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1. 发明申请

WO2009079532A3 DOWN-REGULATION OF GENE EXPRESSION USING ARTIFICIAL MICRORNAS 审中-公开
标题翻译：使用人工微阵列降低基因表达
公开(公告)号：WO2009079532A3
公开(公告)日：2009-09-17
申请号：PCT/US2008087082
申请日：2008-12-17
申请人： DU PONT , MCGONIGLE BRIAN
发明人： MCGONIGLE BRIAN
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8218 , C12N15/8216 , C12N15/8242 , C12N15/8261 , Y02A40/146
摘要： Isolated nucleic acid fragments comprising precursor miRNAs, and artificial miRNAs and their use in down-regulating gene expression are described.
摘要翻译：描述了包含前体miRNA和人造miRNA的分离的核酸片段及其在下调基因表达中的用途。

2. 发明申请

WO0037652A3 FLAVONOID BIOSYNTHETIC ENZYMES 审中-公开
标题翻译：黄酮类生物合成酶
公开(公告)号：WO0037652A3
公开(公告)日：2000-11-16
申请号：PCT/US9930337
申请日：1999-12-20
申请人： DU PONT , FAMODU OMOLAYO O , MCGONIGLE BRIAN , ODELL JOAN T , FADER GARY M , FALCO SAVERIO CARL
发明人： FAMODU OMOLAYO O , MCGONIGLE BRIAN , ODELL JOAN T , FADER GARY M , FALCO SAVERIO CARL
IPC分类号： C12N9/02 , C12N9/10 , C12N15/53 , C12N15/54 , C12N15/82 , C12Q1/02 , C12Q1/68
CPC分类号： C12N9/0071 , C12N9/1007 , C12N15/8209 , C12N15/8243 , C12N15/825
摘要： This invention relates to an isolated nucleic acid fragment encoding a flavonoid biosynthetic enzyme. The invention also relates to the construction of a chimeric gene encoding all or a portion of the flavonoid biosynthetic enzyme, in sense or antisense orientation, wherein expression of the chimeric gene results in production of altered levels of the flavonoid biosynthetic enzyme in a transformed host cell.
摘要翻译：本发明涉及编码类黄酮生物合成酶的分离的核酸片段。本发明还涉及以正义或反义方向构建编码全部或部分类黄酮生物合成酶的嵌合基因，其中嵌合基因的表达导致转化的宿主细胞中类黄酮生物合成酶水平的改变。

3. 发明申请

WO2007061845A2 DELTA-9 ELONGASES AND THEIR USE IN MAKING POLYUNSATURATED FATTY ACIDS 审中-公开
标题翻译： DELTA-9长链和它们在制备聚氨酯脂肪酸中的应用
公开(公告)号：WO2007061845A2
公开(公告)日：2007-05-31
申请号：PCT/US2006044676
申请日：2006-11-16
申请人： DU PONT , DAMUDE HOWARD GLENN , MCGONIGLE BRIAN , ZHU QUINN QUN , XUE ZHIXIONG
发明人： DAMUDE HOWARD GLENN , MCGONIGLE BRIAN , ZHU QUINN QUN , XUE ZHIXIONG
IPC分类号： C12N9/10 , C12N15/82
CPC分类号： C12N15/8247 , C11B1/025 , C12N9/1029 , C12P7/6427 , C12P7/6463 , C12P7/6472
摘要： Isolated nucleic acid fragments and recombinant constructs comprising such fragments encoding delta-9 elongases along with a method of making long-chain polyunsaturated fatty acids (PUFAs) using these delta-9 elongases in plants.
摘要翻译：分离的核酸片段和包含编码Δ-9延伸酶的这种片段的重组构建物以及在植物中使用这些δ-9延长酶制备长链多不饱和脂肪酸（PUFA）的方法。

4. 发明申请

WO2006076717A3 A NOVEL CYTOCHROME P450 MONOOXYGENASE 审中-公开
标题翻译：一种新型CYTOCHROME P450 MONOOXYGENASE
公开(公告)号：WO2006076717A3
公开(公告)日：2006-12-14
申请号：PCT/US2006001549
申请日：2006-01-13
申请人： DU PONT , MCGONIGLE BRIAN , FALCO SAVERIO CARL , EVERARD JOHN D , SWINSON NICOLE A
发明人： MCGONIGLE BRIAN , FALCO SAVERIO CARL , EVERARD JOHN D , SWINSON NICOLE A
IPC分类号： C12N9/02 , A01H1/00 , A01H5/00 , A23K1/00 , C07K14/415 , C12P7/02
CPC分类号： C12N9/0077 , C12N15/8243 , C12N15/8247 , C12P7/04
摘要： This invention relates to an isolated polynucleotide encoding a cytochrome P450 monooxygenase that in the presence of linoleic acid results in production of 1-octen-3-ol. The invention also relates to the construction of a recombinant DNA construct comprising all or a portion of the polynucleotide encoding the cytochrome P450 monooxygenases of the invention, in sense or antisense orientation, wherein expression of the recombinant DNA construct results in production of altered levels 1-octen-3-ol in a transformed host cell.
摘要翻译：本发明涉及编码细胞色素P450单加氧酶的分离的多核苷酸，其在亚油酸存在下导致1-辛烯-3-醇的产生。本发明还涉及以有义或反义方向构建包含编码本发明的细胞色素P450单加氧酶的全部或部分多核苷酸的重组DNA构建体，其中重组DNA构建体的表达导致产生改变的1- 辛烯-3-醇在转化的宿主细胞中的表达。

5. 发明申请

WO2005121347A3 RECOMBINANT CONSTRUCTS FOR USE IN REDUCING GENE EXPRESSION 审中-公开
标题翻译：用于减少基因表达的重组构建体
公开(公告)号：WO2005121347A3
公开(公告)日：2006-08-03
申请号：PCT/US2005020776
申请日：2005-06-09
申请人： DU PONT , MCGONIGLE BRIAN , STOOP JOHAN M
发明人： MCGONIGLE BRIAN , STOOP JOHAN M
IPC分类号： C12N15/82
CPC分类号： C12N15/8247 , C12N15/8216 , C12N15/8218 , C12N15/8245
摘要： Recombinant constructs useful for reducing the expression of at least one target nucleic acid fragment of interest and any substantially similar endogenous nucleic acid fragment of interest are disclosed. In particular, a recombinant construct comprising at least one nucleic acid of interest is inserted between two convergent promoters. A plant or plant organ stably transformed with this construct will have a reduction in expression of the target nucleic acid fragments of interest.
摘要翻译：公开了可用于降低目标的至少一个靶核酸片段和任何基本上相似的感兴趣的内源性核酸片段的表达的重组构建体。特别地，将包含至少一种目的核酸的重组构建体插入两个收敛启动子之间。用该构建体稳定转化的植物或植物器官将具有目标靶核酸片段的表达降低。

6. 发明申请

WO2012003207A3 PLANT SEEDS WITH ALTERED STORAGE COMPOUND LEVELS, RELATED CONSTRUCTS AND METHODS INVOLVING GENES ENCODING PAE AND PAE-LIKE POLYPEPTIDES 审中-公开
标题翻译：具有改变的存储化合物水平的植物种子，涉及编码PAE和类似多聚体的基因的相关构建体和方法
公开(公告)号：WO2012003207A3
公开(公告)日：2012-02-16
申请号：PCT/US2011042326
申请日：2011-06-29
申请人： DU PONT , MEYER KNUT , MCGONIGLE BRIAN , STECCA KEVIN L
发明人： MEYER KNUT , MCGONIGLE BRIAN , STECCA KEVIN L
IPC分类号： C12N15/82 , C12N9/18 , C12N15/55
CPC分类号： C12N15/8245 , C12N9/18 , C12N15/8234 , C12N15/8246 , C12N15/8247 , C12N15/8251 , C12Y301/01006
摘要： This invention is in the field of plant molecular biology. More specifically, this invention pertains to isolated nucleic acid fragments encoding PAE or PAE-Like proteins in plants and seeds and the use of such fragments to modulate expression of a gene encoding PAE or PAE-Like protein activity in a transformed host cell.
摘要翻译：本发明在植物分子生物学领域。更具体地，本发明涉及在植物和种子中编码PAE或PAE-like蛋白质的分离的核酸片段，以及这种片段在转化的宿主细胞中调节编码PAE或PAE-样蛋白质活性的基因表达的用途。

7. 发明申请

WO2009079548A2 DOWN-REGULATION OF GENE EXPRESSION USING ARTIFICIAL MICRORNAS 审中-公开
标题翻译：用人工微核蛋白下调基因表达
公开(公告)号：WO2009079548A2
公开(公告)日：2009-06-25
申请号：PCT/US2008087136
申请日：2008-12-17
申请人： DU PONT , MCGONIGLE BRIAN
发明人： MCGONIGLE BRIAN
IPC分类号： C12N15/82 , A01H5/00
CPC分类号： C12N15/8218 , C12N15/8247 , C12N15/825
摘要： Isolated nucleic acid fragments comprising precursor miRNA, and artificial miRNAs and their use in down-regulating gene expression are described.
摘要翻译：描述了包含前体miRNA的分离的核酸片段和人工miRNA以及它们在下调基因表达中的用途。

8. 发明申请

WO0166773A3 NUCLEIC ACIDS THAT CODE FOR OXIDOSQUALENE CYCLASES 审中-公开
标题翻译：核苷酸氧化酶循环的代码
公开(公告)号：WO0166773A3
公开(公告)日：2003-08-07
申请号：PCT/US0107611
申请日：2001-03-09
申请人： DU PONT , BRYAN GREGORY T , MCGONIGLE BRIAN , MAXWELL CARL A , POTTER SUSAN M , HWANG DER-CHYAN
发明人： BRYAN GREGORY T , MCGONIGLE BRIAN , MAXWELL CARL A , POTTER SUSAN M , HWANG DER-CHYAN
IPC分类号： A23J3/16 , A61K38/00 , C12N9/90 , C12N15/61 , C12N15/82 , C12P33/00 , A01H5/00 , A23L1/00 , A61K38/16 , C07K14/415 , C12N15/11 , C12N15/86
CPC分类号： A23J3/16 , A23V2002/00 , A61K38/00 , C12N9/90 , C12N15/8243 , C12N2799/021 , C12P33/00 , A23V2300/21
摘要： This invention relates to an isolated nucleic acid fragment encoding an oxidosqualene cyclase. The invention also relates to the construction of a chimeric gene encoding all or a portion of the isolated polynucleotides of the invention, in sense or antisense orientation, operably linked to a suitable regulatory sequence.
摘要翻译：本发明涉及编码氧化四氢叶酸环化酶的分离的核酸片段。本发明还涉及在正义或反义方向上编码全部或部分本发明的分离的多核苷酸的嵌合基因的构建，其可操作地连接到合适的调节序列。

9. 发明申请

WO2010062518A4 SULFONYLUREA-RESPONSIVE REPRESSOR PROTEINS 审中-公开
标题翻译：磺酰脲类响应性抑制剂蛋白质
公开(公告)号：WO2010062518A4
公开(公告)日：2010-08-05
申请号：PCT/US2009061661
申请日：2009-10-22
申请人： PIONEER HI BRED INT , DU PONT , LASSNER MICHAEL , LOOGER LOREN L , MCBRIDE KEVIN E , MCGONIGLE BRIAN
发明人： LASSNER MICHAEL , LOOGER LOREN L , MCBRIDE KEVIN E , MCGONIGLE BRIAN
IPC分类号： C07K14/195
CPC分类号： C07K14/245 , C07K14/195 , C12N15/635 , C12N15/8217 , C12N15/8238 , C12N15/8278
摘要： Compositions and methods relating to the use of sulfonylurea-responsive repressors are provided. Compositions include polypeptides that specifically bind to an operator, wherein the specific binding is regulated by a sulfonylurea compound. Compositions also include polynucleotides encoding the polypeptides as well as constructs, vectors, prokaryotic and eukaryotic cells, and eukaryotic organisms including plants and seeds comprising the polynucleotide, and/or produced by the methods. Also provided are methods to provide a sulfonylurea-responsive repressor to a cell or organism, and to regulate expression of a polynucleotide of interest in a cell or organism, including a plant or plant cell.
摘要翻译：提供了与使用磺酰脲类应答抑制剂有关的组合物和方法。组合物包括与操纵子特异性结合的多肽，其中特异性结合受磺酰脲类化合物调节。组合物还包括编码多肽的多核苷酸以及构建体，载体，原核和真核细胞以及真核生物，包括包含该多核苷酸的植物和种子，和/或通过所述方法产生。还提供了向细胞或生物体提供磺酰脲类反应性阻遏物并调节目的多核苷酸在细胞或生物体（包括植物或植物细胞）中的表达的方法。

10. 发明申请

WO2005089198A3 TRANSGENIC SOYBEAN SEEDS HAVING REDUCED ACTIVITY OF LIPOXYGENASES 审中-公开
标题翻译：具有降低LIPOXYGENASES活性的转基因大豆种子
公开(公告)号：WO2005089198A3
公开(公告)日：2009-04-23
申请号：PCT/US2005008075
申请日：2005-03-09
申请人： DU PONT , FALCO S CARL , MCGONIGLE BRIAN , MAXWELL CARL A
发明人： FALCO S CARL , MCGONIGLE BRIAN , MAXWELL CARL A
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： C12N15/8243 , C12N15/8247
摘要： The present invention concerns a transgenic soybean plant producing seed having reduced activity of seed lipoxygenases, when compared to a soybean plant expressing wild type activity of native seed lipoxygenases, the transgenic soybean plant having a nucleic acid fragment from at least a portion of at least one soybean seed lipoxygenase gene, wherein the nucleic acid fragment is capable of suppressing expression of native seed lipoxygenases and has been introduced into the soybean plant by transformation. The present invention also concerns a transgenic soybean plant producing seed having reduced activity of seed lipoxygenases and a second native enzyme, when compared to a soybean plant expressing wild type activity of native seed lipoxygenases and the second native enzyme, the transgenic soybean plant having a first nucleic acid fragment from at least a portion of at least one soybean seed lipoxygenase gene, wherein the first nucleic acid fragment is capable of suppressing expression of said native seed lipoxygenases, and a second nucleic acid fragment from at least a portion of at least one second native enzyme gene, wherein the second nucleic acid fragment is capable of suppressing expression of the native second enzyme, wherein the first nucleic acid fragment and the second nucleic acid fragment have been introduced into the soybean plant by transformation, and wherein the second enzyme is selected from the group consisting of an enzyme of the lipid oxidation pathway, fatty acid desaturation pathway, phenylpropanoid pathway, triterpenoid pathway, and combinations thereof. Methods of suppressing wild type activity of native soybean seed lipoxygenases, alone or in combination with suppression of a second native enzyme are also embodied by the present invention.
摘要翻译：本发明涉及与表达天然种子脂氧合酶的野生型活性的大豆植物相比，产生种子脂氧合酶活性降低的转基因大豆植物，转基因大豆植物具有至少一部分至少一种的核酸片段大豆种子脂氧合酶基因，其中所述核酸片段能够抑制天然种子脂氧合酶的表达，并通过转化被引入大豆植物。本发明还涉及当与表达天然种子脂氧合酶和第二天然酶的野生型活性的大豆植物相比时，产生种子脂氧合酶和第二天然酶活性降低的转基因大豆植物，转基因大豆植物具有第一至少一部分大豆种子脂氧合酶基因的核酸片段，其中所述第一核酸片段能够抑制所述天然种子脂氧合酶的表达，以及第二核酸片段至少部分至少一个第二天然酶基因，其中第二核酸片段能够抑制天然的第二酶的表达，其中通过转化将第一核酸片段和第二核酸片段引入大豆植物中，并且其中选择第二种酶来自由脂质氧化途径的酶组成的组，脂肪酸des 致敏途径，苯丙素途径，三萜途径及其组合。本发明也体现了抑制天然大豆种子脂氧合酶单独或与抑制第二天然酶结合的方法。

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