会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 8. 发明申请
    • BIOMARKERS OF VULNERABLE A THEROSCLEROTIC PLAQUES AND METHODS OF USE
    • 易爆炸药物的生物标志物及其使用方法
    • WO2006093973A2
    • 2006-09-08
    • PCT/US2006007111
    • 2006-02-28
    • UNIV MASSACHUSETTSKIM YOUNG HKIM DUCKSOORUSCKOWSKI NANCY
    • KIM YOUNG HKIM DUCKSOORUSCKOWSKI NANCY
    • C07K14/47C07K7/08C07K14/001G01N33/573G01N33/57484G01N2333/908
    • The present invention provides compositions suitable for use as biomarkers of vulnerable plaques as well as methods for the use of such compositions. In preferred embodiments, specific molecular imaging agents are provided that permit the selective identification of vulnerable plaques in coronary and other arteries using non- invasive imaging methods. Such specific molecular imaging agents comprise a binding partner linked to a detectable label that can be used in vivo to visualize vulnerable plaques. In certain preferred embodiments, the binding partner is a peptide that binds selectively to a component of a vulnerable plaque. In other preferred embodiments, the binding partner is an antibody that binds selectively to a component of a vulnerable plaque. In other preferred embodiments, the binding partner is a portion of a polypeptide displayed by a bacteriophage that binds selectively to a component of a vulnerable plaque. In preferred embodiments, the component of a vulnerable plaque is myeloperoxidase or a portion thereof.
    • 本发明提供适合用作脆弱斑块生物标志物的组合物以及使用这种组合物的方法。 在优选的实施方案中,提供允许使用非侵入性成像方法在冠状动脉和其它动脉中选择性鉴定易受伤害的斑块的特定分子显像剂。 这样的特异性分子显像剂包含与可检测标记连接的结合配偶体,其可以在体内用于显现易受侵袭的斑块。 在某些优选的实施方案中,结合配偶体是选择性地结合易损斑块的组分的肽。 在其它优选的实施方案中,结合配偶体是选择性结合易损斑块组分的抗体。 在其它优选实施方案中,结合配偶体是通过噬菌体展示的多肽展示的部分,所述噬菌体选择性地结合易损斑块的成分。 在优选的实施方案中,脆性斑块的组分是髓过氧化物酶或其一部分。