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1. 发明专利

AU2003299659A1 ORAL DRUG DELIVERY SYSTEM 未知
公开(公告)号：AU2003299659A1
公开(公告)日：2004-07-09
申请号：AU2003299659
申请日：2003-12-15
申请人： SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C , DURECT CORP , YUM SU IL
发明人： SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C , YUM SU IL
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485 , A61K9/00

2. 发明申请

WO2004054542A3 ORAL DRUG DELIVERY SYSTEM COMPRISING HIGH VISCOSITY LIQUID CARRIER MATERIALS 审中-公开
标题翻译：包含高粘度液体载体材料的口服药物输送系统
公开(公告)号：WO2004054542A3
公开(公告)日：2004-08-26
申请号：PCT/US0340156
申请日：2003-12-15
申请人： DURECT CORP , YUM SU IL , SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C
发明人： YUM SU IL , SCHOENHARD GRANT , TIPTON ARTHUR J , GIBSON JOHN W , MIDDLETON JOHN C
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485
CPC分类号： A61K31/485 , A61K9/0053 , A61K9/48 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/4458 , A61K47/14 , A61K47/26 , A61K47/38 , Y10S514/96
摘要： Dosage forms and drug delivery devices suitable for administration of pharmaceutical compounds and compositions, including the oral drug administration of compounds.
摘要翻译：适用于药物化合物和组合物施用的剂型和药物递送装置，包括化合物的口服药物施用。

3. 发明专利

AU2003299659A8 Oral drug delivery system comprising high viscosity liquid carrier materials 未知
公开(公告)号：AU2003299659A8
公开(公告)日：2004-07-09
申请号：AU2003299659
申请日：2003-12-15
申请人： GIBSON JOHN W , YUM SU IL , DURECT CORP , MIDDLETON JOHN C , TIPTON ARTHUR J , SCHOENHARD GRANT
发明人： SCHOENHARD GRANT , MIDDLETON JOHN C , GIBSON JOHN W , TIPTON ARTHUR J , YUM SU IL
IPC分类号： A61K9/48 , A61K9/52 , A61K31/485

4. 发明申请

WO2004052336A3 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE 审中-公开
标题翻译：高粘度液体控制输送系统和医疗或手术装置
公开(公告)号：WO2004052336A3
公开(公告)日：2006-06-15
申请号：PCT/US0339311
申请日：2003-12-10
申请人： DURECT CORP , GIBSON JOHN W , MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J
发明人： GIBSON JOHN W , MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J
IPC分类号： A61K8/60 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K9/70 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00 , A61K9/10 , A61F6/06 , A61F9/02 , A61K9/20 , A61L27/00 , A61L25/00
CPC分类号： A61K47/10 , A61K8/60 , A61K9/0014 , A61K9/0019 , A61K9/0024 , A61K9/0073 , A61K9/1647 , A61K9/4858 , A61K9/7015 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/0015 , A61L24/0026 , A61L26/0066 , A61L27/54 , A61L31/16 , A61L2300/252 , A61L2300/402 , A61L2300/43 , A61L2300/602 , A61Q5/006
摘要： The present invention relates to novel nonpolymeric compounds and compositions that form liquid, high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.
摘要翻译：本发明涉及形成液体，高粘度材料的新型非聚合物和组合物，其适于以受控的方式递送生物活性物质，并用作医疗或手术装置。该材料可以任选地用溶剂稀释以形成较低粘度的材料，使得材料易于施用。该溶剂可以是水不溶性或水溶性的，其中水溶性溶剂在体内快速扩散或迁移离开材料，留下较高粘度的液体材料。

5. 发明申请

WO0228366A3 DEVICES AND METHODS FOR MANAGEMENT OF INFLAMMATION 审中-公开
标题翻译：用于管理炎症的装置和方法
公开(公告)号：WO0228366A3
公开(公告)日：2002-12-12
申请号：PCT/US0131652
申请日：2001-10-09
申请人： DURECT CORP , CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
发明人： CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
IPC分类号： A61K9/00 , A61K9/22 , A61K31/352 , A61K31/37
CPC分类号： A61K9/0024 , A61K31/352
摘要： Devices and methods for the sustained release into a subject of an inhibitor of mast cell-mediated inflammation, specifically sustained-release of sodium cromoglycate as a prophylactic to prevent acute asthma attacks.
摘要翻译：用于持续释放到肥大细胞介导的炎症抑制剂的受试者的装置和方法，特别是缓释色甘酸钠作为预防性急性哮喘发作的预防剂。

6. 发明申请

WO0228366A9 DEVICES AND METHODS FOR MANAGEMENT OF INFLAMMATION 审中-公开
标题翻译：用于管理炎症的装置和方法
公开(公告)号：WO0228366A9
公开(公告)日：2003-02-13
申请号：PCT/US0131652
申请日：2001-10-09
申请人： DURECT CORP , CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
发明人： CHAN TAI WAH , JOHNSON RANDOLPH M , MIKSZTAL ANDREW R , TIPTON ARTHUR J , GIBSON JOHN W , MEADOR STACEY K
IPC分类号： A61K9/00 , A61K9/22 , A61K31/352 , A61K31/37
CPC分类号： A61K9/0024 , A61K31/352
摘要： Devices and methods for the sustained release into a subject of an inhibitor of mast cell-mediated inflammation, specifically sustained-release of sodium cromoglycate as a prophylactic to prevent acute asthma attacks.
摘要翻译：用于持续释放到肥大细胞介导的炎症抑制剂的受试者的装置和方法，特别是缓释色甘酸钠作为预防性急性哮喘发作的预防剂。

7. 发明专利

IL176649A POLYMERIC IMPLANTS, PREFERABLY CONTAINING A MIXTURE OF PEG AND PLG, FOR CONTROLLED RELEASE OF ACTIVE AGENTS, PREFERABLY A GNRH 未知
公开(公告)号：IL176649A
公开(公告)日：2011-12-29
申请号：IL17664906
申请日：2006-06-29
申请人： DURECT CORP , GIBSON JOHN W , TIPTON ARTHUR J
发明人： GIBSON JOHN W , TIPTON ARTHUR J
IPC分类号： A61K9/00 , A61K9/16 , A61K9/20 , A61K38/09 , A61K38/24

8. 发明申请

WO0066087A9 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
标题翻译：基于乳液的微粒制备工艺
公开(公告)号：WO0066087A9
公开(公告)日：2001-07-12
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.
摘要翻译：提供了制造优选含有活性剂的微粒的方法。在一个优选的实施方案中，该方法涉及制备（1）在聚合物和第一溶剂的溶液中含有试剂的分散相; （2）含有表面活性剂，与第一溶剂完全或部分不混溶的第二溶剂和足以使连续相饱和的第一溶剂的连续相; 和（3）作为聚合物的非溶剂的萃取相，连续相组分的溶剂和第一溶剂的溶剂，其中第一溶剂在萃取相中的溶解度为约0.1％至25％重量％。然后，将分散相和连续相混合形成乳液，然后将乳液与适量的萃取相短暂混合，以在分散相和连续相的界面处诱导皮肤形成。剩余溶剂通过蒸发工艺步骤除去。乳化和溶剂去除步骤优选以连续方法进行。与其他基于提取的方法相比，在蒸发之前的简单提取步骤使来自微粒的活性剂的损失最小化，并且减少了所需的提取相体积。还提供了替代乳化方法和溶剂去除方法，如增量提取，深冷提取或膜分离，并且可以以各种组合使用以制造微粒。

9. 发明申请

WO0066087A8 EMULSION-BASED PROCESSES FOR MAKING MICROPARTICLES 审中-公开
公开(公告)号：WO0066087A8
公开(公告)日：2001-04-05
申请号：PCT/US0011781
申请日：2000-05-02
申请人： SOUTHERN BIOSYSTEMS INC , GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
发明人： GIBSON JOHN W , HOLL RICHARD J , TIPTON ARTHUR J
IPC分类号： A61K9/16 , B01J13/12
CPC分类号： B01J13/125 , A61K9/1647 , A61K9/1694 , Y10T428/2984 , Y10T428/2985
摘要： Processes for making microparticles, preferably containing an active agent, are provided. In a preferred embodiment, the process involves preparing (1) a dispersed phase containing an agent in a solution of polymer and a first solvent; (2) a continuous phase containing a surfactant, a second solvent that is totally or partially immiscible with the first solvent, and sufficient first solvent to saturate the continuous phase; and (3) an extraction phase that is a nonsolvent for the polymer, a solvent for the continuous phase components, and a solvent for the first solvent, wherein the first solvent has solubility in the extraction phase of between about 0,1 % and 25 % by weight. Then, the dispersed phase and the continuous phase are mixed to form an emulsion, and the emulsion is then briefly mixed with a suitable quantity of extraction phase to induce skin formation at the interface of the dispersed and continuous phases. Remaining solvent is removed by an evaporation process step. The emulsification and solvent removal steps are preferably conducted in a continuous process. The brief extraction step prior to evaporation minimizes the loss of active agent from the microparticles, and reduces the required volume of extraction phase as compared to other extraction-based processes. Alternate emulsification methods and solvent removal methods, such as incremental extraction, cryogenic extraction, or membrane separation, also are provided, and can be used in various combinations to make microparticles.

10. 发明专利

AU2003297848A1 HIGH VISCOSITY LIQUID CONTROLLED DELIVERY SYSTEM AND MEDICAL OR SURGICAL DEVICE 未知
公开(公告)号：AU2003297848A1
公开(公告)日：2004-06-30
申请号：AU2003297848
申请日：2003-12-10
申请人： GIBSON JOHN W , MILLER STACEY S , DURECT CORP
发明人： MILLER STACEY S , MIDDLETON JOHN C , TIPTON ARTHUR J , GIBSON JOHN W
IPC分类号： A61K8/60 , A61K9/00 , A61K9/14 , A61K9/16 , A61K9/48 , A61K9/70 , A61K47/14 , A61K47/26 , A61K47/34 , A61L15/20 , A61L15/44 , A61L24/00 , A61L26/00 , A61L27/54 , A61L31/16 , A61Q11/00
摘要： The present invention relates to novel nonpolymeric compounds and compositions that form liquid high viscosity materials suitable for the delivery of biologically active substances in a controlled fashion, and for use as medical or surgical devices. The materials can optionally be diluted with a solvent to form a material of lower viscosity, rendering the material easy to administer. This solvent may be water insoluble or water soluble, where the water soluble solvent rapidly diffuses or migrates away from the material in vivo, leaving a higher viscosity liquid material.

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