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1. 发明申请

WO2007042271A8 NUTRACEUTICAL COMPOSITION FOR THE TREATMENT OF MUSCLE WASTING 审中-公开
标题翻译：用于治疗肌肉废物的营养组合物
公开(公告)号：WO2007042271A8
公开(公告)日：2008-08-28
申请号：PCT/EP2006009814
申请日：2006-10-11
申请人： DSM IP ASSETS BV , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WOLFRAM SWEN
发明人： RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WOLFRAM SWEN
IPC分类号： A61K31/05 , A23L1/30 , A61K31/353 , A61P21/00
CPC分类号： A61K31/353 , A23L33/10 , A61K31/05
摘要： The use of at least one component selected from the group consisting of EGCG, hydroxytyrosol, resveratrol and derivatives, metabolites or analogues thereof in the manufacture of a nutraceutical composition for the prevention and treatment of muscle wasting leading to muscle loss, atrophy and other associated muscle disorders in animals, in particular mammals including humans.
摘要翻译：使用至少一种选自EGCG，羟基酪醇，白藜芦醇及其衍生物，代谢物或类似物的组分在制备营养组合物中用于预防和治疗导致肌肉损失的肌肉消瘦，萎缩和其它相关肌肉动物，特别是哺乳动物，包括人类的疾病。

2. 发明申请

WO2007042271A3 NUTRACEUTICAL COMPOSITION FOR THE TREATMENT OF MUSCLE WASTING 审中-公开
标题翻译：用于治疗肌肉消耗的营养组合物
公开(公告)号：WO2007042271A3
公开(公告)日：2008-02-14
申请号：PCT/EP2006009814
申请日：2006-10-11
申请人： DSM IP ASSETS BV , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WOLFRAM SWEN
发明人： RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WOLFRAM SWEN
IPC分类号： A61K31/05 , A23L1/30 , A61K31/353 , A61P21/00
CPC分类号： A61K31/353 , A23L33/10 , A61K31/05
摘要： The use of at least one component selected from the group consisting of EGCG, hydroxytyrosol, resveratrol and derivatives, metabolites or analogues thereof in the manufacture of a nutraceutical composition for the prevention and treatment of muscle wasting leading to muscle loss, atrophy and other associated muscle disorders in animals, in particular mammals including humans.
摘要翻译：选自EGCG，羟基酪醇，白藜芦醇及其衍生物，代谢物或其类似物的至少一种组分在制备用于预防和治疗肌肉萎缩导致肌肉萎缩，萎缩和其他相关肌肉的营养组合物中的用途动物疾病，特别是包括人类在内的哺乳动物。

3. 发明申请

WO2007134867A2 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：WO2007134867A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007004627
申请日：2007-05-24
申请人： DSM IP ASSETS BV , D ORAZIO DANIEL , RAEDERSTORFF DANIEL , SCHUELER GOEDE , WANG-SCHMIDT YING , WERTZ KARIN , WOLFRAM SWEN
发明人： D ORAZIO DANIEL , RAEDERSTORFF DANIEL , SCHUELER GOEDE , WANG-SCHMIDT YING , WERTZ KARIN , WOLFRAM SWEN
IPC分类号： A61P21/00 , A23L1/30 , A61K31/12 , A61K31/166 , A61K31/352 , A61P1/00 , A61P9/00 , A61P9/10 , A61P19/02
CPC分类号： A23K20/111 , A23L2/52 , A23L33/10 , A23V2002/00 , A61K31/12 , A61K31/166 , A61K31/352 , A23V2200/316 , A23V2200/328 , A23V2200/326 , A23V2200/318 , A23V2200/32
摘要： The present invention refers to compounds of the general formulae Ia to Ie as defined above for use as/in a composition (especially foods and dietary supplements, cosmetic, as well as pharmaceutical compositions) for the prevention and improvement of muscular disorders and for the improvement of muscle function. Other fields of use are disorders connected to impaired lipid metabolism, impaired glucose metabolism and impaired insulin action, obesity, overweight conditions, eating disorders such as bulimia and anorexia nervosa, cardiovascular diseases, atherosclerosis, vascular diseases, heart failure, inflammatory disorders such as arthritis, rheumatoid arthritis, osteoarthritis, gout, gastrointestinal disorders such as inflammatory bowel syndrome, Crohn's disease, gastritis, irritable bowel syndrome and ulcerative colitis, skin related conditions such as psoriasis, eczema, burns, dermatitis, and allergy,, respiratory disorders such as asthma, chronic obstructive pulmonary disease (COPD), allergic diseases, and/or bone disorders such as osteoporosis and osteopenia. The compounds may also be used for bodyshaping, for improving the muscle : fat ratio or for accelerating skin wound healing. The present invention is also directed to dietary compositions such as (fortified) food, beverages, (fortified) feed, food additives, beverage additives, feed additives, clinical nutrition, dietary supplements, functional food, functional feed and nutraceuticals and to pharmaceutical compositions containing such compounds, to methods of treating the above mentioned disorders/diseases in mammals including humans and to the compounds of the formula I themselves. Another object of the present invention is the use of such compounds for the manufacture of a composition for the treatment of such disorders/diseases as mentioned above.
摘要翻译：本发明涉及如上定义的用于预防和改善肌肉疾病和改善的组合物（特别是食品和膳食补充剂，化妆品以及药物组合物）中的上述通式Ia至Ie的化合物的肌肉功能。其他使用领域是与脂质代谢受损，葡萄糖代谢受损和胰岛素作用受损，肥胖症，超重症状，进食障碍如贪食症和神经性厌食症，心血管疾病，动脉粥样硬化，血管疾病，心力衰竭，炎症性疾病如关节炎相关的疾病，类风湿性关节炎，骨关节炎，痛风，胃肠道疾病如肠炎综合征，克罗恩病，胃炎，肠易激综合征和溃疡性结肠炎，皮肤相关病症如牛皮癣，湿疹，烧伤，皮炎和过敏，呼吸系统疾病如哮喘，慢性阻塞性肺疾病（COPD），过敏性疾病和/或骨骼疾病如骨质疏松症和骨质减少。这些化合物也可用于体脂整形，用于改善肌肉：脂肪比例或用于加速皮肤伤口愈合。本发明还涉及饮食组合物，例如（强化）食品，饮料，（强化）饲料，食品添加剂，饮料添加剂，饲料添加剂，临床营养，膳食补充剂，功能性食品，功能性饲料和营养食品，以及含有这些化合物，涉及治疗哺乳动物（包括人）和式I本身化合物的上述疾病/疾病的方法。本发明的另一个目的是使用这些化合物来制备用于治疗如上所述的这种疾病/疾病的组合物。

4. 发明申请

WO2007042272A2 NOVEL USE OF NUTRACEUTICAL COMPOSITIONS COMPRISING RESVERATROL 审中-公开
标题翻译：使用包含RESVERATROL的营养组合物的新用途
公开(公告)号：WO2007042272A2
公开(公告)日：2007-04-19
申请号：PCT/EP2006009815
申请日：2006-10-11
申请人： DSM IP ASSETS BV , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WOLFRAM SWEN
发明人： RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WOLFRAM SWEN
IPC分类号： A61K31/05 , A61P43/00
CPC分类号： A61K31/353 , A23L33/10 , A23L33/12 , A23L33/15 , A61K31/05 , A61K2300/00
摘要： The use of resveratrol, a derivative, metabolite or analogue thereof, in combination with at least one additional component selected from EGCG, coenzyme Q-IO, genistein, lycopene, hydroxytyrosol and polyunsaturated fatty acids in the manufacture of a nutraceutical composition for delaying aging and/or for the treatment or prevention of age-related diseases in animals, in particular in mammals including humans.
摘要翻译：在制备用于延迟衰老的营养药物组合物中使用白藜芦醇，其衍生物，代谢产物或类似物与至少一种选自EGCG，辅酶Q-10，染料木素，番茄红素，羟基酪醇和多不饱和脂肪酸的另外的组分的组合，以及 /或用于治疗或预防动物，特别是包括人在内的哺乳动物中的年龄相关疾病。

5. 发明申请

WO2009103754A3 NOVEL USE OF 3,3'-DIINDOLYLMETHANE 审中-公开
标题翻译： 3,3'-DIINDOLYLMETHANE的新用途
公开(公告)号：WO2009103754A3
公开(公告)日：2009-11-12
申请号：PCT/EP2009051958
申请日：2009-02-19
申请人： DSM IP ASSETS BV , HUG HUBERT , MUSSELR BERND , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING
发明人： HUG HUBERT , MUSSELR BERND , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING
IPC分类号： A23L1/30 , A61K31/404 , A61P17/00 , A61P43/00
CPC分类号： A61K31/404 , A23L33/10 , A23L33/105
摘要： The present invention relates to a novel use of 3,3'-diindolylmethane (CAS1968-05-4) and/or its derivatives in the form of a pharmaceutical and/or nutritional composition to retard or delay typical signs of aging and/or age-related pathological changes.
摘要翻译：本发明涉及以药物和/或营养组合物形式的3,3'-二吲哚基甲烷（CAS1968-05-4）和/或其衍生物的新用途，以延缓或延缓老化和/或老化的典型迹象相关病理变化。

6. 发明申请

WO2008061755A8 DIETARY AND PHARMACEUTICAL COMPOSITIONS CONTAINING CARNOSOL AND/OR ROSMANOL AND THEIR USES 审中-公开
标题翻译：含有卡罗糖醇和/或罗莫诺的膳食和药物组合物及其用途
公开(公告)号：WO2008061755A8
公开(公告)日：2009-07-30
申请号：PCT/EP2007010133
申请日：2007-11-22
申请人： DSM IP ASSETS BV , NESTEC SA , FOWLER ANN , GORALCZYK REGINA , KILPERT CLAUS , MOHAJERI HASAN , RAEDERSTORFF DANIEL , DE SAIZIEU ANTOINE , SCHUELER GOEDE , WANG-SCHMIDT YING , WEHRLI CHRISTOF
发明人： FOWLER ANN , GORALCZYK REGINA , KILPERT CLAUS , MOHAJERI HASAN , RAEDERSTORFF DANIEL , DE SAIZIEU ANTOINE , SCHUELER GOEDE , WANG-SCHMIDT YING , WEHRLI CHRISTOF
IPC分类号： A23L1/30 , A23K1/16 , A61K36/00
CPC分类号： A61K31/365 , A23K20/10 , A23K20/111 , A23L33/105 , A61K2300/00
摘要： The present invention refers to carnosol and rosmanol for use (as medicament) in the treatment of a disorder connected to reduced neurotransmission, cognitive dysfunction and/or symptoms caused by headache and/or migraine, as well as to dietary and pharmaceutical compositions and their uses.
摘要翻译：本发明涉及用于治疗与减少的神经传递，认知功能障碍和/或由头痛和/或偏头痛引起的症状相关的病症的鼠属溶胶和rosmanol，以及饮食和药物组合物及其用途。

7. 发明申请

WO2009144093A8 HYDROXYTYROSOL BENEFITS MITOCHONDRIA 审中-公开
标题翻译：羟喹诺酮益生菌
公开(公告)号：WO2009144093A8
公开(公告)日：2011-01-06
申请号：PCT/EP2009054585
申请日：2009-04-17
申请人： DSM IP ASSETS BV , LIU JIANKANG , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WERTZ KARIN
发明人： LIU JIANKANG , RAEDERSTORFF DANIEL , WANG-SCHMIDT YING , WERTZ KARIN
IPC分类号： A61K31/05 , A23L1/00 , A61K36/63 , A61P1/16 , A61P7/00 , A61P9/00 , A61P21/00
CPC分类号： A61K31/05 , A61K36/63
摘要： Hydroxytyrosol or olive juice containing hydroxytyrosol can be used to maintain or increase mitochondrial biogenesis in cardiac muscle, skeletal muscles, and liver tissue.
摘要翻译：含有羟基酪醇的羟基酪醇或橄榄汁可用于维持或增加心肌，骨骼肌和肝组织中的线粒体生物发生。

8. 发明申请

WO2006131326B1 NOVEL USE OF (-)-EPIGALLOCATECHIN GALLATE 审中-公开
标题翻译：（ - ） - EPIGALLOCATECHIN GALLATE的新用途
公开(公告)号：WO2006131326B1
公开(公告)日：2007-11-01
申请号：PCT/EP2006005410
申请日：2006-06-07
申请人： DSM IP ASSETS BV , RAEDERSTORFF DANIEL , RIEGGER CHRISTOPH , THIELECKE FRANK
发明人： RAEDERSTORFF DANIEL , RIEGGER CHRISTOPH , THIELECKE FRANK
IPC分类号： A61P3/04 , A61K31/352 , A61K31/522 , A61K45/06 , A61P3/06
CPC分类号： A61K45/06 , A61K31/352 , A61K31/522
摘要： The present invention refers to the use of (-) -epigallocatechin gallate, preferably in combination with a sympathomimeticum, preferably caffeine, .
摘要翻译：本发明涉及（ - ） - 表没食子儿茶素没食子酸酯的使用，优选与拟交感神经元，优选咖啡因组合使用，否则改善脂肪代谢和碳水化合物代谢，从而改善多种病理生理条件。

9. 发明申请

WO2006125651A2 NOVEL USE OF ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物的新用途
公开(公告)号：WO2006125651A2
公开(公告)日：2006-11-30
申请号：PCT/EP2006005005
申请日：2006-05-24
申请人： DSM IP ASSETS BV , FOWLER ANN , RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH
发明人： FOWLER ANN , RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH
IPC分类号： A61K31/343 , A61P11/00 , A61P19/02 , A61P19/06 , A61P29/00
CPC分类号： A61K31/343
摘要： The present invention relates to the use of compounds of the formula (I) wherein the clotted line is an optional bond; R 1 is butyl or butyryl if R 2 is hydroxyl but is butyl if R 2 is hydrogen; or R 1 and R 2 taken together are 1-butylidene optionally substituted by hydroxyl, methyl, or 3- (a,ß-dimethylacrylyloxy)-pentylidenyl; X is a residue selected from the group consisting of X1 , X2, X3, X4, and X5; wherein X is X2, X3or X5 if the dotted line in formula (I) is absent ;and X is X1 , X4 or X5 if the dotted line signifies a bond in formula (I) above; R 3 is hydroxyl or butyryl; and n is 1 or 2, as agents for the prevention, control and treatment of conditions requiring modulation of inflammation in mammals. In another aspect, the present invention relates to the use of compounds of the formula (I) as active ingredients in the manufacture of medicaments/compositions for the prevention, control and treatment of conditions requiring modulation of inflammation. The compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the management of pain, fever and injuries, especially sport injuries. Moreover, the compounds of formula (I) as defined above may also be useful (for the manufacture of a composition) for the maintenance and regeneration of articular cartilage.
摘要翻译：本发明涉及式（I）化合物的用途，其中凝血线是任选的键; 如果R 2是羟基，则R 1是丁基或丁酰基，如果R 2是氢，则是丁基; 或R 1和R 2一起是任选被羟基，甲基或3-（a，β-二甲基丙烯酰氧基） - 戊酰基取代的1-亚丁基; X是选自X1，X2，X3，X4和X5的残基; 其中，如果不存在式（I）中的虚线，X为X 2，X 3或X 5;如果虚线表示上述式（I）中的键，X为X 1，X 4或X 5; R 3是羟基或丁酰基; 和n为1或2，作为预防，控制和治疗需要调节哺乳动物炎症的病症的药剂。另一方面，本发明涉及式（I）化合物作为活性成分在制备用于预防，控制和治疗需要调节炎症的病症的药物/组合物中的用途。如上定义的式（I）化合物也可用于治疗疼痛，发烧和损伤，特别是运动损伤（用于制造组合物）。此外，如上定义的式（I）化合物也可用于维持和再生关节软骨（用于制备组合物）。

10. 发明申请

WO2008061720A3 USE OF TRICYCLIC DITERPENES AND THEIR DERIVATIVES FOR THE TREATMENT, CO-TREATMENT OR PREVENTION OF INFLAMMATORY DISORDERS AND/OR JOINT DISORDERS 审中-公开
标题翻译：治疗，治疗或预防感染性疾病和/或联合疾病的三环磷酸酯及其衍生物的使用
公开(公告)号：WO2008061720A3
公开(公告)日：2008-10-23
申请号：PCT/EP2007010071
申请日：2007-11-21
申请人： DSM IP ASSETS BV , RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH , WEHRLI CHRISTOF
发明人： RAEDERSTORFF DANIEL , SCHUELER GOEDE , SCHWAGER JOSEPH , WEHRLI CHRISTOF
IPC分类号： A61K31/05 , A23K1/16 , A23K1/18 , A61K8/34 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/49 , A61K31/122 , A61K31/192 , A61K31/216 , A61K31/343 , A61P17/00 , A61P17/16 , A61P19/02
CPC分类号： A61K31/192 , A23K20/105 , A23K50/40 , A23L33/105 , A23V2002/00 , A61K8/347 , A61K8/35 , A61K8/365 , A61K8/37 , A61K8/4973 , A61Q17/04 , A61Q19/005 , A61Q19/08 , A23V2200/324 , A23V2250/21
摘要： The present invention refers to the use of at least one tricyclic diterpenes for the manufacture of a nutraceutical or pharmaceutical for the treatment, co-treatment or prevention of inflammatory disorders and/ or joint disorders.
摘要翻译：本发明涉及至少一种三环二萜用于制备用于治疗，共同治疗或预防炎症性疾病和/或关节病症的营养药物或药物的用途。

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