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1. 发明申请

WO2016004152A3 SYSTEMS AND METHODS FOR MODEL-BASED OPTIMIZATION OF SPINAL CORD STIMULATION ELECTRODES AND DEVICES 审中-公开
公开(公告)号：WO2016004152A3
公开(公告)日：2016-01-07
申请号：PCT/US2015/038735
申请日：2015-07-01
申请人： DUKE UNIVERSITY , GRILL, Warren, M. , HOWELL, Bryan
发明人： GRILL, Warren, M. , HOWELL, Bryan
IPC分类号： A61B5/053
摘要： Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices are disclosed. According to an aspect a method includes providing a patient-specific electro anatomical model including the spine, spinal cord, and a map of target neural elements and non-target neural elements. The method also includes using model electrodes to stimulate the target neural elements. Further, the method includes determining differences in activation thresholds between the target neural elements and the non-target neural elements in a plurality of different configurations of the model electrodes. The method also includes generating an optimal spinal cord stimulation electrode configuration based on the determined differences in activation thresholds.

2. 发明公开

EP3164068A2 SYSTEMS AND METHODS FOR MODEL-BASED OPTIMIZATION OF SPINAL CORD STIMULATION ELECTRODES AND DEVICES 审中-公开
标题翻译：系统和方法用于脊髓刺激电极与器件基于模型的优化
公开(公告)号：EP3164068A2
公开(公告)日：2017-05-10
申请号：EP15814864.3
申请日：2015-07-01
申请人： Duke University
发明人： GRILL, Warren, M. , HOWELL, Bryan
IPC分类号： A61B5/053
CPC分类号： G16H50/50 , A61N1/0551 , A61N1/36185 , A61N1/37241 , G06F17/13 , G06F19/00
摘要： Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices are disclosed. According to an aspect a method includes providing a patient-specific electroanatomical model including the spine, spinal cord, and a map of target neural elements and non-target neural elements. The method also includes using model electrodes to stimulate the target neural elements. Further, the method includes determining differences in activation thresholds between the target neural elements and the non-target neural elements in a plurality of different configurations of the model electrodes. The method also includes generating an optimal spinal cord stimulation electrode configuration based on the determined differences in activation thresholds.
摘要翻译：脊髓刺激电极和设备的基于模型的优化的系统和方法是游离缺失盘。。根据方面的方法包括：提供患者特定的模型包括电解剖脊椎，脊髓，和地图的目标神经元和非神经靶元素。因此，该方法包括使用模型电极来刺激所述目标神经元。此外，该方法包括：在目标神经元，并在模型电极的不同配置的多个非目标神经元之间的激活阈值的确定性采矿差异。该方法包括基于在激活阈值确定性开采差异脊髓刺激电极配置产生如此完美。

3. 发明申请

WO2016209682A1 SYSTEMS AND METHODS FOR UTILIZING MODEL-BASED OPTIMIZATION OF SPINAL CORD STIMULATION PARAMETERS 审中-公开
标题翻译：使用基于模型的脊髓刺激参数优化的系统和方法
公开(公告)号：WO2016209682A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/037571
申请日：2016-06-15
申请人： DUKE UNIVERSITY
发明人： GRILL, Warren, M. , HOWELL, Bryan , LAD, Shivanand, P.
IPC分类号： G06F19/00 , A61N1/36 , A61N1/05
CPC分类号： A61N1/0551 , A61N1/05 , A61N1/36 , A61N1/36071 , A61N1/36125 , A61N1/36128 , G06F19/00 , G16H20/30 , G16H50/50
摘要： Systems, methods, and devices are disclosed for optimizing patient-specific stimulation parameters for spinal cord stimulation. A patient-specific anatomical model is developed based on a pre-operative image, and a patient-specific electrical model is developed based on the anatomical model. The inputs to the electric model are chosen, and the model is used to calculate a distribution of electrical potentials within the modeled domain. Models of neural elements are stimulated with the electric potentials and used to determine which elements are directly activated by the stimulus. Information about the models inputs and which neural elements are active is applied to a cost function. Based on the value of the cost function, the inputs to the optimization process may be adjusted. Inputs to the optimization process include lead/electrode array geometry, lead configuration, lead positions, and lead signal characteristics, such as pulse width, amplitude, frequency and polarity.
摘要翻译：公开了用于优化用于脊髓刺激的患者特异性刺激参数的系统，方法和装置。基于手术前图像开发了患者特异性解剖模型，并且基于解剖模型开发了患者特定的电模型。选择电模型的输入，并且使用该模型来计算建模域内的电势分布。用电位刺激神经元的模型，并用于确定哪些元素被刺激直接激活。有关模型输入和哪些神经元有效的信息应用于成本函数。基于成本函数的值，可以调整优化过程的输入。优化过程的输入包括引线/电极阵列几何形状，引线配置，引线位置和引脚信号特性，如脉冲宽度，幅度，频率和极性。

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