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1. 发明申请

WO2018057420A1 USE OF LOW PH ACTIVE ALPHA-1,4/1,6-GLYCOSIDE HYDROLASES AS A FEED ADDITIVE FOR RUMINANTS TO ENHANCE STARCH DIGESTION 审中-公开
标题翻译：低PH值活性α-1,4 / 1,6-糖苷水解物作为反刍动物饲料添加剂增强淀粉消化的研究
公开(公告)号：WO2018057420A1
公开(公告)日：2018-03-29
申请号：PCT/US2017/051758
申请日：2017-09-15
申请人： DUPONT NUTRITION BIOSCIENCES APS , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： YU, Shukun , KRAGH, Karsten Matthias , LI, Wenting
IPC分类号： A23K20/189 , A23K10/14 , A23K50/10
摘要： Disclosed are uses at least one alpha-1,4/1,6-glycoside hydrolase (GLCH) as a feed additive for a ruminant wherein said hydrolase: (a) has at least 20% activity at pH less than or equal to 3 in the presence of pepsin as compared to activity of the hydrolase at pH 6 in the presence of pepsin, (b) said hydrolase is active in at least two of three digestive chambers of a ruminant comprising a rumen, an abomasum and a small intestine and (c) the hydrolase works with pancreatic amylase to increase glucose yield.
摘要翻译：公开了使用至少一种α-1,4 / 1,6-糖苷水解酶（GLCH）作为用于反刍动物的饲料添加剂，其中所述水解酶：（a）具有至少20％的活性（b）所述水解酶在反刍动物的三个消化室中的至少两个消化室中是活性的，所述反刍动物消化室包含瘤胃，在胃蛋白酶存在下pH小于或等于3，而在胃蛋白酶存在下，（c）水解酶与胰淀粉酶一起增加葡萄糖产量。

2. 发明申请

WO2017147060A9 METHOD FOR PRODUCING A PROTEIN HYDROLYSATE EMPLOYING AN ASPERGILLUS FUMIGATUS TRIPEPTIDYL PEPTIDASE 审中-公开
标题翻译：生产蛋白水解产物的方法，其使用ASPERGILLUS FUMIGATUS三磷酸化肽酶
公开(公告)号：WO2017147060A9
公开(公告)日：2017-08-31
申请号：PCT/US2017/018686
申请日：2017-02-21
申请人： DUPONT NUTRITION BIOSCIENCES APS , 2. E. I. DU PONT DE NEMOURS AND COMPANY
发明人： KRAGH, Karsten Matthias , HAANING, Svend , MEINJOHANNS, Ernst , DEGN, Peter Edvard , BAK, Steffen Yde , EISELE, Thomas
IPC分类号： C12P21/06 , A23J3/34 , C12N9/48 , A23K10/10
摘要： The present invention relates to compositions and methods for the production of a hydrolysate comprising at least one endoprotease and a tripeptidyl peptidase capable of cleaving tripeptides from the N-terminus a peptide and/or proteins having one or more of lysine, arginine or glycine in the P1 position wherein said tripeptidyl peptidase is capable of being used at a temperature between 45ºC and 70ºC.
摘要翻译：本发明涉及用于生产水解产物的组合物和方法，所述水解产物包含至少一种内切蛋白酶和能够从N端切割三肽的三肽基肽酶和/或具有一个或多个在P1位置的赖氨酸，精氨酸或甘氨酸，其中所述三肽基肽酶能够在45℃和70℃之间的温度下使用; C。

3. 发明申请

WO2017147060A1 METHOD FOR PRODUCING A PROTEIN HYDROLYSATE EMPLOYING AN ASPERGILLUS FUMIGATUS TRIPEPTIDYL PEPTIDASE 审中-公开
公开(公告)号：WO2017147060A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/018686
申请日：2017-02-21
申请人： DUPONT NUTRITION BIOSCIENCES APS , 2. E. I. DU PONT DE NEMOURS AND COMPANY
发明人： KRAGH, Karsten Matthias , HAANING, Svend , MEINJOHANNS, Ernst , DEGN, Peter Edvard , BAK, Steffen Yde , EISELE, Thomas
IPC分类号： C12P21/06 , A23J3/34 , C12N9/48 , A23K10/10
CPC分类号： C12P21/06 , A23J3/341 , A23J3/346 , A23K10/10 , A23K10/14 , A23K20/147 , A23K20/189 , A23K50/30 , A23K50/60 , A23K50/75 , C12N9/485 , C12Y304/14009 , C12Y304/1401
摘要： The present invention relates to compositions and methods for the production of a hydrolysate comprising at least one endoprotease and a tripeptidyl peptidase capable of cleaving tripeptides from the N-terminus a peptide and/or proteins having one or more of lysine, arginine or glycine in the P1 position wherein said tripeptidyl peptidase is capable of being used at a temperature between 45ºC and 70ºC.

4. 发明申请

WO2019036143A1 USE OF INOCULANTS AND ENZYMES TO INCREASE NUTRIENT RELEASE IN ANIMAL DIETS 审中-公开
公开(公告)号：WO2019036143A1
公开(公告)日：2019-02-21
申请号：PCT/US2018/042581
申请日：2018-07-18
申请人： DUPONT NUTRITION BIOSCIENCES APS , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： YU, Shukun , KRAGH, Karsten Matthias
IPC分类号： A23K10/12 , A23K50/10
摘要： Disclosed are methods for improving the digestibility of high-moisture grain feed and/or rehydrated grain feed for animals which comprises a) processing the grain feed into fragments and b) contacting the grain feed fragments of step (a) with at least one starch hydrolase which is stable and active at a pH less than 5.0, optionally at least one protease, in combination with at least one inoculant comprising at least one bacterial strain.

5. 发明申请

WO2016210395A1 AMINOPEPTIDASES FOR PROTEIN HYDRLYZATES 审中-公开
标题翻译：蛋白质水解酶的氨基酸
公开(公告)号：WO2016210395A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/039494
申请日：2016-06-27
申请人： DUPONT NUTRITION BIOSCIENCES APS , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： KRAGH, Karsten Matthias , HAANING, Svend , MEINJOHANNS, Ernst , EISELE, Thomas , DEGN, Peter Edvard , BAK, Steffen Yde
IPC分类号： C12P21/06 , C12N9/48 , C12N15/80
CPC分类号： C12N9/485 , C07K2319/02 , C12N15/80 , C12P21/06 , C12Y304/11
摘要： The present disclosure provides polypeptides having aminopeptidase activity and isolated nucleic acid sequences encoding the polypeptides. In some embodiments, the disclosure also provides to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the polypeptides. In some embodiments, the present disclosure further provides to methods of obtaining protein hydrolysates useful as flavor improving agents.
摘要翻译：本公开提供了具有氨基肽酶活性的多肽和分离的编码多肽的核酸序列。在一些实施方案中，本公开还提供了包含核酸序列的核酸构建体，载体和宿主细胞以及用于产生多肽的方法。在一些实施方案中，本公开进一步提供了获得可用作风味改善剂的蛋白质水解产物的方法。

6. 发明申请

WO2018005229A1 IN FEED ASSAY OF MICROBIAL PROTEASES USING PEPTIDE SUBSTRATES 审中-公开
标题翻译：用肽底物进行微生物蛋白质的饲料分析
公开(公告)号：WO2018005229A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/038762
申请日：2017-06-22
申请人： DUPONT NUTRITION BIOSCIENCES APS , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： YU, Shukun , SHIPOVSKOV, Stepan , KRAGH, Karsten Matthias
IPC分类号： G01N33/573 , C12Q1/37
CPC分类号： G01N33/573 , C12Q1/37
摘要： A novel in feed assay for microbial proteases, conducted at a pH below 7, using certain peptide substrates is disclosed. This assay can be designed to use at least one additional exogenous microbial peptidase if colorimetric detection and/or quantification is used. If fluorescence is used, then there is no need to add any additional exogenous peptidase(s).
摘要翻译：公开了使用某些肽底物在pH低于7下进行的微生物蛋白酶饲料测定中的新颖方法。如果使用比色检测和/或定量，可将该测定设计为使用至少一种额外的外源微生物肽酶。如果使用荧光，则不需要添加任何额外的外源性肽酶（s）。

7. 发明申请

WO2021007379A1 FAT COATED PARTICULATE ENZYME COMPOSITIONS 审中-公开
公开(公告)号：WO2021007379A1
公开(公告)日：2021-01-14
申请号：PCT/US2020/041301
申请日：2020-07-09
申请人： DUPONT NUTRITION BIOSCIENCES APS , GENENCOR INTERNATIONAL B.V. , DANSICO US INC.
发明人： YU, Shukun , TSE, Kathryn Louise , LI, Wenting , MARCHAL, Leon , VILJANEN, Jouni , KRAGH, Karsten Matthias , HORSMANS POULSEN, Charlotte
IPC分类号： A23K10/18 , A23K20/105 , A23K20/111 , A23K20/158 , A23K20/189 , A23K20/20 , A23K20/22 , A23K20/24 , A23K50/10 , A23K40/30
摘要： Provided herein, inter alia, are granules for inclusion in feed or feed additive compositions as well as methods for making and using the same for improving the performance of a ruminant animal with respect to one or more of improved feed conversion ratio (FCR), improved weight gain, improved feed efficiency, improved carcass quality, and/or improved milk production.

8. 发明申请

WO2020176443A1 PROTEIN HYDROLYSATES WITH INCREASED YIELD OF N-TERMINAL AMINO ACID 审中-公开
公开(公告)号：WO2020176443A1
公开(公告)日：2020-09-03
申请号：PCT/US2020/019598
申请日：2020-02-25
申请人： DUPONT NUTRITION BIOSCIENCES APS , DANISCO US INC.
发明人： DEGN, Peter Edvard , GU, Xiaogang , KRAGH, Karsten Matthias , SORG, Robin Anton , BAK, Steffen Yde , HAANING, Svend , TANG, Xinyue , HAO, Helong , KOLKMAN, Marc Anton Bernhard
IPC分类号： C12N9/48
摘要： The present invention related to a method for preparing a protein hydrolysate from a proteinaceous material by contacting the material with a proteolytic enzyme mixture having a proline specific exopeptidase. In particular, the proline specific exopeptidase is an aminopeptidase specific for at the five amino acid N-terminal sequence X-Pro-Gln-Glv-Pro-, where X is any amino acid. The present invention also relates to use of the aminopeptidase with a second exopeptidase and an endopeptidase.

9. 发明申请

WO2016110523A1 PROCESS FOR THE HYDROLYSIS OF KERATIN EMPLOYING PROTEASES 审中-公开
标题翻译：使用KERATIN使用蛋白质的水解方法
公开(公告)号：WO2016110523A1
公开(公告)日：2016-07-14
申请号：PCT/EP2016/050173
申请日：2016-01-07
申请人： DUPONT NUTRITION BIOSCIENCES APS
发明人： HANSTED, Jon Gade , KRAGH, Karsten Matthias , SHIPOVSKOV, Stepan , YU, Shukun
IPC分类号： C12P21/06
CPC分类号： C12P21/06 , A23J3/341
摘要： The present disclosure provides methods and uses for keratin hydrolysates (e.g. feathers hydrolysates).
摘要翻译：本公开提供了角蛋白水解产物（例如羽毛水解产物）的方法和用途。

10. 发明申请

WO2016062855A1 PROLINE TOLERANT TRIPEPTIDYL PEPTIDASES AND USES THEREOF 审中-公开
标题翻译：舒缓耐药肽及其用途
公开(公告)号：WO2016062855A1
公开(公告)日：2016-04-28
申请号：PCT/EP2015/074600
申请日：2015-10-23
申请人： DUPONT NUTRITION BIOSCIENCES APS
发明人： KRAGH, Karsten Matthias , MEINJOHANNS, Ernst , MIASNIKOV, Andrei , MA, Maria , EISELE, Thomas , HAANING, Svend , DEGN, Peter Edvard , BAK, Steffen Yde
IPC分类号： C12N9/48 , C12P21/06 , A23J3/34
CPC分类号： A23J3/34 , A23K10/14 , A23K20/147 , A23K50/30 , A23K50/75 , C12N9/485 , C12P21/06 , C12Y304/14 , C12Y304/14009
摘要： A method for the production of a hydrolysate comprising: (a) admixing at least one protein or a portion thereof with: (A) at least one endoprotease; and (B) (a') at least one proline tolerant tripeptidyl peptidase or fermentate comprising a proline tolerant tripeptidyl peptidase predominantly having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having: Proline at P1; and synthetic amino acids at P1; or (b') at least one proline tolerant tripeptidyl peptidase having exopeptidase activity wherein said proline tolerant tripeptidyl peptidase is capable of cleaving tri-peptides from the N-terminus of peptides having: Proline at PV; and synthetic amino acids at PV; and (b) recovering the hydrolysate. The invention also relates to methods for producing a hydrolysate comprising the use of an endoprotease an exo-tripeptidyl peptidase of the S53 family and an aminopeptidase, to uses of a proline tolerant tripeptidyl peptidase, compositions, food and/or feed additive compositions comprising the same, as well as hydrolysates and uses of proline tolerant tripeptidyl peptidases.
摘要翻译：一种生产水解产物的方法，包括：（a）将至少一种蛋白质或其部分与下列物质混合：（A）至少一种内切蛋白酶; 和（B）（a'）至少一种脯氨酸耐受性三肽基肽酶或发酵物，其包含主要具有外肽酶活性的脯氨酸耐受性三肽基肽酶，其中所述脯氨酸耐受性三肽基肽酶能够从具有以下的肽的N-末端切割三肽：在P1; 和P1的合成氨基酸; 或（b'）至少一种具有外肽酶活性的脯氨酸耐受性三肽基肽酶，其中所述脯氨酸耐受性三肽基肽酶能够从肽的N-末端切割三肽：在PV下具有脯氨酸; 和PV处的合成氨基酸; 和（b）回收水解产物。本发明还涉及用于生产水解产物的方法，其包括使用内切蛋白酶，S53家族的外切三肽基肽酶和氨基肽酶，使用脯氨酸耐受性三肽基肽酶，组合物，包含其的食品和/或饲料添加剂组合物，以及脯氨酸耐受性三肽基肽酶的水解产物和用途。

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