专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009079585A3 COMPOSITIONS AND METHODS FOR TREATING OSTEOLYTIC DISORDERS COMPRISING MMP-14 BINDING PROTEINS 审中-公开
标题翻译：用于治疗包含MMP-14结合蛋白的软骨疾病的组合物和方法
公开(公告)号：WO2009079585A3
公开(公告)日：2009-12-30
申请号：PCT/US2008087236
申请日：2008-12-17
申请人： DYAX CORP , DEVY LAETITIA , DRANSFIELD DANIEL T , WOOD CLIVE R
发明人： DEVY LAETITIA , DRANSFIELD DANIEL T , WOOD CLIVE R
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , C07K2317/56 , C07K2317/565 , C07K2317/76 , Y10T428/13
摘要： Provided are methods and compositions for using MMP- 14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis.
摘要翻译：提供了单独使用MMP-14或MMP-9结合蛋白或与其它治疗剂组合以治疗溶骨性疾病如骨性骨骼肌和骨质疏松症的方法和组合物。

2. 发明申请

WO2007079218A3 METALLOPROTEINASE BINDING PROTEINS 审中-公开
标题翻译：金属蛋白酶结合蛋白
公开(公告)号：WO2007079218A3
公开(公告)日：2008-07-10
申请号：PCT/US2006049566
申请日：2006-12-29
申请人： DYAX CORP , DEVY LAETITIA , PIETERS HENK , LADNER ROBERT C , HOET RENE , DRANSFIELD DANIEL T , WOOD CLIVE R , HENDERIKX MARIA
发明人： DEVY LAETITIA , PIETERS HENK , LADNER ROBERT C , HOET RENE , DRANSFIELD DANIEL T , WOOD CLIVE R , HENDERIKX MARIA
IPC分类号： A61K39/395
CPC分类号： C07K16/40 , A61K51/1075 , A61K2039/505 , C07K16/30 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/573 , G01N2333/96486
摘要： Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described.
摘要翻译：描述了结合基质金属蛋白酶14的蛋白质和使用这些蛋白质的方法。

3. 发明申请

WO2008089070A3 COMBINATION THERAPY FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的组合治疗
公开(公告)号：WO2008089070A3
公开(公告)日：2008-11-27
申请号：PCT/US2008050870
申请日：2008-01-11
申请人： DYAX CORP , WOOD CLIVE R , DRANSFIELD DANIEL T
发明人： WOOD CLIVE R , DRANSFIELD DANIEL T
IPC分类号： A61K41/00
CPC分类号： C07K16/2863 , C07K2317/24 , C07K2317/56
摘要： Disclosed are new methods for treatment of angiogenesis-related disorders. Angiogenesis-related disorders are treated by administration of a Tie1 ectodomain- binding agent and a vascular disrupting agent.
摘要翻译：公开了治疗血管生成相关疾病的新方法。通过施用Tie1胞外域结合剂和血管破坏剂来治疗血管发生相关病症。

4. 发明申请

WO2009097397A3 METALLOPROTEINASE BINDING PROTEINS 审中-公开
标题翻译：金属蛋白酶结合蛋白
公开(公告)号：WO2009097397A3
公开(公告)日：2010-01-07
申请号：PCT/US2009032384
申请日：2009-01-29
申请人： DYAX CORP , WOOD CLIVE R , DRANSFIELD DANIEL T
发明人： WOOD CLIVE R , DRANSFIELD DANIEL T
IPC分类号： C12Q1/37 , C12N9/50
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/55 , C07K2317/76
摘要： Protein-drug conjugates that bind to membrane type matrix metalloproteinases and methods of using such protein-drug conjugates are described.
摘要翻译：描述了结合膜型基质金属蛋白酶的蛋白质 - 药物偶联物和使用这种蛋白质 - 药物偶联物的方法。

5. 发明申请

WO2008048996A9 SEQUENTIAL COMBINATION THERAPY 审中-公开
标题翻译：顺序组合治疗
公开(公告)号：WO2008048996A9
公开(公告)日：2008-09-12
申请号：PCT/US2007081621
申请日：2007-10-17
申请人： DYAX CORP , JAIN RAKESH K , WOOD CLIVE R , DRANSFIELD DANIEL T , ARULANANDAM ANTONIO
发明人： JAIN RAKESH K , WOOD CLIVE R , DRANSFIELD DANIEL T , ARULANANDAM ANTONIO
IPC分类号： A61K38/00
CPC分类号： A61K45/06 , A61K39/3955 , A61K2300/00
摘要： Disclosed are new methods for treatment of angiogenesis-related disorders. Angiogenesis-related disorders are treated by administration of a Tie1 ectodomain-binding agent and a VEGF antagonist agent.
摘要翻译：公开了治疗血管生成相关疾病的新方法。通过施用Tie1胞外域结合剂和VEGF拮抗剂来治疗血管发生相关病症。

6. 发明申请

WO2008048996A2 SEQUENTIAL COMBINATION THERAPY 审中-公开
公开(公告)号：WO2008048996A2
公开(公告)日：2008-04-24
申请号：PCT/US2007081621
申请日：2007-10-17
申请人： DYAX CORP , JAIN RAKESH K , WOOD CLIVE R , DRANSFIELD DANIEL T , ARULANANDAM ANTONIO
发明人： JAIN RAKESH K , WOOD CLIVE R , DRANSFIELD DANIEL T , ARULANANDAM ANTONIO
IPC分类号： A01N57/00
CPC分类号： A61K45/06 , A61K39/3955 , A61K2300/00
摘要： Disclosed are new methods for treatment of angiogenesis-related disorders. Angiogenesis-related disorders are treated by administration of a Tie1 ectodomain-binding agent and a VEGF antagonist agent.

7. 发明申请

WO2006020706A3 TIE COMPLEX BINDING PROTEINS 审中-公开
标题翻译： TIE复合结合蛋白
公开(公告)号：WO2006020706A3
公开(公告)日：2006-10-12
申请号：PCT/US2005028413
申请日：2005-08-09
申请人： DYAX CORP , WOOD CLIVE R , DRANSFIELD DANIEL T , PIETERS HENK , HOET RENE , HUFTON SIMON E
发明人： WOOD CLIVE R , DRANSFIELD DANIEL T , PIETERS HENK , HOET RENE , HUFTON SIMON E
IPC分类号： C07K16/28 , A61K39/395 , C07H21/04
CPC分类号： G01N33/574 , A61K2039/505 , A61K2039/507 , C07K16/2863 , C07K2317/21 , C07K2317/55 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92 , G01N2333/705 , G01N2333/91215
摘要： Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.
摘要翻译： Tie1和Tie2是受体酪氨酸激酶蛋白，其包括跨膜结构域。 Tie1和Tie2存在于内皮细胞上。本公开描述了结合Tie1，Tie2和Ang的试剂，例如抗体，包括抑制内皮细胞活性和血管生成的抗体。该药剂可用于治疗血管生成相关疾病。

8. 发明申请

WO2012129517A3 EVALUATING PROTEIN EXPRESSION IN PATIENT STRATIFICATION AND OTHER THERAPEUTIC, DIAGNOSTIC AND PROGNOSTIC METHODS FOR CANCER 审中-公开
标题翻译：评估患者分娩中的蛋白质表达和其他治疗，诊断和预后方法
公开(公告)号：WO2012129517A3
公开(公告)日：2014-05-01
申请号：PCT/US2012030398
申请日：2012-03-23
申请人： DYAX CORP , DRANSFIELD DANIEL T
发明人： DRANSFIELD DANIEL T
IPC分类号： C12Q1/68
CPC分类号： G01N33/574 , G01N33/573 , G01N2333/96494
摘要： Provided are compositions and methods for quantifying the expression or activity of MMP-14, MMP-9, TIMP-I, and/or MMP-2 and other biomarkers of cancer, for example, osteotropic cancer, breast cancer, lung cancer, melanoma, pancreatic cancer, colon cancer or prostate cancer, which may be used diagnostically (e.g., to identify patients who have cancer, or a particular subclass of cancer) and prognostically (e.g., to identify patients who are likely to develop cancer or respond well to a particular therapeutic for treating cancer). Kits for detecting MMP-14 and other biomarkers and for the practice of the methods incorporating such detection are also described herein. Specifically, in certain embodiments, provided are methods of utilizing expression of and/or expression ratios of any two of MMP-14, MMP-2, TIMP (e.g., TIMP-I), and MMP-9 in tumors and other cancer cells in order to stratify patients and identify those who would benefit from MMP-14 inhibitor treatment.
摘要翻译：提供了用于定量MMP-14，MMP-9，TIMP-1和/或MMP-2和其它癌症生物标志物的表达或活性的组合物和方法，例如骨性癌，乳腺癌，肺癌，黑素瘤，胰腺癌，结肠癌或前列腺癌，其可以在诊断上使用（例如，鉴定患有癌症的患者或癌症的特定亚类）和预后（例如，鉴定可能发展为癌症或对特别治疗癌症）。本文还描述了用于检测MMP-14和其他生物标志物的试剂盒以及结合这种检测的方法的实践。具体地，在某些实施方案中，提供了利用肿瘤和其它癌细胞中MMP-14，MMP-2，TIMP（例如TIMP-1）和MMP-9中任意两种的表达和/或表达比例的方法命令分层患者，并确定谁将受益于MMP-14抑制剂治疗。

9. 发明申请

WO03074005A8 KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开
标题翻译： KDR和VEGF / KDR结合肽及其在诊断和治疗中的应用
公开(公告)号：WO03074005A8
公开(公告)日：2005-07-21
申请号：PCT/US0306731
申请日：2003-03-03
申请人： DYAX CORP , BRACCO INT BV , SATO AARON K , SEXTON DANIEL J , LADNER ROBERT C , DRANSFIELD DANIEL T , SWENSON ROLF E , MARINELLI EDMUND R , RAMALINGAM KONDAREDDIAR , NUNN ADRIAN D , VON WRONSKI MATHEW A , SHRIVASTAVA AJAY , POCHON SIBYLLE , BUSSAT PHILIPPE , ARBOGAST CHRISTOPHE , PILLAI RADHAKRISHNA , FAN HONG , LINDER KAREN E , SONG BO , NANJAPPAN PALANIAPPA
发明人： SATO AARON K , SEXTON DANIEL J , LADNER ROBERT C , DRANSFIELD DANIEL T , SWENSON ROLF E , MARINELLI EDMUND R , RAMALINGAM KONDAREDDIAR , NUNN ADRIAN D , VON WRONSKI MATHEW A , SHRIVASTAVA AJAY , POCHON SIBYLLE , BUSSAT PHILIPPE , ARBOGAST CHRISTOPHE , PILLAI RADHAKRISHNA , FAN HONG , LINDER KAREN E , SONG BO , NANJAPPAN PALANIAPPA
IPC分类号： A61K38/00 , A61K49/22 , A61K51/08 , C07K7/08 , C07K14/00 , C07K14/52 , C07K14/71 , C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , A61K49/223 , A61K51/088 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00
摘要： The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e . g ., having a K D

10. 发明申请

WO2004078778A3 PEPTIDES THAT SPECIFICALLY BIND HGF RECEPTOR (cMet) AND USES THEREOF 审中-公开
标题翻译：特异性结合HGF受体（cMet）及其用途
公开(公告)号：WO2004078778A3
公开(公告)日：2004-11-18
申请号：PCT/US2004006473
申请日：2004-03-03
申请人： DYAX CORP , BRACCO INT BV , SATO AARON K , DRANSFIELD DANIEL T , LADNER ROBERT C , SHRIVASTAVA AJAY , NANJAPPAN PALANIAPPA
发明人： SATO AARON K , DRANSFIELD DANIEL T , LADNER ROBERT C , SHRIVASTAVA AJAY , NANJAPPAN PALANIAPPA
IPC分类号： A61K38/00 , A61K38/10 , A61K47/48 , A61K49/00 , A61K51/08 , C07K20060101 , C07K1/00 , C07K7/08 , C07K14/475 , C12N7/00 , G01N33/53
CPC分类号： C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
摘要翻译：公开了具有结合cMet或包含cMet和HGF的复合物的能力的多肽或多聚体多肽构建体及其使用方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式