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1. 发明申请

WO2007017168A1 PROCESS FOR THE PREPARATION OF UBIHYDROQUINONES AND UBIQUINONES 审中-公开
标题翻译：制备UBIHYDROQUINONES和UBIQUINONES的方法
公开(公告)号：WO2007017168A1
公开(公告)日：2007-02-15
申请号：PCT/EP2006/007645
申请日：2006-08-02
申请人： DSM IP ASSETS B.V. , AQUINO, Fabrice , BONRATH, Werner , BOHRER, Patrick , HUGENTOBLER, Max , NETSCHER, Thomas , RADSPIELER, Alexander
发明人： AQUINO, Fabrice , BONRATH, Werner , BOHRER, Patrick , HUGENTOBLER, Max , NETSCHER, Thomas , RADSPIELER, Alexander
IPC分类号： C07C46/06 , C07C50/28 , C07C41/30 , C07C43/23
CPC分类号： C07C46/02 , C07C41/30 , C07C50/28 , C07C43/215 , C07C43/23
摘要： A process for the preparation of ubihydroquinones and ubiquinones by condensation of a prenol or isoprenol with a hydroquinone or derivative thereof in the presence of 0.005 - 1.0 mol% of a catalyst which is a Broensted-acid, a Lewis-acid from the group consisting of a derivative of Bi or In or an element of group 3 of the periodic table of the elements, a heteropolyacid, an NH- or a CH-acidic compound, and optionally oxidizing the ubihydroquinone obtained.
摘要翻译：一种在0.005-1.0摩尔％的催化剂（Broensted-acid），路易斯酸（Lewis酸）的存在下，由Prenol或异戊二烯醇与氢醌或其衍生物缩合制备二氢醌和泛醌的方法， Bi或In的衍生物或元素周期表第3族的元素，杂多酸，NH-或CH-酸性化合物，以及任选地氧化所获得的二氢醌。

2. 发明申请

WO2016059169A1 USE OF A COSMETIC COMPOSITION COMPRISING 10-HYDROXYSTEARIC ACID 审中-公开
标题翻译：使用包含10-羟基酸的化妆品组合物
公开(公告)号：WO2016059169A1
公开(公告)日：2016-04-21
申请号：PCT/EP2015/073912
申请日：2015-10-15
申请人： DSM IP ASSETS B.V.
发明人： IMFELD, Dominik , RADSPIELER, Alexander , SCHUETZ, Rolf
IPC分类号： A61K8/365 , A61K8/67 , A61Q17/04 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/365 , A61K8/671 , A61Q7/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08
摘要： The present invention relates to the cosmetic use of topical compositions comprising 10- hydroxystearic acid, a salt or ester thereof, for application to human skin for improving the condition and appearance of skin more particularly as an anti-wrinkle, for promoting a homogenous skin tone, for reduction of skin pore size, as a photo-protecting agent, and/or for improvement of the skin barrier function.
摘要翻译：本发明涉及包含10-羟基硬脂酸及其盐或酯的局部用组合物在化妆品中的用途，用于改善皮肤的状况和外观，特别是作为抗皱纹，用于促进均匀的肤色，用于减少皮肤孔径，作为光保护剂，和/或用于改善皮肤屏障功能。

3. 发明申请

WO2015185373A1 NOVEL BLEND 审中-公开
标题翻译：新的混合
公开(公告)号：WO2015185373A1
公开(公告)日：2015-12-10
申请号：PCT/EP2015/061322
申请日：2015-05-21
申请人： DSM IP ASSETS B.V.
发明人： KLOCK, Jochen , SCHUELER, Goede , ROSENBERGER, Volker , RADSPIELER, Alexander
IPC分类号： A61Q19/10 , C08K5/04 , C08K5/092 , C08K5/1545
CPC分类号： A61Q19/10 , A61K8/365 , A61K8/42 , A61K8/60 , A61K8/8152
摘要： The present invention relates to a blend comprising saccharide isomerate, water, citric acid, sodium citrate and an acrylic emulsion polymer obtainable by emulsion polymerization of a monomer composition consisting of a mixture of methacrylic acid, ethyl acrylate and n-butyl methacrylate and optionally panthenol. The premixed blend is particularly suitable for the incorporation into skin cleansing formulations to impart a smooth and soft skin feel.
摘要翻译：本发明涉及包含糖异构体，水，柠檬酸，柠檬酸钠和通过由甲基丙烯酸，丙烯酸乙酯和甲基丙烯酸正丁酯和任选的泛醇混合物组成的单体组合物的乳液聚合而获得的丙烯酸乳液聚合物的共混物。预混混合物特别适合于并入皮肤清洁制剂中以赋予平滑和柔软的皮肤感觉。

4. 发明申请

WO2005023740A3 PROCESS FOR THE PREPARATION OF STILBENE DERIVATIVES 审中-公开
公开(公告)号：WO2005023740A3
公开(公告)日：2005-03-17
申请号：PCT/EP2004/009669
申请日：2004-08-31
申请人： DSM IP ASSETS B.V. , HAERTER, Ralph , LEMKE, Ulrike , RADSPIELER, Alexander
发明人： HAERTER, Ralph , LEMKE, Ulrike , RADSPIELER, Alexander
IPC分类号： C07C37/18
摘要： A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process.

5. 发明授权

EP1915333B1 PROCESS FOR THE PREPARATION OF UBIHYDROQUINONES AND UBIQUINONES 有权
标题翻译：工艺用于生产和UBIHYDROCHINONEN泛醌
公开(公告)号：EP1915333B1
公开(公告)日：2015-06-03
申请号：EP06776559.4
申请日：2006-08-02
申请人： DSM IP Assets B.V.
发明人： AQUINO, Fabrice , BONRATH, Werner , BOHRER, Patrick , HUGENTOBLER, Max , NETSCHER, Thomas , RADSPIELER, Alexander
IPC分类号： C07C46/02 , C07C46/06 , C07C50/28 , C07C41/30 , C07C43/23
CPC分类号： C07C46/02 , C07C41/30 , C07C50/28 , C07C43/215 , C07C43/23

6. 发明授权

EP1442014B1 MANUFACTURE OF RETINOIDS 有权
标题翻译：维甲酸的生产
公开(公告)号：EP1442014B1
公开(公告)日：2007-03-21
申请号：EP02779506.1
申请日：2002-10-24
申请人： DSM IP Assets B.V.
发明人： RADSPIELER, Alexander , RUETTIMANN, August
IPC分类号： C07C403/08 , C07C403/10 , C07C403/14
CPC分类号： C07C403/14 , C07B2200/09 , C07C403/04 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/22 , C07C2601/16
摘要： A process for the manufacture of retinal (I) comprises reacting a 5-(2,6,6-trimethyl-cyclohex-1-enyl)-1,4-pentadiene derivative (IIa) or a 5-(2,6,6-trimethyl-cyclohex-2-enyl)-1,4-pentadiene derivative (IIb) or a 5-(2,6,6-trimethyl-2-cyclohexen-1-ylidene)-1-pentene derivative (IIc) or a 5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-1-en-4-yne derivative (IId) or a 5-(2,6,6-trimethyl-cyclohex-2-enyl)-penta-1-en-4-yne derivative (IIe) with a 1,3-butadiene derivative H2C=C(CH3)CCH=CHOR4 (III) in the presence of a Lewis or Brönsted acid and subjecting the compound obtained in each case [(IVa), (IVb), (IVc), (IVd) or (IVe), respectively] to basic or acidic conditions to eliminate therefrom the moiety R2H and thus produce, according to the immediate precursor, retinal itself or a particular derivative thereof [(I'), (I''), (Va) or (Vb), respectively] and, where in two cases such derivative is produced featuring a triple bond [derivative (Va) or (Vb)], hydrogenating this to produce retinal (I) or the derivative (I'), respectively, and each case where a derivative (I') or (I'') has been produced, isomerizing this under basic or acidic conditions or in the presence of a metal catalyst to the desired retinal (I). The so-produced retinal is usually in the form of an isomeric mixture, normally as (9 E/Z, 13 E/Z)-retinal, and this can be isomerized according to a further inventive aspect to (all-E)-retinal by the acid-catalysed formation of an adduct of (all-E)-retinal with hydroquinone in crystalline form. The so obtained (all-E)-retinal-hydroquinone adduct can then if desired be converted to vitamin A alcohol in the predominantly (all-E)-isomeric form by a method known per se. The novel starting materials (IIa), (IIb), (IIc), (IVI) and (IIe) represent a still further inventive aspect. Retinal is a valuable intermediate in the synthesis of further vitamin A compounds (retinoids). The retinoids, particularly vitamin A alcohol (retinol), are known to be valuable substances which promote the well-being of humans, inter alia in respect of vision, the immune system and growth, and for this reason are often used as components of multivitamin preparations and as additives for certain food- and feedstuffs.

7. 发明公开

EP2965785A1 Novel use 审中-公开
标题翻译： Neuartige Verwendung
公开(公告)号：EP2965785A1
公开(公告)日：2016-01-13
申请号：EP14176720.2
申请日：2014-07-11
申请人： DSM IP Assets B.V.
发明人： KLOCK, Jochen , SCHUELER, Goede , ROSENBERGER, Volker , RADSPIELER, Alexander
IPC分类号： A61Q19/00 , A61Q19/10 , A61K8/81
CPC分类号： A61Q19/00 , A61K8/8152 , A61Q19/10
摘要： The present invention relates to skin cleansing composition comprising an anionic surfactant and an acrylic emulsion polymer obtainable by emulsion polymerization of a monomer composition consisting of a mixture of methacrylic acid, ethyl acrylate and n-butyl methacrylate, characterized in that the acrylic emulsion polymer is incorporated into the skin cleansing composition in a concentration ranging from 0.1 to 2 wt.-% based on the total weight of the composition. Furthermore the invention relates to the use of an acrylic emulsion polymer obtainable by emulsion polymerization of a monomer composition consisting of a mixture of methacrylic acid, ethyl acrylate and n-butyl methacrylate as skin conditioning agent.
摘要翻译：本发明涉及包含阴离子表面活性剂和通过由甲基丙烯酸，丙烯酸乙酯和甲基丙烯酸正丁酯的混合物组成的单体组合物的乳液聚合而获得的丙烯酸乳液聚合物的皮肤清洁组合物，其特征在于将丙烯酸乳液聚合物掺入以组合物总重量的0.1至2重量％的浓度进入皮肤清洁组合物。此外，本发明涉及通过由甲基丙烯酸，丙烯酸乙酯和甲基丙烯酸正丁酯的混合物组成的单体组合物通过乳液聚合获得的丙烯酸乳液聚合物作为皮肤调理剂的用途。

8. 发明公开

EP1442014A1 MANUFACTURE OF RETINOIDS 有权
标题翻译： HERSTELLUNG VON RETINOIDEN
公开(公告)号：EP1442014A1
公开(公告)日：2004-08-04
申请号：EP02779506.1
申请日：2002-10-24
申请人： DSM IP Assets B.V.
发明人： RADSPIELER, Alexander , RUETTIMANN, August
IPC分类号： C07C403/08 , C07C403/10 , C07C403/14
CPC分类号： C07C403/14 , C07B2200/09 , C07C403/04 , C07C403/08 , C07C403/10 , C07C403/12 , C07C403/22 , C07C2601/16
摘要： A process for the manufacture of retinal (I) comprises reacting a 5-(2,6,6-trimethyl-cyclohex-1-enyl)-1,4-pentadiene derivative (IIa) or a 5-(2,6,6-trimethyl-cyclohex-2-enyl)-1,4-pentadiene derivative (IIb) or a 5-(2,6,6-trimethyl-2-cyclohexen-1-ylidene)-1-pentene derivative (IIc) or a 5-(2,6,6-trimethyl-cyclohex-1-enyl)-penta-1-en-4-yne derivative (IId) or a 5-(2,6,6-trimethyl-cyclohex-2-enyl)-penta-1-en-4-yne derivative (IIe) with a 1,3-butadiene derivative H2C=C(CH3)CCH=CHOR4 (III) in the presence of a Lewis or Brönsted acid and subjecting the compound obtained in each case [(IVa), (IVb), (IVc), (IVd) or (IVe), respectively] to basic or acidic conditions to eliminate therefrom the moiety R2H and thus produce, according to the immediate precursor, retinal itself or a particular derivative thereof [(I'), (I''), (Va) or (Vb), respectively] and, where in two cases such derivative is produced featuring a triple bond [derivative (Va) or (Vb)], hydrogenating this to produce retinal (I) or the derivative (I'), respectively, and each case where a derivative (I') or (I'') has been produced, isomerizing this under basic or acidic conditions or in the presence of a metal catalyst to the desired retinal (I). The so-produced retinal is usually in the form of an isomeric mixture, normally as (9 E/Z, 13 E/Z)-retinal, and this can be isomerized according to a further inventive aspect to (all-E)-retinal by the acid-catalysed formation of an adduct of (all-E)-retinal with hydroquinone in crystalline form. The so obtained (all-E)-retinal-hydroquinone adduct can then if desired be converted to vitamin A alcohol in the predominantly (all-E)-isomeric form by a method known per se. The novel starting materials (IIa), (IIb), (IIc), (IVI) and (IIe) represent a still further inventive aspect. Retinal is a valuable intermediate in the synthesis of further vitamin A compounds (retinoids). The retinoids, particularly vitamin A alcohol (retinol), are known to be valuable substances which promote the well-being of humans, inter alia in respect of vision, the immune system and growth, and for this reason are often used as components of multivitamin preparations and as additives for certain food- and feedstuffs.
摘要翻译：制备视网膜（I）的方法包括使5-（2,6,6-三甲基 - 环己-1-烯基）-1,4-戊二烯衍生物（IIa）或5-（2,6,6 - 三甲基 - 环己-2-烯基）-1,4-戊二烯衍生物（IIb）或5-（2,6,6-三甲基-2-环己烯-1-亚基）-1-戊烯衍生物（IIc）或 5-（2,6,6-三甲基 - 环己-1-烯基） - 戊-1-烯-4-炔衍生物（IId）或5-（2,6,6-三甲基 - 环己-2-烯基） - 戊-1-烯-4-炔衍生物（IIe）与1,3-丁二烯衍生物H 2 C-C（CH 3）CCH-CHOR 4（III）在路易斯或布朗斯台德酸存在下反应，情况[（IVa），（IVb），（IVc），（IVd）或（IVe）]分解为碱性或酸性条件以从其中除去部分R 2 H，从而根据直接前体产生视网膜本身或特定衍生物[（I'），（I“），（Va）或（Vb）]，并且在两种情况下，以三键[衍生物（Va）或（Vb）]为特征的衍生物，这产生视网膜（I）或衍生物（I'），以及衍生物（I'）或（I“）的每种情况，在碱性或酸性条件下或在金属催化剂存在下使其异构化为所需的视网膜（I ）。如此产生的视网膜通常为异构体混合物的形式，通常为（9E / Z，13E / Z） - 视网膜，并且其可以根据另外的发明方面异构化为（全E） - 视神经通过酸性催化形成（全E） - 视黄酸与氢醌的结晶形式的加合物。如果需要，可以通过本身已知的方法将如此获得的（全E） - 视黄醛 - 氢醌加合物转化为主要（全E）异构体形式的维生素A醇。新型起始原料（IIa），（IIb），（IIc），（IVI）和（IIe）代表又一发明方面。视网膜是合成其他维生素A化合物（类视黄醇）的有价值的中间体。维生素A，特别是维生素A酒精（视黄醇）已知是促进人类福祉的有价值物质，特别是在视力，免疫系统和生长方面，因此通常用作多种维生素的组分制剂和某些食品和饲料的添加剂。

9. 发明授权

EP3206659B1 USE OF A COSMETIC COMPOSITION COMPRISING 10-HYDROXYSTEARIC ACID 有权
公开(公告)号：EP3206659B1
公开(公告)日：2019-12-25
申请号：EP15780898.1
申请日：2015-10-15
申请人： DSM IP Assets B.V.
发明人： IMFELD, Dominik , RADSPIELER, Alexander , SCHUETZ, Rolf
IPC分类号： A61K8/365 , A61K8/67 , A61Q17/04 , A61Q19/00 , A61Q19/08

10. 发明公开

EP3206659A1 USE OF A COSMETIC COMPOSITION COMPRISING 10-HYDROXYSTEARIC ACID 有权
标题翻译：使用含有10-羟基硬脂酸的化妆品组合物
公开(公告)号：EP3206659A1
公开(公告)日：2017-08-23
申请号：EP15780898.1
申请日：2015-10-15
申请人： DSM IP Assets B.V.
发明人： IMFELD, Dominik , RADSPIELER, Alexander , SCHUETZ, Rolf
IPC分类号： A61K8/365 , A61K8/67 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to the cosmetic use of topical compositions comprising 10-hydroxystearic acid, a salt or ester thereof, for application to human skin for improving the condition and appearance of skin more particularly as an anti-wrinkle, for promoting a homogenous skin tone, for reduction of skin pore size, as a photo-protecting agent, and/or for improvement of the skin barrier function.
摘要翻译：本发明涉及包含10-羟基硬脂酸，其盐或酯的局部用组合物的化妆用途，其用于施用于人类皮肤以改善皮肤的状况和外观，更具体地用作抗皱纹，用于促进均匀肤色，减少皮肤孔径，作为光保护剂，和/或改善皮肤屏障功能。

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