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1. 发明申请

WO2013028856A3 SYSTEMS AND METHODS FOR REDUCING BODY TEMPERATURE 审中-公开
标题翻译：减少体温的系统和方法
公开(公告)号：WO2013028856A3
公开(公告)日：2013-04-25
申请号：PCT/US2012052055
申请日：2012-08-23
申请人： DYNASIL BIOMEDICAL CORP , ERICSON DANIEL GRANT
发明人： ERICSON DANIEL GRANT
IPC分类号： A61F7/12
CPC分类号： A61F7/106 , A61F7/12 , A61F2007/0057 , A61F2007/006
摘要： Systems and methods for lowering the body temperature of a patient or inducing hypothermia are generally described. In certain embodiments, the core body temperature of a patient can be lowered by using a heat exchanger. In certain embodiments, the heat exchanger of configured to facilitate transfer of heat from an intubation gas to a cooling fluid prior to delivering the intubation gas to the patient (e.g., to the patient's lungs).
摘要翻译：通常描述用于降低患者体温或诱导体温降低的系统和方法。在某些实施例中，可以通过使用热交换器来降低患者的核心体温。在某些实施例中，所述热交换器被配置为在将插管气体递送到患者（例如，到患者的肺）之前有助于将热量从插管气体传递到冷却流体。

2. 发明申请

WO2013116633A3 TISSUE PATCHES AND ASSOCIATED SYSTEMS, KITS, AND METHODS 审中-公开
标题翻译：组织配线和相关系统，套件和方法
公开(公告)号：WO2013116633A3
公开(公告)日：2013-10-10
申请号：PCT/US2013024322
申请日：2013-02-01
申请人： DYNASIL BIOMEDICAL CORP
发明人： ERICSON DANIEL GRANT
IPC分类号： A61L15/32 , A61L15/34 , A61L15/58 , A61L15/64 , A61L24/00 , A61L24/10
CPC分类号： A61L15/32 , A61K9/0014 , A61K9/7023 , A61L15/24 , A61L15/28 , A61L15/34 , A61L15/58 , A61L15/64 , A61L24/001 , A61L24/0042 , A61L24/106 , A61L2300/418 , A61L2400/04 , A61L2400/06
摘要： Tissue patches and associated systems and methods are described. Certain embodiments are related to inventive systems and methods in which tissue patches can be made quickly and robustly without the use of complicated fabrication or sterilization equipment. For example, in some embodiments, tissue patches are made by applying a compressive force to a liquid medium comprising fibrinogen (and/or fibrin) between two surfaces (e.g., within a syringe or other chamber). A filter can be placed within or near the volume in which the compressive force is applied to the liquid medium such that unwanted material (e.g., water, blood cells, and the like) is passed through the filter while desirable components (e.g., fibrin, fibrinogen, and/or other desirable components) are retained by the filter to form the patch. In this way, the concentration of fibrin (and/or fibrinogen) within the liquid medium can be increased, potentially dramatically, as the compressive force is applied to the liquid-containing composition. In addition, in some embodiments, at least a portion of the fibrinogen and/or fibrin can chemically react (e.g., the fibrinogen can polymerize to form fibrin and/or the fibrin can cross-link) during application of the compressive force. Reaction and concentration can lead to the formation of a highly-concentrated, mechanically robust patch that can be handled relatively easily and provide good structural reinforcement at a wet site, such as a bleeding wound.
摘要翻译：描述组织贴片及相关系统和方法。某些实施方案涉及本发明的系统和方法，其中可以快速而鲁棒地制备组织块，而不需要使用复杂的制造或灭菌设备。例如，在一些实施例中，通过在包括纤维蛋白原（和/或纤维蛋白）在两个表面之间（例如在注射器或其它腔室内）的液体介质施加压缩力来制造组织贴片。过滤器可以放置在体积内或附近，其中压力施加到液体介质上，使得不需要的材料（例如水，血细胞等）通过过滤器，同时期望的组分（例如纤维蛋白，纤维蛋白原和/或其它所需组分）被过滤器保留以形成贴剂。以这种方式，当压缩力施加到含液体组合物时，液体介质中纤维蛋白（和/或纤维蛋白原）的浓度可能会显着增加。此外，在一些实施方案中，在施加压缩力期间，纤维蛋白原和/或纤维蛋白的至少一部分可以发生化学反应（例如，纤维蛋白原可以聚合以形成纤维蛋白和/或纤维蛋白可以交联）。反应和浓缩可导致形成高度集中，机械强度高的贴片，其可相对容易地处理并在湿部位例如出血伤口提供良好的结构加强。

3. 发明申请

WO2012125955A3 METHODS AND MATERIALS FOR PROLONGING USEFUL STORAGE OF RED BLOOD CELL PREPARATIONS AND PLATELET PREPARATIONS 审中-公开
标题翻译：延长红细胞制剂和血小板制剂有效储存的方法和材料
公开(公告)号：WO2012125955A3
公开(公告)日：2012-12-27
申请号：PCT/US2012029510
申请日：2012-03-16
申请人： MAYO FOUNDATION , DYNASIL BIOMEDICAL CORP , JOYNER MICHAEL J , ERICSON DANIEL GRANT
发明人： JOYNER MICHAEL J , ERICSON DANIEL GRANT
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
CPC分类号： C12N5/0644 , A01N1/0226 , A01N1/0263
摘要： This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using CO2 to store red blood cells in a manner that (a) reduces the level of glucose or 2,3-DPG consumption of or reduces the level of 2,3-DPG production by a red blood cell preparation, (b) reduces the level of lactate formation by a red blood cell preparation, and/or (c) reduces the pH level of a red blood cell preparation are provided. Such methods and materials can result in prolonging the useful lifespan of the red blood cells of the red blood cell preparation. This document also provides methods and materials involved in prolonging useful storage of platelet preparations. For example, methods and materials for storing platelets in a manner that reduces platelet metabolism, that preserves platelet function, and/or that reduces the risk of bacterial contamination are provided.
摘要翻译：本文件提供了提高红细胞制剂储存能力的方法和材料。例如，用以下方式使用CO 2储存红细胞的方法和材料：（a）降低葡萄糖或2,3-DPG消耗的水平或降低红细胞的2,3-DPG产生水平（b）降低红细胞制剂的乳酸形成水平，和/或（c）降低红细胞制剂的pH水平。这样的方法和材料可以延长红细胞制剂的红细胞的使用寿命。该文件还提供了涉及延长血小板制剂有用储存的方法和材料。例如，提供了以降低血小板代谢，保持血小板功能和/或降低细菌污染风险的方式储存血小板的方法和材料。

4. 发明专利

AU2012228972A1 Methods and materials for prolonging useful storage of red blood cell preparations and platelet preparations 未知
公开(公告)号：AU2012228972A1
公开(公告)日：2013-10-24
申请号：AU2012228972
申请日：2012-03-16
申请人： DYNASIL BIOMEDICAL CORP , MAYO FOUND MEDICAL EDUCATION & RES
发明人： JOYNER MICHAEL J , ERICSON DANIEL GRANT
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
摘要： This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using CO

5. 发明专利

CA2830420A1 METHODS AND MATERIALS FOR PROLONGING USEFUL STORAGE OF RED BLOOD CELL PREPARATIONS AND PLATELET PREPARATIONS 未知
公开(公告)号：CA2830420A1
公开(公告)日：2012-09-20
申请号：CA2830420
申请日：2012-03-16
申请人： MAYO FOUNDATION , DYNASIL BIOMEDICAL CORP
发明人： JOYNER MICHAEL J , ERICSON DANIEL GRANT
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
摘要： This document provides methods and materials for enhancing the storage capabilities of red blood cell preparations. For example, methods and materials for using CO2 to store red blood cells in a manner that (a) reduces the level of glucose or 2,3-DPG consumption of or reduces the level of 2,3-DPG production by a red blood cell preparation, (b) reduces the level of lactate formation by a red blood cell preparation, and/or (c) reduces the pH level of a red blood cell preparation are provided. Such methods and materials can result in prolonging the useful lifespan of the red blood cells of the red blood cell preparation. This document also provides methods and materials involved in prolonging useful storage of platelet preparations. For example, methods and materials for storing platelets in a manner that reduces platelet metabolism, that preserves platelet function, and/or that reduces the risk of bacterial contamination are provided.

6. 发明专利

BR112013023740A2 métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta 未知
公开(公告)号：BR112013023740A2
公开(公告)日：2016-08-02
申请号：BR112013023740
申请日：2012-03-16
申请人： DYNASIL BIOMEDICAL CORP , MAYO FOUNDATION
发明人： ERICSON DANIEL GRANT , JOYNER MICHAEL J
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
摘要： patente de invenção: métodos e materiais para prolongamento da armazenagem útil de preparações de glóbulo vermelho e preparações de plaqueta este documento fornece métodos e materiais para realce das capacidades de armazenagem de preparações de glóbulo branco. por exemplo, métodos e materiais para uso de co^ 2^ para armazenar glóbulos vermelhos de uma maneira que (a) redução do nível de consumo de glicose ou 2,3-dpg ou redução do nível de produção de 2,3-dpg por uma preparação de glóbulo vermelho, (b) redução o nível de formação de lactato por uma preparação de glóbulo vermelho, e/ou (c) redução do nível de ph de uma preparação de glóbulo vermelho sejam reduzidos. tais métodos e materiais podem tais métodos e materiais podem resultar no prolongamento do tempo de vida útil dos glóbulos vermelhos da preparação de glóbulo vermelho. este documento também fornece métodos e materiais envolvidos no prolongamento de armazenagem de preparações de plaqueta. por exemplo, métodos e materiais para armazenar plaquetas de uma maneira que a redução de metabolismo de plaqueta, que a preservação da função de plaqueta, e/ou que a redução do risco de contaminação bacteriana sejam fornecidas.

7. 发明公开

EP2685815A4 METHODS AND MATERIALS FOR PROLONGING USEFUL STORAGE OF RED BLOOD CELL PREPARATIONS AND PLATELET PREPARATIONS 审中-公开
标题翻译：方法和材料续期存储的红细胞，血小板的制剂的使用
公开(公告)号：EP2685815A4
公开(公告)日：2014-09-17
申请号：EP12757403
申请日：2012-03-16
申请人： MAYO FOUNDATION , DYNASIL BIOMEDICAL CORP
发明人： JOYNER MICHAEL J , ERICSON DANIEL GRANT
IPC分类号： A01N1/02 , A61J1/05 , C12N5/02
CPC分类号： C12N5/0644 , A01N1/0226 , A01N1/0263

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