人： Min-Seok Cho , Nicola Maggiarosa , Ki-Soo Lee , Heon-Yong Kwon , Jong-Sang Park , Joon-Hee Cho , Yong-Ho Lee , Byung-Ryul Lee , Seon-Kyoung Kim , Dae-Sik Hong
发明人： Min-Seok Cho , Nicola Maggiarosa , Ki-Soo Lee , Heon-Yong Kwon , Jong-Sang Park , Joon-Hee Cho , Yong-Ho Lee , Byung-Ryul Lee , Seon-Kyoung Kim , Dae-Sik Hong
IPC分类号： C07F17/00
CPC分类号： C08F210/16 , C08F4/65908 , C08F4/65912 , C08F4/65927 , C08F210/14 , C08F2500/03
摘要： The present invention relates to an amine bridged metallocene catalyst, a method for producing the same, and a method for producing an ethylene-alpha olefin copolymer, which comprises polymerizing ethylene and alpha olefin in the presence of an olefin polymerization catalyst composition including a metallocene catalyst. The amine bridged metallocene catalyst may be produced by reacting one or more of substituted or unsubstituted cyclopentadiene and substituted or unsubstituted fluorene with amine to bridge them with nitrogen, and reacting them with a transition metal to coordinate them.
摘要翻译：本发明涉及一种胺桥连金属茂催化剂，其制备方法和乙烯-α-烯烃共聚物的制备方法，该方法包括在包含茂金属催化剂的烯烃聚合催化剂组合物存在下聚合乙烯和α-烯烃。胺桥连金属茂催化剂可以通过使一个或多个取代或未取代的环戊二烯和取代或未取代的芴与胺反应来制备，使其与氮桥连，并使它们与过渡金属反应以进行配位。

10. 发明授权

US06517869B1 Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake 有权
标题翻译：用于通过组织和细胞摄取递送生物活性剂的带正电荷的聚（α-（ω-氨基烷基）柠檬酸）
公开(公告)号：US06517869B1
公开(公告)日：2003-02-11
申请号：US09595691
申请日：2000-06-16
申请人： Jong-Sang Park , Min-Hyo Seo
发明人： Jong-Sang Park , Min-Hyo Seo
IPC分类号： A61K914
CPC分类号： A61K9/1647 , A61K47/34 , A61K47/593 , A61K47/60 , C08G63/6852 , C08L67/04 , Y10S977/724 , Y10S977/775 , Y10S977/788 , Y10S977/792 , Y10S977/793 , Y10S977/907 , Y10S977/915 , Y10S977/928 , Y10S977/929 , Y10S977/93
摘要： A biodegradable, positively-charged aminoalkyl polyester polymer for the delivery of bioactive agents, such as DNA, RNA, oligonucleotides is disclosed. Biologically active moieties, such as drugs, ligands, and the like, can be coupled to the free amino groups of the polymer.
摘要翻译：公开了用于递送生物活性剂如DNA，RNA，寡核苷酸的可生物降解的带正电荷的氨基烷基聚酯聚合物。生物活性部分，例如药物，配体等可以与聚合物的游离氨基偶联。

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