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1. 发明专利

CA2346896A1 3-TETRAHYDROPYRIDIN-4-YL INDOLES FOR TREATMENT OF PSYCHOTIC DISORDERS 未知
公开(公告)号：CA2346896A1
公开(公告)日：2000-04-27
申请号：CA2346896
申请日：1999-10-15
申请人： DUPHAR INT RES
发明人： TULP MARTINUS T M , VISSER GERBEN M , VAN DER HEIJDEN JOHANNES A M , VAN HES ROELOF , TIPKER JACOBUS , VAN VLIET BERNARD , KRUSE CORNELIS G
IPC分类号： A61K31/435 , A61K31/475 , A61P25/18 , A61P25/22 , A61P25/24 , C07D401/14
摘要： The invention relates to a novel group 3-tetrahydropyridin-4-yl indoles havi ng interesting pharmacological properties. These compounds have general formula (I) wherein: R1 is halogen, CF3, alkyl (1-3C), alkoxy (1-3C), CN or SCH3; m the value 0, 1 or 2; R2 is H or alkyl (1-3C); n has the value 3, 4, 5 or 6; R3 is halogen, alkyl (1-4C); or alkoxy (1-4C); p has the value 0, 1, or 2 and salts thereof.

2. 发明专利

AT72435T 未知
公开(公告)号：AT72435T
公开(公告)日：1992-02-15
申请号：AT87201706
申请日：1987-09-09
申请人： DUPHAR INT RES
发明人： VAN WIJNGAARDEN INEKE , KRUSE CORNELIS G , VAN HES ROELOF , VAN DER HEYDEN JOHANNES A M
IPC分类号： A61K31/40 , A61P25/00 , C07D207/32 , C07D207/333 , C07D207/335 , C07D403/04 , C07D405/04 , C07D521/00
摘要： The invention relates to a group of new phenyl, pyrrolidin-2-yl substituted 5-ring heterocyclic compounds of the formula wherein A is an unsaturated heterocylic 5-ring having at least one nitrogen or oxygen atom in the ring, with the proviso that the phenyl substituent is in a meta-position with respect to the 2-pyrrolidinyl substituent. The compounds have interesting pharmacological, notably antipsychotic properties.

4. 发明专利

KE3856A BENZOYLUREA COMPOUNDS,AND PESTICIDAL AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME 未知
公开(公告)号：KE3856A
公开(公告)日：1989-05-05
申请号：KE385689
申请日：1989-01-06
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , GROSSCURT ARNOLDUS C , VAN HES ROELOF
IPC分类号： A01N47/34 , A61K31/17 , C07C127/22

5. 发明专利

CA1247609A BENZOYLUREA COMPOUNDS, AND PESTICIDAL COMPOSITIONS COMPRISING SAME 未知
公开(公告)号：CA1247609A
公开(公告)日：1988-12-28
申请号：CA445613
申请日：1984-01-19
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , GROSSCURT ARNOLDUS C , VAN HES ROELOF
IPC分类号： A01N47/34 , A01P7/04 , C07C273/18 , C07C275/54 , C07C127/22
摘要： The invention relates to new benzoylurea compounds of the general formula wherein R1 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen, and alkyl and haloalkyl having 1-4 carbon atoms, R2 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl, and R3 is a hydrogen atom or represents 1-3 alkyl and/or alkenyl groups each having 1-6 carbon atoms, or wherein R3 together with the cyclohexyl ring to which it is attached forms a bi- or polycyclic hydrocarbyl group having 8-14 carbon atoms. The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare.

6. 发明专利

HU193667B INSECTICIDES AND ACARICIDES COMPRISING BENZOYL-UREA DERIVATIVES AND PROCESS FOR PREPARING THE BENZOYL-UREA DERIVATIVES 未知
公开(公告)号：HU193667B
公开(公告)日：1987-11-30
申请号：HU26184
申请日：1984-01-23
申请人： DUPHAR INT RES
发明人： BROUWER MARIUS S , GROSSCURT ARNOLDUS C , VAN HES ROELOF
IPC分类号： A01N47/34 , A01P7/04 , C07C273/18 , C07C275/54 , A01N47/20 , C07C127/22
摘要： The invention relates to new benzoylurea compounds of the general formula wherein R1 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of halogen and alkyl and haloalkyl having 1-4 carbon atoms, R2 is a hydrogen atom or represents 1 or 2 substituents which are selected from the group consisting of chlorine, methyl and trifluoromethyl, and R3 is a hydrogen atom or represents 1-3 alkyl and/or alkenyl groups each having 1-6 and/or 2-6 carbon atoms respectively, or wherein R3 together with the cyclohexyl ring to which it is attached forms a bi- or polycyclic hydrocarbyl group having 8-14 carbon atoms and, if desired, substituted with 1-3 alkyl groups each having 1-4 carbon atoms. The compounds have an insecticidal and acaricidal activity. After having been processed to compositions, the compounds may be used for the control of insects and/or mites in a dosage from 1 to 5000 g of active substance per hectare.

7. 发明专利

AT14309T 未知
公开(公告)号：AT14309T
公开(公告)日：1985-08-15
申请号：AT82200542
申请日：1982-05-06
申请人： DUPHAR INT RES
发明人： VAN HES ROELOF , CROSSCURT ARNOLDUS CORNELIS
IPC分类号： A01N47/36 , A01N43/56 , A01N47/38 , A01P7/04 , C07D231/06

8. 发明专利

DD157071A5 未知
公开(公告)号：DD157071A5
公开(公告)日：1982-10-13
申请号：DD22710681
申请日：1981-01-20
申请人： DUPHAR INT RES
发明人： VAN HES ROELOF , GROSSCURT ARNOLDUS C , BALK WOUTER
IPC分类号： C07D275/04 , A01N41/06 , A01N43/36 , A01N43/40 , A01N43/80 , C07C67/00 , C07C301/00 , C07C303/38 , C07C303/40 , C07C311/16 , C07D275/06 , A01N31/08
摘要： The invention relates to new sulphonyl compounds of the general formula wherein X is a halogen atom, a phenoxy group, or an alkyl group or alkoxy group having 1-4 carbon atoms and substituted, if desired, with halogen; R1 is a cyano group, and R2 is an amino group which, if desired, may be substituted with halogen, with one or two alkenyl groups or alkynyl groups having 2-6 carbon atoms or with one or two alkyl groups having 1-6 carbon atoms, which alkyl groups, together with the nitrogen atom to which they are bound, may form a saturated heterocyclic ring, which ring may also contain a second hetero atom selected from the group consisting of nitrogen, oxygen and sulphur, or which alkyl groups may be substituted with an alkoxy group, having 1-4 carbon atoms, or with a dialkylamino group having 2-6 carbon atoms the alkyl groups of which, together with the nitrogen atom to which they are bound, may form a saturated heterocyclic ring; or wherein R1 and R2 together form a S,S-dialkylsulphoximido group the alkyl groups of which comprise 1-4 carbon atoms, or a 1-amino-2-azavinylene group, of which the amino group is substituted, if desired, with a cycloalkylcarbamoyl group having 4-8 carbon atoms, an alkylcarbamoyl group having 2-5 carbon atoms, a dialkylamino group the alkyl group of which comprise 1-4 carbon atoms, or an alkyl group having 1-4 carbon atoms which alkyl group may be substituted with a hydroxy group or one or more halogen atoms; or wherein R1 and R2 together form a 1-imino-2-azaethylene group of which the ring nitrogen is substituted with an alkyl group or alkenyl group having 1-4 carbon atoms, and of which the imino group may be substituted with a substituted or non-substituted phenylcarbamoyl group, having aphicidal activity. After having been processed to compositions, the compounds may be used for the control of aphids in agriculture, horticulture and forestry in a dosage from 20 to 5,000 g of active substance per hectare.

9. 发明专利

DE69904849T2 未知
公开(公告)号：DE69904849T2
公开(公告)日：2003-11-13
申请号：DE69904849
申请日：1999-10-15
申请人： DUPHAR INT RES
发明人： TULP T M , VAN DER HEIJDEN A M , VAN VLIET BERNARD , TIPKER JACOBUS , VAN HES ROELOF , KRUSE G , VISSER M
IPC分类号： A61K31/435 , A61K31/475 , A61P25/18 , A61P25/22 , A61P25/24 , C07D401/14
摘要： The invention is related to the following compounds:wherein all variables are as defined in the specification. The compounds are useful for treating psychotic disorders.

10. 发明专利

DK1121356T3 未知
公开(公告)号：DK1121356T3
公开(公告)日：2003-03-24
申请号：DK99952604
申请日：1999-10-15
申请人： DUPHAR INT RES
发明人： TULP MARTINUS T M , VAN DER HEIJDEN JOHANNES A M , VAN VLIET BERNARD , TIPKER JACOBUS , VAN HES ROELOF , KRUSE CORNELIS G , VISSER GERBEN M
IPC分类号： A61K31/435 , A61K31/475 , A61P25/18 , A61P25/22 , A61P25/24 , C07D401/14
摘要： The invention is related to the following compounds:wherein all variables are as defined in the specification. The compounds are useful for treating psychotic disorders.

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