专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011034723A1 IMPROVED DEVICE AND METHOD FOR DELIVERY OF A MEDICAMENT 审中-公开
标题翻译：用于递送药物的改进的装置和方法
公开(公告)号：WO2011034723A1
公开(公告)日：2011-03-24
申请号：PCT/US2010/047271
申请日：2010-08-31
申请人： DUKE UNIVERSITY , ROSE, Jed, E. , ROSE, Seth, D. , TURNER, James, Edward , MURUGESAN, Thangaraju
发明人： ROSE, Jed, E. , ROSE, Seth, D. , TURNER, James, Edward , MURUGESAN, Thangaraju
IPC分类号： A61K9/14
CPC分类号： A61K9/12 , A24F47/00 , A61K9/0073 , A61K31/465 , A61K47/12 , A61M11/007 , A61M11/041 , A61M11/042 , A61M11/047 , A61M15/00 , A61M15/002 , A61M15/06 , A61M2205/3368 , A61M2205/8206 , A61M2209/045
摘要： The disclosure relates to an improved method of enhancing nicotine concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and/or harm reduction. The disclosure further relates various devices and device design principles for practicing these methods.
摘要翻译：本公开涉及一种改善气态载体中尼古丁浓度的方法。该方法适用于尼古丁的输送，用于各种疾病中的治疗效果，特别是用于烟草制品停止，替代和/或减少伤害的尼古丁。本公开进一步涉及用于实施这些方法的各种设备和设备设计原理。

2. 发明申请

WO2010107613A1 TOBACCO-BASED NICOTINE AEROSOL GENERATION SYSTEM 审中-公开
标题翻译：基于烟草的NICOTINE气溶胶生成系统
公开(公告)号：WO2010107613A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/026614
申请日：2010-03-09
申请人： DUKE UNIVERSITY , ROSE, Seth, D. , TURNER, James, Edward , MURUGESAN, Thangaraju , ROSE, Jed, E.
发明人： ROSE, Seth, D. , TURNER, James, Edward , MURUGESAN, Thangaraju , ROSE, Jed, E.
IPC分类号： A61M11/00
CPC分类号： A24F47/008 , A24F47/002 , A24F47/006 , A61M11/042 , A61M11/047 , A61M15/06 , A61M2206/14
摘要： The invention relates to devices and methods for delivering nicotine and/or other alkaloids from tobacco, other plants and other natural sources. More particularly, the invention relates to devices and methods for delivering an aerosol of nicotine to a user's lungs without combustion of the nicotine source materials.
摘要翻译：本发明涉及从烟草，其他植物和其他天然来源递送尼古丁和/或其他生物碱的装置和方法。更具体地，本发明涉及用于将烟碱气雾剂输送到用户的肺而不燃烧尼古丁源材料的装置和方法。

3. 发明申请

WO2008121610A1 DEVICE AND METHOD FOR DELIVERY OF A MEDICAMENT 审中-公开
标题翻译：用于递送药物的装置和方法
公开(公告)号：WO2008121610A1
公开(公告)日：2008-10-09
申请号：PCT/US2008/058122
申请日：2008-03-25
申请人： DUKE UNIVERSITY , ROSE, Jed, E. , ROSE, Seth, D. , TURNER, James, Edward , MURUGESAN, Thangaraju
发明人： ROSE, Jed, E. , ROSE, Seth, D. , TURNER, James, Edward , MURUGESAN, Thangaraju
IPC分类号： A61M11/00 , A61M15/00
CPC分类号： A61K31/465 , A24B15/167 , A24F47/002 , A24F47/004 , A61K9/007 , A61K9/1617 , A61K31/4439 , A61M11/041 , A61M11/047 , A61M15/009 , A61M15/0091 , A61M15/06 , A61M2205/071 , A61M2205/8206
摘要： The disclosure relates to a method of enhancing nicotine or other medicament concentrations in a gaseous carrier. The methods are adaptable to the delivery of nicotine or other medicaments for therapeutic effect in various diseases, in particular nicotine for tobacco product use cessation, substitution and/or harm reduction. The disclosure further relates various devices and device design principles for practicing these methods.
摘要翻译：本公开涉及一种在气态载体中增强尼古丁或其他药物浓度的方法。该方法适用于尼古丁或其他药物的递送，用于各种疾病中的治疗效果，特别是用于烟草制品停止，替代和/或伤害减少的尼古丁。本公开进一步涉及用于实施这些方法的各种设备和设备设计原理。

4. 发明申请

WO2009089024A8 NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
公开(公告)号：WO2009089024A8
公开(公告)日：2009-07-16
申请号：PCT/US2009/000098
申请日：2009-01-08
申请人： DUKE UNIVERSITY , THE UNITED STATES GOVERNMENT as represented by THE DEPARTMENT OF VETERANS AFFAIRS , MARX, Christine, E. , ROSE, Jed, E.
发明人： MARX, Christine, E. , ROSE, Jed, E.
IPC分类号： A61K31/566 , A61K31/57 , A61P25/28 , A61P25/30
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

5. 发明申请

WO2009105655A1 METHODS AND COMPOSITIONS FOR PREDICTING SUCCESS IN ADDICTIVE SUBSTANCE CESSATION AND FOR PREDICTING A RISK OF ADDICTION 审中-公开
标题翻译：用于预测吸入物质成分和预测接种风险的方法和组合物
公开(公告)号：WO2009105655A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/034694
申请日：2009-02-20
申请人： DUKE UNIVERSITY , ROSE, Jed, E. , UHL, George, R.
发明人： ROSE, Jed, E. , UHL, George, R.
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156
摘要： The present invention relates to genetic polymorphisms that are associated with dependence on an addictive substance. In particular, the present invention relates to a method for predicting success in addictive substance cessation in a subject, such as predicting success in nicotine cessation. In some embodiments, nicotine cessation is accompanied by a nicotine replacement source and/or an antidepressant. The invention further provides a method for identifying a subject who has an increased risk of becoming dependent on an addictive substance. In some embodiments, the addictive substance is nicotine. Also provided are isolated nucleic acid molecules containing the polymorphisms and reagents for detecting the polymorphic nucleic acid molecules.
摘要翻译：本发明涉及与依赖于成瘾物质相关的遗传多态性。特别地，本发明涉及一种预测成人上皮症状成功的方法，例如预测尼古丁戒烟的成功。在一些实施方案中，尼古丁停止伴随着尼古丁替代来源和/或抗抑郁药。本发明还提供了一种用于鉴定具有增加依赖于成瘾物质的风险增加的受试者的方法。在一些实施方案中，成瘾物质是尼古丁。还提供了含有用于检测多态性核酸分子的多态性和试剂的分离的核酸分子。

6. 发明申请

WO2010107815A1 NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
标题翻译：神经性甾体组合物及其使用方法
公开(公告)号：WO2010107815A1
公开(公告)日：2010-09-23
申请号：PCT/US2010/027513
申请日：2010-03-16
申请人： DUKE UNIVERSITY , ROSE, Jed, E. , MARX, Christine, E.
发明人： ROSE, Jed, E. , MARX, Christine, E.
IPC分类号： A61K31/56
CPC分类号： A61K31/57 , A61K31/5685 , A61K45/06 , G01N33/6896 , G01N33/94 , G01N2800/304
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), progesterone (PROG), precursors thereof, metabolites thereof, pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.
摘要翻译：提供了改善受试者神经精神障碍症状的方法。还提供了用于改善受试者戒烟所产生的至少一种身体症状或至少一种心理症状的方法，用于改善受试者中阿尔茨海默病或其他认知障碍症状的方法，改善精神分裂症症状的方法，分裂感觉障碍或其他精神病性障碍，用于改善受试者的抑郁症状的方法，改善受试者双相情感障碍症状的方法，改善创伤后应激障碍症状或其他焦虑症状的方法在一个主题中，用于预测受试者的自杀倾向，自杀意念，自杀行为或其组合的方法，改善受试者的疼痛障碍症状的方法，改善受试者的神经变性疾病的方法，方法用于改善受试者的创伤性脑损伤的症状，改善sl的方法受试者的睡眠障碍以及用于改善受试者的认知功能的方法。在一些实施方案中，所述方法包括向有需要的受试者施用有效量的神经活性类固醇组合物，其包含孕烯醇酮（PG），异哌可酮（ALLO），脱氢表雄酮（DHEA），孕酮（PROG），其前体，其代谢物，其可接受的盐，其衍生物或其组合。

7. 发明公开

EP2249840A1 NEUROACTIVE STEROID COMPOSITIONS AND METHODS OF USE THEREFOR 审中-公开
标题翻译： NEURO ACTIVE类固醇组合物及其使用方法
公开(公告)号：EP2249840A1
公开(公告)日：2010-11-17
申请号：EP09700339.6
申请日：2009-01-08
申请人： Duke University , The United States Government As Represented By The Department Of Veterans Affairs
发明人： MARX, Christine, E. , ROSE, Jed, E.
IPC分类号： A61K31/566 , A61K31/57 , A61P25/28 , A61P25/30
CPC分类号： A61K31/57 , G01N33/6896 , G01N33/94 , G01N2800/304 , Y10T436/200833
摘要： Provided are methods for ameliorating a symptom of a neuropsychiatric disorder in a subject. Also provided are methods for ameliorating at least one physical symptom or at least one psychological symptom resulting from tobacco cessation in a subject, methods for ameliorating a symptom of Alzheimer's disease or other cognitive disorder in a subject, methods for ameliorating a symptom of schizophrenia, schizoaffective disorder, or other psychotic disorder in a subject, methods for ameliorating a symptom of a depressive disorder in a subject, methods for ameliorating a symptom of bipolar disorder in a subject, methods for ameliorating a symptom of post-traumatic stress disorder or other anxiety disorder in a subject, methods for predicting a predisposition to suicide, suicidal ideation, suicidal behavior, or a combination thereof in a subject, methods for ameliorating a symptom of a pain disorder in a subject, methods for ameliorating a neurodegenerative disorder in a subject, methods for ameliorating a symptom of traumatic brain injury in a subject, methods for ameliorating a sleep disorder in a subject, and methods for improving cognitive functioning in a subject. In some embodiments, the methods include administering to a subject in need thereof an effective amount of a neuroactive steroid composition comprising pregnenolone (PG), allopregnanolone (ALLO), dehydroepiandrosterone (DHEA), pharmaceutically acceptable salts thereof, derivatives thereof, or combinations thereof.

8. 发明申请

WO1994017679A1 DRY POWDER DELIVERY SYSTEM 审中-公开
标题翻译：干粉输送系统
公开(公告)号：WO1994017679A1
公开(公告)日：1994-08-18
申请号：PCT/US1994001394
申请日：1994-02-08
申请人： ADVANCED THERAPEUTIC PRODUCTS, INC. , DUKE UNIVERSITY
发明人： ADVANCED THERAPEUTIC PRODUCTS, INC. , DUKE UNIVERSITY , ROSE, Jed, E. , BEHM, Frederique , TURNER, James
IPC分类号： A24F47/00
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A dry powder delivery system includes a cartridge (42) and a mouthpiece (44). The cartridge includes a matrix (58) containing a measured amount of a dry powder compound. A porous element (56) may be provided containing a dessicant compound or the dessicant compound may be impregnated into the matrix (58). The mouthpiece (44) includes a tubular housing (60).
摘要翻译：一种干粉递送系统包括一个盒（42）和一个接口（44）。盒包括含有测量量的干粉末化合物的基质（58）。可以提供含有干燥剂的多孔元件（56），或者可以将干燥剂化合物浸渍到基质（58）中。接口（44）包括管状壳体（60）。

9. 发明公开

EP0683632A1 DRY POWDER DELIVERY SYSTEM 失效
标题翻译：供应系统干粉。
公开(公告)号：EP0683632A1
公开(公告)日：1995-11-29
申请号：EP94908736.0
申请日：1994-02-08
申请人： ADVANCED THERAPEUTIC PRODUCTS, INC. , DUKE UNIVERSITY
发明人： ROSE, Jed, E. , BEHM, Frederique , TURNER, James
IPC分类号： A24F47 , A61K9 , A61M15
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A dry powder delivery system includes a cartridge (42) and a mouthpiece (44). The cartridge includes a matrix (58) containing a measured amount of a dry powder compound. A porous element (56) may be provided containing a dessicant compound or the dessicant compound may be impregnated into the matrix (58). The mouthpiece (44) includes a tubular housing (60).

10. 发明授权

EP0683632B1 DRY POWDER DELIVERY SYSTEM 失效
标题翻译：供应系统干粉
公开(公告)号：EP0683632B1
公开(公告)日：2004-05-19
申请号：EP94908736.5
申请日：1994-02-08
申请人： ADVANCED THERAPEUTIC PRODUCTS, INC. , DUKE UNIVERSITY
发明人： ROSE, Jed, E. , BEHM, Frederique , TURNER, James
IPC分类号： A24F47/00
CPC分类号： A61K9/007 , A24F47/002 , A61M11/001 , A61M15/00 , A61M15/0006 , A61M15/0028 , A61M15/0036 , A61M15/0041 , A61M15/06 , A61M2202/062 , A61M2202/064 , Y10T137/5196
摘要： A dry powder delivery system includes a cartridge (42) and a mouthpiece (44). The cartridge includes a matrix (58) containing a measured amount of a dry powder compound. A porous element (56) may be provided containing a dessicant compound or the dessicant compound may be impregnated into the matrix (58). The mouthpiece (44) includes a tubular housing (60).

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式