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1. 发明申请

WO2006084722A2 NOVEL GENE STS 15 审中-公开
标题翻译：新基因STS 15
公开(公告)号：WO2006084722A2
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001217
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/14 , C12P17/04
CPC分类号： C12P7/60 , C12N9/14 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

2. 发明申请

WO2006084721A1 ALCOHOL DEHYDROGENASE GENE FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：来自葡萄糖酸氧化酶的酒精脱氢酶基因
公开(公告)号：WO2006084721A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001216
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/04 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0006
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在从微生物生产维生素C中的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

3. 发明申请

WO2006084729A1 GENE RCS O1 审中-公开
公开(公告)号：WO2006084729A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001224
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/02 , C12P17/04
CPC分类号： C12N9/0055 , C12N9/0006 , C12N9/0057 , C12P17/04
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

4. 发明申请

WO2006084723A1 GENE STS 17 审中-公开
标题翻译：基因STS 17
公开(公告)号：WO2006084723A1
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001218
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/00 , C12P17/04
CPC分类号： C12P17/04 , C07K14/195 , C12P7/60
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

5. 发明申请

WO2006084706A2 NOVEL GENE STS 07 审中-公开
标题翻译：新基因ST 07
公开(公告)号：WO2006084706A2
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001198
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
CPC分类号： C12P17/04 , C07K14/195
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成（以下也称为维生素C）的蛋白质的新鉴定的基因。本发明还涉及包含新基因及其片段的全长多核苷酸序列的多核苷酸，由多核苷酸及其片段编码的新多肽及其功能等同物。本发明还涉及所述多核苷酸和多肽在从微生物生产维生素C中作为生物技术工具的用途，其中所述多核苷酸和/或编码多肽的修饰对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/方法。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

6. 发明申请

WO2006084704A3 NOVEL GENE STS 01 审中-公开
公开(公告)号：WO2006084704A3
公开(公告)日：2006-08-17
申请号：PCT/EP2006/001196
申请日：2006-02-10
申请人： DSM IP ASSETS B.V. , CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N15/11 , C07K14/705
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

7. 发明公开

EP1846440A1 GENE FOR COENZYME PQQ SYNTHESIS PROTEIN B FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译： GEN辅酶PQQ合成蛋白B FROM氧化葡糖杆菌
公开(公告)号：EP1846440A1
公开(公告)日：2007-10-24
申请号：EP06706855.1
申请日：2006-02-10
申请人： DSM IP Assets B.V.
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C07K14/195 , C12P17/04
CPC分类号： C12P7/60 , C07K14/195 , C12P17/04
摘要： The present invention relates to a newly identified gene that encodes a protein that is involved in the synthesis of L-ascorbic acid (hereinafter also referred to a Vitamin C). The protein is coenzyme PQQ synthesis protein B. The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

8. 发明公开

EP1846551A1 GENE RCS 25 审中-公开
标题翻译：基因RCS 25
公开(公告)号：EP1846551A1
公开(公告)日：2007-10-24
申请号：EP06706854.4
申请日：2006-02-10
申请人： DSM IP Assets B.V.
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/00 , C12P17/04
CPC分类号： C12P17/04 , C07K14/195
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成的蛋白质（以下也称为维生素C）的新鉴定的基因。本发明的特征还在于包含新基因及其片段的全长多核苷酸序列的多核苷酸，由该多核苷酸及其片段编码的新多肽以及它们的功能等价物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在由微生物生产维生素C中的用途，由此修饰所述多核苷酸和/或编码的多肽对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/过程。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

9. 发明公开

EP1846565A1 GENE RCS 21 审中-公开
标题翻译：基因RCS 21
公开(公告)号：EP1846565A1
公开(公告)日：2007-10-24
申请号：EP06706853.6
申请日：2006-02-10
申请人： DSM IP Assets B.V.
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12P17/04 , C12P7/60
CPC分类号： C12P17/04 , C07K14/195
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.
摘要翻译：本发明涉及编码参与L-抗坏血酸合成的蛋白质（以下也称为维生素C）的新鉴定的基因。本发明的特征还在于包含新基因及其片段的全长多核苷酸序列的多核苷酸，由该多核苷酸及其片段编码的新多肽以及它们的功能等价物。本发明还涉及所述多核苷酸和多肽作为生物技术工具在由微生物生产维生素C中的用途，由此修饰所述多核苷酸和/或编码的多肽对产量，产量和/或所述微生物中发酵产物的生产效率。还包括使用多核苷酸和修饰的多核苷酸序列转化宿主微生物的方法/过程。本发明还涉及基因工程微生物及其用于直接生产维生素C的用途。

10. 发明公开

EP1846555A1 ALCOHOL DEHYDROGENASE GENE FROM GLUCONOBACTER OXYDANS 审中-公开
标题翻译：醇酸脱氢酶一氧化氮氧化酶
公开(公告)号：EP1846555A1
公开(公告)日：2007-10-24
申请号：EP06706842.9
申请日：2006-02-10
申请人： DSM IP Assets B.V.
发明人： CHEVREUX, Bastien , MAYER, Anne Françoise , MEURY, Anja , MOUNCEY, Nigel John , SHINJOH, Masako
IPC分类号： C12N9/04 , C12P17/04
CPC分类号： C12P17/04 , C12N9/0006
摘要： The present invention relates to newly identified genes that encode proteins that are involved in the synthesis of L-ascorbic acid (hereinafter also referred to as Vitamin C). The invention also features polynucleotides comprising the full-length polynucleotide sequences of the novel genes and fragments thereof, the novel polypeptides encoded by the polynucleotides and fragments thereof, as well as their functional equivalents. The present invention also relates to the use of said polynucleotides and polypeptides as biotechnological tools in the production of Vitamin C from microorganisms, whereby a modification of said polynucleotides and/or encoded polypeptides has a direct or indirect impact on yield, production, and/or efficiency of production of the fermentation product in said microorganism. Also included are methods/processes of using the polynucleotides and modified polynucleotide sequences to transform host microorganisms. The invention also relates to genetically engineered microorganisms and their use for the direct production of Vitamin C.

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